Review
Economics
Xiaoxiao Ling, Andrea Gabrio, Alexina Mason, Gianluca Baio
Summary: This study reviewed the methods used to handle missing multi-item questionnaire data in randomized controlled trials. Multiple imputation and complete case analysis were the most popular methods. Missing cost data were often imputed at the item-level through multiple imputation, while missing quality of life data were usually imputed at a more aggregated time point level during the follow-up.
Article
Medicine, General & Internal
James Griffin, Edward T. Davis, Helen Parsons, Elke Gemperle Mannion, Chetan Khatri, David R. Ellard, Mark J. Blyth, Nicholas David Clement, David Deehan, Nicholas Flynn, Josephine Fox, Nicholas J. Grant, Fares S. Haddad, Charles E. Hutchinson, James Mason, Bishal Mohindru, Chloe E. H. Scott, Toby O. Smith, John A. Skinner, Andrew D. Toms, Sophie Rees, Martin Underwood, Andrew Metcalfe
Summary: This article discusses the introduction of robotic-assisted knee replacement systems worldwide and highlights the lack of high-quality evidence on their clinical and cost-effectiveness. The trial aims to evaluate the clinical and cost-effectiveness of robotic-assisted knee replacement compared to traditional methods, providing high-quality evidence on this technology.
Article
Multidisciplinary Sciences
Shalika Bohingamu Mudiyanselage, Jo Stevens, Julian Toscano, Mark A. Kotowicz, Christopher L. Steinfort, Robyn Hayles, Jennifer J. Watts
Summary: The study evaluates the cost-effectiveness of a personalised telehealth intervention for managing chronic diseases in the long term. The pilot study compared the costs and effectiveness of telehealth monitoring with usual care and found that the intervention resulted in a significant improvement in health-related quality of life at an additional cost per patient. The study suggests that offering the program to a larger population may be necessary to achieve cost-effectiveness.
Article
Geriatrics & Gerontology
Robert Howard, Rebecca Gathercole, Rosie Bradley, Emma Harper, Lucy Davis, Lynn Pank, Natalie Lam, Emma Talbot, Emma Hooper, Rachel Winson, Bethany Scutt, Victoria Ordonez Montano, Samantha Nunn, Grace Lavelle, Andrew Bateman, Peter Bentham, Alistair Burns, Barbara Dunk, Kirsty Forsyth, Chris Fox, Fiona Poland, Iracema Leroi, Stanton Newman, John O'Brien, Catherine Henderson, Martin Knapp, John Woolham, Richard Gray
Summary: The study found that the use of assistive technology and telecare (ATT) did not significantly prolong the time for people with dementia to live independently and was not cost-effective. Participants in the ATT group had fewer quality-adjusted life years (QALYs) based on participant-reported EQ-5D at 104 weeks.
Article
Respiratory System
Ramon Luengo-Fernandez, Filipa Landeiro, Rob Hallifax, Najib M. Rahman
Summary: This study conducted an economic evaluation and found that outpatient ambulatory management is a cost-effective option for the management of primary pneumothorax.
Article
Medicine, General & Internal
Lindsay Spekreijse, Rob Simons, Bjorn Winkens, Frank van den Biggelaar, Carmen Dirksen, Marjolijn Bartels, Ronald de Crom, Oege Goslings, Maurits Joosse, Jocelyn Kasanardjo, Peter Lansink, Theodorus Ponsioen, Nic Reus, Jan Schouten, Rudy Nuijts
Summary: This study evaluates the safety, effectiveness, and cost-effectiveness of immediate sequential bilateral cataract surgery (ISBCS) versus delayed sequential bilateral cataract surgery (DSBCS). The results show that ISBCS is non-inferior to DSBCS in terms of safety and effectiveness, and it is superior in cost-effectiveness.
Article
Medicine, General & Internal
Domenico Giacco, Agnes Chevalier, Megan Patterson, Thomas Hamborg, Rianna Mortimer, Yan Feng, Martin Webber, Penny Xanthopoulou, Stefan Priebe
Summary: This study aims to evaluate the impact of structured social coaching on the quality of life of patients with psychosis. The intervention was developed based on the literature and refined through stakeholder involvement. It is hypothesized that improving social contacts can enhance quality of life, with assessments conducted over a 6-month period and cost-effectiveness analysis considered.
Article
Geriatrics & Gerontology
Arkers Kwan Ching Wong, Frances Kam Yuet Wong, Ching So
Summary: The study suggests that adding a home-based preventive self-care health management program may have cost effects for community-dwelling older adults in Hong Kong.
