Article
Medicine, General & Internal
Agnieszka Bartczak-Rutkowska, Lidia Tomkiewicz-Pajak, Katarzyna Kawka-Paciorkowska, Natalia Bajorek, Aleksandra Cieplucha, Mariola Ropacka-Lesiak, Olga Trojnarska
Summary: A study investigated the maternal and fetal outcomes of women who had undergone the Fontan procedure in two Polish medical centers. Among 26 pregnancies, 11 ended in miscarriages and 15 resulted in 16 live births. Fetal complications were observed in 9 live births, with prematurity being the most common. Obstetrical complications occurred in 6 pregnancies, including placental abruption, premature rupture of membranes, and antepartum hemorrhage. Specialized care from experienced cardiologists and obstetricians is necessary for these women.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Karishma P. Ramlakhan, Daniel Tobler, Matthias Greutmann, Markus Schwerzmann, Lucia Baris, Anji T. Yetman, Petros Nihoyannopoulos, Pravin Manga, Eric Boersma, Aldo P. Maggioni, Mark R. Johnson, Roger Hall, Jolien W. Roos-Hesselink
Summary: The study examined outcomes of pregnancy in women with aortic coarctation and found low rates of MACE and hypertensive disorders, suggesting pregnancy in these women may be safer and better tolerated than previously appreciated.
Article
Obstetrics & Gynecology
Shannon L. Son, Lauren L. Hosek, Miranda C. Stein, Amanda A. Allshouse, Anna B. Catino, Arvind K. Hoskoppal, Daniel A. Cox, Kevin J. Whitehead, Ian M. Lindsay, Sean Esplin, Torri D. Metz
Summary: This retrospective longitudinal cohort study found an association between pregnancy and subsequent long-term adverse cardiovascular outcomes in individuals with congenital heart disease. These findings can provide important information for counseling and guidance of individuals with congenital heart disease who are considering pregnancy.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Soohyun A. Chang, Parm Khakh, Mikyla Janzen, Terry Lee, Marla Kiess, Valerie Rychel, Jasmine Grewal
Summary: This study investigates the levels and temporal trends of NT-proBNP and hs-cTnI in pregnant women with preexisting cardiac disease and assesses their association with pregnancy outcomes. The results show that NT-proBNP remains stable throughout pregnancy with a transient increase during labor and delivery, and higher levels are observed in certain subgroups of stable cardiac patients. An NT-proBNP level of 200 pg/mL can be used in the diagnosis of heart failure and preeclampsia in pregnant women with cardiac disease.
CIRCULATION-HEART FAILURE
(2022)
Article
Cardiac & Cardiovascular Systems
Yang Liu, Yanna Li, Jun Zhang, Wenjuan Zhao, Zhaoliang Bao, Xiaolong Ma, Yichen Zhao, Cheng Zhao, Kemin Liu, Qing Ye, Lixiao Su, Yao Yang, Jing Yang, Gang Li, Xiangming Fan, Jiangang Wang
Summary: This study conducted a comparative analysis of complications and outcomes in pregnant women with and without congenital heart disease (CHD) in Beijing. The results indicated that women with CHD had longer hospital stays, higher death rates, and greater risks of comorbidities and adverse events compared to women without CHD. Greater attention should be paid to pregnant women with CHD and their infants.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Barbara Wichert-Schmitt, Jasmine Grewal, A. Kinga Malinowski, Birgit Pfaller, Katie L. Losenno, Marla C. Kiess, Jack M. Colman, Wendy Tsang, Jennifer Mason, Samuel C. Siu, Candice K. Silversides
Summary: This study examined the outcomes of pregnant women with bioprosthetic valves (BPVs) and the association with structural valve dysfunction (SVD). The results showed that SVD negatively affected pregnancy outcomes, particularly in cases of left-sided BPV.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Yang Liu, Yanna Li, Jun Zhang, Yichen Zhao, Kemin Liu, Jiachen Li, Mingming Zhao, Hong Gu, Xiangming Fan, Jiangang Wang
Summary: This study retrospectively analyzed and followed up on pregnant women with Eisenmenger syndrome (ES) admitted to Beijing Anzhen Hospital between 2010 and 2019 to explore the outcomes of the mothers and their offspring. The study found significant differences in age, gestational age, percutaneous oxygen saturation, Apgar score, and heart failure between the maternal death and non-death groups. The study recommends pregnancy termination if ES occurs during early pregnancy and highlights the importance of multidisciplinary cooperation to improve the prognosis of the mothers and their offspring.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Obstetrics & Gynecology
Nicole R. Gavin, Jerome J. Federspiel, Theresa Boyer, Scott Carey, Kristin C. Darwin, Alexia Debrosse, Garima Sharma, Ari Cedars, Anum Minhas, Arthur J. Vaught
Summary: A retrospective cohort study showed that pregnant women with cardiac disease are more likely to undergo cesarean delivery, which is associated with a higher rate of severe maternal morbidity.
