Article
Cardiac & Cardiovascular Systems
Mihaly Karolyi, Matthias Eberhard, Tobias Gloor, Malgorzata Polacin, Robert Manka, Vedran Savic, Andre R. Plass, Paul Robert Vogt, Hatem Alkadhi, Martin O. Schmiady
Summary: Early routine postoperative assessment of coronary artery bypass graft surgery (CABG) with computed tomography angiography (CTA) reveals both cardiac and non-cardiac findings with a high frequency, affecting clinical management in a substantial proportion of patients.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Medicine, General & Internal
Cristiano Spadaccio, David Rose, Antonio Nenna, Rebecca Taylor, Mohamad Nidal Bittar
Summary: In patients undergoing coronary artery bypass grafting (CABG), conservative management may be a safe and viable option for hemodynamically stable patients experiencing significant but non-critical bleeding. It may have advantages in terms of reducing postoperative morbidities and hospital stay.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Yu-Ting Cheng, Dong-Yi Chen, Victor Chien-Chia Wu, An-Hsun Chou, Shang-Hung Chang, Pao-Hsien Chu, Shao-Wei Chen
Summary: The effect of previous coronary stenting on subsequent coronary artery bypass graft is inconclusive. This retrospective study using Taiwan's National Health Insurance Database found that previous coronary stenting before multivessel coronary artery bypass graft significantly increased 30-day mortality but did not affect late survival. However, patients who had coronary stenting before coronary artery bypass graft experienced more revascularization events during late follow-up.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Donald S. Likosky, Raymond J. Strobel, Xiaoting Wu, Robert S. Kramer, Baron L. Hamman, James K. Brevig, Michael P. Thompson, Amir A. Ghaferi, Min Zhang, Eric J. Lehr
Summary: This study evaluated whether interhospital variation in mortality rates for coronary artery bypass grafting was driven by complications and failure to rescue. The study found a positive correlation between hospital failure to rescue rates and complications, suggesting that early recognition and management of complications are important factors in improving the success of coronary artery bypass grafting.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Biochemistry & Molecular Biology
Alexander Vladimirovich Ivanov, Mikhail Aleksandrovich Popov, Arkady Andreevich Metelkin, Valery Vasil'evich Aleksandrin, Evgeniy Gennad'evich Agafonov, Maria Petrovna Kruglova, Ekaterina Vladimirovna Silina, Victor Aleksandrovich Stupin, Ruslan Andreevich Maslennikov, Aslan Amirkhanovich Kubatiev
Summary: Coronary artery disease (CAD) and coronary artery bypass graft (CABG) are associated with a decrease in blood glutathione (bGSH) level. This study aimed to examine the associations of bGSH with glucose and plasma aminothiols in CAD patients before CABG and in the early postoperative period. The results showed that bGSH and its redox status were lower in CAD patients at admission, and CABG had no significant effect on these parameters except for an increase in the bGSH/hemoglobin ratio. Additionally, an association was found between an increase in oxidized GSH in the blood after surgery and fasting glucose levels.
Article
Multidisciplinary Sciences
Chun Dai, Hongbo Xu, Tianshu Chu, Boyang Cao, Jianjun Ge
Summary: This study investigated the relationship between body mass index (BMI) and postoperative mortality in patients undergoing CABG surgery plus valve replacement. The results showed a non-linear relationship between BMI and postoperative mortality after adjusting for confounding factors.
Article
Medicine, General & Internal
Tzu-Hsiang Lin, Chi-Wei Wang, Ching-Hui Shen, Keng-Hao Chang, Chih-Hung Lai, Tsun-Jui Liu, Kuan-Ju Chen, Yu-Wei Chen, Wen-Lieng Lee, Chieh-Shou Su
Summary: The study found that in real-world practice, robotic-assisted CABG (R-CABG) for patients with multivessel coronary artery disease (MVD) was associated with lower in-hospital and long-term mortalities compared to conventional CABG (C-CABG). However, there were no significant differences between the two groups in terms of target lesion revascularization, target vessel revascularization, myocardial infarction, and stroke.
