Article
Nutrition & Dietetics
Jose Ronaldo Ribeiro da Costa, Roberto Fernandes da Costa, Ciro Alexandre Merces Goncalves, Michelle Vasconcelos de Oliveira Borges, Paulo Francisco De Almeida-Neto, Gilmara Gomes De Assis, Breno Guilherme De Araujo Tinoco Cabral, Paulo Moreira Silva Dantas
Summary: Obesity burdens global public health systems, requiring the identification and proposal of valid anthropometric indices for the prevention and treatment of obesity and associated diseases. The study found that the Body Adiposity Index (BAI) had low validity in estimating body fat percentage, while a new mathematical model was identified as a good option for assessing body composition in Brazilian adults.
FRONTIERS IN NUTRITION
(2022)
Article
Chemistry, Multidisciplinary
Silvana Alfei, Andrea Spallarossa, Matteo Lusardi, Guendalina Zuccari
Summary: Water-soluble formulations of pyrazole derivative CR232 were prepared using two different nanotechnological approaches. CR232-G5K NPs showed a complex release profile following Weibull kinetics, while CR232-SUVs displayed a constant prolonged release profile following zero-order kinetics. Both strategies successfully improved the solubility of CR232.
Article
Orthopedics
Qizhao Tan, Zhongwei Yang, Xing Xin, Bin Yang, Zhili Xing, Feng Li, Ke Zhang, Yun Tian, Tengjiao Zhu
Summary: POSTN plays a role in the process of osteoarthritis, but its serum level is not sufficient to serve as a biomarker for osteoarthritis.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Review
Emergency Medicine
Binyamin Sikander, Jacob Rosenberg, Siv Fonnes
Summary: This scoping review included 65 biomarkers from 52 studies, involving 14,312 patients. Routine biomarkers had poor diagnostic accuracy, with sensitivity ranging from 15% to 100% and specificity between 27% and 100%. Novel biomarkers are still in the early stage of study and lack accuracy and cost-benefit analysis.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2023)
Article
Multidisciplinary Sciences
Farshad Nassiri, Jeff Liu, Vikas Patil, Yasin Mamatjan, Justin Z. Wang, Rupert Hugh-White, Andrew M. Macklin, Shahbaz Khan, Olivia Singh, Shirin Karimi, Rosario I. Corona, Lydia Y. Liu, Caroline Y. Chen, Ankur Chakravarthy, Qingxia Wei, Bharati Mehani, Suganth Suppiah, Andrew Gao, Adriana M. Workewych, Ghazaleh Tabatabai, Paul C. Boutros, Gary D. Bader, Daniel D. de Carvalho, Thomas Kislinger, Kenneth Aldape, Gelareh Zadeh
Summary: Meningiomas, the most common primary intracranial tumor in adults, often require surgery due to lack of effective medical therapies. This study introduced four consensus molecular groups of meningioma, which accurately predicted clinical outcomes and informed therapeutic options. Single-cell RNA sequencing revealed inter-individual variations in meningioma biology, highlighting the importance of molecular classification in guiding treatment strategies.
Article
Chemistry, Multidisciplinary
Qun Zhao, Guangrong Meng, Guangchen Li, Carol Flach, Richard Mendelsohn, Roger Lalancette, Roman Szostak, Michal Szostak
Summary: This study reports the synthesis, catalytic activity, and full structural and electronic characterization of novel, sterically-bulky NHC ligands based on the hash peralkylation concept. The new ligands have been commercialized and show broad activity in various cross-coupling reactions. The generality of the approach in ligand design is demonstrated through facile synthesis of different NHC ligands.
Review
Biochemistry & Molecular Biology
Josef Jampilek, Katarina Kralova
Summary: Climate change and environmental contamination caused by human activities have a growing negative impact on human life. Developing technologies and sophisticated materials, such as graphene-based nanomaterials, could help overcome these negative effects. Graphene-based nanomaterials have promising applications in various fields including medicine and agriculture, but their potential negative effects on living organisms should be carefully considered.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Physics, Multidisciplinary
David Richard, Geert Kapteijns, Julia A. Giannini, M. Lisa Manning, Edan Lerner
Summary: The study proposes a simple definition of shear transformation zones (STZs) based on the harmonic approximation of a glass's energy, which is shown to be more broadly applicable than previous anharmonic definitions. An open-source library is provided for analyzing low-lying STZs in computer glasses and laboratory materials. The results represent a methodological advancement towards characterizing mechanical disorder in glasses and understanding their yielding behavior.
PHYSICAL REVIEW LETTERS
(2021)
Article
Physics, Multidisciplinary
Franziska Strasser, Stephen M. Barnett, Monika Ritsch-Marte, Gregor Thalhammer
Summary: We propose a method to measure the optical torque applied to particles of arbitrary shape using the change of angular momentum of light. The method allows for the determination of all torque components from a single interference pattern and the retrieval of the required phase using an iterative algorithm. This method provides access to the torque pertaining to individual particles as well as separate spin or orbital parts of the total torque.
