Review
Cardiac & Cardiovascular Systems
Patrick W. Serruys, Hironori Hara, Scot Garg, Hideyuki Kawashima, Bjarne L. Norgaard, Marc R. Dweck, Jeroen J. Bax, Juhani Knuuti, Koen Nieman, Jonathon A. Leipsic, Saima Mushtaq, Daniele Andreini, Yoshinobu Onuma
Summary: Coronary computed tomography angiography (CTA) has undergone significant technological advancements and is now considered a high-accuracy substitute for conventional invasive coronary angiography in diagnosing and making treatment decisions for patients with suspected coronary artery disease.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
David C. Rotzinger, Virginie Magnin, Allard C. van der Wal, Silke Grabherr, Salah D. Qanadli, Katarzyna Michaud
Summary: Multiphase postmortem CT angiography (PMCTA) can be used to detect plaque enhancement as a surrogate marker of inflammation, providing a noninvasive method for evaluating inflammation in coronary plaques.
EUROPEAN RADIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Sara Papp, Gyoergy Barczi, Julia Karady, Marton Kolossvary, Zsofia D. Drobni, Judit Simon, Melinda Boussoussou, Borbala Vattay, Balint Szilveszter, Gyoergy Jermendy, Bela Merkely, Pal Maurovich-Horvat
Summary: The study found that the presence of myocardial bridging on the left anterior descending artery is not associated with increased plaque volumes in the LAD segment proximal to the bridging. In fact, plaque quantity was smaller in the bridging segment compared to control segments.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Marton Kolossvary, Gary Gerstenblith, David A. Bluemke, Elliot K. Fishman, Raul N. Mandler, Thomas S. Kickler, Shaoguang Chen, Sandeepan Bhatia, Shenghan Lai, Hong Lai
Summary: This study utilized coronary CT angiography and radiomic analysis to evaluate the impact of cocaine use, HIV infection, and ASCVD risk on plaque morphologic characteristics. The results showed that different risk factors had distinct effects on plaque features, and there was no overlap between parameters associated with elevated ASCVD risk or cocaine use and HIV infection.
Article
Cardiac & Cardiovascular Systems
Akos Varga-Szemes, U. Joseph Schoepf, Pal Maurovich-Horvat, Rui Wang, Lei Xu, Danielle M. Dargis, Tilman Emrich, Andrew J. Buckler
Summary: The study evaluated the feasibility of using plaque morphology assessment from CCTA to estimate non-invasive FFR, which outperformed traditional stenosis interpretation and showed comparable sensitivity and specificity. The results suggest that non-invasive plaque morphology-based FFR assessment may be a useful tool for predicting lesion-specific ischemia in hemodynamically significant CAD.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Changjing Feng, Rui Chen, Siting Dong, Wei Deng, Shushen Lin, Xiaomei Zhu, Wangyan Liu, Yi Xu, Xiaohu Li, Yinsu Zhu
Summary: By analyzing clinical data and CCTA images of 400 patients, it was found that FAI and NCPB were independent risk factors for coronary plaque progression. Combining conventional parameters with radiomics features derived from CCTA can better predict plaque progression.
EUROPEAN RADIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Carlos Collet, Edoardo Conte, Saima Mushtaq, Sofie Brouwers, Toshiro Shinke, Ahmet Umit Coskun, Zhongyue Pu, Diaa Hakim, Peter Howard Stone, Daniele Andreini
Summary: The most common pathophysiological mechanism in acute coronary syndromes (ACS) is plaque rupture followed by intracoronary thrombus formation, while the second most common underlying substrate is plaque erosion. Various imaging techniques like optical coherence tomography (OCT) have emerged as promising tools for evaluating plaque features associated with erosion, shedding light on the complex pathophysiology of ACS.
Article
Radiology, Nuclear Medicine & Medical Imaging
Runlei Ma, Marly van Assen, Daan Ties, Gert Jan Pelgrim, Randy van Dijk, Grigory Sidorenkov, Peter M. A. van Ooijen, Pim van der Harst, Rozemarijn Vliegenthart
Summary: This study found that lesion-specific PCAT(MA) in arteries with plaque was higher than proximal PCAT(MA) in arteries without plaque, and lesion-specific PCAT(MA) was higher in non-calcified and mixed plaques compared to calcified plaques, and in minimal stenosis compared to severe.
EUROPEAN RADIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Omar Dzaye, Alexander C. Razavi, Michael J. Blaha, Martin Bodtker Mortensen
Summary: Recent studies have shown that atherosclerotic plaque burden, rather than luminal stenosis, is the main driver of ASCVD risk in patients with coronary artery disease. While patients with obstructive CAD are generally at higher risk for ASCVD events, this is due to their higher plaque burden rather than the presence of stenosis. Studies also suggest that optimizing medical therapy instead of early revascularization is crucial for improving prognosis in these patients.