JOURNAL OF PERINATOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Samuel C. Siu, Douglas S. Lee, Mohammed Rashid, Jiming Fang, Peter C. Austin, Candice K. Silversides
Summary: The study found that women with heart disease are at high risk for adverse long-term cardiovascular outcomes after pregnancy, including mortality, heart failure, and arrhythmias. Current pregnancy risk prediction tools can help identify those at highest risk for long-term cardiovascular events among women with heart disease.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Syed Shahyan Bakhtiyar, Sara Sakowitz, Konmal Ali, Nikhil L. Chervu, Arjun Verma, Ming-Sing Si, David D'Alessandro, Peyman Benharash
Summary: The study evaluates the survival rate after heart transplantation in adults with single and biventricular CHD and compares it to that of non-CHD transplant recipients. Single-ventricle physiology is associated with higher short-term mortality, but 10-year conditional survival is similar for biventricular CHD patients and most single-ventricle CHD patients, and notably better for biventricular CHD patients compared to non-CHD heart transplant recipients.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Astrid Elisabeth Lammers, Gerhard-Paul Diller, Rieke Lober, Mareike Moellers, Renate Schmidt, Robert M. Radke, Fernando De-Torres-Alba, Gerrit Kaleschke, Ursula Marschall, Ulrike M. Bauer, Joachim Gerss, Dominic Enders, Helmut Baumgartner
Summary: This population-based study reveals a reassuringly low maternal mortality rate in a highly developed healthcare system. However, maternal and neonatal morbidity/mortality were significantly increased in women with adult congenital heart disease (ACHD) and their offspring compared to non-ACHD controls, highlighting the importance of specialized care and pre-pregnancy counseling.
EUROPEAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Astrid Elisabeth Lammers, Gerhard-Paul Diller, Rieke Lober, Mareike Moellers, Renate Schmidt, Robert M. Radke, Fernando De-Torres-Alba, Gerrit Kaleschke, Ursula Marschall, Ulrike M. Bauer, Joachim Gerss, Dominic Enders, Helmut Baumgartner
Summary: This population-based study revealed a reassuringly low maternal mortality rate in a highly developed healthcare system. However, maternal morbidity and neonatal morbidity/mortality were significantly increased in women with ACHD and their offspring compared to non-ACHD controls, highlighting the need for specialized care and pre-pregnancy counselling.
EUROPEAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Qian Zhang, Fang Zhu, Guocheng Shi, Chen Hu, Weituo Zhang, Puzhen Huang, Chunfeng Zhu, Hong Gu, Dong Yang, Qiangqiang Li, Yonghua Niu, Hao Chen, Ruixiang Ma, Ziyi Pan, Huixian Miao, Xin Zhang, Genxia Li, Yabing Tang, Guyuan Qiao, Yichen Yan, Zhongqun Zhu, Hao Zhang, Fengzhen Han, Yanna Li, Jianhua Lin, Huiwen Chen
Summary: This study evaluated the pregnancy outcomes in women with congenital heart disease (CHD) with and without pulmonary hypertension (PH). The results showed that women with CHD-associated mild PH had better pregnancy outcomes compared to those with moderate-to-severe PH, with similar outcomes to women with CHD and no PH.
