Article
Cardiac & Cardiovascular Systems
Emilia Dugo, Andrea Barison, Giancarlo Todiere, Crysanthos Grigoratos, Giovanni Donato Aquaro
Summary: The use of cocaine is a major health problem with associated acute and chronic cardiovascular complications. Cocaine users have a higher risk of myocardial infarction, hypertensive crises, arrhythmias, and other complications. Cardiac magnetic resonance is a valuable tool for assessing myocardial damage and should be considered for symptomatic cocaine users.
HEART FAILURE REVIEWS
(2022)
Review
Emergency Medicine
Jennifer Wang, Priya S. Patel, Sanketh Andhavarapu, Vera Bzihlyanskaya, Eric Friedman, Maniraj Jeyaraju, Jamie Palmer, Alison Raffman, Ali Pourmand, Quincy K. Tran
Summary: This study analyzed 16 studies involving 3269 patients and found that the overall prevalence of AMI among CPCC patients was 4.7%. While the prevalence of AMI was relatively low in low risk patients, high risk patients were associated with a higher prevalence of AMI, highlighting the importance of risk stratification for appropriate treatment.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Multidisciplinary Sciences
V. M. Cruz-Atienza, J. Tago, C. Villafuerte, M. Wei, R. Garza-Giron, L. A. Dominguez, V. Kostoglodov, T. Nishimura, S. I. Franco, J. Real, M. A. Santoyo, Y. Ito, E. Kazachkina
Summary: The study suggests that the devastating earthquakes in Mexico between 2017 and 2019 may be related to slow slip events. It shows how seismic and aseismic events are interrelated, with the Mw 8.2 intraslab earthquake of 8 September 2017 altering the mechanical properties of the plate interface and disrupting slow slip cycles at a regional scale.
NATURE COMMUNICATIONS
(2021)
Review
Cardiac & Cardiovascular Systems
Loukianos S. Rallidis, Iosif Xenogiannis, Emmanouil S. Brilakis, Deepak L. Bhatt
Summary: The proportion of young individuals with acute myocardial infarction (AMI) has increased in recent years. Despite less extensive coronary atherosclerosis, young AMI patients still have poor long-term prognosis. They share similar risk factors with older patients for obstructive coronary artery disease, except for higher prevalence of smoking, lipid disorders, and family history of premature coronary artery disease, and lower prevalence of diabetes mellitus and hypertension. Nonobstructive coronary artery myocardial infarction is relatively common among young AMI patients, requiring specific diagnostic and treatment approaches.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Youheng Wang, Rusheng Zhao, Chengyan Wu, Xuefei Liang, Lei He, Libo Wang, Xuehui Wang
Summary: Myocardial remodeling refers to structural and functional disorders of the heart caused by molecular biological changes in the cardiac myocytes. Sirt1 plays a role in regulating myocardial remodeling through processes such as oxidative stress, apoptosis, autophagy, and inflammation. Understanding the involvement of Sirt1 in myocardial remodeling and heart failure can contribute to the prevention and treatment of heart failure.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Gastroenterology & Hepatology
Pan Jiang, Zehao Feng, Li Sheng, Chenxi Hu, Xiang Ma, Shouyan Zhang, Lianming Wu, Xiao Xiao, Qixia Wang, Canjie Guo, Dekai Qiu, Jingyuan Fang, Jianrong Xu, Merrill Eric Gershwin, Meng Jiang, Xiong Ma, Jun Pu
Summary: This study identifies clinically silent cardiac impairment in PBC patients without cardiac manifestations, using cardiac imaging techniques. Specific CMR patterns of myocardial involvement were detected, allowing for optimal screening and potentially timely therapies for early myocardial impairment.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Multidisciplinary Sciences
Birte Weber, Ina Lackner, Meike Baur, Florian Gebhard, Roman Pfeifer, Paolo Cinelli, Sascha Halvachizadeh, Michel Teuben, Hans-Christoph Pape, Armin Imhof, Miriam Lipiski, Nikola Cesarovic, Miriam Kalbitz
Summary: The study found complex myocardial and valvular impairment after multiple trauma in pigs, emphasizing the importance of timely detection and treatment of EMD and progressive valvular dysfunction.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Yanaira Alonso-Caraballo, Tracy L. Fetterly, Emily T. Jorgensen, Allison M. Nieto, Travis E. Brown, Carrie R. Ferrario
Summary: CP-AMPARs in the nucleus accumbens mediate cue-triggered motivation for food and cocaine. Junk-food consumption increases silent synapses and subsequently increases CP-AMPAR levels in male rats, while it does not induce AMPAR plasticity in females but may instead alter NMDAR-mediated transmission. These studies reveal sex differences in the effects of junk-food on NAc synaptic plasticity.
NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Yun-Jiu Cheng, Yu-He Jia, Feng-Juan Yao, Wei-Yi Mei, Yuan-Sheng Zhai, Ming Zhang, Su-Hua Wu
Summary: This study demonstrates that incident silent myocardial infarction (SMI) is independently associated with an increased risk of sudden cardiac death (SCD) in the general population, particularly in white individuals, men, and younger age groups. Additional research is needed to investigate screening for SMI and the role of standard post-myocardial infarction therapy.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Mehdi H. Shishehbor, Yulanka Castro-Dominguez
Summary: Cardiogenic shock is a serious complication in patients with acute myocardial infarction, and patients with concomitant peripheral artery disease may have higher mortality risk. Currently, there is a lack of data on the outcomes of these patients.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Psychiatry
Angela Sanna, Valentina Bini, Paola Badas, Giorgio Corona, Gabriele Sanna, Lara Marcasciano, Maria Chiara De Vivo, Marco Diana
Summary: This study explores the long-term therapeutic effect of bilateral intermittent theta-burst stimulation (iTBS) in cocaine use disorder (CUD) and highlights the importance of maintenance treatment in consolidating abstinence and reducing drop-out rates.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Neurosciences
Camilla Nicolucci, Mariana Lapo Pais, A. C. Santos, Fabiana M. Ribeiro, Pedro M. C. C. Encarnacao, Ana L. M. Silva, I. F. Castro, Pedro M. M. Correia, Joao F. C. A. Veloso, Julie Reis, Marina Z. Lopes, Maria F. Botelho, Frederico C. Pereira, Denise G. Priolli
Summary: This study aims to evaluate the morphological brain changes caused by a single low dose of cocaine, which induces alterations in the prefrontal cortex and hippocampus despite having no impact on behavioral performance.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Cardiac & Cardiovascular Systems
Astri Astuti, Achmad Hafiedz Azis Kartamihardja, Muhammad Adniel Ilhamy, Muhammad Dinnar Fahlavi, Nuraini Yasmin Kusumawardhani, Melawati Hasan, Laniyati Hamijoyo
Summary: Determining the etiology of myocardial dissection complicating left sinus of Valsalva aneurysm in silent Takayasu arteritis can be challenging, but clinical criteria and various imaging modalities may help in diagnosis. Optimal medical treatment as an alternative to surgery may lead to satisfactory outcomes in such cases.
