Editorial Material
Endocrinology & Metabolism
Rachel L. Batterham
Summary: Weight stigma, a treatment widely advocated in the healthcare field for a prevalent chronic medical condition, has been proven by a large body of evidence to have detrimental effects on health and increased mortality risk.
NATURE REVIEWS ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Moran Livne-Margolin, Itay Tokatly Latzer, Orit Pinhas-Hamiel, Gil Harari, Anat Achiron
Summary: The study found that the disability level in individuals with MS was not correlated with disease duration, lifestyle habits, or overweight/obesity, but was associated with central obesity.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Plant Sciences
Ningning Zhang, Benedikt Venn, Catherine E. Bailey, Ming Xia, Erin M. Mattoon, Timo Muehlhaus, Ru Zhang
Summary: Moderate high temperature has dynamic effects in the green alga Chlamydomonas reinhardtii depending on the carbon availability. Carbon metabolism is important in the thermotolerance of photosynthetic cells.
JOURNAL OF EXPERIMENTAL BOTANY
(2023)
Review
Endocrinology & Metabolism
Jiayi Sun, Xin Shen, Hui Liu, Siying Lu, Jing Peng, Haibin Kuang
Summary: Caloric restriction (CR) is an intervention that affects female reproduction by regulating the hypothalamic and peripheral mediators, impacting fertility while preserving reproductive capacity. Understanding the comprehensive effects of CR on the central and peripheral systems, as well as its relationship with reproductive-associated diseases, can provide better strategies for managing and preventing female reproductive dysfunctions.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2021)
Article
Nutrition & Dietetics
Daniela Palleri, Ylenia Bartolacelli, Anna Balducci, Simone Bonetti, Rossana Zanoni, Cristina Ciuca, Valentina Gesuete, Ambra Bulgarelli, Tammam Hasan, Luca Ragni, Emanuela Angeli, Gaetano Domenico Gargiulo, Andrea Donti
Summary: The study aimed to describe the growth parameters of Italian children with congenital heart disease (CHD) compared to healthy children. Anthropometric data of pediatric patients with CHD and healthy controls were collected. The results showed that healthy children had better growth indicators in terms of age, height, and weight compared to children with CHD, and the latter group exhibited higher rates of stunting and underweight.
Article
Physiology
Naresh C. Bal, Subash C. Gupta, Meghna Pant, Danesh H. Sopariwala, Geoffrey Gonzalez-Escobedo, Joanne Turner, John S. Gunn, Christopher R. Pierson, Scott Q. Harper, Jill A. Rafael-Fortney, Muthu Periasamy
Summary: Sarcolipin (SLN) is a regulator of the SERCA pump and its expression is significantly upregulated during muscle development and in disease states. Studies suggest that upregulation of SLN in disease might be detrimental for muscle function, while in muscle diseases, SLN expression increases progressively with severity.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Endocrinology & Metabolism
Lea Pietri, Roch Giorgi, Audrey Begu, Manon Lojou, Marie Koubi, Raphael Cauchois, Rachel Grangeot, Noemie Dubois, Gilles Kaplanski, Rene Valero, Sophie Beliard
Summary: The study found a significant association between excess body weight and severe forms of COVID-19, with excess body weight patients having a higher risk of serious events independently of their age. Excess body weight was identified as the sole predictor for developing severe events linked to SARS-CoV-2 infection.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Article
Nutrition & Dietetics
Ligia J. Dominguez, Alfredo Gea, Liz Ruiz-Estigarribia, Carmen Sayon-Orea, Ujue Fresan, Mario Barbagallo, Miguel Ruiz-Canela, Miguel A. Martinez-Gonzalez
Summary: This study found that low dietary magnesium intake (less than 200 mg/d) was associated with an increased risk of developing hypertension in a Mediterranean population, especially in overweight/obese individuals. Adherence to the Mediterranean diet did not modify this association.
Review
Neurosciences
Xinpeng Deng, Ziliang Hu, Shengjun Zhou, Yiwen Wu, Menglin Fu, Chenhui Zhou, Jie Sun, Xiang Gao, Yi Huang
Summary: This review summarizes the latest research on single-cell sequencing in acute ischemic stroke (AIS). It explores the phenotypes and functions of various brain cell types, such as microglia, astrocytes, oligodendrocytes, neurons, and neutrophils, and their subtypes at different time points following AIS. The review focuses on the interactions between microglia and astrocytes, oligodendrocytes, and neurons, revealing diverse roles and the possibility of interconversion between different subclusters.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Review
Endocrinology & Metabolism
Beatriz Rodrigues Risuenho Peinado, Deborah Ribeiro Frazao, Leonardo Oliveira Bittencourt, Renata Duarte de Souza-Rodrigues, Maria Tereza Campos Vidigal, Douglas Teixeira da Silva, Luiz Renato Paranhos, Marcela Barauna Magno, Nathalia Carolina Fernandes Fagundes, Lucianne Cople Maia, Rafael Rodrigues Lima
Summary: Obesity is a growing public health problem and food consumption decisions, influenced by taste perceptions, play an important role. A systematic review found an association between obesity and taste alterations, indicating the need for further research to confirm this hypothesis using more sensitive methods.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Elizabeth Benites, Esmeralda Carrillo, Martha Heras
Summary: This study evaluated the effects of methotrexate and etanercept treatment in psoriasis and verified their response to the PASI index. The results showed that treatment with etanercept and methotrexate had favorable effects on moderate and severe psoriasis.