Review
Cardiac & Cardiovascular Systems
Isabel Hardee, Lydia Wright, Courtney McCracken, Emily Lawson, Matthew E. Oster
Summary: This study evaluated maternal and neonatal outcomes of pregnancies among women with congenital heart disease (CHD) in the modern era, finding that pregnancy in women with CHD typically has a successful outcome in both mother and child. However, as maternal CHD severity increases, the risk of numerous morbidities and neonatal mortality also increases. These findings may be helpful in counseling women with CHD, especially those with severe lesions, who plan to become pregnant.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Obstetrics & Gynecology
Jennifer A. McCoy, Yuli Y. Kim, Annique Nyman, Lisa D. Levine
Summary: This study aimed to evaluate the association between prolonged labor (=24 hours) and adverse peripartum maternal cardiac outcomes in pregnant patients with congenital heart disease. After adjusting for confounders, it was found that patients who experienced prolonged labor had a 2.7-fold increase in the odds of adverse cardiac outcomes. Particularly, patients who underwent a cesarean delivery after prolonged labor had a 6.8-fold increase in the odds of adverse cardiac outcomes.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Samuel C. Siu, Melody Lam, Britney Allen, Lucie Richard, Salimah Z. Shariff, Pallav Garg, Candice K. Silversides, Joel G. Ray
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2019)
Review
Cardiac & Cardiovascular Systems
Rohan D. D'Souza, Candice K. Silversides, George A. Tomlinson, Samuel C. Siu
CANADIAN JOURNAL OF CARDIOLOGY
(2020)
Article
Cardiac & Cardiovascular Systems
Birgit Pfaller, Gnalini Sathananthan, Jasmine Grewal, Jennifer Mason, Rohan D'Souza, Danna Spears, Marla Kiess, Samuel C. Siu, Candice K. Silversides
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2020)
Article
Medicine, Research & Experimental
Rohan D'Souza, Chelsea Hall, Mathew Sermer, Samuel Siu, Candice Silversides
Article
Obstetrics & Gynecology
Samuel C. Siu, Kari L. Evans, Michael R. Foley
CLINICAL OBSTETRICS AND GYNECOLOGY
(2020)
Article
Cardiac & Cardiovascular Systems
Barbara Wichert-Schmitt, Katherine Elizabeth Steckham, Birgit Pfaller, Jack Marc Colman, Rachel Maya Wald, Mathew Sermer, Jennifer Mason, Samuel Chi Bun Siu, Candice Kristeen Silversides
Summary: In women with mitral stenosis, mitral valve gradient and right ventricular systolic pressure increase during the third trimester of pregnancy, and adverse cardiac events are associated with elevated values of these parameters. Women with baseline mitral valve mean gradient ≤ 10 mm Hg and normal right ventricular systolic pressure have the lowest risk for adverse cardiac events during pregnancy.
AMERICAN JOURNAL OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Robin Ducas, Brahmdeep S. Saini, Kenichiro Yamamura, Catriona Bhagra, Davide Marini, Candice K. Silversides, S. Lucy Roche, Jack M. Colman, John C. Kingdom, Mathew Sermer, Kate Hanneman, Mike Seed, Rachel M. Wald
Summary: Maternal-fetal hemodynamics can be well characterized in pregnancy using MRI. Impaired adaptation to pregnancy in women with heart disease appears to be associated with adverse pregnancy outcomes.
