Article
Biotechnology & Applied Microbiology
Hae Sang Park, Ji Seung Lee, Chang-Beom Kim, Kwang-Ho Lee, In-Sun Hong, Harry Jung, Hanna Lee, Young Jin Lee, Olatunji Ajiteru, Md Tipu Sultan, Ok Joo Lee, Soon Hee Kim, Chan Hum Park
Summary: In this study, we successfully created a three-dimensional bioprinted artificial larynx using rabbit's chondrocyte-laden gelatin methacryloyl (GelMA)/glycidyl-methacrylated hyaluronic acid (GMHA) hybrid bioink. We incorporated a polycaprolactone (PCL) outer framework with pores to provide structural strength and a suitable microenvironment for the printed cells. Our novel fluidics supply (FS) system improved cell viability during the printing process, leading to the generation of a large-scale cell-laden artificial laryngeal framework. Animal studies confirmed the functionality of the transplanted 3D bio-larynx, offering potential for clinical applications in laryngectomy patients.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Veterinary Sciences
Brad M. Matz, Ralph A. Henderson, Stephanie S. Lindley, Annette N. Smith
Summary: The report describes the surgical technique and outcomes of total laryngectomy in six dogs. Postoperative quality of life was similar to permanent tracheostomy. Surgical margin status is essential for patient prognosis, and complications were mostly tracheostomy-related.
VETERINARY AND COMPARATIVE ONCOLOGY
(2021)
Article
Otorhinolaryngology
Gabriele Molteni, Andy Bertolin, Luca Gazzini, Andrea Sacchetto, Daniele Marchioni
Summary: Open partial laryngectomies continue to be a crucial aspect of conservative management for laryngeal cancer. The European Laryngological Society presented a detailed classification of open partial horizontal laryngectomies in 2014, focusing on the main surgical steps and modular approach for tumor removal.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2022)
Article
Otorhinolaryngology
Vivianne Landry, Apostolos Christopoulos, Louis Guertin, Eric Bissada, Paul Tabet, Ilyes Berania, Emilie Royal-Lajeunesse, Marie-Jo Olivier, Tareck Ayad
Summary: The study aimed to determine patterns of alaryngeal voice acquisition and predictive factors of vocal rehabilitation (VR) failure following total laryngectomy (TL) at a large Canadian tertiary care center. The data of 197 laryngectomized patients were analyzed, and it was found that successful VR was achieved in 59.0% of patients, while 41.0% failed to adopt an alaryngeal voice as their principal means of communication at 1 year postoperatively. The use of tracheoesophageal puncture (TEP) was associated with higher VR success rates compared with the artificial larynx and esophageal voice, and low socioeconomic status was identified as the independent predictor of VR failure.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2023)
Review
Medicine, General & Internal
Stephane Hans, Robin Baudouin, Marta P. Circiu, Florent Couineau, Quentin Lisan, Lise Crevier-Buchman, Jerome R. Lechien
Summary: This article discusses the historical evolution of partial laryngectomy techniques, indications, and surgical outcomes. Throughout the 19th and 20th centuries, advancements in local anesthesia, general anesthesia, and diagnostic technologies contributed to the improved efficacy of partial laryngectomies.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Computer Science, Interdisciplinary Applications
Adrien Mialland, Ihab Atallah, Agnes Bonvilain
Summary: Total laryngectomy is a curative treatment for laryngeal cancer, but it leads to difficulties in breathing, speaking, and swallowing for patients. Restoration of these functions is possible through tracheostomy and various techniques for phonation and swallowing. However, there is currently no definitive restoration technique for the natural airway, and non-invasive detection methods are limited in accuracy. The feasibility of an effective swallowing detection is crucial for the development of an implantable active artificial larynx and the restoration of aero-digestive tracts.
MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING
(2023)
Article
Otorhinolaryngology
Sarah Sussman, Ramez Philips, Bryan Renslo, Alyssa Givens, Brian Swendseid, Patrick Tassone, Richard A. Goldman, Joseph M. Curry, David M. Cognetti, Adam J. Luginbuhl
Summary: The study found that preoperative tracheostomy did not increase the risk of complications after total laryngectomy. Additionally, the timing of tracheostomy creation was not found to adversely affect clinical outcomes.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Article
Otorhinolaryngology
Ellen Tokarz, Adam R. Szymanowski, John T. Loree, Joseph Muscarella
Summary: The study revealed a serious gap in knowledge regarding emergent airway care in patients with tracheostomies and laryngectomies among medical students and internal medicine residents, highlighting the need for formal airway education.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2021)
Article
Otorhinolaryngology
Michael P. Wu, Tessa Goldsmith, Allison Holman, Rachael Kammer, Anuraag Parikh, Elliana K. Devore, Kevin S. Emerick, Derrick T. Lin, Daniel G. Deschler, Jeremy D. Richmon, Mark A. Varvares, Matthew R. Naunheim
Summary: A retrospective study on head and neck squamous cell carcinoma patients revealed that non-IMRT approaches and pulmonary comorbidities are associated with the need for laryngectomy for dysfunction after radiation or chemoradiation.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2021)
Review
Oncology
Thomas K. Hoffmann
Summary: Complete removal of the larynx (total laryngectomy) offers a curative approach for advanced laryngeal and pharyngeal cancer, while resulting in the loss of voice can be compensated by functional rehabilitation with a significant quality of life improvement. The surgical procedure including neck dissection is highly standardised and safe.
Article
Otorhinolaryngology
A. Mudry, S. Vergez
Summary: The aim of this historical vignette is to delve into the description and use of the first artificial larynx, developed by Carl Gussenbauer, and used after Theodor Billroth's first total laryngectomy, performed on December 31, 1873.
EUROPEAN ANNALS OF OTORHINOLARYNGOLOGY-HEAD AND NECK DISEASES
(2023)
Article
Medicine, Research & Experimental
Maxwell Y. Lee, Mario Belfiglio, Johnathan Zeng, Christopher W. Fleming, Shlomo Koyfman, Nikhil P. Joshi, Eric Lamarre, Brandon Prendes, Joseph Scharpf, Robert R. Lorenz, Neil M. Woody, David J. Adelstein, Jessica L. Geiger, Deborah J. Chute, Jamie A. Ku
Summary: Objective Organ preservation treatment has become more common for advanced laryngeal cancer compared to primary total laryngectomy. This study compared the oncologic and functional outcomes of these approaches. The survival rates did not differ between total laryngectomy and organ preservation treatment in T4 patients, but in T3 patients, organ preservation treatment had worse disease-free survival, possibly due to a higher rate of local recurrence. Total laryngectomy patients had comparable swallowing and speech outcomes with organ preservation treatment patients.
Article
Otorhinolaryngology
O. Laccourreye, D. Garcia, A. Mudry
Summary: This study compared the survival and treatment outcomes of laryngeal cancer patients in the 19th and 21st centuries through retrospective analysis. The results showed that total laryngectomy has improved survival and locoregional control rates in 21st-century patients, with advancements in adjuvant treatments and phonation modalities.
EUROPEAN ANNALS OF OTORHINOLARYNGOLOGY-HEAD AND NECK DISEASES
(2023)
Article
Otorhinolaryngology
Rohith S. Voora, Bharat A. Panuganti, Mitchell Flagg, Tyler Nelson, Nikhil V. Kotha, Edmund M. Qiao, Alexander S. Qian, Abhishek Kumar, Tyler F. Stewart, Brent Rose, Joseph Califano, Philip A. Weissbrod, Loren K. Mell, Ryan K. Orosco
Summary: Recurrence patterns in T4a laryngeal squamous cell cancer (LSCC) differ between patients treated with chemoradiotherapy (CRT) and those who undergo surgery. Surgery is associated with lower rates of locoregional and distant recurrence, improved overall and larynx cancer mortality outcomes.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2022)
Article
Medicine, Research & Experimental
Ollivier Laccourreye, Dominique Garcia, Fabienne Haroun, Dac H. Nguyen, Philippe Giraud, Haitham Mirghani
Summary: This study aims to document the 10-year oncologic outcome of primary total laryngectomy (TL) for patients with cT3-4M0 endolaryngeal squamous cell carcinoma (SCC). The results showed a 10-year actuarial local control estimate of 89.7%. Local recurrence significantly reduced nodal control, distant metastasis control, and survival. Postoperative complications, persistent index SCC, intercurrent disease, and metachronous second primary cancer were important factors affecting patient survival.
