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Inactivation of Cops5 in smooth muscle cells causes abnormal reproductive hormone homeostasis and development in mice

PUBLISHED June 30, 2023 (DOI: https://doi.org/10.54985/peeref.2306p3662949)



Zhibing Zhang1 , Qian Huang1 , Yonghong Man2 , Wei Li1 , Qi Zhou2 , Shuo Yuan2 , Yi Tian Yap1 , Neha Nayak1 , Ling Zhang2 , Shizheng Song2 , Joseph Dunbar1 , Todd Leff1 , Xu Yang3
  1. Wayne State University
  2. Wuhan University of Science and Technology
  3. Hospital for Special Surgery, New York, NY, United States

Conference / event

The 46th Annual Meeting of American Society of Andrology, April 2021 (La Jolla, United States)

Poster summary

Our study indicates that loss of Cops5 in smooth muscle cells can result in profound changes in organ development and tissue cytoarchitecture, particularly in reproductive and immunologic organs and bone. Impaired steroid hormone production maybe the primary cause for these disorders.


COPS5, Smooth muscle cells, Endocrine system

Research areas

Zoology, Molecular and Cellular Biosciences, Biological Sciences, Immunology, Genetics


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  1. National Institute of Health (No. HD105944)

Supplemental files

No data provided

Additional information

Competing interests
No competing interests were disclosed.
Data availability statement
Data sharing not applicable to this poster as no datasets were generated or analyzed during the current study.
Creative Commons license
Copyright © 2023 Zhang et al. This is an open access work distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Zhang, Z., Huang, Q., Man, Y., Li, W., Zhou, Q., Yuan, S., Yap, Y., Nayak, N., Zhang, L., Song, S., Dunbar, J., Leff, T., Yang, X. Inactivation of Cops5 in smooth muscle cells causes abnormal reproductive hormone homeostasis and development in mice [not peer reviewed]. Peeref 2023 (poster).
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