CANADIAN JOURNAL OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Birgit Pfaller, Angelo Dave Javier, Jasmine Grewal, Nadia Gabarin, Jack Colman, Marla Kiess, Rachel M. Wald, Mathew Sermer, Samuel C. Siu, Candice K. Silversides
Summary: This study aimed to determine the frequency of adverse cardiac events in pregnant women with moderate or severe regurgitant valve lesions. Results indicated that women with multivalve disease had the highest rate of adverse events, while those with aortic regurgitation and pulmonary regurgitation were at lower risk.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Emilie Laflamme, Rachel M. Wald, S. Lucy Roche, Candice K. Silversides, Sara A. Thorne, Jack M. Colman, Lee Benson, Mark Osten, Eric Horlick, Erwin Oechslin, Rafael Alonso-Gonzalez
Summary: In a study of 215 patients with pulmonary valve stenosis (PVS) who underwent surgical valvotomy or balloon valvuloplasty, it was found that the majority of patients remained asymptomatic after a median follow-up of 38.6 years. Predictors of reinterventions and complications included RVOT intervention, presence of associated defects, and older age at the time of first repair.
Editorial Material
Cardiac & Cardiovascular Systems
Judith Therrien, Jack Colman, Erwin Oechslin, David J. Barron, Curt J. Daniels, Robin Ducas, Paul Khairy, Candice Silversides, Ariane Marelli
CANADIAN JOURNAL OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Ariane Marelli, Luc Beauchesne, Jack Colman, Robin Ducas, Jasmine Grewal, Michelle Keir, Paul Khairy, Erwin Oechslin, Judith Therrien, Isabelle F. Vonder Muhll, Rachel M. Wald, Candice Silversides, David J. Barron, Lee Benson, Pierre-Luc Bernier, Eric Horlick, Reda Ibrahim, Giuseppe Martucci, Krishnakumar Nair, Nancy C. Poirier, Heather J. Ross, Helmut Baumgartner, Curt J. Daniels, Michelle Gurvitz, Jolien W. Roos-Hesselink, Adrienne H. Kovacs, Christopher J. McLeod, Barbara J. Mulder, Carole A. Warnes, Gary D. Webb
Summary: This article presents guidelines for interventions in adults with congenital heart disease (ACHD), which were developed using the ADAPTE process. The guidelines cover various interventions for different cardiac conditions and include flow diagrams to assist clinical decision-making. The article acknowledges the lack of high-quality evidence in ACHD guidelines and emphasizes that the recommendations are meant to facilitate dialogue between clinicians, interventional cardiologists, surgeons, and patients making complex decisions.
CANADIAN JOURNAL OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Barbara Wichert-Schmitt, Jasmine Grewal, A. Kinga Malinowski, Birgit Pfaller, Katie L. Losenno, Marla C. Kiess, Jack M. Colman, Wendy Tsang, Jennifer Mason, Samuel C. Siu, Candice K. Silversides
Summary: This study examined the outcomes of pregnant women with bioprosthetic valves (BPVs) and the association with structural valve dysfunction (SVD). The results showed that SVD negatively affected pregnancy outcomes, particularly in cases of left-sided BPV.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Obstetrics & Gynecology
Samuel C. Siu, Melody Lam, Britney Le, Pallav Garg, Candice K. Silversides, Joel G. Ray
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2020)
Correction
Cardiac & Cardiovascular Systems
Karen K. Stout, Curt J. Daniels, Jamil A. Aboulhosn, Biykem Bozkurt, Craig S. Broberg, Jack M. Colman, Stephen R. Crumb, Joseph A. Dearani, Stephanie Fuller, Michelle Gurvitz, Paul Khairy, Michael J. Landzberg, Arwa Saidi, Anne Marie Valente, George F. Van Hare
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2019)
Correction
Cardiac & Cardiovascular Systems
Karen K. Stout, Curt J. Daniels, Jamil A. Aboulhosn, Biykem Bozkurt, Craig S. Broberg, Jack M. Colman, Stephen R. Crumb, Joseph A. Dearani, Stephanie Fuller, Michelle Gurvitz, Paul Khairy, Michael J. Landzberg, Arwa Saidi, Anne Marie Valente, George F. Van Hare
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2019)