Article
Oncology
Sophie Deneuve, Lolane Dentand, Myriam Pannard, Agnes Dupret-Bories, Eric Roux Pierre, Lara Nokovitch, Toufic Renno, Olivia Perol, Francois Virard, Beatrice Fervers, Preau Marie
Summary: The study examines the experience of patients with no identified risk factors who have survived oral cavity squamous cell cancers (OCSCCs). These patients face stigma due to the absence of known causes and may benefit from guidance and support in prevention.
EUROPEAN JOURNAL OF CANCER CARE
(2022)
Article
Oncology
Pierre Mattei, Emilien Chabrillac, Bastien Cabarrou, Agnes Dupret-Bories, Sebastien Vergez, Jerome Sarini, Raphael Lopez, Lucie Piram, Thomas Brun, Anouchka Modesto
Summary: The study evaluated the outcomes of adjuvant interstitial brachytherapy for oral cavity squamous cell carcinoma (SCC) and compared low-dose-rate (LDR) and pulsed-dose-rate (PDR) BT. The results showed that both LDR and PDR BT provided satisfactory oncological outcomes with good tolerance in treating SCC post-surgery.
STRAHLENTHERAPIE UND ONKOLOGIE
(2022)
Article
Otorhinolaryngology
B. Benbassat, F. Cros, A. Dupret-Bories, T. Meresse
Summary: The advent of free flaps has revolutionized complex reconstructive surgeries, but prior surgeries and treatments can limit the choice of recipient vessels and increase the risk of venous congestion. In cases of early flap salvage, the technique of cephalic vein transposition can be a simple and reliable solution.
EUROPEAN ANNALS OF OTORHINOLARYNGOLOGY-HEAD AND NECK DISEASES
(2022)
Article
Biochemistry & Molecular Biology
Varvara Gribova, Lauriane Petit, Leyla Kocgozlu, Cendrine Seguin, Sylvie Fournel, Antoine Kichler, Nihal Engin Vrana, Philippe Lavalle
Summary: This study presents a hyaluronic acid (HA) hydrogel with triple activity: antimicrobial, immunomodulatory, and miRNA delivery agent. The hydrogel has shown to decrease inflammatory response, accelerate fibroblast migration, and deliver miRNA into cells. This hydrogel system is of great importance for the treatment of infected wounds and foreign body response modulation.
MACROMOLECULAR BIOSCIENCE
(2022)
Article
Oncology
Emilien Chabrillac, Sebastien Lamy, Pascale Grosclaude, Fanny Cros, Benjamin Vairel, Jerome Sarini, Sebastien Vergez, Antoine Nebout, Pierre Bories, Agnes Dupret-Bories
Summary: This study aims to identify the socio-professional and behavioral factors influencing decision-making between surgical and non-surgical treatment in Upper AeroDigestive Tract (UADT) oncology. Through an online survey among surgeons and oncologists in France, the study found that factors such as age and number of patients treated per year can influence their decision to choose surgical treatment or not.
Review
Engineering, Biomedical
Jordan Beurton, Ariane Boudier, Amedea Barozzi Seabra, Nihal Engin Vrana, Igor Clarot, Philippe Lavalle
Summary: This article provides an overview of the design of nitric oxide (NO) delivering surfaces for biomedical purposes, focusing on the advances made in the past 5 years. The localized supply of NO is of interest due to its various biological effects. Depending on the generated NO flux, the surface can mimic physiological release profiles to provide activity on the vascular endothelium or antibacterial activity. The article emphasizes the importance of selecting the appropriate coating for the substrate, matching the kinetics of NO release/generation to the targeted biological application, and considering the biocompatibility and stability of the surface. It provides a critical perspective to assist readers in designing NO delivering surfaces according to their specific requirements and therapeutic purposes.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Otorhinolaryngology
Thanaphone Banh Chong, Pascale Grosclaude, Emilien Chabrillac, Stephanie Lozano, Sebastien Vergez, Loic Mourey, Agnes Dupret-Bories
Summary: This study aimed to assess the survival benefit of optimal vs suboptimal management in elderly patients with upper aerodigestive tract cancer and to determine if comprehensive geriatric assessment (CGA) was a prognostic factor for survival. The results showed that optimal treatment was associated with better overall survival, and receiving CGA seemed to provide benefits for patients with lower G8 scores.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Oncology
Paul Mazerolle, Carine Fuchsmann, Philippe Schultz, Nadia Benmoussa, Olivier Malard, Alexandre Bozec, Sophie Deneuve, Mireille Folia, Marion Perreard, Audrey Lasne-Cardon, Emilien Chabrillac, Sebastien Vergez, Leonor Chaltiel, Agnes Dupret-Bories
Summary: Salvage TG or TGL may be considered as an acceptable treatment option for last-resort situations, despite the controversy surrounding these procedures.
