Article
Medicine, General & Internal
Artur Dziewierz, Barbara Zdzierak, Krzysztof P. Malinowski, Zbigniew Siudak, Wojciech Zasada, Tomasz Tokarek, Michal Zabojszcz, Magdalena Dolecka-Slusarczyk, Dariusz Dudek, Stanislaw Bartus, Andrzej Surdacki, Tomasz Rakowski
Summary: The impact of diabetes mellitus on periprocedural outcomes of ST-segment elevation myocardial infarction patients undergoing primary percutaneous coronary intervention was assessed using data from a large registry in Poland. Diabetes was identified as an independent predictor of periprocedural mortality, although this effect may be partially explained by the overall higher risk profile of diabetic patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Gonul Zeren, Ilhan Ilker Avci, Mustafa Azmi Sungur, Barid Simsek, Aylin Sungur, Mehmet Fatih Yilmaz, Fatma Can, Ufuk Gurkan, Can Yucel Karabay
Summary: The presence of ectatic non-IRA without ectatic IRA in patients with STEMI increases the risk of ST within the first month after pPCI.
POSTGRADUATE MEDICAL JOURNAL
(2022)
Article
Public, Environmental & Occupational Health
Tou-Yuan Tsai, Jen-Feng Lin, Yu-Kang Tu, Jian-Heng Lee, Yu -Ting Hsiao, Sheng-Feng Sung, Ming-Jen Tsai
Summary: This study developed and validated algorithms for distinguishing STEMI and NSTEMI cases in Taiwan's NHI database, providing valuable reference for accurate identification.
CLINICAL EPIDEMIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Ahmet Demirkiran, Nina W. van der Hoeven, Gladys N. Janssens, Jorrit S. Lemkes, Henk Everaars, Peter M. van de Ven, Nikki van Pouderoijen, Yvonne J. M. van Cauteren, Maarten A. H. van Leeuwen, Alexander Nap, Paul F. Teunissen, Luuk H. G. A. Hopman, Sebastiaan C. A. M. Bekkers, Martijn W. Smulders, Niels van Royen, Albert C. van Rossum, Lourens F. H. J. Robbers, Robin Nijveldt
Summary: This study compared cardiovascular magnetic resonance-derived left ventricular function, strain, and infarct size characteristics in patients with transient ST-segment elevation myocardial infarction (TSTEMI), ST-segment elevation myocardial infarction (STEMI), and non-ST-segment elevation myocardial infarction (NSTEMI). The results showed that TSTEMI patients had better LV function and smaller infarct size compared to STEMI patients, and their characteristics were more similar to NSTEMI patients.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2022)
Article
Cardiac & Cardiovascular Systems
Mengjin Hu, Ye Lu, Shuping Wan, Bao Li, Xiaojin Gao, Jingang Yang, Haiyan Xu, Yuan Wu, Lei Song, Shubin Qiao, Fenghuan Hu, Yang Wang, Wei Li, Chen Jin, Yuejin Yang
Summary: This study evaluated the prognostic influence of right ventricular myocardial infarction (RVMI) on patients with inferior ST-segment elevation myocardial infarction (STEMI). The results showed that RVMI did not increase all-cause mortality in the contemporary reperfusion era, but it was associated with a higher risk of major adverse cardiac and cerebrovascular events. Timely reperfusion treatment was found to decrease all-cause mortality.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Engineering, Biomedical
Hirofumi Kujiraoka, Takaaki Tsuchiyama, Dai Inagaki, Kiyotaka Yoshida, Seiji Fukamizu
Summary: ELCA improves the myocardial blush grade and reduces the incidence of intraoperative slow- or no-reflow phenomenon in patients with STEMI. It is especially effective for patients with long onset-to-balloon time STEMI.