Article
Medicine, General & Internal
Eleanore D. Sternberg, Jackie Cook, Ludovic P. Ahoua Alou, Serge Brice Assi, Alphonsine A. Koffi, Dimi T. Doudou, Carine J. Aoura, Rosine Z. Wolie, Welbeck A. Oumbouke, Eve Worrall, Immo Kleinschmidt, Raphael N'Guessan, Matthew B. Thomas
Summary: The study evaluated the effectiveness of lethal house lures in malaria control, showing that screening plus Eave Tubes can effectively reduce malaria incidence, has a high cost-effectiveness, and no serious adverse events associated with the intervention were reported.
Article
Medicine, General & Internal
Nadine Rasenberg, Marienke van Middelkoop, Sita M. A. Bierma-Zeinstra, Mohamed El Alili, Patrick Bindels, J. Bosmans
Summary: The study found that custom-made insoles are not cost-effective compared to GP-led usual care for plantar heel pain. Clinicians should be cautious in prescribing custom-made insoles for plantar heel pain as a primary intervention.
Article
Medicine, Research & Experimental
Karen Morgan, Mei-See Man, Rachael Bloomer, Madeleine Cochrane, Melissa Cole, Sandi Dheensa, Nathan Eisenstadt, Gene Feder, Daisy M. Gaunt, Rwth Leach, Rebecca Kandiyali, Sian Noble, Tim J. Peters, Beverly A. Shirkey, Helen Cramer
Summary: This study aims to estimate the effectiveness and cost-effectiveness of a perpetrator programme for men.
Article
Orthopedics
Alison Hammond, Yeliz Prior, Sarah Cotterill, Chris Sutton, Elizabeth Camacho, Calvin Heal, Jo Adams, Yvonne Hough, Terence W. O'Neill, Jill Firth
Summary: This study compared the clinical and cost effectiveness of arthritis gloves and placebo gloves in patients with rheumatoid arthritis and persistent hand pain. The results showed that arthritis gloves did not have a clinically important effect on hand pain, function, or stiffness, and were not cost-effective.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Public, Environmental & Occupational Health
Yuanyuan Liang, Amanda J. Driscoll, Priyanka D. Patel, Shrimati Datta, Merryn Voysey, Neil French, Leslie P. Jamka, Marc Y. R. Henrion, Latif Ndeketa, Matthew B. Laurens, Robert S. Heyderman, Melita A. Gordon, Kathleen M. Neuzil
Summary: This study evaluates the appropriateness of using a test-negative design to assess the effectiveness of typhoid conjugate vaccines and compares the results with a randomised controlled trial. The findings suggest that the test-negative design is accurate and precise in estimating vaccine effectiveness and can be used for post-introduction studies of typhoid conjugate vaccines.
LANCET GLOBAL HEALTH
(2023)
Article
Medicine, General & Internal
Padraig Dixon, William Hollingworth, Katie Pike, Rosy Reynolds, Margaret Stoddart, Alasdair MacGowan
Summary: This study assessed the cost-effectiveness of rapid microbial identification by MALDI-TOF mass spectrometry for bloodstream infections. The results indicate that adjunctive MALDI-TOF diagnosis may not be cost-effective when measured as cost per death avoided at 28 days.
Article
Medicine, General & Internal
Lidia Garcia-Perez, Yolanda Ramallo-Farina, Laura Vallejo-Torres, Leticia Rodriguez-Rodriguez, Himar Gonzalez-Pacheco, Beatriz Santos-Hernandez, Miguel Angel Garcia-Bello, Ana Maria Wagner, Montserrat Carmona, Pedro G. Serrano-Aguilar
Summary: This study analyzed the cost-effectiveness of multicomponent interventions for patients with T2DM in primary care in the Canary Islands. The results showed that the intervention strategy for patients (PTI) was the cost-effective option.
Article
Psychology, Clinical
K. J. S. Lewis, K. Tilling, K. Gordon-Smith, K. E. A. Saunders, A. Di Florio, L. Jones, I Jones, M. C. O'Donovan, J. Heron
Summary: This study examined the longitudinal relationships between sleep and mood in individuals with bipolar disorder. The results showed bidirectional relationships between insomnia and depressive symptoms, but weak support for bidirectional relationships between insomnia and (hypo)manic symptoms. The strength of these associations varied depending on age, gender, bipolar subtype, and history of rapid cycling.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Pediatrics
Hannah B. Edwards, Maria Theresa Redaniel, Carlos Sillero-Rejon, Ruta Margelyte, Tim J. Peters, Kate Tilling, William Hollingworth, Hugh McLeod, Pippa Craggs, Elizabeth Hill, Sabi Redwood, Jenny Donovan, Emma Treloar, Ellie Wetz, Natasha Swinscoe, Gary A. Ford, John Macleod, Karen Luyt
Summary: This study evaluated the effectiveness and cost-effectiveness of the National PReCePT Programme in increasing the use of magnesium sulfate in preterm births. The results showed that the implementation of the NPP significantly increased the uptake of magnesium sulfate in preterm births in 137 maternity units in England. From a societal and lifetime perspective, the NPP generated health gains and cost savings, making it a cost-effective intervention.
