Journal
HAUTARZT
Volume 60, Issue 10, Pages 826-829Publisher
SPRINGER
DOI: 10.1007/s00105-008-1699-4
Keywords
Biologics; Lupus erythematosus; ANA; Adalimumab; TNF-alpha inhibitors
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Patients treated with TNF-alpha inhibitors frequently have serum autoantibodies, but only a few develop clinically apparent lupus erythematosus. The TNF-alpha inhibitor adalimumab is a fully humanized antibody and seems to induce autoantibodies less frequently than other drugs of this group. We report on a patient with rheumatoid arthritis, who developed anti-histone antibodies and lupus tumidus after eight months on adalimumab therapy.
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