Molecular interactions of paraben family of pollutants with embryonic neuronal proteins of Danio rerio: A step ahead in computational toxicity towards Adverse Outcome Pathway
Swastik Chakraborty, Prerna Mahesh Gaidhani · Jan 30, 2024
This research investigates how paraben chemicals, which are commonly found in products affect environments. The study specifically focuses on nine types of parabens and their impact, on 17 proteins involved in the early development of zebrafish embryos. To analyze these effects scientists used software to predict protein structures and identify binding sites. The results indicated a connection between the length of the parabens carbon chain and its ability to bind with these proteins. Benzyl Paraben exhibited highest affinities among all. The study shed light on the toxicity and mutagenicity of the paraben family raising concerns about their disruption of crucial biological processes during embryonic development. It emphasizes the need, for measures and strict regulations to address these risks effectively.
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