Review
Clinical Neurology
Effrosyni Koutsouraki, Koukoulidis Theodoros, Georgiadou Eleni, Kalampouka Marianna, Nikolaidou Areti, Koukoulidou Ariadni, Michmizos Dimitrios
Summary: Multiple sclerosis (MS) is a chronic progressive disease affecting both the central nervous system (CNS) and autonomic nervous system (ANS), leading to a range of urological, sexual, gastrointestinal, cardiovascular, and thermoregulatory disorders as well as increased fatigue. The manifestations of ANS dysfunction in MS are often underestimated due to the non-specificity of symptoms and limited evaluation in clinical practice. The underlying mechanisms causing these disorders have yet to be fully investigated, hindering targeted etiological treatment. Early diagnosis and individualized treatment regimens, incorporating multiple approaches, have shown the best results in managing ANS dysfunction in MS patients.
JOURNAL OF NEUROLOGY
(2023)
Review
Biochemistry & Molecular Biology
Benedetta Russo, Marika Menduni, Patrizia Borboni, Fabiana Picconi, Simona Frontoni
Summary: This review discusses the role of the autonomic nervous system in obesity and insulin-resistance, highlighting the bi-directional effects of related mechanisms, and exploring the neural, hormonal, and nutritional mechanisms involved. Leptin is emphasized for its crucial role in appetite regulation, glucose homeostasis, and energy expenditure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Francesca Massimello, Lucia Billeci, Alessio Canu, Maria Magdalena Montt-Guevara, Gaia Impastato, Maurizio Varanini, Andrea Giannini, Tommaso Simoncini, Paolo Mannella
Summary: This study examined the effect of music stimulation on fetal heart rate and autonomic nervous system activity. The results showed that music stimulation can enhance fetal heart rate variability without changing the mean value of fetal heart rate. This effect is mainly attributed to the activation of the parasympathetic nervous system, indicating that music can induce a state of relaxation in the fetus.
FRONTIERS IN MEDICINE
(2022)
Article
Nutrition & Dietetics
Francisca de Castro Mendes, Ines Paciencia, Joao Cavaleiro Rufo, Mariana Farraia, Diana Silva, Patricia Padrao, Luis Delgado, Vanessa Garcia-Larsen, Andre Moreira, Pedro Moreira
Summary: The study found a positive association between vegetable diversity consumption and the ANS response in school-aged children, indicating a potential early link between diet and health.
Article
Endocrinology & Metabolism
Yotam Kolben, Sarah Weksler-Zangen, Yaron Ilan
Summary: Adropin, a peptide hormone, plays a significant role in energy homeostasis and metabolic regulation, influenced by circadian rhythms. The autonomic nervous system and circadian clocks are crucial in regulating metabolic pathways and energy balance, with chronotherapy showing beneficial effects in various systems. There is potential for adropin to act as a mediator in the metabolic system-autonomic nervous system axis, with personalized adropin and circadian rhythm-based platforms for chronotherapy being discussed for enhancing treatment efficacy.
Article
Multidisciplinary Sciences
Yurika Nishida, Sumie Yamada, Yoshiro Nakagawa, Tomoki Aoyama
Summary: This study aimed to explore the relationship between task interest and physiological changes in the autonomic nervous system among healthy individuals, as well as its correlation with psychological characteristics. The findings showed a negative correlation between task interest and cardiac sympathetic index during the uninteresting task. Task interest may contribute to reducing mental and physiological loads and suppressing sympathetic dominance.
Article
Neurosciences
Tri Huu Doan, Yuma Sato, Masayuki Matsumoto, Tadachika Koganezawa
Summary: The lateral habenula regulates autonomic cardiovascular responses through activation of different neural pathways including cardiac parasympathetic nerves and cardiovascular sympathetic nerves. The stimulation effects of lateral habenula are likely mediated by 5-HT1A and 5-HT2 receptors, while other 5-HT receptors do not affect its actions.
FRONTIERS IN NEUROSCIENCE
(2021)
Review
Clinical Neurology
Lukasz Rzepinski, Pietro Emiliano Doneddu, Claudia Cutelle, Monika Zawadka-Kunikowska, Eduardo Nobile-Orazio
Summary: The aim of this review was to investigate the prevalence and type of autonomic dysfunction (AD) in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). It was found that AD in CIDP may indicate comorbid diseases and facilitate differentiation from other neuropathies. Further research is needed to understand the impact of autonomic impairment on disability and response to therapy in CIDP.