Article
Medicine, General & Internal
Alice Renou, Anne-Valerie Guizard, Emilien Chabrillac, Gautier Defossez, Pascale Grosclaude, Sophie Deneuve, Sebastien Vergez, Benedicte Lapotre-Ledoux, Sandrine D. Plouvier, Agnes Dupret-Bories, FRANCIM Network
Summary: This study analyzed the evolution of the incidence of oral cavity cancers (OCC) among elderly patients in France from 1990 to 2018 and compared it to other cancers sharing the same main risk factors. The results showed a 72% increase in the number of OCC cases in women over 70 years old, while the number of cases in men remained stable. For laryngeal and hypopharyngeal cancers, there was a decrease in incidence in elderly men and an increase in elderly women, but to a lesser extent than OCC. Therefore, the incidence of OCC has been increasing in elderly subjects in France, particularly in women, since the 1990s, and cannot be solely explained by population aging, growth, or alcohol and tobacco consumption.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Tijana Sustersic, Varvara Gribova, Milica Nikolic, Philippe Lavalle, Nenad Filipovic, Nihal Engin Vrana
Summary: Layer-by-layer film (LbL) coatings made of polyelectrolytes are a powerful tool for surface modification and have applications in various fields. Machine learning algorithms, particularly the Extra Tree Regressor, can accurately predict coating thickness and optimize the development process. This research has important implications for the biomedical field and potential applications in antimicrobial, anti-inflammatory, and antiviral properties.
Article
Oncology
Pierre Mattei, Delphine Dghayem, Agnes Dupret-Bories, Jerome Sarini, Benjamin Vairel, Louis -David Riviere, Sebastien Vergez, Amelie Lusque, Emilien Chabrillac
Summary: This study aimed to compare the rate of occult contralateral neck metastases (OCNM) in oral and oropharyngeal squamous cell carcinomas (SCC) reaching or crossing the midline and identify risk factors for OCNM. The study found that tumor origin and clinical N-status should carry the most weight when deciding the indications for contralateral elective neck dissection (END) in patients with oral and oropharyngeal SCC extending close to or beyond the midline, rather than the extent of midline involvement itself.
Review
Engineering, Biomedical
Christelle Bertsch, Helene Marechal, Varvara Gribova, Benjamin Levy, Christian Debry, Philippe Lavalle, Lea Fath
Summary: Tissue engineering has the potential to restore damaged tissues by combining cells with specific scaffolds. This review focuses on the recent advances in design and application of bilayered scaffolds for the regeneration of various tissues. The limitations and challenges in scaling up production and clinical studies are also discussed.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Medicine, General & Internal
Mariam H. Mella, Emilien Chabrillac, Agnes Dupret-Bories, Mathilde Mirallie, Sebastien Vergez
Summary: Minimally invasive surgery, specifically transoral robotic surgery (TORS), has become popular in the field of surgical oncology for the treatment of head and neck cancer. TORS utilizes wristed instruments and a magnified three-dimensional view for enhanced surgical comfort and safety in hard-to-access areas. However, the expansion of TORS must be based on high-level evidence to ensure comparable oncological outcomes to traditional approaches. This narrative review evaluates the current role of TORS in head and neck cancer treatment and identifies remaining knowledge gaps.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Chemistry, Analytical
Varvara Gribova, Jesus Manuel Antunez Dominguez, Alan Morin, Julia Sepulveda Diaz, Philippe Lavalle, Nihal Engin Vrana
Summary: Implants and prostheses are commonly used in repairing damaged tissues or treating diseases, and genotoxicity is an essential feature to investigate before their market release. However, genotoxicity tests are not readily available to biomaterials researchers due to their complexity. In order to address this issue, a simplified genotoxicity test was developed, starting from a simplified Ames test in Petri dishes and then miniaturizing it in a microfluidic chip. This optimized microfluidic chip system can significantly improve the availability and observation of genotoxicity tests for biomaterials developers.
ANALYTICAL METHODS
(2023)
