Review
Surgery
Abdur Rauf, Tareq Abu-Izneid, Anees Ahmed Khalil, Nabia Hafeez, Ahmed Olatunde, Mominur Rahman, Prabhakar Semwal, Yahya Saleh Al-Awthan, Omar Salem Bahattab, Ishaq N. Khan, Muhammad Arslan Khan, Rohit Sharma
Summary: This review discusses the potential and direction of using nanoparticle drug delivery systems for the treatment of COVID-19. Utilizing nanotechnology can increase the bioavailability of drugs, reduce toxicity, and enhance efficacy. Nanoparticles can also deliver vaccine antigens, playing a significant role in the effectiveness of COVID-19 vaccines. However, nanoparticle drug delivery systems still face challenges.
INTERNATIONAL JOURNAL OF SURGERY
(2022)
Review
Nutrition & Dietetics
Mauro Finicelli, Anna Di Salle, Umberto Galderisi, Gianfranco Peluso
Summary: The Mediterranean Diet, originating from the eating practices of people living in the Mediterranean basin, has shown to have beneficial effects on health and specific diseases. Clinical trials have provided evidence of its anti-inflammatory, anti-oxidant properties, and its effectiveness in controlling waist circumference and obesity. Strict and long-lasting adherence to the diet, as well as the beneficial effects of specific components, are valuable insights for intervention improvements.
Article
Nutrition & Dietetics
Shih-Hao Wu, Kuan-Lin Chen, Chin Hsu, Hang-Cheng Chen, Jian-Yu Chen, Sheng-Yan Yu, Yi-Jie Shiu
Summary: Creatine supplementation is effective for muscle growth in healthy young individuals with adequate training but further well-designed, long-term RCTs with larger sample sizes are needed to confirm its effects in other populations.
Article
Hematology
Stacy E. Croteau, Michael Wang, Allison P. Wheeler
Summary: Therapies aimed at prolonging clotting factor circulation time, manipulating the balance of coagulant and anti-coagulant proteins, or introducing new genetic material dominate hemophilia clinical trials. The improvement of health outcomes for hemophilia patients has been significant with the availability of clotting factor concentrates and primary prophylaxis. Emerging treatments aim to reduce current challenges, but must not introduce new health risks and should support similar or improved outcomes.
AMERICAN JOURNAL OF HEMATOLOGY
(2021)
Article
Hematology
Khaled M. Musallam, Rayan Bou-Fakhredin, Maria Domenica Cappellini, Ali T. Taher
Summary: The treatment landscape for beta-thalassemia patients is rapidly evolving, with unmet needs still existing for both transfusion-dependent and non-transfusion-dependent patients. Novel therapies targeting the underlying pathology in beta-thalassemia are currently in clinical trials, focusing on alpha/non-alpha-globin chain imbalance, ineffective erythropoiesis, and iron dysregulation.
AMERICAN JOURNAL OF HEMATOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Ranim Mahmoud, Virginia Kimonis, Merlin G. Butler
Summary: Prader-Willi syndrome (PWS) is a complex neurodevelopmental disorder caused by genetic abnormalities. The most common defect is a deletion of genetic material on chromosome 15. PWS is characterized by hyperphagia and food-seeking behavior, leading to obesity and associated health issues. Currently, there are no approved treatments for PWS, but various clinical trials are investigating potential therapeutic agents.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cardiac & Cardiovascular Systems
Hussam Al Ghorani, Felix Goetzinger, Michael Boehm, Felix Mahfoud
Summary: This review summarizes and discusses relevant clinical trials in epidemiology, diagnostics, and treatment of hypertension published in 2020 and 2021. The trials cover various aspects such as hypertension onset age, blood pressure monitoring methods, exercise-induced hypertension, treatment of hypertension in patients with SARS-CoV-2 infection, management of high-risk patient groups, and the interplay between nutrition and hypertension. The review also highlights insights into renal denervation for hypertension treatment and emphasizes on personalized risk assessment in elderly patients.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Review
Immunology
Hamidreza Akhbariyoon, Yasaman Azizpour, Marjan Fakhrizadeh Esfahani, Maryam Sadat Mirbagheri Firoozabad, Mehrdad Rabiee Rad, Kiarash Sadeghian Esfahani, Neda Khoshavi, Negin Karimi, Asal Shirinisaz, Fatemeh Abedi, Maryam Rabiee Rad, Parisa Sharifi
Summary: Advances in cancer immunotherapy have led to the development of immune checkpoint inhibitors targeting CTLA4, PD1, and PD-L1, which have shown promise in activating T cells to kill cancer cells. Clinical trials of ICIs in various cancers, including HCC, RCC, HL, NHL, NSCLC, and HNSCC, have demonstrated potential to change the treatment landscape.
