Article
Otorhinolaryngology
Jong-Lyel Roh
Summary: Supraglottic laryngectomy has undergone advancements from open to transoral endoscopic approaches, particularly with the use of lasers, endoscopes, ultrasonic devices, and robotics. Transoral laser-assisted microsurgery has emerged as an effective alternative to partial laryngectomy or non-surgical therapies, providing faster functional recovery. A new technique called transoral laser-assisted infrahyoid supraglottic laryngectomy allows for tumor removal while preserving crucial structures, resulting in optimal preservation of laryngopharyngeal function and minimal complications.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Article
Otorhinolaryngology
Jorge Basterra, Natsuki Oishi, Jose Ramon Alba, Enrique Zapater
Summary: The aim of this study was to demonstrate the surgical technique of horizontal supraglottic laryngectomy for T3 carcinomas using transoral approach with microelectrodes and radiofrequency. The results showed that this technique has the advantages of short surgical time and high hemostatic effectiveness.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2023)
Article
Medicine, Research & Experimental
Marialessia Damiani, Giuseppe Mercante, Mohammed Abdellaoui, Joanne Guerlain, Antoine Moya-Plana, Odile Casiraghi, Stephane Temam, Yungan Tao, Philippe Gorphe
Summary: In intermediate-size laryngeal carcinoma amenable to supraglottic laryngectomy, pathological features are associated with tumor size according to group stratification based on tumor location.
Article
Environmental Sciences
Carmelo Saraniti, Francesco Ciodaro, Cosimo Galletti, Salvatore Gallina, Barbara Verro
Summary: This study compared the swallowing outcomes of endoscopic supraglottic laryngectomy (ESL) and open partial horizontal laryngectomy type I (OPHL I). The results showed that ESL had fewer cases of laryngeal penetration and aspiration at 3 months post-op, but there were no statistically significant differences between the two surgeries in terms of laryngeal penetration and aspiration at 12 months post-op. This suggests that successful outcomes depend on careful patient selection and the surgeon's experience.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Otorhinolaryngology
Togay Muderris, Ergun Sevil, Fatih Gul
Summary: This study investigated the long-term functional and oncologic outcomes of transoral robotic supraglottic laryngectomy (TORS-SGL). The results showed that TORS-SGL has excellent functional results for T1, T2, and selected T3 supraglottic tumors, and provides acceptable long-term oncologic results compared to alternative treatment modalities.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2024)
Article
Otorhinolaryngology
Gabriele Molteni, Andy Bertolin, Luca Gazzini, Andrea Sacchetto, Daniele Marchioni
Summary: Open partial laryngectomies continue to be a crucial aspect of conservative management for laryngeal cancer. The European Laryngological Society presented a detailed classification of open partial horizontal laryngectomies in 2014, focusing on the main surgical steps and modular approach for tumor removal.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2022)
Article
Otorhinolaryngology
Marco de Vincentiis, Antonio Greco, Flaminia Campo, Francesca Candelori, Massimo Ralli, Mario Di Traglia, Andrea Colizza, Francesca Cambria, Jacopo Zocchi, Valentina Manciocco, Giuseppe Spriano, Raul Pellini
Summary: This study analyzed the oncologic outcomes of open partial horizontal laryngectomy (OPHL) and identified prognostic factors affecting survival of patients with laryngeal cancer. The findings suggest that OPHL can be a successful treatment for advanced laryngeal cancer, but careful patient selection is crucial.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Article
Biology
Elena Molina-Fernandez, Jose M. Palacios-Garcia, Ramon Moreno-Luna, Tomas Herrero-Salado, Julio Ventura-Diaz, Serafin Sanchez-Gomez, Angel Vilches-Arenas
Summary: The worldwide incidence rate of laryngeal cancer is decreasing, but the 5-year survival rate has decreased from 66% to 63% in recent years. The study evaluated the survival rate of patients with laryngeal cancer according to the disease stage and treatment method. The results showed that patients who underwent surgical treatment had a higher chance of survival than those treated with chemoradiotherapy.