BMC CARDIOVASCULAR DISORDERS
(2021)
Article
Cardiac & Cardiovascular Systems
Paul Valensi, Narimane Berkane, Sara Pinto, Nicolas Sellier, Michael Soussan, Minh Tuan Nguyen, Emmanuel Cosson
Summary: The study aimed to test the validity of the 2019 guidelines for cardiovascular risk stratification by the ESC-EASD. The most effective strategy for screening silent myocardial ischemia (SMI) in asymptomatic patients was found to be performing stress myocardial scintigraphy in patients with severe target organ damage and in those without severe damage but with high coronary artery calcium (CAC) score.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Endocrinology & Metabolism
Wei Wang, Le Kuai, Mengtao Zhang, Yue Li, Jieyu Shen, Yan Hou
Summary: The study found that high concentrations of Chlo can impair cardiac function and cause mitochondrial damage by downregulating Dap3 expression.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Cardiac & Cardiovascular Systems
Subhi J. Al'Aref, Ahmed M. Altibi, Abdallah Malkawi, Munthir Mansour, Lohendran Baskaran, Ahmad Masri, Hind Rahmouni, Raffaele Abete, Daniele Andreini, Giovanni Aquaro, Andrea Barison, Jan Bogaert, Giovanni Camastra, Samuela Carigi, Nazario Carrabba, Grazia Casavecchia, Stefano Censi, Gloria Cicala, Edoardo Conte, Carlo N. De Cecco, Manuel De Lazzari, Gabriella Di Giovine, Mauro Di Roma, Monica Dobrovie, Marta Focardi, Nicola Gaibazzi, Annalaura Gismondi, Matteo Gravina, Marco Guglielmo, Chiara Lanzillo, Massimo Lombardi, Valentina Lorenzoni, Jordi Lozano-Torres, Davide Margonato, Chiara Martini, Francesca Marzo, Piergiorgio Masci, Ambra Masi, Riccardo Memeo, Claudio Moro, Saima Mushtaq, Alberto Nese, Alessandro Palumbo, Anne Giulia Pavon, Patrizia Pedrotti, Mauro Pepi, Martina Perazzolo Marra, Silvia Pica, Silvia Pradella, Cristina Presicci, Mark G. Rabbat, Claudia Raineri, Jose' F. Rodriguez-Palomares, Stefano Sbarbati, U. Joseph Schoepf, Angelo Squeri, Nicola Sverzellati, Rolf Symons, Emily Tat, Mauro Timpani, Giancarlo Todiere, Adele Valentini, Akos Varga-Szemes, Alessandra Volpe, Laura Fusini, Andrea Igoren Guaricci, Jurg Schwitter, Gianluca Pontone
Summary: Right ventricular systolic dysfunction (RVSD) is an important determinant of outcomes in heart failure (HF) patients. Cardiac magnetic resonance (CMR) is a reliable method to assess RV function and predict all-cause mortality in HF patients. The prognostic value of RVSD is more pronounced in certain subgroups.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Lamia Ait Ali, Chiara Marrone, Duarte Saraiva Martins, Diala Khraiche, Pierluigi Festa, Nicola Martini, Giuseppe Santoro, Giancarlo Todiere, Elena Panaioli, Damien Bonnet, Nathalie Boddaert, Giovanni Donato Aquaro, Francesca Raimondi
Summary: According to this study, cardiac magnetic resonance and syncope are independent predictors of cardiovascular events in children with hypertrophic cardiomyopathy.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Stefano Figliozzi, Georgios Georgiopoulos, Pedro M. Lopes, Klemens B. Bauer, Sara Moura-Ferreira, Lara Tondi, Saima Mushtaq, Stefano Censi, Anna Giulia Pavon, Ilaria Bassi, Maria Luz Servato, Arco J. Teske, Federico Biondi, Domenico Filomena, Silvia Pica, Camilla Torlasco, Denisa Muraru, Pierre Monney, Giuseppina Quattrocchi, Viviana Maestrini, Luciano Agati, Lorenzo Monti, Patrizia Pedrotti, Bert Vandenberk, Angelo Squeri, Massimo Lombardi, Antonio M. Ferreira, Juerg Schwitter, Giovanni Donato Aquaro, Amedeo Chiribiri, Jose F. Rodriguez Palomares, Ali Yilmaz, Daniele Andreini, Anca Florian, Tim Leiner, Joao Abecasis, Luigi Paolo Badano, Jan Bogaert, Pier-Giorgio Masci
Summary: In patients with mitral valve prolapse (MVP) without moderate-to-severe mitral regurgitation or left ventricular dysfunction, mitral annulus disjunction (MAD) and myocardial fibrosis determined by late gadolinium enhancement (LGE) cardiac MRI were found to be associated with adverse outcomes.