NEUROLOGICAL SCIENCES
(2023)
Review
Behavioral Sciences
Nicholas V. Alen, Grant S. Shields, Adele Nemer, Indira A. D'souza, Marcela J. Ohlgart, Camelia E. Hostinar
Summary: Parental socialization may influence the development of children's autonomic nervous system, particularly the parasympathetic nervous system. A meta-analysis revealed that positive parenting is positively associated with higher resting parasympathetic nervous system activity in children. This association is more pronounced in experimental studies and when the sample includes children with a clinical condition.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Review
Clinical Neurology
Ivan Adamec, Magdalena Krbot Skoric, Mario Habek
Summary: Multiple sclerosis (MS) is traditionally considered a disease of the central nervous system (CNS), but emerging evidence suggests that it also affects the peripheral nervous system (PNS). Studies have shown signs of demyelination and functional involvement in the PNS of individuals with MS, particularly in the autonomic nervous system (ANS). Further research is needed to fully understand the frequency and significance of PNS involvement in MS.
NEUROLOGICAL SCIENCES
(2021)
Review
Immunology
Angela Boahen, Dailun Hu, Murray J. Adams, Philip K. Nicholls, Wayne K. Greene, Bin Ma
Summary: This review explores the connections between the central nervous system (CNS) and the peripheral nervous system (PNS) with the immune system, focusing on the impact of these interactions on health and disease. Understanding these neuroimmune interactions could lead to new therapeutic approaches for neurological, neuroimmunological, infectious, inflammatory, and immunological disorders.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biology
Yi-Chia Shan, Wei Fang, Jih-Huah Wu
Summary: A feasible and integrated system was proposed to measure and affect the autonomic nervous system (ANS) status. The test results show that stimulating the Neiguan (PC6) acupoint can inhibit the sympathetic nervous system (SNS), while stimulating the Shenmen (HT7) acupoint can activate the SNS.
Article
Neurosciences
Zhanhao Zhao, Li Li, Chen Xin, Yaqun Yin, Rong Zhang, Jing Guo
Summary: This study used bibliometric analysis to assess the current status and research trends of acupuncture on autonomic function. The results showed that the majority of top-cited articles came from the USA, and neurosciences/neurology was the most studied research area. The study also found an increasing trend in research on the anti-inflammatory effects of acupuncture associated with autonomic function.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Immunology
Danny Rahal, Sarah M. Tashjian, Maira Karan, Naomi Eisenberger, Adriana Galvan, Andrew J. Fuligni, Paul D. Hastings, Steve W. Cole
Summary: The study found that higher parasympathetic nervous system activity, as indicated by higher RSA, was associated with increased expression of Type I interferon response genes in circulating leukocytes, but not with inflammatory gene expression. This suggests a previously unrecognized immunoregulatory aspect of autonomic nervous system function and highlights a potential biological pathway by which parasympathetic nervous system activity may impact health.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Biochemistry & Molecular Biology
Katharina Scherschel, Hanna Braeuninger, Andrea Moelders, Nadine Erlenhardt, Ehsan Amin, Christiane Jungen, Ulrike Pape, Diana Lindner, Dane M. Chetkovich, Nikolaj Kloecker, Christian Meyer
Summary: TRIP8b has been found to play a role in modulating atrial electrophysiology in the intrinsic cardiac nervous system, potentially beyond its role in sino-nodal control of the heart. In vitro electrophysiological studies showed that TRIP8b-deficient mouse hearts exhibit increased refractory periods in certain areas, but no differences were observed in heart rate and ventricular refractory period between genotypes. Additionally, while Trip8b mRNA was detected in the ICNS, TRIP8b protein was not detectable.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Andrea Rossi, Alberto Giannoni, Martina Nesti, Pasquale Notarstefano, Vincenzo Castiglione, Gianluca Solarino, Lucio Teresi, Gianluca Mirizzi, Vincenzo Russo, Luca Panchetti, Umberto Startari, Andrea Ripoli, Francesco Gentile, Amato Santoro, Nicoletta Botto, Giancarlo Casolo, Juan Sieira, Maurizio Pieroni, Pasquale Santangeli, Michele Emdin, Marcello Piacenti
Summary: Heterogeneity of refractory periods in the right ventricular outflow tract (RVOT) and right ventricular (RV) apex is a strong independent predictor of life-threatening arrhythmias in patients with Brugada syndrome (BrS), beyond traditional predictors and inducibility of ventricular tachycardia/ventricular fibrillation at electrophysiological study (EPS).