Article
Oncology
Stephanie Flukes, Marc A. Cohen, Louise M. Cunningham, Richard J. Wong, Jennifer R. Cracchiolo
Summary: This study examined 30 patients who underwent total laryngectomy for thyroid carcinoma and found that the surgery is safe for treating locally advanced thyroid cancer with acceptable rates of locoregional control.
JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Otorhinolaryngology
Zaid Al-Qurayshi, Amanda L. Ngouajio, Marisa R. Buchakjian
Summary: This study examined the treatment modalities for early-stage supraglottic squamous cell carcinoma and found that the surgical group had a higher rate of T upstaging, which may contribute to the lower overall survival in the radiotherapy group.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Article
Otorhinolaryngology
Michael R. Papazian, Michael S. Chow, Adam S. Jacobson, Theresa Tran, Mark S. Persky, Michael J. Persky
Summary: This study compared different surgical treatment options for supraglottic SCC and found that transoral robotic surgery (TORS) had better outcomes and survival rates compared to open partial laryngectomy and transoral laser microsurgery (TLM).
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2023)
Article
Medicine, Research & Experimental
Bharat Akhanda Panuganti, Rohith Voora, Charles Coffey, Ryan Orosco, Philip A. Weissbrod, Joseph Califano
Summary: This study compared the overall survival outcomes of transoral laser microsurgery (TLM) with neck dissection versus definitive radiotherapy in patients with T2N0 supraglottic squamous cell carcinoma. The results showed that TLM was associated with better overall survival compared to radiotherapy.
Article
Otorhinolaryngology
Marco Fantini, Erika Crosetti, Nicole Pizzorni, Andrea Elio Sprio, Andy Bertolin, Giuseppe Rizzotto, Antonio Schindler, Giovanni Succo
Summary: This study evaluates voice and communication outcomes after open partial horizontal laryngectomies, finding that the results are heterogeneous and may be influenced by multiple factors. Understanding variables with a substantial impact on phonatory outcomes can assist clinicians in decision-making and postoperative rehabilitation.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Article
Oncology
Shenshan Jia, Yanying Wang, Hongjiang He, Cheng Xiang
Summary: The study demonstrated that superselective neck dissection (SSND) removing lymph nodes in levels IIA and III is safe and effective for patients with supraglottic squamous cell carcinoma (SCC) of the larynx and clinically negative neck. The spinal accessory nerve function was maintained without compromising clinical outcome.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Review
Otorhinolaryngology
Flaminia Campo, Francesco Mazzola, Giulia Bianchi, Valentina Manciocco, Massimo Ralli, Antonio Greco, Isabella Sperduti, Marco de Vincentiis, Raul Pellini
Summary: This study aimed to investigate the oncologic outcomes of open partial laryngectomy (OPL) in untreated pT3 laryngeal cancer and compare them with total laryngectomy (TL). A total of 805 patients who underwent OPL were included, and the 5-year overall survival (OS), disease-specific survival (DSS), disease-free survival (DFS), and locoregional recurrence-free survival (LFS) rates were calculated. The analysis also compared TL and OPL, showing no significant differences in survival and disease control rates. Therefore, accurate patient selection is crucial when choosing the surgical approach.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2023)
Article
Oncology
Roberto Gallus, Irene H. Nauta, Linda Marklund, Davide Rizzo, Claudia Crescio, Luca Mureddu, Paolo Tropiano, Giovanni Delogu, Francesco Bussu
Summary: In the current version of TNM (AJCC 8th edition), IHC is recommended for HPV detection in oropharyngeal squamocellular carcinoma. However, its reliability and applicability in different populations, especially in de-intensification protocols, are debatable. This paper discusses its limits and suggests possible actions to overcome these limitations.