Article
Environmental Sciences
Giovanni Donato Aquaro, Benedetta Guidi, Michele Emdin, Angela Pucci, Enrica Chiti, Alessandro Santurro, Matteo Scopetti, Federico Biondi, Aniello Maiese, Emanuela Turillazzi, Giovanni Camastra, Lorenzo Faggioni, Dania Cioni, Vittorio Fineschi, Emanuele Neri, Marco Di Paolo
Summary: This study evaluated the accuracy of post-mortem cardiac magnetic resonance (PMCMR) for diagnosing the cardiac causes of sudden death. The results showed that PMCMR had high sensitivity and specificity in identifying the cardiac cause of sudden death, and could be considered as a valuable tool for forensic diagnosis.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Computer Science, Information Systems
Miriam Basile, Simone Cauzzo, Alejandro Luis Callara, Domenico Montanaro, Valentina Hartwig, Maria Sole Morelli, Francesca Frijia, Alberto Giannoni, Claudio Passino, Michele Emdin, Nicola Vanello
Summary: Noninvasive studies of central respiratory control are crucial for understanding central apneas and periodic breathing. Functional magnetic resonance imaging (fMRI) is used to study brainstem and cortical-subcortical centers. However, the vasodilatory effects of CO2 and physiological noise make it challenging to distinguish specific from non-specific effects in fMRI. This study investigates the supralinear relationship between CO2 and BOLD signal to determine neural activation specificity.
Article
Cardiac & Cardiovascular Systems
Giovanni Donato Aquaro, Carmelo De Gori, Lorenzo Faggioni, Maria Luisa Parisella, Dania Cioni, Riccardo Lencioni, Emanuele Neri
Summary: Late gadolinium enhancement (LGE) is a crucial technique in cardiac magnetic resonance for tissue characterization, providing diagnostic and prognostic assessment of cardiomyopathies. LGE can accurately differentiate between ischemic and non-ischemic heart disease, and help diagnose different cardiomyopathies. LGE can be caused by increased interstitial space or myocardial fibrosis. The exact pattern of LGE is important for non-ischemic cardiomyopathies.
EUROPEAN HEART JOURNAL SUPPLEMENTS
(2023)
Review
Medicine, General & Internal
Roberto Licordari, Giancarlo Trimarchi, Lucio Teresi, Davide Restelli, Francesca Lofrumento, Alessia Perna, Mariapaola Campisi, Cesare de Gregorio, Patrizia Grimaldi, Danila Calabro, Francesco Costa, Antonio Giovanni Versace, Antonio Micari, Giovanni Donato Aquaro, Gianluca Di Bella
Summary: Hypertrophic cardiomyopathy (HCM) is a genetic heart disease characterized by thickening of the heart muscle. Cardiac magnetic resonance (CMR) imaging has emerged as a powerful tool for the assessment of HCM and its phenocopies. CMR can accurately quantify hypertrophy, assess fibrosis, and differentiate HCM from other diseases with similar features.
JOURNAL OF CLINICAL MEDICINE
(2023)
Letter
Cardiac & Cardiovascular Systems
Matteo Parollo, Lorenzo Mazzocchetti, Andrea Di Cori, Luca Segreti, Raffaele De Lucia, Gino Grifoni, Valentina Barletta, Lorenzo Faggioni, Giovanni Donato Aquaro, Emanuele Neri, Antonio Canu, Stefano Viani, Ezio Soldati, Antonio Berruezo, Giulio Zucchelli
Review
Radiology, Nuclear Medicine & Medical Imaging
Michela Gabelloni, Lorenzo Faggioni, Maria Chiara Brunese, Carmine Picone, Roberta Fusco, Giovanni Donato Aquaro, Dania Cioni, Emanuele Neri, Nicoletta Gandolfo, Andrea Giovagnoni, Vincenza Granata
Summary: Pleural mesothelioma (PM) is an aggressive disease with a strong causal relationship with asbestos exposure, posing challenges in diagnosis and treatment. Timely and accurate staging using available imaging techniques is crucial for effective management. Our aim is to provide an updated overview of the role of multimodal medical imaging in PM management.