LASERS IN MEDICAL SCIENCE
(2023)
Article
Cardiac & Cardiovascular Systems
Philipp-Johannes Jensch, Thomas Stiermaier, Sebastian Johannes Reinstadler, Hans-Josef Feistritzer, Steffen Desch, Georg Fuernau, Suzanne de Waha-Thiele, Holger Thiele, Ingo Eitel
Summary: In patients with ST-elevation myocardial infarction (STEMI), peri-infarct zone (PIZ) emerged as an independent predictor of major adverse cardiac events (MACE). The extent of PIZ can serve as a potential novel marker for optimized risk stratification in STEMI patients.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Shih-Sheng Chang, Chiung-Ray Lu, Ke-Wei Chen, Zhe-Wei Kuo, Shao-Hua Yu, Shih-Yi Lin, Hong-Mo Shi, Hei-Tung Yip, Chia-Hung Kao
Summary: This study investigated the prognostic differences between elderly patients with ST-elevation myocardial infarction (STEMI) and non-ST-elevation myocardial infarction (NSTEMI) by analyzing data from the Longitudinal Health Insurance Database in Taiwan. The results showed that there was no difference in cardiovascular and all-cause mortality between STEMI and NSTEMI in patients who received revascularization. However, in patients who did not receive revascularization, NSTEMI was associated with a higher risk of all-cause death. Moreover, there was no difference in major bleeding between STEMI and NSTEMI patients aged ≥65 years old.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Aida Soufiani, Hamza Chraibi, Ilyasse Asfalou, Noha El Ouafi, Mustapha El Hattaoui, Rachida Habbal, Ali Chaib, Rokya Fellat, Hafid Akoudad, Aatif Benyass, Mohamed Cherti, Redouane Abouqal, Nesma Bendagha, Samir Ztot
Summary: MR-MI is the first national Moroccan registry for ST-elevation myocardial infarction (STEMI), aiming to assess patient management modalities and highlight the clinical and therapeutic characteristics of this pathology on a national scale.
BMC CARDIOVASCULAR DISORDERS
(2023)
Article
Medicine, General & Internal
Yong Hoon Kim, Ae-Young Her, Seung-Woon Rha, Cheol Ung Choi, Byoung Geol Choi, Ji Bak Kim, Soohyung Park, Dong Oh Kang, Ji Young Park, Sang-Ho Park, Myung Ho Jeong
Summary: Using a new-generation drug-eluting stent, the study compared the 2-year clinical outcomes of patients with diabetes mellitus (DM) and non-DM concomitant with a non-ST-segment elevation myocardial infarction (NSTEMI) and an ST-segment elevation myocardial infarction (STEMI) who underwent percutaneous coronary intervention. The results showed higher non-CD rates in patients with DM and higher CD rates in patients without DM in the NSTEMI group.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Adrien Pascaud, Antonildes Assuncao, Gabriel Garcia, Eloi Vacher, Serge Willoteaux, Fabrice Prunier, Alain Furber, Loic Biere
Summary: After myocardial infarction, left atrial remodeling occurs along with left ventricular remodeling, and it is influenced by factors such as age and infarct size. The study highlights the importance of evaluating left atrial changes and their relationship with left ventricular remodeling after myocardial infarction.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Christina Tiller, Martin Reindl, Magdalena Holzknecht, Ivan Lechner, Felix Simma, Johannes Schwaiger, Agnes Mayr, Gert Klug, Axel Bauer, Sebastian Johannes Reinstadler, Bernhard Metzler
Summary: In STEMI patients treated with pPCI, hs-CRP was independently associated with 4 months IS reduction as determined by CMR, suggesting a pathophysiological interplay between inflammation and adverse infarct healing in survivors of acute STEMI.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Medicine, General & Internal
Yong Hoon Kim, Ae-Young Her, Myung Ho Jeong, Byeong-Keuk Kim, Sung-Jin Hong, Seung-Jun Lee, Chul-Min Ahn, Jung-Sun Kim, Young-Guk Ko, Donghoon Choi, Myeong-Ki Hong, Yangsoo Jang
Summary: The study compared the 2-year major clinical outcomes between STEMI and NSTEMI patients who are current smokers treated with PCI, and found no significant difference in outcomes. Further research is needed to confirm these results.