Review
Otorhinolaryngology
Francesco Bussu, Luca Tagliaferri, Claudia Crescio, Davide Rizzo, Roberto Gallus, Claudio Parrilla, Bruno Fionda, Valentina Lancellotta, Gian Carlo Mattiucci, Jacopo Galli
Summary: This study aims to define the current standard of care for nasal vestibule squamous cell carcinoma (NVSCC). Through reviewing recent acquisitions, it is found that the current staging system is inadequate. Current evidence suggests that brachytherapy is at least equivalent to surgery and superior to external beams in terms of oncological outcomes, and superior to both modalities in terms of cosmesis and function for the treatment of primary lesions without bone invasion.
ACTA OTO-LARYNGOLOGICA
(2023)
Article
Oncology
Willem Frederik Julius Scheurleer, Luca Tagliaferri, Johannes A. A. Rijken, Claudia Crescio, Davide Rizzo, Gian Carlo Mattiucci, Frank A. A. Pameijer, Remco de Bree, Bruno Fionda, Mischa de Ridder, Francesco Bussu
Summary: This retrospective study aimed to evaluate the staging systems for cancer of the nasal vestibule. The distribution of stages varied widely among the four evaluated systems, with the classification proposed by Bussu et al. showing the most balanced allocation of patients. The widespread adoption of a single system and the introduction of a designated topography code could improve data reporting and understanding of the disease. Further analysis is needed to determine the best classification system for nasal vestibule carcinoma.
Review
Health Care Sciences & Services
Anna Pisani, Fabiola Paciello, Valeria Del Vecchio, Rita Malesci, Eugenio De Corso, Elena Cantone, Anna Rita Fetoni
Summary: Brain-derived neurotrophic factor (BDNF) plays a crucial role in the central nervous system and sensory structures such as olfactory and auditory systems. It has been shown to have protective effects, promoting neuronal growth and survival, and modulating synaptic plasticity. However, conflicting data exist on BDNF expression and functions in the cochlear and olfactory structures. Studies suggest that BDNF levels may serve as a biomarker in neurodegenerative diseases, including Alzheimer's disease, hearing loss, and olfactory impairment. This review summarizes current research on BDNF in the brain and sensory domains, highlighting the potential of BDNF as a biomarker for early diagnosis and therapeutic target.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Medicine, General & Internal
Cristian Locci, Caterina Cenere, Giovanni Sotgiu, Mariangela Valentina Puci, Laura Saderi, Davide Rizzo, Francesco Bussu, Roberto Antonucci
Summary: Adenotonsillectomy (AT) has significant improvements in clinical and functional outcomes for children with obstructive sleep apnea syndrome (OSAS), although residual OSAS may occur in severe cases. Long-term post-surgical follow-up is highly recommended.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Pier Paolo Mattogno, Matteo Zoli, Quintino Giorgio DAlessandris, Daniele Bongetta, Valerio Maria Caccavella, Mario Rigante, Giuseppe Maria Della Pepa, Diego Mazzatenta, Liverana Lauretti, Alessandro Olivi, Giannantonio Spena, Cesare Zoia
Summary: The study aimed to assess the role of the Endoscopic Endonasal Approach (EEA) in the ultra-early management of selected neurosurgical emergencies. The results showed that EEA is a safe and effective technique with good outcomes in centers with adequate experience.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Bruno Fionda, Francesco Bussu, Elisa Placidi, Enrico Rosa, Valentina Lancellotta, Claudio Parrilla, Tiziano Zinicola, Martina De Angeli, Francesca Greco, Mario Rigante, Mariangela Massaccesi, Maria Antonietta Gambacorta, Luca Indovina, Marco De Spirito, Luca Tagliaferri
Summary: Integrational radiotherapy is an effective treatment for early stages nasal vestibule tumors, with high local control rates and low toxicity profiles. This study proposes novel strategies to reduce dose to organs at risk, including the use of metal shields for the eyes and the use of mouth swabs to push away the mandible. The results show statistically significant dose reduction for both strategies.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Oncology
Carolina Noya, Quintino Giorgio D'Alessandris, Francesco Doglietto, Roberto Pallini, Mario Rigante, Pier Paolo Mattogno, Marco Gessi, Nicola Montano, Claudio Parrilla, Jacopo Galli, Alessandro Olivi, Liverana Lauretti
Summary: Clival chordomas are aggressive skull base tumors that require surgery and radiotherapy for effective treatment. Molecular targeted drugs have a limited role. Younger age, Ki67 = 5% tumors, and adjuvant radiotherapy are associated with improved survival.