Review
Cardiac & Cardiovascular Systems
Vincenzo Russo, Erika Parente, Antonella Groppelli, Giulia Rivasi, Marco Tomaino, Alessio Gargaro, Daniele Giacopelli, Andrea Ungar, Gianfranco Parati, Artur Fedorowski, Richard Sutton, J. Gert van Dijk, Michele Brignole
Summary: This review discusses the timing of tilt-induced asystole and loss of consciousness (LOC) in tilt-testing methodology. The commonly used Italian protocol is not always followed strictly, allowing for reassessment of the incidence of asystole during early tilt-down compared to late, established LOC. Asystole is less common in early tilt down and decreases with increasing age, but more common if LOC is established as the test-end point, and it is age-independent. The review also highlights the usefulness of asystole occurrence as a guide for pacemaker therapy in highly symptomatic older vasovagal syncope patients.
Article
Biochemistry & Molecular Biology
Simona Daniele, Simona Saporiti, Stefano Capaldi, Deborah Pietrobono, Lara Russo, Uliano Guerrini, Tommaso Laurenzi, Elham Ataie Kachoie, Luca Palazzolo, Vincenzo Russo, Maria Pia Abbracchio, Ivano Eberini, Maria Letizia Trincavelli
Summary: GPR17, a key regulator of myelination, is activated by endogenous ligands and pro-inflammatory molecules. This study investigates the structural and functional interactions between GPR17 and chemokine receptors CXCR2 and CXCR4. The results show that these receptors can form heterodimers and modulate intracellular cAMP levels. This cross-talk between receptors could impact the neuroinflammatory environment associated with demyelinating events.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Vincenzo Russo, Dario Fabiani, Silvia Leonardi, Emilio Attena, Giuliano D'Alterio, Ciro Cotticelli, Anna Rago, Sara Sarpa, Benedicta Maione, Antonio D'Onofrio, Paolo Golino, Gerardo Nigro
Summary: This study aimed to evaluate the effect of dual pathway inhibition on plasma inflammation and coagulation markers in patients with CAD and/or PAD. The results showed a significant reduction in IL-6 and fibrinogen levels, as well as an increase in GDF-15 levels after 24 weeks of dual pathway inhibition treatment. Hemoglobin, renal function, and cardiovascular homeostasis biomarkers remained stable over time. Dual pathway inhibition treatment was associated with a reduction in inflammation biomarkers.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Andreina Carbone, Roberta Bottino, Emilio Attena, Valentina Parisi, Maddalena Conte, Antonello D'Andrea, Egidio Imbalzano, Paolo Golino, Vincenzo Russo
Summary: This study aimed to investigate the efficacy and safety of oral anticoagulation therapy in elderly patients with atrial fibrillation. The results showed that anaemic patients aged 80 and above had a significantly increased risk of major bleeding, particularly intracranial hemorrhage, and mortality during oral anticoagulation therapy.
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2023)
Review
Biochemistry & Molecular Biology
Andreina Carbone, Roberta Bottino, Antonello D'Andrea, Vincenzo Russo
Summary: Currently, direct oral anticoagulants (DOACs) are the first-line anticoagulant strategy for non-valvular atrial fibrillation (NVAF) patients, showing equal efficacy and greater safety compared to warfarin. However, the results of DOAC trials cannot be extrapolated to specific populations such as obese, elderly, frail, and cancer patients, which are common in clinical practice. Additionally, the evidence for DOAC use in patients with bioprosthetic heart valves is limited and controversial. This review aims to clarify the best anticoagulant strategy for these special and understudied subpopulations.
Article
Cardiac & Cardiovascular Systems
Vincenzo Russo, Giovanni Papaccioli, Valeria Maddaloni, Adriano Caputo, Nicola Pepe, Anna Rago, Michele Maiorino, Paolo Golino, Gerardo Nigro
Summary: We present a case of drug-induced type 1 Brugada syndrome with a high risk of arrhythmia associated with a mutation in the Lamin A/C gene.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Giovanni Luca Botto, Matteo Ziacchi, Gerardo Nigro, Antonio D'Onofrio, Antonio Dello Russo, Pietro Francia, Stefano Viani, Ennio Pisano, Giovanni Bisignani, Fabrizio Caravati, Federico Migliore, Paolo De Filippo, Luca Ottaviano, Roberto Rordorf, Michele Manzo, Fabio Lorenzo Canevese, Mariolina Lovecchio, Sergio Valsecchi, Luca Checchi
Summary: This study aimed to compare the survival from device-related complications and inappropriate shocks between patients who had the S-ICD generator positioned in the intermuscular (IM) space and those in the traditional subcutaneous (SC) pocket. The results showed that the IM group had a lower risk of complications compared to the SC group, as well as a lower risk of the composite of complications and inappropriate shocks. There was no significant difference in the risk of appropriate shocks between the two groups, and no significant interaction with variables such as gender, age, body mass index, and ejection fraction.