CURRENT OPINION IN CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Maia Osborne-Grinter, Jacek Kwiecinski, Mhairi Doris, Priscilla McElhinney, Sebastien Cadet, Philip D. Adamson, Alastair J. Moss, Shirjel Alam, Amanda Hunter, Anoop S. Shah, Nicholas L. Mills, Tania Pawade, Chengjia Wang, Jonathan R. Weir-McCall, Giles Roditi, Edwin J. R. van Beek, Leslee J. Shaw, Edward D. Nicol, Daniel Berman, Piotr J. Slomka, David E. Newby, Marc R. Dweck, Damini Dey, Michelle C. Williams
Summary: Coronary artery calcification is a marker of cardiovascular risk, but its association with different plaque subtypes is unclear. In stable chest pain patients, having a zero CACS does not guarantee a perfect prognosis and cannot rule out obstructive coronary artery disease, non-obstructive plaque, or adverse plaque phenotypes such as low-attenuation plaque.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2022)
Article
Cardiac & Cardiovascular Systems
A. Maxim Bax, Alexander R. van Rosendael, Xiaoyue Ma, Inge J. van den Hoogen, Umberto Gianni, Sara W. Tantawy, Emma J. Hollenberg, Daniele Andreini, Mouaz H. Al-Mallah, Matthew J. Budoff, Filippo Cademartiri, Kavitha Chinnaiyan, Jung Hyun Choi, Edoardo Conte, Hugo Marques, Pedro de Araujo Goncalves, Ilan Gottlieb, Martin Hadamitzky, Jonathon A. Leipsic, Erica Maffei, Gianluca Pontone, Sanghoon Shin, Yong-Jin Kim, Byoung Kwon Lee, Eun Ju Chun, Ji Min Sung, Sang-Eun Lee, Renu Virmani, Habib Samady, Peter H. Stone, Daniel S. Berman, James K. Min, Jagat Narula, Fay Y. Lin, Hyuk-Jae Chang, Leslee J. Shaw
Summary: The study found that atherosclerotic plaque burden and composition varied across the major epicardial coronary arteries, with lower burden and different compositions in the LCx compared to the LAD and RCA.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2021)
Article
Medicine, General & Internal
Zhijie Jian, Guolin Yao, Huafeng Guo, Hui Liu, Bolin Li, Bolang Yu, Jian Yang, Lele Cheng
Summary: This study aimed to investigate the association of coronary plaque compositions with rapid lesion volume progression in patients with type 2 diabetes mellitus. The results showed that baseline calcified plaque volume is an independent protective factor for the rapid progression of coronary atherosclerosis in these patients. Therefore, calcified plaque volume should be considered in risk stratification for patients with type 2 diabetes mellitus.
ANNALS OF MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Evangelos Tzolos, Priscilla McElhinney, Michelle C. Williams, Sebastien Cadet, Mark R. Dweck, Daniel S. Berman, Piotr J. Slomka, David E. Newby, Damini Dey
Summary: The study aimed to evaluate the repeatability of pericoronary adipose tissue (PCAT) attenuation and non-calcified plaque burden (NCP) measurements from coronary CT angiography (CTA). Results demonstrate high intraobserver and interobserver repeatability for these measurements, suggesting they are a reliable method for quantifying cardiovascular risk.
JOURNAL OF CARDIOVASCULAR COMPUTED TOMOGRAPHY
(2021)
Article
Cardiac & Cardiovascular Systems
Ki-Bum Won, Byoung Kwon Lee, Fay Y. Lin, Martin Hadamitzky, Yong-Jin Kim, Ji Min Sung, Edoardo Conte, Daniele Andreini, Gianluca Pontone, Matthew J. Budoff, Ilan Gottlieb, Eun Ju Chun, Filippo Cademartiri, Erica Maffei, Hugo Marques, Pedro de Araujo Goncalves, Jonathon A. Leipsic, Sang-Eun Lee, Sanghoon Shin, Jung Hyun Choi, Renu Virmani, Habib Samady, Kavitha Chinnaiyan, Daniel S. Berman, Jagat Narula, Leslee J. Shaw, Jeroen J. Bax, James K. Min, Hyuk-Jae Chang
Summary: In patients without baseline coronary plaques, glycemic control status is strongly associated with the risk of rapid plaque progression (RPP). Regular monitoring of glycemic control status may be helpful for preventing the rapid progression of coronary atherosclerosis, irrespective of baseline risk factors.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Wanwan Wen, Mingxin Gao, Mingkai Yun, Jingjing Meng, Wenyuan Yu, Ziwei Zhu, Yi Tian, Tiantian Mou, Yandong Zhang, Marcus Hacker, Sijin Li, Yang Yu, Xiang Li, Xiaoli Zhang
Summary: This study evaluated the association between in vivo coronary 18F-NaF PET/CT activity and ex vivo histological characteristics in vascular plaque. The results showed that coronary 18F-NaF activity is correlated with plaque vulnerability and inflammatory cytokines expression, and it can be used as a tool for detecting high-risk coronary plaque and improving risk stratification in CAD patients.
JACC-CARDIOVASCULAR IMAGING
(2023)