Article
Health Care Sciences & Services
Po-Shun Hsu, Jia-Lin Chen, Shih-Ying Sung, Yi-Ting Tsai, Chih-Yuan Lin, Yi-Fan Wu, Chien-Sung Tsai
Summary: This study compares the hemorheological and inflammatory changes before and after coronary artery bypass graft (CABG) surgery and finds that hyperviscosity persists for almost one week after the surgery. Inflammatory markers are also correlated with hemorheological changes. Understanding the interplay between inflammation and hemorheological properties is crucial for patient care.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Eun Ji Seo, Joonhwa Hong, Hyeon-Ju Lee, Youn-Jung Son
Summary: This systematic review evaluated the perioperative predictors of new-onset POAF after isolated CABG, identifying various risk factors that could be used for monitoring and early intervention to reduce negative clinical outcomes. The study included nine high-quality articles, with findings suggesting that factors such as old age, renal failure, and heart failure are associated with an increased risk of new-onset POAF after CABG.
BMC CARDIOVASCULAR DISORDERS
(2021)
Article
Cardiac & Cardiovascular Systems
Masafumi Ono, Shigetaka Kageyama, Neil O'Leary, Mohammed S. El-Kurdi, Jochen Reinoehl, Eric Solien, Richard W. Bianco, Mirko Doss, Bart Meuris, Renu Virmani, Martijn Cox, Yoshinobu Onuma, Patrick W. Serruys
Summary: This study demonstrates the feasibility and effectiveness of a novel biorestorative graft in an ovine coronary artery bypass graft model, suggesting its potential as an alternative to saphenous vein grafts. These findings could pave the way for the first-in-man trial of using this new material for coronary artery bypass graft patients who struggle with harvesting SVGs.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2023)
Article
Cardiac & Cardiovascular Systems
Garry W. Hamilton, Diem Dinh, Julian Yeoh, Angela L. Brennan, Jordan Fulcher, Anoop N. Koshy, Matias B. Yudi, Christopher M. Reid, David L. Hare, Melanie Freeman, Dion Stub, William Chen, Stephen J. Duffy, Andrew Ajani, Jaishankar Raman, Omar Farouque, David J. Clark
Summary: This study reports the characteristics of arterial graft stenoses and evaluates the feasibility of radial artery percutaneous coronary intervention (PCI). The results show that patients undergoing radial artery PCI had earlier presentation, less frequent acute coronary syndrome, and more common intervention at the ostial or distal anastomosis compared with saphenous vein graft PCI. Patients undergoing radial artery PCI were more likely to have diabetes, peripheral vascular disease, and non-ST-segment elevation myocardial infarction compared with those undergoing native PCI.
JACC-CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Kiran Sarathy, George A. Wells, Kuljit Singh, Etienne Couture, Aun Yeong Chong, Fraser Rubens, Marie Lordkipanidze, Jean-Francois Tanguay, Derek So
Summary: For patients with acute coronary syndromes requiring coronary artery bypass surgery, a more potent antiplatelet regimen may reduce mortality rates. There are potential clinical benefits in terms of platelet quiescence.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Israel O. Bolanle, Kirsten Riches-Suman, Mahmoud Loubani, Ritchie Williamson, Timothy M. Palmer
Summary: Coronary artery bypass graft (CABG) using autologous saphenous vein remains the gold standard for treating CAD patients, but those with T2DM are at higher risk of graft failure. Protein O-GlcNAcylation has emerged as a key mechanism in the pathogenesis of vein graft failure in T2DM, providing potential therapeutic targets for new drug development.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Article
Medicine, General & Internal
Francesca Toto, Tiziano Torre, Lucia Turchetto, Viviana Lo Cicero, Sabrina Soncin, Catherine Klersy, Stefanos Demertzis, Enrico Ferrari
Summary: This study compared the efficacy of three solutions in preserving the endothelial cell integrity of saphenous vein grafts. The results showed that DuraGraft better protected the grafts against ischemic-induced apoptosis compared to saline solution. Prolonged ischemia was associated with extended endothelium damage, and none of the studied solutions protected the vein grafts.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Mario Gaudino, Irbaz Hameed, N. Bryce Robinson, Yongle Ruan, Mohamed Rahouma, Ajita Naik, Viola Weidenmann, Michelle Demetres, Derrick Y. Tam, David L. Hare, Leonard N. Girardi, Giuseppe Biondi-Zoccai, Stephen E. Fremes
Summary: This study conducted a network meta-analysis to compare the angiographic patency rates of various conduits used in coronary bypass surgery. The results showed that radial artery and no-touch saphenous vein grafts were associated with significantly lower graft occlusion rates compared to conventionally harvested saphenous vein, with radial artery ranking as the best conduit.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Canxia Shi, Joseph Pierre Aboumsallem, Navin Suthahar, Aniek O. de Graaf, Joop H. Jansen, Isabelle A. van Zeventer, Valentina Bracun, Sanne de Wit, Elles M. Screever, Pieter F. van den Berg, Wouter C. Meijers, Ron T. Gansevoort, Stephan J. L. Bakker, Pim van der Harst, Herman H. W. Sillje, Gerwin Huls, Rudolf A. de Boer
Summary: This study aimed to analyze the association between clonal hematopoiesis of indeterminate potential (CHIP) and incident heart failure (HF) in a European population cohort. Results showed that CHIP mutations were correlated with age, smoking, hypertension, and cardiovascular biomarkers, but the frequency of CHIP was similar between individuals with incident HF and control participants. However, among people younger than 65 years, CHIP mutations were more frequently detected in the case cohort and significantly associated with new-onset HF.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
S. N. Voorrips, E. M. Boorsma, J. C. Beusekamp, R. A. DE -boer, M. A. Connelly, R. P. F. Dullaart, P. Van-der-meer, D. J. Van-veldhuisen, A. A. Voors, K. Damman, B. D. Westenbrink
Summary: This study analyzed the ketone body production in patients with acute decompensated heart failure and found that ketone body concentrations were significantly increased during acute decompensation. However, treatment with empagliflozin had no significant effect on ketone body concentrations. These findings provide insights into the metabolic characteristics of acute heart failure.