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2023)
Article
Medicine, General & Internal
Scott R. Walter, Joni Jackson, Gareth Myring, Maria Theresa Redaniel, Ruta Margelyte, Rebecca Gardiner, Michael D. Clarke, Megan Crofts, Hugh McLeod, William Hollingworth, David Phillips, Peter Muir, Jonathan Steer, Jonathan Turner, Paddy J. Horner, Frank De Vocht
Summary: This study evaluated the impact of a new clinic-based rapid sexually transmitted infection testing, diagnosis and treatment service on healthcare delivery and resource needs. The results showed that the introduction of the clinic-based testing system significantly reduced the time-to-notification and the rate of gonorrhoea swabs, and overall service costs decreased by 7.5%. These findings support the widespread implementation of clinic-based testing in sexual health services.
Article
Economics
Irina Pokhilenko, Luca M. M. Janssen, Aggie T. G. Paulus, Ruben M. W. A. Drost, William Hollingworth, Joanna C. Thorn, Sian Noble, Judit Simon, Claudia Fischer, Susanne Mayer, Luis Salvador-Carulla, Alexander Konnopka, Leona Hakkaart van Roijen, Valentin Brodszky, A-La Park, Silvia M. A. A. Evers
Summary: This study provides a detailed description of the practical application of a stepwise approach to the development of a multi-sectoral Resource Use Measurement (RUM) instrument. It highlights the need for additional steps to ensure a uniform methodological basis, harmonization of questionnaire modules, and involvement of a broader range of stakeholders due to the complexity of developing a multi-sectoral RUM instrument.
APPLIED HEALTH ECONOMICS AND HEALTH POLICY
(2023)
Article
Substance Abuse
Scott A. McDonald, Gareth Myring, Norah E. Palmateer, Andrew McAuley, Lewis Beer, John F. Dillon, William Hollingworth, Rory Gunson, Matthew Hickman, Sharon J. Hutchinson
Summary: This study aimed to assess the impact of direct-acting antiviral (DAA) therapy on the quality of life (QoL) of people who inject drugs (PWID) with chronic hepatitis C virus (HCV) infection. The findings suggest that successful DAA therapy may not lead to a durable improvement in QoL among PWID, although there may be a transient improvement around the time of sustained virologic response.
Article
Health Care Sciences & Services
Joanna C. Thorn, Emma L. Turner, Eleanor I. Walsh, Jenny L. Donovan, David E. Neal, Freddie C. Hamdy, Richard M. Martin, Sian M. Noble
Summary: Introducing a single PSA screening test for men aged 50-69 across England and Wales could lead to very high initial secondary-care costs.
BMC HEALTH SERVICES RESEARCH
(2023)
Article
Nutrition & Dietetics
Russell Jago, Ruth Salway, Danielle House, Robert Walker, Lydia Emm-Collison, Kate Sansum, Katie Breheny, Tom Reid, Sarah Churchward, Joanna G. Williams, Charlie Foster, William Hollingworth, Frank de Vocht
Summary: The COVID-19 pandemic has had a significant impact on children's physical activity, resulting in a decrease in moderate-to-vigorous physical activity during lockdowns. While there was little change in parental activity levels post-COVID lockdown, it is important to examine if these patterns persist.
INTERNATIONAL JOURNAL OF BEHAVIORAL NUTRITION AND PHYSICAL ACTIVITY
(2023)
Article
Medicine, Research & Experimental
Fiona E. E. Lithander, Emma Tenison, Jan Ypinga, Angelika Halteren, Matthew D. D. Smith, Katherine Lloyd, Edward W. W. Richfield, Danielle E. E. Brazier, Micheal O. Breasail, Agnes J. J. Smink, Chris Metcalfe, William Hollingworth, Bas Bloem, Marten Munneke, Yoav Ben-Shlomo, Sirwan K. L. Darweesh, Emily J. J. Henderson
Summary: This study aims to evaluate whether a complex and innovative model of integrated care can improve patients' ability to achieve personal goals, have a positive impact on health and symptom burden, and be more cost-effective compared to usual care.
