Article
Chemistry, Analytical
Zimu Li, Min Zhu, Fang Li, Zhi Li, Anqi Zhao, Mohammad A. Haghighatbin, Hua Cui
Summary: This study presents a multicolor chemiluminescence sensing strategy for the discrimination of five antioxidants. By fabricating multilayer paper chips and utilizing chemiluminescence reactions, unique R, G, and B values were generated in the chemiluminescence images for antioxidant discrimination. The experimental results demonstrate the accuracy and feasibility of this strategy in identifying antioxidants.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Nanoscience & Nanotechnology
Huijuan Zhang, Dong Wang, Duan Zhang, Tongtong Zhang, Longkun Yang, Zhipeng Li
Summary: A surface-enhanced Raman scattering (SERS) substrate functionalized with I- was developed for rapid and sensitive Hg2+ sensing on a microfluidic platform. The sensor demonstrated fast response, high sensitivity, and good selectivity towards Hg2+, with detectable concentrations as low as 1 fM. Real water sample detection showed promising results for on-site Hg2+ detection.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Analytical
Tana Sebechlebska, Eva Vaneckova, Marta Katarzyna Choinska-Mlynarczyk, Tomas Navratil, Lukasz Poltorak, Andrea Bonini, Federico Vivaldi, Viliam Kolivoska
Summary: Fused deposition modeling 3D printing using electrically conductive filaments is an attractive tool for manufacturing sensing devices. This study explores the capabilities of 3D printed electrodes to measure electric properties of materials. The authors demonstrate the functionality of a bimaterial FDM-3DP platform for sensing conductivity and permittivity of liquids by impedance measurements. Additionally, they propose an original idea of using impedance measurements to investigate dimensions of 3D printed channels as base structures of microfluidic devices, complemented by optical microscopic analysis.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Abdurrahim Yilmaz, Zeynep Karavelioglu, Gizem Aydemir, Ali Anil Demircali, Rahmetullah Varol, Ali Kosar, Huseyin Uvet
Summary: This study presents a functional system utilizing an untethered magnetic microrobot to create wounds in a microfluidic platform without negative effects on cells. The study also investigates the effect of different wound geometries on wound healing, finding that triangle-shaped wounds heal the slowest and plus-shaped wounds heal the fastest. This research could pave the way for the use of microrobots in lab-on-a-chip devices and potential application in 3D cell cultures.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Biophysics
Gaolin Li, Yuan Ji, Yihui Wu, Yongshun Liu, Huan Li, Yimeng Wang, Mingbo Chi, Hongyan Sun, Hongquan Zhu
Summary: In this study, a multistage microfluidic CTCs sorting method was presented, which involved size-based sorting using a two-array DLD chip, purification of CTCs mixed with leukocytes using a stiffness-based cone channel chip, and cell type identification using Raman techniques. The entire sorting process was label free, highly pure, high-throughput and efficient. The system developed with four parallelized DMC two-array DLD chips achieved a sample processing rate of 2.5 mL per minute with a recovery efficiency of 96.30 ± 2.10% and a purity of 98.25 ± 2.48%. A cone channel chip based on solid and hydrodynamic coupled analysis was developed to improve the purity of CTCs mixed with leukocytes by 1.8-fold.
BIOSENSORS & BIOELECTRONICS
(2023)
Review
Chemistry, Analytical
Peng Zhou, Wei Quan, Kai Wei, Zihua Liang, Jinsheng Hu, Lu Liu, Gen Hu, Ankang Wang, Mao Ye
Summary: In recent years, chip-scale atomic devices, especially chip-scale atomic magnetometers, have shown great potential in biomedical imaging, such as high resolution magnetocardiography and magnetoencephalography. This paper reviews the application of vertical cavity surface emitting lasers (VCSELs) as integrated pumping sources in chip-scale atomic devices. It discusses the integration of VCSELs in various atomic bio-sensing devices with different operating environments, the mode and polarization control of VCSELs in specific applications, and the packaging of VCSELs based on different atomic devices. Finally, it provides a detailed review of VCSEL-based chip-scale atomic magnetometers used for cardiac and brain magnetometry.