JOURNAL OF CARDIAC FAILURE
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Christian Mueller, Tamar S. Muench-Gerber, Rudolf A. de Boer
EUROPEAN HEART JOURNAL
(2023)
Article
Medicine, General & Internal
Navin Suthahar, Kan Wang, Victor W. Zwartkruis, Stephan J. L. Bakker, Silvio E. Inzucchi, Tim R. Eijgenraam, Fariba Ahmadizar, Eric G. Sijbrands, Ron T. Gansevoort, Lyanne M. Kieneker, Dirk J. van Veldhuisen, Maryam Kavousi, Rudolf A. de Boer
Summary: Relative fat mass (RFM), a novel anthropometric equation based on height and waist measurements, is strongly associated with incident type-2 diabetes (T2D) and shows potential as a predictor of future diabetes risk in the general population, outperforming BMI, waist circumference, and waist-to-hip ratio.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Jawad H. Butt, Kieran F. Docherty, Brian L. Claggett, Akshay S. Desai, James C. Fang, Magnus Petersson, Anna Maria Langkilde, Rudolf A. de Boer, Jose Walter Cabrera Honorio, Adrian F. Hernandez, Silvio E. Inzucchi, Mikhail N. Kosiborod, Lars Kober, Carolyn S. P. Lam, Felipe A. Martinez, Piotr Ponikowski, Marc S. Sabatine, Orly Vardeny, Eileen O'Meara, Jose F. K. Saraiva, Sanjiv J. Shah, Muthiah Vaduganathan, Pardeep S. Jhund, Scott D. Solomon, John J. V. McMurray
Summary: Black people have a higher incidence and prevalence of heart failure than White people, and they may have worse outcomes once HF has developed. This study examined the outcomes and response to treatment with dapagliflozin in Black and White patients with heart failure. The results showed that dapagliflozin had consistent benefits in both Black and White patients, with greater absolute benefits in Black patients.
JACC-HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Jawad H. Butt, Toru Kondo, Mingming Yang, Pardeep S. Jhund, Kieran F. Docherty, Muthiah Vaduganathan, Brian L. Claggett, Adrian F. Hernandez, Carolyn S. P. Lam, Silvio E. Inzucchi, Felipe A. Martinez, Rudolf A. de Boer, Mikhail N. Kosiborod, Akshay S. Desai, Lars Kober, Piotr Ponikowski, Marc S. Sabatine, Sanjiv J. Shah, Natalia Zaozerska, Ulrica Wilderang, Olof Bengtsson, Scott D. Solomon, John J. McMurray
Summary: This study aimed to assess the efficacy and safety of dapagliflozin in patients with heart failure, particularly in those with peripheral artery disease (PAD). The results showed that dapagliflozin was equally effective in patients with and without PAD and did not increase the risk of amputation.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Safia Chatur, Muthiah Vaduganathan, Brian Claggett, Orly Vardeny, Akshay S. Desai, Pardeep S. Jhund, Rudolf A. de Boer, Carolyn S. P. Lam, Mikhail N. Kosiborod, Sanjiv J. Shah, Felipe Martinez, Silvio E. Inzucchi, Adrian F. Hernandez, Tariq Haddad, Sumeet S. Mitter, Zi Michael Miao, Magnus Petersson, Anna Maria Langkilde, John J. McMurray, Scott D. Solomon
Summary: In this study, the safety and efficacy of dapagliflozin were evaluated according to different diuretic therapies and its influence on diuretic use. The results showed that dapagliflozin had consistent clinical benefits in terms of reducing heart failure worsening and cardiovascular death across different diuretic categories and doses, with a similar safety profile. Dapagliflozin also significantly reduced the need for loop diuretics over time.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Ankeet S. Bhatt, Mikhail N. Kosiborod, Muthiah Vaduganathan, Brian L. Claggett, Z. Michael Miao, Ian J. Kulac, Carolyn S. P. Lam, Adrian F. Hernandez, Felipe Martinez, Silvio E. Inzucchi, Sanjiv J. J. Shah, Rudolf A. de Boer, Pardeep S. Jhund, Akshay S. Desai, Magnus Petersson, Anna Maria Langkilde, John J. V. McMurray, Scott D. Solomon
Summary: In this study, the effects of dapagliflozin on health status in heart failure patients were examined. The results showed that dapagliflozin improved health status in patients across the full range of left ventricular ejection fraction (LVEF).
