Review
Nutrition & Dietetics
Fardowsa Abdi, Saania Zuberi, Jedid-Jah Blom, David Armstrong, Maria Ines Pinto-Sanchez
Summary: A gluten-free diet is essential for treating celiac disease and may improve symptoms in non-celiac gluten/wheat sensitivity. However, adopting a gluten-free diet or a gluten-restricted diet may increase the risk of malnutrition and nutrient deficiencies. Therefore, patients with these conditions should undergo nutritional assessment and monitoring, and receive multidisciplinary care for long-term nutrition management.
Article
Nutrition & Dietetics
Juan Manuel Rodriguez, Virginia Estevez, Karla Bascunan, Jimena Ayala, Magdalena Araya
Summary: This study assessed gluten contamination in oat-based gluten-free products and found that they are currently highly contaminated. It is urgent to regulate and implement protocols to ensure safe consumption of these products.
FRONTIERS IN NUTRITION
(2022)
Article
Nutrition & Dietetics
Michele J. Alkalay
Summary: Lactose malabsorption, celiac disease, non-celiac gluten sensitivity, and irritable bowel syndrome are conditions associated with food triggers and can cause nutritional detriments. This review provides an overview of the complex nutritional elements of these disorders, which is critical for medical providers to recognize.
Review
Food Science & Technology
Laryssa Rosa de Sousa Franckilin, Anna Clara Paiva Menezes Dos Santos, Flavio Eduardo Dias Araujo Freitas, Isabela Garbazza Vieira, Carlos Eduardo de Freitas Jorge, Daniela Godoy Neri, Maria Vitoria Cota de Abreu, Janaina Koenen Fonseca, Renato Guimaraes Loffi, Giselle Foureaux
Summary: Gluten, the most common protein in wheat, is associated with celiac disease, wheat allergy, and non-celiac gluten sensitivity. These disorders have similar clinical manifestations but differ in development pathways and diagnostic criteria. A gluten-free diet is the most effective treatment for celiac disease and may also lead to improvements in neuropathologies and the gut microbiome.
FOOD REVIEWS INTERNATIONAL
(2023)
Review
Nutrition & Dietetics
Aner Cardo, Itziar Churruca, Arrate Lasa, Virginia Navarro, Maialen Vazquez-Polo, Gesala Perez-Junkera, Idoia Larretxi
Summary: Celiac disease (CD) is an autoimmune disorder of the small intestine that requires a gluten-free diet (GFD) for effective treatment. Nutritional imbalances may occur in adults with CD following GFD, but deficiencies can improve as intestinal mucosa recovers over time. Monitoring nutrient intake, especially plant proteins and essential nutrients, is important to prevent nutritional deficiencies in the long term.
Review
Nutrition & Dietetics
Bara Aljada, Ahmed Zohni, Wael El-Matary
Summary: The gluten-free diet is popular for treating immune-mediated disorders caused by gluten, but it has disadvantages like high costs, nutritional deficiencies, and social and psychological barriers. Close follow-up with patients following the diet is recommended, and more data is needed to assess its effectiveness in managing mental and cognitive disorders.
Review
Gastroenterology & Hepatology
Jaimy Villavicencio Kim, George Y. Wu
Summary: Elevated aminotransferases in celiac disease patients can normalize with a strict gluten-free diet, especially in those with cryptogenic liver disease. The relationship between liver damage and intestinal permeability may play a role in the elevation of aminotransferases in celiac disease. Routine monitoring of liver enzymes and adherence to a gluten-free diet is recommended for celiac disease patients, with further investigation needed if there is no improvement despite strict compliance with the diet.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2021)
Review
Immunology
Leonardo Biscetti, Gioacchino De Vanna, Elena Cresta, Ilenia Corbelli, Lorenzo Gaetani, Letizia Cupini, Paolo Calabresi, Paola Sarchielli
Summary: There is evidence supporting the role of the immune system in headache pathogenesis, with changes in cytokine profile and lymphocyte subsets in headache patients. Immunological alterations may predispose some patients to immunological and autoimmune diseases, while pathogenic mechanisms of autoimmune disorders can favor the onset of headaches. Investigating the association between headache and immunological/autoimmune disorders can have implications in clinical practice.
