Phenotypic drug profiling in droplet microfluidics for better targeting of drug-resistant tumors

Two repeated low doses of doxorubicin are more effective than a single high dose against tumors overexpressing P-glycoprotein

(2015) Chiara Riganti et al.   CANCER LETTERS

Centrifugal microfluidic platform for single-cell level cardiomyocyte-based drug profiling and screening

(2015) W. Espulgar et al.   LAB ON A CHIP

Digital microfluidics for time-resolved cytotoxicity studies on single non-adherent yeast cells

(2015) P. T. Kumar et al.   LAB ON A CHIP

Temporally sequenced anticancer drugs overcome adaptive resistance by targeting a vulnerable chemotherapy-induced phenotypic transition

(2015) Aaron Goldman et al.   Nature Communications

Single-cell mRNA sequencing identifies subclonal heterogeneity in anti-cancer drug responses of lung adenocarcinoma cells

(2015) Kyu-Tae Kim et al.   GENOME BIOLOGY

Laminar flow mediated continuous single-cell analysis on a novel poly(dimethylsiloxane) microfluidic chip

(2014) Bin Deng et al.   ANALYTICA CHIMICA ACTA

Exosome Transfer from Stromal to Breast Cancer Cells Regulates Therapy Resistance Pathways

(2014) Mirjam C. Boelens et al.   CELL

Blocking Hedgehog release from pancreatic cancer cells increases paracrine signaling potency

(2014) H. Damhofer et al.   JOURNAL OF CELL SCIENCE

Cloud-Enabled Microscopy and Droplet Microfluidic Platform for Specific Detection of Escherichia coli in Water

(2014) Alexander Golberg et al.   PLoS One

Single-cell analyses of transcriptional heterogeneity during drug tolerance transition in cancer cells by RNA sequencing

(2014) M.-C. W. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reduced Intracellular Drug Accumulation in Drug-Resistant Leukemia Cells is Not Only Solely Due to MDR-Mediated Efflux but also to Decreased Uptake

(2014) Angela Oliveira Pisco et al.   Frontiers in Oncology

Cell-Based Drug Combination Screening with a Microfluidic Droplet Array System

(2013) Guan-Sheng Du et al.   ANALYTICAL CHEMISTRY

Probing cell–cell communication with microfluidic devices

(2013) Feng Guo et al.   LAB ON A CHIP

Screening Compounds with a Novel High-Throughput ABCB1-Mediated Efflux Assay Identifies Drugs with Known Therapeutic Targets at Risk for Multidrug Resistance Interference

(2013) Megan R. Ansbro et al.   PLoS One

Analytical tools for characterizing heterogeneity in organelle content

(2012) Robbyn K Anand et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Gene expression alterations in doxorubicin resistant MCF7 breast cancer cell line

(2012) Shatha AbuHammad et al.   GENOMICS

Rapid screening of antibiotic toxicity in an automated microdroplet system

(2012) Krzysztof Churski et al.   LAB ON A CHIP

Droplet microfluidics for high-throughput biological assays

(2012) Mira T. Guo et al.   LAB ON A CHIP

Variable Clonal Repopulation Dynamics Influence Chemotherapy Response in Colorectal Cancer

(2012) A. Kreso et al.   SCIENCE

Microfluidic Device with Chemical Gradient for Single-Cell Cytotoxicity Assays

(2011) Masahito Hosokawa et al.   ANALYTICAL CHEMISTRY

A simple and fast microfluidic approach of same-single-cell analysis (SASCA) for the study of multidrug resistance modulation in cancer cells

(2011) XiuJun Li et al.   LAB ON A CHIP

High-resolution dose-response screening using droplet-based microfluidics

(2011) O. J. Miller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-Cell Mass Cytometry of Differential Immune and Drug Responses Across a Human Hematopoietic Continuum

(2011) S. C. Bendall et al.   SCIENCE

p-Glycoprotein ABCB5 and YB-1 expression plays a role in increased heterogeneity of breast cancer cells: correlations with cell fusion and doxorubicin resistance

(2010) Ji Yeon Yang et al.   BMC CANCER

Microfluidic lab-on-a-chip platforms: requirements, characteristics and applications

(2010) Daniel Mark et al.   CHEMICAL SOCIETY REVIEWS

Heterogeneous Blood-Tumor Barrier Permeability Determines Drug Efficacy in Experimental Brain Metastases of Breast Cancer

(2010) P. R. Lockman et al.   CLINICAL CANCER RESEARCH

Inhibitory effects of persistent apoptotic cells on monoclonal antibody production in vitro

(2010) Christopher D. Gregory et al.   mAbs

Interaction between circulating galectin-3 and cancer-associated MUC1 enhances tumour cell homotypic aggregation and prevents anoikis

(2010) Qicheng Zhao et al.   Molecular Cancer

Actin reorganization in CHO AA8 cells undergoing mitotic catastrophe and apoptosis induced by doxorubicin

(2010) Grzanka   ONCOLOGY REPORTS

Chip-Based Dynamic Real-Time Quantification of Drug-Induced Cytotoxicity in Human Tumor Cells

(2009) Donald Wlodkowic et al.   ANALYTICAL CHEMISTRY

Analysis of Nonadherent Apoptotic Cells by a Quantum Dots Probe in a Microfluidic Device for Drug Screening

(2009) Liang Zhao et al.   ANALYTICAL CHEMISTRY

Cell Fusion as a Hidden Force in Tumor Progression

(2009) X. Lu et al.   CANCER RESEARCH

Droplet microfluidic technology for single-cell high-throughput screening

(2009) E. Brouzes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Same-Single-Cell Analysis for the Study of Drug Efflux Modulation of Multidrug Resistant Cells Using a Microfluidic Chip

(2008) XiuJun Li et al.   ANALYTICAL CHEMISTRY

Chemical Analysis of Single Cells

(2008) Laura M. Borland et al.   Annual Review of Analytical Chemistry

Single-step doxorubicin-selected cancer cells overexpress the ABCG2 drug transporter through epigenetic changes

(2008) A M Calcagno et al.   BRITISH JOURNAL OF CANCER

MCF7 Side Population Cells with Characteristics of Cancer Stem/Progenitor Cells Express the Tumor Antigen MUC1

(2008) K. Engelmann et al.   CANCER RESEARCH

Droplet-Based Microfluidic Platforms for the Encapsulation and Screening of Mammalian Cells and Multicellular Organisms

(2008) Jenifer Clausell-Tormos et al.   CHEMISTRY & BIOLOGY

Controlled encapsulation of single-cells into monodisperse picolitre drops

(2008) Jon F. Edd et al.   LAB ON A CHIP

Live cells-based cytotoxic sensorchip fabricated in a microfluidic system

(2007) Ken-Ichi Wada et al.   BIOTECHNOLOGY AND BIOENGINEERING