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Mark Jansen, A. F. Schmidt, J. J. M. Jans, I. Christiaans, S. N. van der Crabben, Y. M. Hoedemaekers, D. Dooijes, J. D. H. Jongbloed, L. G. Boven, R. H. Lekanne Deprez, A. A. M. Wilde, J. van der Velden, R. A. de Boer, J. P. van Tintelen, F. W. Asselbergs, A. F. Baas
Summary: In this study, acylcarnitines were evaluated as potential biomarkers for hypertrophic cardiomyopathy (HCM). The study found that several acylcarnitines were significantly increased in patients with severe HCM, and some were also increased in patients with mild HCM. Additionally, certain acylcarnitines were associated with measures of HCM severity. Prospective studies are needed to further investigate the prognostic value of these biomarkers.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Ali A. A. Al-Mubarak, Niels Grote Beverborg, Victor Zwartkruis, Colinda van Deutekom, Martin H. H. de Borst, Ron T. T. Gansevoort, Stephan J. L. Bakker, Daan J. J. Touw, Rudolf A. A. de Boer, Peter van der Meer, Michiel Rienstra, Nils Bomer
Summary: This study aimed to investigate the association between micronutrient deficiencies and the development of atrial fibrillation (AFib). Selenium deficiency was found to be associated with new-onset AFib in non-smoking participants.
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
Article
Oncology
Pieter F. van den Berg, Joseph Pierre Aboumsallem, Elles M. Screever, Canxia Shi, Sanne de Wit, Valentina Bracun, Laura I. Yousif, Lotte Geerlings, Dongyu Wang, Jennifer E. Ho, Stephan J. L. Bakker, Bert van der Vegt, Herman H. W. Sillje, Rudolf A. de Boer, Wouter C. Meijers
Summary: The fibrosis-related biomarker galectin-3 (gal-3) is associated with new-onset cancer and heart failure (HF) in males, but not in females.
JACC: CARDIOONCOLOGY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
K. Mcdowell, P. Welsh, K. Docherty, D. A. Morrow, R. A. De Boer, E. O'meara, S. E. Inzucchi, L. Kober, M. N. Kosiborod, F. A. Martinez, A. M. Langkilde, S. D. Solomon, N. Sattar, M. S. Sabatine, J. J. V. Mcmurray
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
L. M. G. Laura Marieke Gezina Meems, S. Li, G. Krenning, C. J. Boogerd, H. H. W. Sillje, C. Withaar, R. A. De Boer
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Peikert, P. Goyal, M. Vaduganathan, B. L. Claggett, A. S. Desai, P. S. Jhund, M. N. Kosiborod, C. S. P. Lam, S. E. Inzucchi, F. A Martinez, R. A. De Boer, A. F. Hernandez, S. J. Shah, J. J. V. Mcmurray, S. D. Solomon
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
T. B. Petersen, N. Suthahar, F. W. Asselbergs, M. De Bakker, K. M. Akkerhuis, A. A. Constantinescu, J. Van Ramshorst, P. D. Katsikis, P. J. Van Der Spek, V. A. Umans, R. A. De Boer, E. Boersma, D. Rizopoulos, I. Kardys
EUROPEAN JOURNAL OF HEART FAILURE
(2023)