Journal
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
Volume 33, Issue 9, Pages 1309-1314Publisher
WILEY-BLACKWELL
DOI: 10.1002/hed.21606
Keywords
nasopharyngeal carcinoma; skull-base invasion; prognostic value; magnetic resonance imaging; grading
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Funding
- Science Foundation of Key Hospital, Ministry of Health P.R. China [2007-353]
- Hi-Tech Research and Development Program of China [2006AA02AA404]
- International Cooperation Foundation of Guangdong Science and Technology Department of China [2008B050100039]
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Background. Our aim was to grade MRI-detected skull-base invasion in nasopharyngeal carcinoma and evaluate the prognostic value of the grading. Methods. The MRI scans and medical records of 924 patients with histologically diagnosed nondisseminated nasopharyngeal carcinoma were reviewed retrospectively. Results. MRI-detected skull-base invasion was not found to be an independent prognostic factor for overall survival, distant metastasis-free survival, or local relapse-free survival (p > .05 for all). Grading of skull-base erosion according to the site of invasion was found to be an independent prognostic factor for both overall survival (p = .003 and p = .006, respectively) and distant metastasis-free survival (p = .001 for both) in the 512 patients with skull-base invasions and 315 patients with T3 disease. Conclusions. MRI-detected skull-base invasion is not an independent prognostic factor for nasopharyngeal carcinoma. However, grading according to the site of invasion as either low grade or severe has prognostic value. (C) 2010 Wiley Periodicals, Inc. Head Neck 33: 1309-1314, 2011
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