Article
Cardiac & Cardiovascular Systems
Roberto Rordorf, Stefano Viani, Mauro Biffi, Paolo Pieragnoli, Federico Migliore, Antonio D'Onofrio, Gerardo Nigro, Pietro Francia, Paola Ferrari, Antonio Dello Russo, Antonio Bisignani, Luca Ottaviano, Pietro Palmisano, Fabrizio Caravati, Ennio Pisano, Antonio Pani, Giovanni Luca Botto, Mariolina Lovecchio, Sergio Valsecchi, Alessandro Vicentini
Summary: By studying 1468 S-ICD recipients, it was found that adopting the high arrhythmia detection cut-off rates, as demonstrated in the UNTOUCHED study, can significantly reduce the occurrence of inappropriate shocks.
Article
Cardiac & Cardiovascular Systems
Vincenzo Russo, Erika Parente, Marco Tomaino, Angelo Comune, Antonella Sabatini, Nunzia Laezza, Domenico Carretta, Gerardo Nigro, Anna Rago, Paolo Golino, Michele Brignole
Summary: This study compared the effectiveness of the traditional nitroglycerin head-up tilt test (HUTT) and a shorter duration fast protocol in diagnosing cases of hypotension and bradycardia. The results showed that the fast protocol had a similar positivity rate and hemodynamic response distribution compared to the traditional protocol. Therefore, the fast protocol can be used as an alternative to the traditional protocol.
EUROPEAN HEART JOURNAL
(2023)
Article
Cell Biology
Laura Raccosta, Maura Marinozzi, Susan Costantini, Daniela Maggioni, Lorena Maria Ferreira, Gianfranca Corna, Paola Zordan, Angela Sorice, Diego Farinello, Silvia Bianchessi, Michela Riba, Dejan Lazarevic, Paolo Provero, Matthias Mack, Attilio Bondanza, Ivan Nalvarte, J-A Gustafsson, Valeria Ranzani, Francesco De Sanctis, Stefano Ugel, Silvere Baron, Jean-Marc A. Lobaccaro, Lorenzo Pontini, Manuela Pacciarini, Catia Traversari, Massimiliano Pagani, Vincenzo Bronte, Giovanni Sitia, Per Antonson, Andrea Brendolan, Alfredo Budillon, Vincenzo Russo
Summary: Lipid and cholesterol metabolism play a crucial role in tumor cell behavior and tumor microenvironment. Perturbing the lipidome of tumor microenvironment by genetic and pharmacological approaches, we discovered that the expression of sulfotransferase 2B1b and the treatment with a new LXR antagonist can promote monoctye-derived antigen-presenting cells in tumor and synergize with immunotherapy.
CELL DEATH & DISEASE
(2023)
Article
Medicine, General & Internal
Pierpaolo Di Micco, Francesca Futura Bernardi, Giuseppe Camporese, Mario Biglietto, Alessandro Perrella, Tiziana Ciarambino, Vincenzo Russo, Egidio Imbalzano
Summary: Nattokinase (NK) is a food-derived protease with multiple activities, including improving fibrinolytic activities, regulating blood pressure, and antiplatelet activities. NK can be taken orally and reaches its peak concentration after 12 hours. In addition, it has potential antithrombotic activity. All these activities have been studied in animals and humans in vitro and in vivo. However, clinical trials are needed to confirm its efficacy and safety.
ITALIAN JOURNAL OF MEDICINE
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Vincenzo Russo, Mirella Limatola, Corina Valentina De Santis Ciacci, Alfredo Mauriello
JOURNAL OF ARRHYTHMIA
(2023)
Article
Social Sciences, Interdisciplinary
Emanuela Ingusci, Enrico Ciavolino, Fulvio Signore, Margherita Zito, Vincenzo Russo, Chiara Ghislieri
Summary: This study explores the role of personal resources such as self-efficacy and optimism in increasing academic engagement and protecting against technostress. Findings suggest that self-efficacy and optimism have direct negative effects on technostress, with self-efficacy also increasing academic engagement. Additionally, academic engagement mediates the impact of technostress on students' lives.
SOCIAL SCIENCES-BASEL
(2023)
Meeting Abstract
Surgery
D. Khan, K. Tariq, K. Lee, E. Dyson, V. Russo, L. Watkins, A. Russo
BRITISH JOURNAL OF SURGERY
(2023)