Inactivation of Cops5 in smooth muscle cells causes abnormal reproductive hormone homeostasis and development in mice

Authors

Zhibing Zhang¹ , Qian Huang¹ , Yonghong Man² , Wei Li¹ , Qi Zhou² , Shuo Yuan² , Yi Tian Yap¹ , Neha Nayak¹ , Ling Zhang² , Shizheng Song² , Joseph Dunbar¹ , Todd Leff¹ , Xu Yang³

1. Wayne State University
2. Wuhan University of Science and Technology
3. Hospital for Special Surgery, New York, NY, United States

Conference / event

The 46th Annual Meeting of American Society of Andrology, April 2021 (La Jolla, United States)

Poster summary

Our study indicates that loss of Cops5 in smooth muscle cells can result in profound changes in organ development and tissue cytoarchitecture, particularly in reproductive and immunologic organs and bone. Impaired steroid hormone production maybe the primary cause for these disorders.

Keywords

COPS5, Smooth muscle cells, Endocrine system

Research areas

Zoology, Molecular and Cellular Biosciences, Biological Sciences, Immunology, Genetics

References

1. Pan Y, Yang H, Claret FX. Emerging roles of Jab1/CSN5 in DNA damage response, DNA repair, and cancer. Cancer Biol Ther. 2014;15(3):256-262.
2. Cavadini S, Fischer ES, Bunker RD, et al. Cullin-RING ubiquitin E3 ligase regulation by the COP9 signalosome. Nature. 2016;531(7596):598-603.
3. Suisse A, Bekes M, Huang TT, Treisman JE. The COP9 signalosome inhibits Cullin-RING E3 ubiquitin ligases independently of its deneddylase activity. Fly (Austin). 2018;12(2):118-126.
4. Yuan C, Wang D, Liu G, Pan Y. Jab1/Cops5: a promising target for cancer diagnosis and therapy. Int J Clin Oncol. 2021;26(7):1159-1169.
5. Stobdan T, Akbari A, Azad P, et al. New Insights into the Genetic Basis of Monge's Disease and Adaptation to High-Altitude. Mol Biol Evol. 2017;34(12):3154-3168.
6. Malhotra AG, Jha M, Singh S, Pandey KM. Construction of a Comprehensive Protein-Protein Interaction Map for Vitiligo Disease to Identify Key Regulatory Elements: A Systemic Approach. Interdiscip Sci. 2018;10(3):500-514.
7. Asare Y, Ommer M, Azombo FA, et al. Inhibition of atherogenesis by the COP9 signalosome subunit 5 in vivo. Proc Natl Acad Sci U S A. 2017;114(13):E2766-E2775.
8. Sheng Z, Xu Y, Li F, Wang S, Huang T, Lu P. CSN5 attenuates Ang II-induced cardiac hypertrophy through stabilizing LKB1. Exp Cell Res. 2019;376(1):11-17.
9. Wang R, Wang H, Carrera I, Xu S, Lakshmana MK. COPS5 protein overexpression increases amyloid plaque burden, decreases spinophilin-immunoreactive puncta, and exacerbates learning and memory deficits in the mouse brain. J Biol Chem. 2015;290(14):9299-9309.
10. Cayli S, Eyibilen A, Gurbuzler L, et al. Jab1 expression is associated with TGF-beta1 signaling in chronic rhinosinusitis and nasal polyposis. Acta Histochem. 2012;114(1):12-17.

Funding

1. National Institute of Health (No. HD105944)

Supplemental files

No data provided

Additional information

Competing interests

No competing interests were disclosed.

Data availability statement

Data sharing not applicable to this poster as no datasets were generated or analyzed during the current study.

Creative Commons license

Copyright © 2023 Zhang et al. This is an open access work distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.