Journal
LAB ON A CHIP
Volume 15, Issue 2, Pages 448-458Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4lc00768a
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Funding
- SMART (Singapore-MIT Alliance for Research and Technology) center
- BioSyM IRG
- DARPA DLT (Dialysis-Like Therapeutics) program, under SSC Pacific [N66001-11-1-4182]
- NIH [2R01HL098032]
- institute for Transfusion Medicine
- Hemophilia Center of Western Pennsylvania
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In this study, the effects of prolonged storage on several biophysical properties of red blood cells (RBCs) were investigated. Single cell deformability was used as an important criterion in determining subgroups of RBCs evolved during storage lesion. A deformability-based microfluidic cell sorting technology was applied, which demonstrates the ability to enrich and separate the less deformable subpopulations of stored blood. These less deformable RBC subpopulations were then associated with other important markers such as osmotic fragility indicating cell integrity as well as microparticle content. This work demonstrates a systematic methodology to both monitor and improve banked blood quality, thereby reducing risks related to blood transfusion.
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