Review
Chemistry, Analytical
Mayank Garg, Nicole Pamme
Summary: Microfluidics has revolutionized measurement science by enabling low sample consumption, fast readout, and high throughput. The incorporation of nanomaterials, particularly graphene analogues, has further enhanced these features, especially in electrochemical analysis systems. However, there has been less research on the use of other graphene analogues for microfluidic biosensors. This review aims to highlight the scientific advancements in analytical chemistry applications related to a wider range of 2-D materials and specifically focuses on microfluidic electrochemical and optical sensors.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)
Review
Engineering, Multidisciplinary
Hongtao Dang, Mingshu Chen, Jin Li, Wei Liu
Summary: Optical micro/nanofibers have advantages such as high coupling efficiency, low loss, and high sensitivity, making them suitable for applications in all-optical transmission, environmental monitoring, and life sciences. Microfiber knot resonators are used to explore novel micro/nano-photonic devices and improve sensor performance through careful design and packaging with sensitive materials.
Article
Food Science & Technology
S. Syama, P. V. Mohanan
Summary: Human-on-a-chip (HoC) technology provides a fast and cost-effective alternative approach for drug screening, allowing for a more realistic simulation of the human system's structure and function, overcoming the limitations of traditional research methods.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2021)
Article
Chemistry, Analytical
Jiayu Li, Yuhan Cui, Qiucheng Xie, Tao Jiang, Siyuan Xin, Peng Liu, Tianfeng Zhou, Qin Li
Summary: The flow cytometer is a powerful and widely accepted measurement device in biological studies and clinical diagnostics. To meet the requirements of portable and point-of-care scenarios, a miniaturized flow cytometer based on an all-glass microfluidic chip (AG-UFCM) has been developed, which enables accurate blood analysis and four-part leukocyte differential count based on single fluorescence staining.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Applied
Minglu Wang, Ying Wang, Xiangyang Li, Hongyan Zhang
Summary: The photothermal-sensing microfluidic paper-based analytical chip (PT-Chip) developed in this study enables accurate and sensitive screening of diethylstilbestrol (DES) residue in foods, which is of significant importance for food safety warning.
Article
Biochemical Research Methods
Kunpeng Cai, Shruti Mankar, Taiga Ajiri, Kentaro Shirai, Tasuku Yotoriyama
Summary: The study introduces a fully integrated high-throughput microfluidic circulatory fluorescence-activated cell sorting system capable of significantly increasing the purity of rare cells in a short period of time and effectively enriching different types of cells. Through a sequential sorting process and efficient contamination-free design, effective enrichment of clinical rare cells has been achieved.
Review
Chemistry, Multidisciplinary
Yu Cheng, Si Da Ling, Yuhao Geng, Yundong Wang, Jianhong Xu
Summary: Microfluidic technology offers a controllable and efficient method for producing high-quality quantum dots, which can be used for bio-sensing and bio-imaging applications. It also serves as an effective platform to understand the synthetic mechanism and optimize reaction parameters for quantum dot production.
NANOSCALE ADVANCES
(2021)
Article
Multidisciplinary Sciences
Qinghao Meng, Jing Ding, Bo Peng, Boyan Zhang, Siyu Qian, Bo Su, Cunlin Zhang
Summary: In this study, a THz microfluidic chip was fabricated using cycloolefin copolymers with high transmission of THz waves. The THz modulation characteristics of TiO2, Ag, and Fe3O4 nanosols under different fields were investigated. It was found that all three nanosols exhibited broadband modulation performance.
Article
Chemistry, Analytical
Khaled Alsabbagh, Tim Hornung, Achim Voigt, Sahba Sadir, Taleieh Rajabi, Kerstin Lange
Summary: The microfluidic chip for electrochemical impedance spectroscopy (EIS) serves as a biosensor for label-free detection of proteins, with specific focus on cardiac troponin I as a diagnostic biomarker. The study demonstrates the successful functionalization of electrodes and specific antibody binding, showing promise for the specific detection of clinically relevant concentrations of cardiac markers.