Article
Medicine, Research & Experimental
Jerome R. Lechien, Francois Bobin, Vinciane Muls, Sven Saussez, Stephane Hans
Summary: This study aimed to investigate the impact of obesity and overweight on patients with laryngopharyngeal reflux (LPR), finding that obese patients were more likely to have gastroesophageal reflux disease (GERD) and acid LPR compared to normal weight and overweight patients. Obesity was associated with a more severe LPR disease, requiring more frequent proton pump inhibitor therapy.
Article
Environmental Sciences
Qiuyun Xu, Xiuqing Shao, Yajuan Shi, Li Qian, Xuan Zhou, Wenyou Qin, Meng Zhang
Summary: The uneven distribution of selenium in soils leads to varying effects on earthworms, with low and medium exposure concentrations not significantly affecting growth, and only high concentrations leading to growth inhibition. Selenium exposure alters the metabolism of certain amino acids and selenoamino acids, affecting overall metabolism levels at medium and high exposure concentrations. Reactive oxygen species derived at high concentrations are likely responsible for the growth inhibition effect of selenium on earthworms.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Nutrition & Dietetics
Ahsan Hameed, Edyta Adamska-Patruno, Joanna Godzien, Przemyslaw Czajkowski, Urszula Miksza, Karolina Pietrowska, Joanna Fiedorczuk, Monika Moroz, Witold Bauer, Julia Sieminska, Maria Gorska, Adam Jacek Kretowski, Michal Ciborowski
Summary: The study used metabolomics to investigate the mechanisms by which high-carbohydrate meals contribute to the development of metabolic syndrome. It found that overweight/obese individuals had dysregulated metabolic pathways after consuming high-carbohydrate meals, while normal-weight individuals did not. Consumption of high-carbohydrate meals led to a significant increase in certain metabolites, particularly phospholipids and fatty acid amides, in overweight/obese individuals. The intake of cinnamon and capsicum normalized the concentration of these altered metabolites.
Article
Gastroenterology & Hepatology
Bhairavi Balram, Harshad Joshi, Karen Wong, Karen I. Kroeker, Levinus A. Dieleman, Brendan P. Halloran, Daniel C. Baumgart, Farhad Peerani
Summary: This study found that continuing 5-ASA therapy in ulcerative colitis patients escalated to infliximab did not provide additional benefit in controlling inflammation, and was not associated with increased likelihood of achieving clinical and endoscopic remission.
DIGESTIVE DISEASES AND SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Louise Linde, Sivagowry Rasalingam Mork, Emilie Gregers, Jo Bonding Andreasen, Jens Flensted Lassen, Hanne Berg Ravn, Henrik Schmidt, Lars Peter Riber, Sisse Anette Thomassen, Helle Laugesen, Hans Eiskjaer, Christian Juhl Terkelsen, Steffen Christensen, Mariann Tang, Hasse Moeller-Soerensen, Lene Holmvang, Jesper Kjaergaard, Christian Hassager, Jacob Eifer Moller
Summary: This study examined the characteristics of patients with refractory cardiac arrest who were admitted for possible ECPR in Denmark, as well as the reasons for refraining from treatment. The results showed that the main reasons for not initiating ECPR were long duration of prehospital low-flow time, metabolic derangement, and low ETCO2.
Article
Substance Abuse
Alan Manivannan, Morten Schou, Kevin M. Monahan, Robert Helm, Darae Ko, Emil Fosbol, Lars Kober, Finn Gustafsson, Gunnar H. Gislason, Christian Torp-Pedersen, Charlotte Andersson
Summary: Alcoholic cardiomyopathy (ACM) is associated with poor outcomes, but the high mortality is not driven by atrial fibrillation. Oral anticoagulation in ACM has similar stroke and bleeding risks as in dilated cardiomyopathy.
