Synthesis and characterization of polyrotaxane based on mono-6-tosyl-β -cyclodextrin

Authors

Chaijun Lee¹ , Jihyun Lee¹ , Jinwoong Jung² , Ildoo Chung¹

1. Pusan National University
2. Dongah Chemical Co

Conference / event

The 8th Asian Symposium on Advanced Materials (ASAM-8), July 2023 (Novosibirsk, Russian Federation)

Poster summary

β-Cyclodextrin(β-CD) is a type of cyclic oligosaccharide used in various fields such as drug delivery, gene therapy, catalyst, chemical sensor, and liquid crystal. Mono-6-deoxy-6-(p-tolylsulfonyl)-β-cyclodextrin (TsO-β-CD) was synthesized by replacing one hydroxyl group among 21 hydroxyl groups in β-CD under various pH conditions using p-toluenesulfonyl chloride(p-TsCl),and used to synthesis polyrotaxane by threading TsO-β-CD on PPG-diamine with a molecular weight of 2000, followed by end capping using Trt-Gly-OH , N-Hydroxysuccinimide (NHS), ethylene dichloride (EDC). The synthesized CD derivatives and polyrotaxane were characterized by 1HNMR and FTIR spectroscopies.

Keywords

Mono-6-tosyl-β -cyclodextrin, Polyrotaxane, Cyclodextrin, Tosylation

Research areas

Chemical Engineering, Bioengineering, Chemistry, Material Sciences

References

1. Liu, H., Qi, C., Feng, Z. et al. Adsorption of trace thorium(IV) from aqueous solution by mono-modified β-cyclodextrin polyrotaxane using response surface methodology (RSM). J Radioanal Nucl Chem 314, 1607–1618 (2017).
2. Xu, L.; Xing, C.-Y.; Ke, D.; Chen, L.; Qiu, Z.-J.; Zeng, S.-L.; Li, B.-J.; Zhang, S. Amino-Functionalized β-Cyclodextrin to Construct Green Metal−Organic Framework Materials for CO2 Capture. ACS Appl.Mater. Interfaces 2020, 12, 3032−3041.

Funding

1. the Ministry of Trade Industry & Energy (No. 20011422)

Supplemental files

No data provided

Additional information

Competing interests

No competing interests were disclosed.

Data availability statement

The datasets generated during and / or analyzed during the current study are available from the corresponding author on reasonable request.

Creative Commons license

Copyright © 2023 Lee et al. This is an open access work distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.