Review
Neurosciences
Courtney Clyburn, Joseph J. Sepe, Beth A. Habecker
Summary: The autonomic nervous system regulates cardiac function by balancing sympathetic and parasympathetic inputs, with studies showing remodeling of cardiac neurocircuits in disease states, increasing the risk of poor cardiac outcomes for patients.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Cardiac & Cardiovascular Systems
Richard C. Daly, Andrew N. Rosenbaum, Joseph A. Dearani, Alfredo L. Clavell, Naveen L. Pereira, Barry A. Boilson, Robert P. Frantz, Atta Behfar, Shannon M. Dunlay, Richard J. Rodeheffer, John A. Schirger, Timucin Taner, Manish J. Gandhi, Julie K. Heimbach, Charles B. Rosen, Brooks S. Edwards, Sudhir S. Kushwaha
Summary: This study demonstrates the successful transplantation using a heart-after-liver transplantation protocol, which provides profound immunologic protection and prevents adverse immunological outcomes in highly sensitized patients requiring combined heart-liver transplantation. The results show near-elimination of donor specific antibodies and minimal rejection episodes, leading to favorable long-term patient and graft outcomes.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Immunology
Jinwen Lin, Ying Chen, Huijuan Zhu, Kai Cheng, Huiping Wang, Xianping Yu, Mengmeng Tang, Jianghua Chen
Summary: This study demonstrates that remodeling of lymphatic vessels plays a key role in antigen presentation and lymph node activation after kidney transplantation. Higher density of lymphatic vessels is associated with renal dysfunction and pathological changes post-transplantation.
FRONTIERS IN IMMUNOLOGY
(2021)
Editorial Material
Gastroenterology & Hepatology
Roberta Angelico, Bruno Sensi, Tommaso M. Manzia, Giuseppe Tisone, Giuseppe Grassi, Alessandro Signorello, Martina Milana, Ilaria Lenci, Leonardo Baiocchi
Summary: Chronic rejection (CR) is a significant cause of graft injury after liver transplantation, potentially leading to damage to intrahepatic vessels and bile ducts, and even necessitating re-transplantation. Early detection, identification of non-invasive biomarkers, and tailored management of immunosuppression are crucial for the treatment of CR.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Biology
Maren Heimerl, Thomas Gausepohl, Julia H. Mueller, Melanie Ricke-Hoch
Summary: In this manuscript, the role of neuraminidases (NEUs) in cardiovascular diseases is reviewed. NEUs are involved in regulating cell communication and inflammatory responses, playing an important role in cardiac pathologies. Inhibition of NEUs shows promise as a novel treatment strategy for cardiac diseases, as it can reduce inflammation and improve cardiac function.
Article
Health Care Sciences & Services
Silvia Lozano-Edo, Esther Rosello-Lleti, Ignacio Sanchez-Lazaro, Estefania Tarazon, Manuel Portoles, Maryem Ezzitouny, Raquel Lopez-Vilella, Miguel Angel Arnau, Luis Almenar, Luis Martinez-Dolz
Summary: This study found that serum RANGAP1 levels can serve as a non-invasive biomarker for predicting the risk of ACR during the first year after heart transplantation.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Cell Biology
Weixiong Zheng, Lingxiang Yang, Shiming Jiang, Mingxiang Chen, Jinzheng Li, Zuojing Liu, Zhongjun Wu, Jianping Gong, Yong Chen
Summary: Liver transplantation is a effective treatment for end-stage liver disease and significantly prolongs the survival time of patients, but acute and chronic rejection still remain major obstacles. Investigating induced immune tolerance is of crucial theoretical significance and socio-economic value. This paper comprehensively summarizes the important roles of Kupffer cells in establishing immune tolerance after transplantation, including phagocytosis, cell polarization, antigen presentation, and cell membrane proteins, providing a theoretical basis for further study and clinical application of Kupffer cells in liver transplantation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Medicine, General & Internal
Elena Yukie Uebayashi, Hideaki Okajima, Miki Yamamoto, Eri Ogawa, Tatsuya Okamoto, Hironori Haga, Etsurou Hatano
Summary: Antibody-mediated rejection (AMR) of liver allograft transplantation has gained clinical awareness as a potential cause of chronic liver injury and graft failure. The accurate incidence, diagnostic criteria, and treatment protocols of chronic AMR in pediatric patients remain unclear and further research is needed.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Jung-Min Ahn, Frederik M. Zimmermann, Lars Gullestad, Oskar Angeras, Kristjan Karason, Kristoffer Russell, Ketil Lunde, Kozo Okada, Helen Luikart, Kiran K. Khush, Yasuhiro Honda, Nico H. J. Pijls, Sang Eun Lee, Jae-Joong Kim, Seung-Jung Park, Ole-Geir Solberg, William F. Fearon
Summary: The study validated that the index of microcirculatory resistance (IMR) measured early after heart transplantation is associated with subsequent acute rejection at 1 year and clinical events at 10 years. Patients with higher IMR are more likely to experience rejection and major adverse cardiac events, suggesting that early IMR measurement can identify high-risk patients and guide personalized posttransplantation management.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Review
Immunology
Hanwen Zhang, Zhuonan Li, Wei Li
Summary: Macrophages, as a critical part of the immune system, play important roles in transplantation rejection. M1 and M2 macrophages have different functions in acute and chronic rejection, respectively, contributing to tissue damage and poor allograft survival.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Pharmacology & Pharmacy
P. Boknik, J. Eskandar, B. Hofmann, N. Zimmermann, J. Neumann, U. Gergs
Summary: This review provides an overview of the localization and role of cardiac A(2A)-adenosine receptors, as well as their potential involvement in relevant cardiac pathologies. The review also discusses the cardiac utility of A(2A)-AR as therapeutic targets and identifies gaps in knowledge for future research.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Zhe Yang, Fei Han, Tao Liao, Haofeng Zheng, Zihuan Luo, Maolin Ma, Jiannan He, Lei Li, Yongrong Ye, Rui Zhang, Zhengyu Huang, Yannan Zhang, Qiquan Sun
Summary: Artemisinin demonstrates significant immunosuppressive effects in rat cardiac transplantation model, attenuating rejection reactions and prolonging allograft survival. By targeting multiple effector cells, artemisinin effectively reduces T cell-mediated rejection and antibody-mediated rejection, showing potential for clinical use in transplant rejection prevention.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Li Qi, Xuefeng Ni, U. Joseph Schoepf, Akos Varga-Szemes, Liam McGill, Wei Wang, Lingyan Zhang, Song Luo, Jiqiu Wen, Long Jiang Zhang
Summary: After renal transplantation, cardiac structural and functional changes were observed. While some parameters returned to normal levels, left ventricular mass index remained impaired in median 14 months after transplantation.
EUROPEAN RADIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Min Young Kim, Daniel C. Brennan
Summary: Significant progress has been made in the pathophysiology, diagnosis, and treatment of antibody-mediated rejection (ABMR) in recent decades, but effective treatment for chronic ABMR remains a challenge. Chronic ABMR has a distinct phenotype from active ABMR and is mainly caused by de novo donor specific antibodies (DSA), leading to progressive graft injury.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Jiayu Liu, Zhi Yu, Buajieerguli Maimaiti, Qian Meng, Hongmei Meng
Summary: This review provides an overview of the role of polyamines in the pathophysiological processes of epilepsy and their potential as therapeutic targets. It suggests that polyamines may be involved in epilepsy through mechanisms such as interaction with ion channels, antioxidation, and induction of cell damage via toxic metabolite production.