ALCOHOL AND ALCOHOLISM
(2023)
Article
Cardiac & Cardiovascular Systems
Christine Gyldenkerne, Michael Maeng, Lars Kjoller-Hansen, Akiko Maehara, Zhipeng Zhou, Ori Ben-Yehuda, Hans Erik Botker, Thomas Engstrom, Mitsuaki Matsumura, Gary S. Mintz, Ole Froebert, Jonas Persson, Rune Wiseth, Alf I. Larsen, Lisette O. Jensen, Jan E. Nordrehaug, Oyvind Bleie, Elmir Omerovic, Claes Held, Stefan K. James, Ziad A. Ali, Hans C. Rosen, Gregg W. Stone, David Erlinge
Summary: Patients with diabetes have a higher risk of major adverse cardiac events due to both treated culprit lesions and untreated nonculprit lesions. However, this study did not identify diabetes-related high-risk plaque characteristics using multimodality imaging.
Article
Cardiac & Cardiovascular Systems
Kirstine Norregaard Hansen, Lisette Okkels Jensen, Michael Maeng, Martin Kirk Christensen, Manijeh Noori, Johnny Kahlert, Lars Jakobsen, Anders Junker, Phillip Freeman, Julia Ellert-Gregersen, Bent Raungaard, Christian Juhl Terkelsen, Karsten Tange Veien, Evald Hoj Christiansen
Summary: This study compared the efficacy of biodegradable polymer drug-eluting stents (O-SES) and biodegradable polymer biolimus-eluting stents (N-BES) in percutaneous coronary intervention. The findings showed no significant difference in the 5-year target lesion failure rate between the two stents, but the O-SES had a lower rate of definite stent thrombosis in the first year. However, this difference was not maintained after 5 years.
CIRCULATION-CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Manan Pareek, Kristian H. Kragholm, Anna Meta Dyrvig Kristensen, Muthiah Vaduganathan, Jannik L. Pallisgaard, Christina Byrne, Tor Biering-Sorensen, Christina Ji-Young Lee, Anders Nissen Bonde, Martin Bodtker Mortensen, Michael Maeng, Emil L. Fosbol, Lars Kober, Niels Thue Olsen, Gunnar H. Gislason, Deepak L. Bhatt, Christian Torp-Pedersen
Summary: The study found that individuals suspected of acute coronary syndrome who had consecutively elevated high-sensitivity troponin concentrations had the highest risk of death, while those with consecutively normal hsTnT concentrations had very low mortality rates, regardless of changes between measurements.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Jonas Bruhn, Morten Malmborg, Caroline H. Garred, Pauline Ravn, Deewa Zahir, Charlotte Andersson, Gunnar Gislason, Christian Torp-Pedersen, Kristian Kragholm, Emil Fosbol, Jawad H. Butt, Ninian N. Lang, Mark C. Petrie, John McMurray, Lars Kober, Morten Schou
Summary: This study investigated the temporal trends of new onset cancer in patients with HF between 1997 and 2016. It found that the incidence of cancer did not increase over time in HF patients, but long-term survival following an HF diagnosis significantly increased.
EUROPEAN HEART JOURNAL
(2023)
Article
Genetics & Heredity
Jonas Ghouse, Vinicius Tragante, Gustav Ahlberg, Soren A. Rand, Jakob B. B. Jespersen, Eva Birgitte Leinoe, Christoffer Rasmus Vissing, Linea Trudso, Ingileif Jonsdottir, Karina Banasik, Soren Brunak, Sisse R. R. Ostrowski, Ole B. B. Pedersen, Erik Sorensen, Christian Erikstrup, Mie Topholm Bruun, Kaspar Rene Nielsen, Lars Kober, Alex H. H. Christensen, Kasper Iversen, David Jones, Kirk U. U. Knowlton, Lincoln Nadauld, Gisli H. H. Halldorsson, Egil Ferkingstad, Isleifur Olafsson, Solveig Gretarsdottir, Pall T. T. Onundarson, Patrick Sulem, Unnur Thorsteinsdottir, Gudmundur Thorgeirsson, Daniel F. F. Gudbjartsson, Kari Stefansson, Hilma Holm, Morten Salling Olesen, Henning Bundgaard
Summary: This study conducts a genome-wide association analysis of venous thromboembolism (VTE) using a large cohort of cases and controls. They identify 93 risk loci, with 62 loci being newly discovered. The study also demonstrates the effectiveness of a VTE polygenic risk score in identifying individuals at high or low risk for VTE. Additionally, they investigate the shared clinical risk factors between venous and arterial thrombosis.
