Review
Cardiac & Cardiovascular Systems
Richard J. Jabbour, Nick Curzen
Summary: Cardiologists in the UK primarily rely on NICE and European Society of Cardiology guidelines for decision-making. This article evaluates the current NICE recommendations on myocardial revascularization and compares them with other major international guidelines. Although there are similarities, subtle differences exist due to variations in evidence base, healthcare systems, and cost-effectiveness models. The clinical implications of these disparities will be analyzed.
Review
Medicine, General & Internal
Alexandra N. Nowbar, Christopher Rajkumar, Rasha K. Al-Lamee, Darrel P. Francis
Summary: Recent randomised controlled trials have overturned traditional beliefs about necessary hospital procedures for stable coronary artery disease patients, leading to discussions about the implications for physicians and patients.
Review
Cardiac & Cardiovascular Systems
Beatrice Bassetti, Erica Rurali, Elisa Gambini, Giulio Pompilio
Summary: Non-pharmacological therapies such as neuromodulation, external counter-pulsation, and coronary sinus constriction have been introduced in guidelines for refractory angina management. However, cell-based therapies, despite evidence of their efficacy, have not yet been included in international guidelines for RA treatment.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Thomas J. Povsic, Timothy D. Henry, E. Magnus Ohman, Carl J. Pepine, Ronald G. Crystal, Todd K. Rosengart, Rickey R. Reinhardt, Howard C. Dittrich, Jay H. Traverse, Geoffrey A. Answini, Nahush A. Mokadam
Summary: The EXACT trial aims to evaluate the safety and efficacy of XC001 gene therapy for patients with refractory angina. The study will monitor adverse events and physiological parameters over a 6-month period to assess the treatment's impact on exercise tolerance and myocardial perfusion, with the goal of informing future clinical research.
AMERICAN HEART JOURNAL
(2021)
Review
Cardiac & Cardiovascular Systems
Konstantinos C. Koskinas, Francois Mach, Lorenz Raber
Summary: Despite advancements in technology and procedures, recurrent coronary events post-PCI are often related to untreated non-culprit lesions and suboptimally controlled cardiovascular risk factors. Lowering atherogenic lipid levels, particularly LDL-C, through intensive statin therapy can halt the progression of coronary atherosclerosis and improve cardiovascular outcomes. Adherence to guideline-recommended treatment goals for LDL-C is crucial for reducing longer-term cardiovascular events following PCI.
Article
Cardiac & Cardiovascular Systems
Bei Zhao, Jie Zhang, Yun Li, Xueyao Feng, Shuai Mao, Zhao Yin, Li Liu, Dapeng Song, Shouli Wang
Summary: This study found that the occurrence of post-PCI acute PE is relatively common, primarily mild, often asymptomatic, and independently associated with procedural time and complexity. PE, considered a marker of cardiac damage, may serve as a significant clinical indicator for long-term prognosis.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Anesthesiology
Jingchao Wei, Shangju Gao, Wenyi Li, Long Zhang, Can Cao, Jinshuai Zhai, Bo Gao
Summary: Percutaneous endoscopic intercostal neurectomy is an effective and safe minimally invasive surgical treatment for refractory intercostal neuralgia, achieving significant pain relief in 13 patients.
Article
Anesthesiology
Brendan Langford, Christine Hunt, Amir Lerman, William D. Mauck
Summary: SCS is utilized to treat refractory angina, and requires a comprehensive evaluation of patients considering their cardiovascular comorbidities. Having baseline data is crucial for assessing treatment success.
Article
Cardiac & Cardiovascular Systems
Pierfrancesco Agostoni, Benjamin Scott, Simone Budassi, Stefan Verheye, Carl Convens, Paul Vermeersch, Carlo Zivelonghi
Summary: The study aimed to assess the feasibility of the Minimalistic Hybrid Approach (MHA) algorithm for chronic total occlusion (CTO) percutaneous coronary intervention (PCI). The results showed that the MHA algorithm was successful in almost every CTO lesion when applied by operators experienced with the wrist approach and hybrid techniques.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2021)
Article
Anesthesiology
Brendan Langford, Christine Hunt, Amir Lerman, William D. Mauck
Summary: This study utilized SAQ to evaluate angina symptoms in 18 patients with RAP undergoing SCS treatment. The majority of patients showed reduced physical limitations, favorable angina frequency scores, and high treatment satisfaction, indicating the effectiveness of SAQ in assessing function, pain, and satisfaction in RAP patients.
Article
Cardiac & Cardiovascular Systems
Stefan Verheye, Pierfrancesco Agostoni, Francesco Giannini, Jonathan M. Hill, Christoph Jensen, Steven Lindsay, Pieter R. Stella, Simon Redwood, Shmuel Banai, Maayan Konigstein
Summary: The REDUCER-I study aims to evaluate the safety and efficacy of the CS Reducer for patients with refractory angina. Among the first 228 patients, the procedural success rate was 99% with sustained improvement in clinical outcomes.
Article
Cardiac & Cardiovascular Systems
Yonggang Sui, Jie Qian, Changdong Guan, Yanlu Xu, Naqiong Wu, Weixian Yang, Yongjian Wu, Kefei Dou, Yuejin Yang, Shubin Qiao, Bo Xu
Summary: This study aimed to investigate the long-term clinical outcomes and risk factors for adverse events in left main ostial lesions following drug-eluting stent implantation. The results showed that PCI treatment for left main ostial lesions achieved favorable long-term outcomes, with a similar myocardial infarction risk compared to the mid-shaft group but a significantly lower risk compared to the distal group.
Article
Health Care Sciences & Services
Ingvild Nordnes Myrbakk, Oddgeir Friborg, Anne Hoye, Terje Steigen, Svein Bergvik
Summary: This study examined the psychometric properties of the Norwegian version of CROQ and found serious issues with its factor structure, ceiling effects, and sensitivity for disease severity and invasive treatment effects. Consequently, the use of CROQ in clinical practice cannot be recommended.
HEALTH AND QUALITY OF LIFE OUTCOMES
(2022)
Article
Physics, Fluids & Plasmas
M. Dillane, E. A. Viktorov, B. Kelleher
Summary: Excitable photonic systems have potential for ultrafast analog computation, much faster than biological neurons. Recently, dual-state quantum dot lasers have emerged as true all-or-none excitable artificial neurons. Deterministic triggering is necessary for applications and has been demonstrated in previous research. This work analyzes the crucial refractory time of the dual-state system, which defines the minimum time between distinct pulses in any train.
Article
Cardiac & Cardiovascular Systems
Benjamin J. R. Buckley, Iris A. de Koning, Stephanie L. Harrison, Elnara Fazio-Eynullayeva, Paula Underhill, Hareld M. C. Kemps, Gregory Y. H. Lip, Dick H. J. Thijssen
Summary: This study compared the impact of exercise-based cardiac rehabilitation (CR) and percutaneous coronary intervention (PCI) on patients with chronic coronary syndrome (CCS). The results showed that compared to PCI, exercise-based CR was associated with significantly lower odds of 18-month all-cause mortality, rehospitalization, and cardiovascular morbidity in CCS patients. Combining PCI with exercise-based CR was only associated with lower incident heart failure.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
