Journal
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
Volume 34, Issue 4, Pages 551-556Publisher
WILEY
DOI: 10.1002/hed.21779
Keywords
IL-23; IL-23 receptor; genetic polymorphism; oral cancer
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Funding
- National Science Council, Taiwan [NSC97-2314-B-040-025-MY3]
- National Science Council, Ministry of Education
- Chung-Shan Medical University
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Background The purpose of this study was to evaluate the influence of genetic polymorphisms of interleukin (IL)-23 and the IL-23 receptor (IL-23R) on the susceptibility to oral cancer. Methods. Polymerase chain reaction- restriction fragment length polymorphism (PCR-RFLP) was used to measure polymorphisms of these genes in 240 controls and 240 patients with oral cancer. Results. Individuals with at least 1 varied C allele of rs10889677 (IL-23R polymorphism) had a 1.553-fold risk (95% confidence interval [CI], 1.073-2.241) of developing oral cancer compared with patients with the wild-type A/ A homozygote. Patients with oral cancer with at least 1 varied C allele of rs10889677 had a 1.931-fold risk of tumor lymph node metastasis compared with patients with the C/C homozygote. Conclusion. The varied C allele of the IL-23R gene may be considered a factor contributing to increased susceptibility and may be a predictive factor for tumor lymph node metastasis in Taiwanese with oral cancer. (C) 2011 Wiley Periodicals, Inc. Head Neck 34: 551-556, 2012
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