Article
Cardiac & Cardiovascular Systems
Carly Adamson, Paul Welsh, Kieran F. Docherty, Rudolf A. de Boer, Mirta Diez, Jaroslaw Drozdz, Andre Dukat, Silvio E. Inzucchi, Lars Kober, Mikhail N. Kosiborod, Charlotta E. A. Ljungman, Felipe A. Martinez, Piotr Ponikowski, Marc S. Sabatine, David A. Morrow, Daniel Lindholm, Ann Hammarstedt, David W. Boulton, Peter J. Greasley, Anna Maria Langkilde, Scott D. Solomon, Naveed Sattar, John J. V. McMurray, Pardeep S. Jhund
Summary: Elevation in IGFBP-7 is associated with worse clinical outcomes in patients with heart failure with reduced ejection fraction. IGFBP-7 provides prognostic information incremental to clinical variables, NT-proBNP, and hsTnT. Dapagliflozin does not modulate IGFBP-7 levels.
JACC-HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Anders Nissen Bonde, Jenny Bjerre, Marco Proietti, Gregory Y. H. Lip, Gunnar Gislason, Mark A. Hlatky
Summary: Men living alone may face challenges in managing chronic medical conditions, with anticoagulation control being significantly worse for this group, which serves as an indicator of self-management.
AMERICAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Jawad H. Butt, Toru Kondo, Mingming Yang, Pardeep S. Jhund, Kieran F. Docherty, Muthiah Vaduganathan, Brian L. Claggett, Adrian F. Hernandez, Carolyn S. P. Lam, Silvio E. Inzucchi, Felipe A. Martinez, Rudolf A. de Boer, Mikhail N. Kosiborod, Akshay S. Desai, Lars Kober, Piotr Ponikowski, Marc S. Sabatine, Sanjiv J. Shah, Natalia Zaozerska, Ulrica Wilderang, Olof Bengtsson, Scott D. Solomon, John J. McMurray
Summary: This study aimed to assess the efficacy and safety of dapagliflozin in patients with heart failure, particularly in those with peripheral artery disease (PAD). The results showed that dapagliflozin was equally effective in patients with and without PAD and did not increase the risk of amputation.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Maria W. Pedersen, Kristian Kragholm, Riina Oksjoki, Jacob E. Moller, Anna Gundlund, Emil Fosbol, Dorte G. Nielsen, Lars Kober, Christian Torp-Pedersen, Peter Sogaard, Niels H. Andersen
Summary: This study describes the characteristics and outcomes of patients with acute type A and type B aortic dissection in Denmark. The study found higher in-hospital mortality for type A aortic dissection and higher mortality rate for discharged patients with type B aortic dissection.
ANNALS OF THORACIC SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Mingming Yang, Toru Kondo, Jawad H. Butt, William T. Abraham, Inder S. Anand, Akshay S. Desai, Lars Kober, Milton Packer, Marc A. Pfeffer, Jean L. Rouleau, Marc S. Sabatine, Scott D. Solomon, Karl Swedberg, Michael R. Zile, Pardeep S. Jhund, John J. McMurray
Summary: Patients with heart failure who have a history of stroke are at a high risk of subsequent cardiovascular events, regardless of ejection fraction. This study investigated the prevalence of stroke history in patients with heart failure and found that they had more vascular comorbidity and worse heart failure compared to those without stroke history. Targeting underutilization of guideline-recommended treatments might improve outcomes in this high-risk population.
EUROPEAN HEART JOURNAL
(2023)
Article
Dentistry, Oral Surgery & Medicine
Andrea Kjellstroem Wagner, Maria D'Souza, Casper N. Bang, Palle Holmstrup, Paul Blanche, Nils-Erik Fiehn, Gunnar Gislason, Christian Torp Pedersen, Christian Damgaard, Claus Henrik Nielsen, Peter Riis Hansen
Summary: This study investigated the association between previous periodontal treatment and recurrent events after first-time MI. The results showed that patients with treated periodontitis prior to first-time MI had a similar risk of recurrent cardiovascular events as patients presumed periodontally healthy. However, patients with no prior dental visits had a significantly increased risk of recurrent events.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Soren K. Nielsen, Frederikke G. Hansen, Torsten B. Rasmussen, Thomas Fischer, Jens F. Lassen, Trine Madsen, Dorthe S. Moller, Ib C. Klausen, John B. Brodersen, Morten S. K. Jensen, Jens Mogensen
Summary: Family screening of relatives of HCM index patients with a normal genetic investigation revealed a small number of affected relatives with a favorable prognosis.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Emilie Sonne-Holm, Matilde Winther-Jensen, Lia E. Bang, Lars Kober, Emil Fosbol, Jorn Carlsen, Jesper Kjaergaard
Summary: This study aimed to assess the dose-response relationship between troponin concentration and 30-day mortality risk, and found that the risk of 30-day mortality increases with increasing troponin concentration.
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2023)