4.3 Article

NON-TARGETED EFFECTS OF IONIZING RADIATION: IMPLICATIONS FOR RISK ASSESSMENT AND THE RADIATION DOSE RESPONSE PROFILE

Journal

HEALTH PHYSICS
Volume 97, Issue 5, Pages 426-432

Publisher

LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/HP.0b013e3181ab98c7

Keywords

radiation dose; radiation, low-level; risk analysis; National Council on Radiation Protection and Measurements

Funding

  1. Battelle Memorial Institute, Pacific Northwest Division [DE-AC05-76RLO 1830]
  2. U.S. Department of Energy (DOE)
  3. Office of Biological and Environmental Research (OBER) Low Dose Science Program

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Radiation risks at low doses remain a hotly debated topic. Recent experimental advances in our understanding of effects occurring in the progeny of irradiated cells, and/or the non-irradiated neighbors of irradiated cells (i.e., non-targeted effects associated with exposure to ionizing radiation), have influenced this debate. The goal of this document is to summarize the current status of this debate and speculate on the potential impact of non-targeted effects on radiation risk assessment and the radiation dose response profile. Health Phys. 97(5):426-432; 2009

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