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Effect on rheological properties and 3D printability of biphasic calcium phosphate microporous particles in hydrocolloid-based hydrogels

PUBLISHED May 22, 2023 (DOI: https://doi.org/10.54985/peeref.2305p4760814)



Helena Herrada-Manchón1 , David Rodríguez-González1 , M.Alejandro Fernández1 , Nathan William Kucko2 , Florénce Barrère-de Groot2 , Enrique Aguilar3
  1. IDONIAL Technology Centre; Gijón (Spain)
  2. Kuros Biosciences, Bilthoven (Netherlands)
  3. Universidad de Oviedo, Oviedo (Spain)

Conference / event

BioIberoamérica 2022, April 2022 (Braga, Portugal)

Poster summary

Since the repair of large-area and complex-shape bone defects remains a significant challenge, 3D printing of on-demand bone graft biomaterials has been emerging as an alternative to autografts in the last years. In that way, it has been widely reported that surface architecture, geometry and microporosity are essential factors for osteoconduction and, in some cases, osteoinduction. Due to the latter, exploring the printability through semi-solid extrusion (SSE) of irregularly-shaped, microporous biphasic calcium phosphate (BCP) granules 150-500 μm in size and with a characteristic submicron surface structure is of particular interest. Due to the physical characteristics of the BCP particles (size, weight, and agglomeration trend), three well-known hydrocolloids (sodium alginate, xanthan gum and gelatin) have been combined to generate stable, homogenous, and printable solid dispersions which, to the best of our knowledge, have not been previously explored.


3D printing, Calcium phosphate, Hydrogel, Rheology

Research areas

Bioengineering, Material Sciences, Chemistry


  1. Li N, Guo R, Zhang ZJ. Bioink Formulations for Bone Tissue Regeneration. Front Bioeng Biotechnol. 2021;9(February):1-17. doi:10.3389/fbioe.2021.630488
  2. van Dijk L, de Groot F, Yuan H, et al. From benchtop to clinic: a translational analysis of the immune response to submicron topography and its relevance to bone healing. Eur Cells Mater. 2021;41:756-773. doi:10.22203/eCM.v041a48
  3. Vu AA, Burke DA, Bandyopadhyay A, Bose S. Effects of surface area and topography on 3D printed tricalcium phosphate scaffolds for bone grafting applications. Addit Manuf. 2021;39(July 2020):101870. doi:10.1016/j.addma.2021.101870
  4. Herrada-Manchón H, Rodríguez-González D, Fernández MA, Kucko NW, Barrère-de Groot F, Aguilar E. Effect on Rheological Properties and 3D Printability of Biphasic Calcium Phosphate Microporous Particles in Hydrocolloid-Based Hydrogels. Gels. 2022;8(1):28. doi:10.3390/gels8010028


  1. European Union’s Horizon 2020 research and innovation program (No. 874790)

Supplemental files

No data provided

Additional information

Competing interests
No competing interests were disclosed.
Data availability statement
The datasets generated during and / or analyzed during the current study are available from the corresponding author on reasonable request.
Creative Commons license
Copyright © 2023 Herrada-Manchón et al. This is an open access work distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Herrada-Manchón, H., Rodríguez-González, D., Fernández, M., Kucko, N., Barrère-de Groot, F., Aguilar, E. Effect on rheological properties and 3D printability of biphasic calcium phosphate microporous particles in hydrocolloid-based hydrogels [not peer reviewed]. Peeref 2023 (poster).
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