Article
Cardiac & Cardiovascular Systems
Gladys N. Janssens, Jorrit S. Lemkes, Nina W. van der Hoeven, Maarten A. H. van Leeuwen, Henk Everaars, Peter M. van de Ven, Stijn L. Brinckman, Jorik R. Timmer, Martijn Meuwissen, Joost C. M. Meijers, Arno P. van der Weerdt, Tim J. F. ten Cate, Jan J. Piek, Clemens von Birgelen, Roberto Diletti, Javier Escaned, Albert C. van Rossum, Robin Nijveldt, Niels van Royen
Summary: Transient STEMI patients present with a different profile of cardiovascular risk factors, angiographic characteristics, and myocardial injury compared to persistent STEMI patients, showing less thrombus burden and myocardial damage. The more effective fibrinolysis in transient STEMI patients may provide insights for future treatment strategies for STEMI.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Bingqi Fu, Xuebiao Wei, Qi Wang, Zhiwen Yang, Jiyan Chen, Danqing Yu
Summary: The study found that elderly patients with STEMI undergoing PCI can be effectively risk-stratified for in-hospital events and 1-year mortality using the Thrombolysis in Myocardial Infarction (TIMI) Risk Index (TRI). In this research, TRI showed good discrimination for predicting in-hospital death, but relatively weaker prediction for acute kidney injury and in-hospital MACEs.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Economics
Monica Hernandez Alava, Steve Pudney, Allan Wailoo
Summary: The aim of this study was to estimate the relationship between EQ-5D-3L and EQ-5D-5L using a single model. A joint statistical model incorporating both variants was estimated using an online survey administered to a large UK sample. The results provide a means of translating evidence between the two variants and mapping can be performed using descriptive system responses, individual utility scores, or summary statistics.
Editorial Material
Emergency Medicine
Hridesh Chatha, Fiona Sampson, Susan Croft, Jen Lewis, Mel Watson, Alexander Robertson, Michael Tonkins, Gabriella Prager
EMERGENCY MEDICINE JOURNAL
(2023)
Review
Emergency Medicine
Fiona C. Sampson, Maxine Johnson
Summary: Pain management in the emergency department (ED) is often inadequate, and this study aimed to understand the barriers and enablers to pain management as perceived by ED staff. The study found that while environmental factors were considered important in quantitative surveys, attitudes played a more significant role according to qualitative studies. Improving feedback and addressing beliefs can help prioritize pain management in the ED.
EMERGENCY MEDICINE JOURNAL
(2023)
Article
Economics
Michael Falk Hvidberg, Monica Hernandez Alava
Summary: This study provides UK/US catalogues of HRQoL utilities based on EQ-5D-3L for 199 chronic conditions using ICD-10 codes and health risks. Regression models controlling for age, sex, comorbidities, and health risks were developed to enable predictions in other populations.
Article
Health Care Sciences & Services
Matthew Franklin, Monica Hernandez Alava
Summary: The study aims to develop mapping models to predict preference-based scores using patient health questionnaires (PHQ-9 and GAD-7). The results show that these mapping functions can accurately predict health utility scores using routinely collected variables.
QUALITY OF LIFE RESEARCH
(2023)
Article
Economics
Monica Hernandez Alava, Stephen E. Pudney, Allan J. Wailoo
Summary: The study aimed to develop methods for assessing the deficiencies of a generic outcome measure (EQ-5D) in specific domains and to judge whether the deficiencies are quantitatively important enough to question evaluations based on the generic instrument. The study focused on breast cancer and analyzed data from the MARIANNE trial. Results suggested that EQ-5D might inadequately capture impacts on personal appearance and relationships, but the bias in quality-adjusted life-year differences is likely to be modest.
Article
Economics
Francis Shupo, Keith R. Abrams, Zanfina Ademi, Grace Wayi-Wayi, Natasa Zibelnik, Matt Kirchmann, Carolyn Rutherford, Kelly Makarounas-Kirchmann
Summary: This paper presents an Australian model for the assessment of the cost-effectiveness of siltuximab for idiopathic Multicentric Castleman Disease (iMCD) in Australia. The model was informed by literature reviews, clinical trial data, and stakeholder input, and estimated an incremental cost-effectiveness ratio of A$84,935 per quality-adjusted life-year (QALY) gained. The results suggest that siltuximab has a 72.1% probability of being cost-effective compared with placebo and best supportive care at a willingness-to-pay threshold of A$100,000 per QALY.
