Journal
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
Volume 33, Issue 1, Pages 45-53Publisher
WILEY
DOI: 10.1002/hed.21398
Keywords
race; head and neck squamous cell carcinoma; survival; disparities; human papillomavirus
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Funding
- NCI NIH HHS [K08 CA132988, K08 CA132988-01A2] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [K08CA132988] Funding Source: NIH RePORTER
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Background. Several studies have documented disparities in head and neck cancer outcomes for black patients in the United States. Recent studies have found that differences in oropharyngeal tumor human papillomavirus (HPV) status may be a cause of this disparity. Methods. In all, 76,817 cases of head and neck squamous cell carcinoma (HNSCC) recorded in the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) program were analyzed. Racial/ethnic groups were studied, for disease-specific survival in both case-matched and non-matched cohorts. Calculation of expected disparity magnitudes based on HPV status was performed using data reported in the literature. Results. A disease-specific survival disparity was demonstrated for Hispanic patients. However, case matching eliminated this disparity. Conversely, the disparity for black patients persisted in matched cohorts. The oropharyngeal subsite was found to be the dominant contributor to this disparity. Conclusions. The survival disparity for Hispanic patients in SEER with HNSCC is explained by differences in presentation and treatment. Also, HPV tumor status is likely a key determinant of the disparity for black patients. (C) 2010 Wiley Periodicals, Inc. Head Neck 33: 45-53, 2011
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