Article
Health Care Sciences & Services
L. M. M. Janssen, I. Pokhilenko, R. M. W. A. Drost, A. T. G. Paulus, J. Thorn, W. Hollingworth, S. Noble, M. Berger, J. Simon, S. M. A. A. Evers, PECUNIA Grp
Summary: This paper presents a step-by-step approach for conducting multinational think-aloud (TA) interviews in the development of resource-use measurement (RUM) instruments. It aims to incorporate the perspectives and cognitive processes of respondents. The transparent publication of TA methods in health economics studies can contribute to the advancement and understanding of qualitative research methods in RUM.
EXPERT REVIEW OF PHARMACOECONOMICS & OUTCOMES RESEARCH
(2023)
Article
Health Care Sciences & Services
Kirsty Garfield, Joanna C. Thorn, Sian Noble, Samantha Husbands, Will Hollingworth
Summary: This study aimed to test the acceptability, feasibility, and criterion and construct validity of the healthcare module of ModRUM. The results showed that ModRUM performed well in these aspects. Further testing is needed within trials.
BMC HEALTH SERVICES RESEARCH
(2023)
Article
Public, Environmental & Occupational Health
Robert Walker, Danielle House, Ruth Salway, Lydia Emm-Collison, Lara E. Hollander, Kate Sansum, Katie Breheny, Sarah Churchward, Joanna G. Williams, Frank de Vocht, William Hollingworth, Charlie Foster, Russell Jago
Summary: This study conducted interviews with parents, school staff, and children to analyze the impact of COVID-19 on children's physical activity. The study found that after the pandemic, children's physical activity habits changed, with a greater reliance on structured and organized activities, which may lead to decreased physical activity levels, especially for girls and children from lower socio-economic households. Therefore, affordable and equitable opportunities should be provided to prevent physical activity and health inequalities.
Article
Public, Environmental & Occupational Health
Ruth Kipping, Miranda Pallan, Kim Hannam, Kate Willis, Alex Dobell, Chris Metcalfe, Russell Jago, Laura Johnson, Rebecca Langford, Corby K. Martin, William Hollingworth, Madeleine Cochrane, James White, Pete Blair, Zoi Toumpakari, Jodi Taylor, Dianne Ward, Laurence Moore, Tom Reid, Megan Pardoe, Liping Wen, Marie Murphy, Anne Martin, Stephanie Chambers, Sharon Anne Simpson
Summary: This study aims to evaluate the effectiveness and cost-effectiveness of the NAP SACC UK intervention to increase physical activity, reduce sedentary time and improve nutritional intake. The study will be conducted through a multi-centre cluster RCT with process and economic evaluation. Nursery managers and staff will receive training and support to assess and improve physical activity and nutrition policies and practices. The control group will receive usual practice.
Article
Nutrition & Dietetics
Robert Walker, Ruth Salway, Danielle House, Lydia Emm-Collison, Katie Breheny, Kate Sansum, Sarah Churchward, Joanna G. Williams, Frank de Vocht, William Hollingworth, Russell Jago
Summary: This study examines the impact of the COVID-19 pandemic on the participation, costs, and provision of active clubs in schools and communities. The findings show that school-based club participation has increased, while community-based club participation has decreased. Children from lower education households are less likely to participate in active clubs, and girls are less likely to attend community clubs. The study also highlights the increase in club costs and the shift towards more affordable and convenient school-based clubs.
INTERNATIONAL JOURNAL OF BEHAVIORAL NUTRITION AND PHYSICAL ACTIVITY
(2023)
Article
Multidisciplinary Sciences
Joel Glynn, Timothy Jones, Mike Bell, Jane Blazeby, Christopher Burton, Carmel Conefrey, Jenny L. Donovan, Nicola Farrar, Josie Morley, Angus Mcnair, Amanda Owen-Smith, Ellen Rule, Gail Thornton, Victoria Tucker, Iestyn Williams, Leila Rooshenas, William Hollingworth
Summary: The EBI programme did not significantly impact the use of the 17 procedures it targeted, as most procedures were already on a downward trend before the guidance was introduced. There was no evidence of changes in trend post EBI, nor any spill-over effects onto related procedures. Geographical variation in procedure rates across English CCGs remained stable both before and after EBI. Further research is needed to understand the barriers and enablers of de-adoption of inappropriate health care to support future efforts.
Article
Psychiatry
Darragh Glavin, Eoin Martino Grua, Carina Akemi Nakamura, Marcia Scazufca, Edinilza Ribeiro dos Santos, Gloria H. Y. Wong, William Hollingworth, Tim J. Peters, Ricardo Araya, Pepijn Van de Ven
Summary: This study used machine learning and PHQ-9 items to identify the most predictive ultrabrief questionnaire for depressive symptomatology and validated its use with external data sets. The study found that alternative PHQ-9 item pairings were more effective than the PHQ-2 for prescreening depressive symptomatology.
JMIR MENTAL HEALTH
(2023)
