PCL/graphene 3D scaffold fabrication and in vitro analysis using a solvent casting and particulate leaching assembly process

PUBLISHED April 28, 2023 (DOI: https://doi.org/10.54985/peeref.2304p4710615)

NOT PEER REVIEWED

5^th Place Peeref Competition

Authors

Silvia Anitasari¹ , Ching-Zong Wu² , Yung-Kang Shen² , Yan-Sin Tsai²

1. Universitas Mulawarman
2. Taipei Medical University

Conference / event

Taiwan International Dental Show, November 2022 (Taipei, Taiwan)

Poster summary

The ideal percentage of PCL/graphene for bone cell proliferation is required; therefore, the characteristics and biodegradation of this composite must be determined prior to continuing biological exploration, such as viability testing. In the current study, a PCL/graphene scaffold with graphene concentrations of 0.5, 1.5, and 2.5 wt% has been produced using solvent casting and particulate leaching methods. Furthermore, the scaffold was cultured with osteoblast-like (MG-63) cells, and the 2.5 wt% G concentration revealed enhanced cell proliferation to other concentrations. This finding suggests that PCL/graphene scaffolds could potentially have biomedical and tissue engineering applications.

Keywords

Polycaprolactone, Graphene, MG-63 cells

Research areas

Material Sciences

References

1. A. Sola, J. Bertacchini, D. A’vella, L. Anselmi, T. Maraldi, S. Marmiroli, M. Messori. Mater Sci Eng. 2019, 96, 153.
2. Y. Tamada, Y. Ikada. Polymer. 1993, 34, 2208.
3. B. Feng, J, Z. Jinkang, W. Zhen, L. Jianxi, C. Jiang, L. Jian, M. Guolin, D. Xin. Biomed Mater. 2011, 6, 015007
4. S. Anitasari. CZ. Wu, YK. Shen, 2023. Bioengineering. 2023,10,305.
5. O. Guler, N. Bagci. J Mater Res Tech. 2020, 9,6808.

Funding

1. Ministry of Science and Technology, Taiwan (No. No. MOST 111-2221-E-038-021)

Supplemental files

No data provided

Additional information

Competing interests

No competing interests were disclosed.

Data availability statement

The datasets generated during and / or analyzed during the current study are available from the corresponding author on reasonable request.

Creative Commons license

Copyright © 2023 Anitasari et al. This is an open access work distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.