CLINICAL IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Ivan Y. Y. Filin, Yuri P. P. Mayasin, Chulpan B. B. Kharisova, Anna V. Gorodilova, Kristina V. V. Kitaeva, Daria S. S. Chulpanova, Valeriya V. V. Solovyeva, Albert A. A. Rizvanov
Summary: Melanoma is a highly aggressive and therapy-resistant cancer, with increasing incidence rates. Conventional methods of treatment often result in relapse. Adjuvant therapies, such as cell-based immunotherapy, can be used to reduce recurrence risk by mobilizing the immune system to kill cancer cells. This review discusses the advantages, challenges, and ongoing clinical trials of cell-based therapy for adjuvant treatment of melanoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Syed Nasir Abbas Bukhari
Summary: A key issue in modern cancer treatment is the resistance to conventional chemotherapy and targeted medicines. Cancer nanotherapeutics aim to overcome these limitations and provide effective treatment through the use of nanoparticulate delivery systems. Various strategies such as passive and active targeting, nano-drug, and combination therapy have shown promising results. However, the complexity of tumor biology and limited understanding of nano-bio interactions hinder the clinical translation and commercialization of cancer nanotherapeutics.
Review
Oncology
Ann Neiheisel, Manpreet Kaur, Nancy Ma, Patty Havard, Anitha K. Shenoy
Summary: The Wnt signaling pathway plays a crucial role in the initiation and progression of various cancers, serving as reliable biomarkers and potential therapeutic targets. The canonical pathway is involved in cell survival and proliferation, while the noncanonical pathway regulates cell polarity and migration. In addition to its biological functions in development and homeostasis, the Wnt pathway is implicated in a range of pathological disorders, particularly cancer.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Review
Cardiac & Cardiovascular Systems
Michael Kunz, Felix Goetzinger, Insa Emrich, Vedat Schwenger, Michael Boehm, Felix Mahfoud
Summary: This article summarizes recent important studies on cardio-renal interactions, including treatments such as finerenone, SGLT2 inhibitors, and chlorthalidone, which may have an impact on clinical practice.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Review
Cell Biology
Li-Kai Huang, Yi-Chun Kuan, Ho-Wei Lin, Chaur-Jong Hu
Summary: Alzheimer's disease is a major cause of dementia, and the approval of new drugs through clinical trials has brought hope to patients. Ongoing clinical trials are focused on exploring the treatment of the disease mechanism and early intervention through new drugs.
JOURNAL OF BIOMEDICAL SCIENCE
(2023)
Editorial Material
Pharmacology & Pharmacy
Xiaofei Wu, Wen Xu, Mengyang Yu, Fan Zhang, Hongyun Wang
Summary: Significant progress has been made in the development of orphan drugs in China, with chemical drugs and biological products being the main focus. The research mainly focuses on homozygous hypercholesterolemia, hemo-philia, multiple sclerosis, and idiopathic pulmonary fibrosis.
PHARMACOLOGICAL RESEARCH
(2022)
Review
Peripheral Vascular Disease
Felix Goetzinger, Michael Kunz, Lucas Lauder, Michael Boehm, Felix Mahfoud
Summary: Hypertension, a common cardiovascular risk factor, is associated with increased morbidity and mortality. Despite available treatments, many patients fail to reach target blood pressure levels. This article summarizes and discusses the most relevant clinical trials in hypertension research published in 2021 and 2022, covering topics such as treatment targets, salt consumption, lifestyle interventions, medication safety, and the role of renal denervation in hypertension management.
HYPERTENSION RESEARCH
(2022)
