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Bilateral optic neuropathy in a middle age female in association with diffuse systemic sclerosis

PUBLISHED June 19, 2023 (DOI: https://doi.org/10.54985/peeref.2306p3813806)



Nishi Prasad1 , Kavita Kumar1 , Aditi Dubey1
  1. Gandhi Medical College, Bhopal

Conference / event

Madhya Pradesh State Ophthalmic Society Conference 2022, October 2022 (Sagar, India)

Poster summary

Systemic sclerosis is a chronic connective tissue autoimmune disorder involving multiple systems in a progressive manner, characterised by fibrosis of the skin and internal organs, and vasculopathy. It affects mainly musculoskeletal, gastrointestinal, renal and cardiopulmonary systems. It is a sporadic disease with worldwide distribution. The hallmark of systemic sclerosis is thickening and fibrosis of the skin which is due to excessive collagen production. In the early stages, evidence of inflammation, autoimmunity and altered microvascular function are common. Overa period of time, progressive and irreversible structural changes in small blood vessesls and fibrosis in multiple organs are seen. Ocular involvement is rare which mainly results as a complication of the disease. It may involve anterior to posterior segment, orbit and extraocular muscles. Here we are presenting a rare case of bilateral optic neuropathy in a female with diffuse systemic sclerosis and interstitial lung disease.


Systemic sclerosis, Optic neuropathy, Bilateral, Interstital lung disease, Visual loss, Rare presentation

Research areas



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  2. Gomes Bde A, Santhiago MR, Magalhaes P, et al. Ocular findings in patients with systemic sclerosis. Clinics. 2011;66(3):379-385. doi:10.1590/s1807-59322011000300003.
  3. Abhilasha B & Raja Rami Reddy P. (2019): Bilateral retinopathy and optic neuropathy associated with systemic sclerosis, Ocular immunology and inflammation, doi:10.1080/09273948.2019.1629604.
  4. Tailor R, Gupta A, Herrick A, et al. Ocular manifestations of scleroderma. Surv Ophthalmol. 2009;54(2):292-304. doi:10.1016/j.survophthal.2008.12.007.
  5. Kreps EO, Carton C, Cutolo M, et al. Ocular involvement in systemic sclerosis: A systematic literature review, it’s not all scleroderma that meets the eye. Semin arthritis Rheum. December 2018. doi:10.1016/j.semarthrit.2018.12.007.
  6. Gabriella S, Zoltan S, Zsuzsa A, Rudolf , et al. A wide spectrum of ocular manifestations signify patients with systemic sclerosis. Ocular immunology and inflammation, (2021) 29:1, 81-89, doi:10.1080/09273948.2019.1657467


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Additional information

Competing interests
No competing interests were disclosed.
Data availability statement
Data sharing not applicable to this poster as no datasets were generated or analyzed during the current study.
Creative Commons license
Copyright © 2023 Prasad et al. This is an open access work distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Prasad, N., Kumar, K., Dubey, A. Bilateral optic neuropathy in a middle age female in association with diffuse systemic sclerosis [not peer reviewed]. Peeref 2023 (poster).
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