JOURNAL OF NEUROINFLAMMATION
(2021)
Review
Food Science & Technology
Xiaoxue Zhu, Xin-Huai Zhao, Qiang Zhang, Na Zhang, Olugbenga P. Soladoye, Rotimi E. Aluko, Yuhao Zhang, Yu Fu
Summary: This article reviews the latest research progress on the relationship between celiac disease (CD) and gluten. It emphasizes the structure and function of gluten peptides related to CD, gluten detection methods, the effects of processing on gluten, and gluten-free diets. The limitations in current CD research are also discussed. This study facilitates a comprehensive understanding of CD and gluten, providing a theoretical reference for future research.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Clinical Neurology
Igor de Oliveira, Pedro Augusto Sampaio Rocha-Filho
Summary: This study reviewed the epidemiology, differential diagnosis, and clinical and laboratory factors associated with the care management of headaches in patients with systemic lupus erythematosus (SLE). Headache is a frequent symptom in SLE patients and can be caused by various underlying conditions, including vascular diseases, aseptic meningitis, neuroinfections, intracranial neoplasms, and intracranial hypertension or hypotension.
Review
Nutrition & Dietetics
Aaron Lerner, Jozelio Freire de Carvalho, Anna Kotrova, Yehuda Shoenfeld
Summary: A gluten-free diet may serve as a novel therapeutic strategy for classical non-gluten-dependent autoimmune conditions, with symptom relief observed in most patients.
Review
Gastroenterology & Hepatology
Benjamin Lebwohl, Alberto Rubio-Tapia
Summary: The incidence of celiac disease is increasing due to both improved recognition and a real increase of the disorder. The reasons for this true rise are unclear, but may be related to environmental factors. Early-life gluten exposure is a major focus of prevention efforts.
Review
Clinical Neurology
Mehrnaz Salahi, Sina Parsa, Delaram Nourmohammadi, Zahra Razmkhah, Omid Salimi, Mohammadreza Rahmani, Saeid Zivary, Monireh Askarzadeh, Mohammad Amin Tapak, Ali Vaezi, Hamidreza Sadeghsalehi, Shirin Yaghoobpoor, Mehran Mottahedi, Setareh Garousi, Niloofar Deravi
Summary: Migraine headaches affect 15% of the population, but the exact pathophysiology is still unclear. Mast cells, immunoglobulin E, histamine, and cytokines may play a role in mediating this disease. The activation of mast cells can trigger the secretion of substances that cause migraine, and stress hormones like corticotropin-releasing hormone (CRH) contribute to its development. Blocking these pathways using immunologic agents may be a potential treatment for migraine.
FRONTIERS IN NEUROLOGY
(2022)
Review
Immunology
Sara Molaaghaee-Rouzbahani, Nastaran Asri, Somayeh Jahani-Sherafat, Davar Amani, Andrea Masotti, Kaveh Baghaei, Abbas Yadegar, Hamed Mirjalali, Mohammad Rostami-Nejad
Summary: This study highlights the importance of Macrophages (MQs) in the development of celiac disease and suggests that balancing the polarization of MQs may be a potential therapeutic target for this disease.
IMMUNITY INFLAMMATION AND DISEASE
(2022)
Review
Immunology
Renata Auricchio, Riccardo Troncone
Summary: Celiac disease is an autoimmune disorder triggered by gluten, with prevention strategies focusing on identifying at-risk individuals and eliminating risk factors. Research has shown that both genetic and environmental factors play a role in the development of the disease, suggesting that future interventions could involve protection from infections, manipulation of microbiota, and modulation of T cells.
FRONTIERS IN IMMUNOLOGY
(2021)