Article
Health Care Sciences & Services
Mahmoud Abdelghany, Ayman Amin, Emilia Degni, Claudia Crescio, Asem Elsani M. A. Hassan, Tarek Ftohy, Francesco Bussu
Summary: The aim of this study is to review the outcomes of postirradiation salvage total laryngectomy (STL) and reconstruction with pectoralis major flap. The overall survival after STL and reconstruction with PMMF is low, but most deaths are due to comorbidities, not cancer progression or recurrence.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Health Care Sciences & Services
Paolo Fois, Luca Mureddu, Alessandra Manca, Simona Varrucciu, Claudia Crescio, Roberto Gallus, Davide Rizzo, Antonio Cossu, Francesco Bussu
Summary: FNAC has high sensitivity and specificity in diagnosing Warthin tumors, but has limitations in non-diagnostic results. Multiparametric evaluation can improve the sensitivity and specificity of FNAC, reduce the number of non-diagnostic results, and safely guide the management of Warthin tumors.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Health Care Sciences & Services
Eugenio De Corso, Giancarlo Ottaviano, Carlotta Pipolo, Elena Cantone, Davide Mattavelli, Matteo Alicandri-Ciufelli, Daniela Lucidi, Marco Caminati, Gianenrico Senna, Carlo Cavaliere, Angelo Ghidini, Stefania Gallo, Alberto Macchi, Sara Torretta, Veronica Seccia, Massimiliano Garzaro, Gian Luca Fadda, Matteo Trimarchi, Ernesto Pasquini, Fabio Pagella, Frank Rikki Canevari, Andrea Preti, Ignazio La Mantia, Jacopo Galli
Summary: Chronic rhinosinusitis with nasal polyps (CRSwNP) has a significant impact on quality of life, and defining disease control is important for determining the best treatment strategy. However, disease control is not standardized, and a universally accepted tool is still missing. A nationwide survey of otorhinolaryngologists in Italy revealed that while international guidelines were known, their implementation was challenging. Clinical symptoms, particularly nasal obstruction, loss of sense of smell, and rhinorrhea, were considered important indicators of disease control.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Health Care Sciences & Services
Giancarlo Ottaviano, Eugenio De Corso, Tommaso Saccardo, Leandro Maria D'Auria, Sonny Zampollo, Giuseppe D'Agostino, Edoardo Mairani, Gabriele De Maio, Bruno Scarpa, Christian Bacci, Vittorio Favero
Summary: This study aimed to evaluate the efficacy of Dupilumab in severe, uncontrolled CRSwNP patients in young-middle adults and elderly populations. The study found that Dupilumab had the same effectiveness in both age groups, making it a safe and reliable treatment option for elderly patients.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Medicine, General & Internal
Valeria Del Vecchio, Laura Tricarico, Anna Pisani, Nicola Serra, Domenico D'Errico, Eugenio De Corso, Teresa Rea, Pasqualina M. Picciotti, Carla Laria, Giuseppe Manna, Annamaria Franze, Rita Malesci, Anna Rita Fetoni
Summary: This study found a link between early sensorineural hearing loss and mild cognitive impairment, as well as their association with potential risk factors. Screening for hearing loss and cognitive impairment can help prevent the progression to dementia. Hypertension and hypercholesterolemia are common pathological factors linking inner ear and brain damage.
MEDICINA-LITHUANIA
(2023)