PHYSICAL REVIEW LETTERS
(2022)
Review
Biochemical Research Methods
Serena Dotolo, Anna Marabotti, Angelo Facchiano, Roberto Tagliaferri
Summary: Drug repurposing involves finding new uses for existing drugs at a lower cost and in a shorter time period. Different computational drug-repurposing strategies, including network-based models, structure-based approaches, and artificial intelligence (AI) approaches, have been applied to COVID-19. Network-based clustering and propagation approaches have been used to identify proteins associated with COVID-19, while structure-based approaches have focused on discovering new applications for existing drugs through interactions with biological targets. AI-based networks, however, require more data before becoming relevant in this context.
BRIEFINGS IN BIOINFORMATICS
(2021)
Article
Engineering, Civil
Yuanyuan Sun, Shaofeng Jia, Ru Jia
Summary: This paper analyzes the classification and hierarchical structure of water rights systems. It further determines the unit water rights systems and mixed water rights systems based on the water rights meta types, which are the most basic elements of water rights systems. The unit water rights systems are the smallest independently existing units that maintain the characteristics of water rights systems, while the mixed water rights systems comprise a mix of different unit systems. By collecting data on objective influencing factors in research units and statistically analyzing the data, the thresholds for all influencing factors in each unit water rights system are estimated. The applicable conditions of each unit water rights system can be determined based on these thresholds.
WATER RESOURCES MANAGEMENT
(2023)
Article
Automation & Control Systems
Hongying Zhang
Summary: The article discusses the design of new biomedical robots based on the origami principle, highlighting two categories of origami patterns applicable to medical devices. However, due to the unevenness of the physical folding structure, analyzing mechanics becomes more complex.
IEEE-ASME TRANSACTIONS ON MECHATRONICS
(2022)
Article
Computer Science, Information Systems
Tzung-Pei Hong, Chen-Chia Chiu, Ja-Hwung Su, Chun-Hao Chen
Summary: Erasable-itemset mining is a commonly used method in production planning to identify itemsets that have little effect on production profits if removed. This paper proposes the use of metamorphic testing to check the correctness of mining results by discovering proper metamorphic relations. Experimental results show that the metamorphic relations can effectively and efficiently assess the mining results.
Review
Biotechnology & Applied Microbiology
Tim Egghe, Rino Morent, Richard Hoogenboom, Nathalie De Geyter
Summary: Antibacterial coatings are essential for preventing implant-related infections. Plasma polymer and polydopamine-based coatings are the most widely studied and versatile approaches, capable of synthesizing different types of antibacterial films. However, more fundamental research is needed before these coatings can be widely used.
TRENDS IN BIOTECHNOLOGY
(2023)
Article
Automation & Control Systems
Hongying Zhang
Summary: The origami principle can be applied to build compact actuators, deployable stents, and minimally invasive surgery devices. Traditional paper-based origami is converted to physical robots, which become complex and challenging to analyze, leading to the proposal of a computational model for analysis and simulation.
IEEE-ASME TRANSACTIONS ON MECHATRONICS
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Catherine M. Otto
Editorial Material
Cardiac & Cardiovascular Systems
Catherine M. Otto
Article
Cardiac & Cardiovascular Systems
Catherine M. Otto
Editorial Material
Cardiac & Cardiovascular Systems
Catherine M. Otto
Editorial Material
Cardiac & Cardiovascular Systems
Catherine M. Otto
Editorial Material
Cardiac & Cardiovascular Systems
Catherine M. Otto
Article
Allergy
William Walter Busse, Ian Douglas Pavord, Shahid Siddiqui, Asif Hameed Khan, Amy Praestgaard, Scott Nash, Juby Anne Jacob-Nara, Paul Jonathan Rowe, Yamo Deniz
Summary: The purpose of this study was to investigate the efficacy of dupilumab in patients with chronic rhinosinusitis with nasal polyps and coexisting asthma. The results showed that dupilumab significantly improved the symptoms of both conditions, regardless of baseline asthma characteristics.
JOURNAL OF ASTHMA AND ALLERGY
(2023)
Article
Health Care Sciences & Services
Imran Howell, Mahdi Mahdi, Mona Bafadhel, Timothy S. C. Hinks, Sanjay Ramakrishnan, James Melhorn, Maisha Jabeen, Ian D. Pavord
Summary: This study aims to compare the clinical recovery between high-FeNO and low-FeNO asthma attacks after acute treatment with oral prednisolone in patients established on long-term asthma mAb treatment. The study data will help power a future randomized placebo-controlled trial of prednisolone treatment for nonsevere attacks in patients treated with asthma mAbs and will provide important information on whether corticosteroid treatment should be FeNO-directed.
JMIR RESEARCH PROTOCOLS
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Catherine M. Otto
Editorial Material
Cardiac & Cardiovascular Systems
Catherine M. Otto
Editorial Material
Cardiac & Cardiovascular Systems
Catherine M. Otto
Editorial Material
Cardiac & Cardiovascular Systems
Catherine M. Otto, Philip D. Adamson, Isabelle van Gelder, Ganesan Karthikeyan, David E. Newby, Kazem Rahimi, Antonio Luiz Pinho Ribeiro, Jae-Kwan Song
Editorial Material
Cardiac & Cardiovascular Systems
Catherine M. Otto
Editorial Material
Cardiac & Cardiovascular Systems
Catherine M. Otto
Editorial Material
Cardiac & Cardiovascular Systems
Catherine M. Otto, Joanna Bartkowiak, Rebecca T. Hahn
