Synthesis and characterization of L-lysine polyurethane (LPU) nanoparticles for drug delivery system

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Authors

Soojeong Choi¹ , Seoeun Oh¹ , Ildoo Chung¹

1. Pusan National University

Conference / event

8th Asian Symposium on Advanced Materials ASAM-8, July 2023 (Novosibirsk, Russian Federation)

Poster summary

To obtain biodegradable biomaterial for matrix of drug delivery, L-lysine polyurethane(LPU) was designed using the biodegradable triblock oligomer polylactide-poly(ethylene glycol)-polylactide(PLA-PEG-PLA) as a soft segment, 1,6-hexamethylene diisocyanate(HMDI) as a hard segment and L-lysine ethyl ester(LEE) as a chain extender. PLA-PEG-PLA was synthesized by ring opening polymerization(ROP) of lactide monomer onto poly(ethylene glycol) core and stannous octoate as a catalyst. LEE was synthesized by esterification of L-lysine with ethanol using thionyl chloride as a catalyst. LPU nanoparticles were fabricated by using water-in-oil-in-water double emulsion technique.

Keywords

Drug delivery system, Biodegradable, Doublbe emulsion method, Ring opening polymerization, Polyurethane

Research areas

Bioengineering, Chemical Engineering, Material Sciences

References

1. Soo-Yong Park, Yang H. Yun, Bum-Joon Park, Hyung-Il Seo, Ildoo Chung, Fabrication and Biological Activities of Plasmid DNA Gene Carrier Nanoparticles Based on Biodegradable L-Tyrosine Polyurethane, Pharmaceuticals, 2022, vol 15, 17-33
2. Soo-Yong Park, Jiin Kang, Ji-Young Yoon, Ildoo Chung, Synthesis and Characterization of Polyfumarateurethane Nanoparticles for Sustained Release of Bupivacaine, Pharmaceutics, 2020, vol 12, 281-293

Funding

1. the National Research Foundation of Korea (NRF) (No. 2022R1I1A30535561162182065300101)

Supplemental files

No data provided

Additional information

Competing interests

No competing interests were disclosed.

Data availability statement

The datasets generated during and / or analyzed during the current study are available from the corresponding author on reasonable request.

Creative Commons license

Copyright © 2023 Choi et al. This is an open access work distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.