JAPANESE JOURNAL OF RADIOLOGY
(2023)
Letter
Medicine, General & Internal
Federico Bigazzi, Beatrice Dal Pino, Chiara Pavanello, Francesco Sbrana, Giovanni D. Aquaro, Vinicio Napoli, Cataldo Palmieri, Andrea Barison, Laura Calabresi, Tiziana Sampietro
Article
Medicine, General & Internal
Andrea Barison, Fabrizio Ricci, Anna Giulia Pavon, Giuseppe Muscogiuri, Giandomenico Bisaccia, Giovanni Camastra, Manuel De Lazzari, Chiara Lanzillo, Mario Raguso, Lorenzo Monti, Sara Vargiu, Patrizia Pedrotti, Marcello Piacenti, Giancarlo Todiere, Gianluca Pontone, Ciro Indolfi, Santo Dellegrottaglie, Massimo Lombardi, Juerg Schwitter, Giovanni Donato Aquaro
Summary: This study assessed the diagnostic yield and extent of metal artifacts in CMR scans of patients with CIEDs. The results showed overall good quality and safety of CMR scans, with minimal adverse events or device malfunctions. ICDs induced more artifacts than PMs or ILRs, and the artifacts were mainly located in specific segments of the LV and RV.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Andrea Barison, Roberto Ceolin, Alessandro Palmieri, Pietro Paolo Tamborrino, Giancarlo Todiere, Chrysanthos Grigoratos, Ignazio Alessio Gueli, Carmelo De Gori, Alberto Clemente, Laura Pistoia, Alessia Pepe, Giovanni Donato Aquaro, Vincenzo Positano, Michele Emdin, Filippo Cademartiri, Antonella Meloni, Michael Henein
Summary: This study derived reference values of left-ventricular (LV) and right-ventricular (RV) strain parameters using feature tracking cardiac magnetic resonance (FT-CMR) in a cohort of 100 healthy subjects. It found gender differences in LV and RV strain values, and a significant correlation between LV strain and LV ejection fraction, and between RV GLS and RV end-diastolic volume.
Article
Medicine, General & Internal
Giovanni Donato Aquaro, Silvia Monastero, Giancarlo Todiere, Andrea Barison, Carmelo De Gori, Crysanthos Grigoratos, Maria Luisa Parisella, Lorenzo Faggioni, Dania Cioni, Riccardo Lencioni, Emanuele Neri
Summary: In a cohort of consecutive patients undergoing cardiac MRI, we compared native T1 mapping to conventional late gadolinium enhancement (LGE) and T2-STIR techniques. The results showed that conventional techniques and T1 mapping were concordant in most patients, but in a few patients, T1 mapping was positive while conventional techniques were negative. Overall, conventional LGE/T2-STIR and T1 mapping are complementary techniques and should be used together in every CMR examination.
Article
Radiology, Nuclear Medicine & Medical Imaging
Giovanni Donato Aquaro, Carmelo De Gori, Giulia Grilli, Roberto Licordari, Andrea Barison, Giancarlo Todiere, Umberto Ianni, Matteo Parollo, Crysanthos Grigoratos, Luca Restivo, Antonio De Luca, Lorenzo Faggioni, Dania Cioni, Gianfranco Sinagra, Gianluca Di Bella, Emanuele Neri
Summary: The prognostic role of left ventricular papillary muscle abnormalities in patients with preserved LV systolic ejection fraction is unclear. This study aimed to evaluate the predictive role of LV papillary muscle abnormalities by CMR in patients with ventricular arrhythmias and preserved LVEF. The results showed that Dark-Paps is a novel prognostic marker in patients with ventricular arrhythmias and preserved ejection fraction.
EUROPEAN RADIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Alberto Aimo, Silvia Burchielli, Andrea Barison, Giovanni Donato Aquaro, Veronica Musetti, Silvia Masotti, Angela Pucci, Martina Modena, Domiziana Terlizzi, Claudio Passino, Michele Emdin
Summary: Pirfenidone does not have additional effects on left ventricular remodeling or fibrosis compared to standard therapy, but its effects are similar to standard therapy alone.
JOURNAL OF CARDIOVASCULAR MEDICINE
(2023)