PHARMACOECONOMICS-OPEN
(2023)
Article
Emergency Medicine
Fiona C. Sampson, Emma L. Knowles, Jaqui Long, Janette Turner, Joanne Coster
Summary: This study explored user and staff perspectives of online NHS111 and found that it is perceived as a useful adjunct but not a replacement for telephone NHS111. The lack of human interaction in the online service results in reduced confidence, hindering the potential for channel shift. However, online NHS111 does provide convenience and widened access for certain subgroups of users.
EMERGENCY MEDICINE JOURNAL
(2023)
Editorial Material
Emergency Medicine
Ashleigh Trimble, Steve Goodacre
EMERGENCY MEDICINE JOURNAL
(2023)
Editorial Material
Emergency Medicine
Steve Goodacre
Summary: Clinical risk prediction models can assist decision making in emergency medicine, but their effectiveness may be compromised by treatment effects during model development. This paper examines the potential impact of treatment effects on prognostic clinical risk prediction and provides practical advice for clinicians to use clinical prediction scores as a tool for clinical judgement rather than making decisions solely based on them.
EMERGENCY MEDICINE JOURNAL
(2023)
Article
Public, Environmental & Occupational Health
A. K. Stevely, D. Mackay, M. H. Alava, A. Brennan, P. S. Meier, A. Sasso, J. Holmes
Summary: The introduction of minimum unit price policy in Scotland did not reduce the proportion of harmful drinkers, but it did decrease the prevalence of hazardous drinking.
Article
Hematology
Sarah Davis, Steve Goodacre, Daniel Horner, Abdullah Pandor, Xavier L. Griffin, Kerstin de Wit, Beverley J. Hunt, Mark Holland
Summary: Background: Surgical inpatients are at a risk of venous thromboembolism (VTE), which can be life-threatening or result in chronic complications. Thromboprophylaxis reduces the VTE risk but incurs costs and may increase bleeding risk. This study investigated the cost-effectiveness of different thromboprophylaxis strategies for surgical inpatients.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Review
Emergency Medicine
Fiona C. Sampson, Maxine Johnson
Summary: Pain is a common presenting feature in the emergency department (ED) but is often undertreated worldwide. This study aims to identify and synthesize research on staff views of barriers and enablers to pain management in the ED. The findings reveal that while staff recognize the importance of pain management, they do not prioritize it as a clinical task, lack understanding of the need for improvement, face difficulties in the ED environment, and have concerns about trusting patients' ability to judge and manage their pain appropriately.
EMERGENCY MEDICINE JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Kang-Ling Wang, Mohammed N. Meah, Anda Bularga, Katherine Oatey, Rachel O'Brien, Jason E. Smith, Nick Curzen, Attila Kardos, Liza Keating, Dirk Felmeden, Robert F. Storey, Steve Goodacre, Carl Roobottom, David E. Newby, RAPID CTCA Investigators
Summary: This study investigated the influence of early CTCA on preventative treatment in patients with suspected acute coronary syndrome. The results showed that early CTCA facilitated targeted individualization of these therapies based on the extent of coronary artery disease.
AMERICAN HEART JOURNAL
(2023)
Article
Emergency Medicine
Rachel McLatchie, Matthew J. Reed, Nicola Freeman, Richard A. Parker, Sarah Wilson, Steve Goodacre, Alicia Cowan, Jessica Boyle, Benjamin Clarke, Ellise Clarke
Summary: The diagnosis of acute aortic syndrome (AAS) is often delayed or missed in the emergency department, with only 0.3% of patients presenting with potential symptoms being confirmed with AAS, yet 7% underwent CTA. Clinical decision tools (CDTs) incorporating clinician gestalt appear to be the most promising approach for improving diagnostic accuracy.
EMERGENCY MEDICINE JOURNAL
(2023)