52 Views · 65 Downloads · ☆☆☆☆☆ 0.0

Mechanism of amitriptyline adsorption on Ca-montmorillonite

PUBLISHED April 23, 2023 (DOI: https://doi.org/10.54985/peeref.2304p2617465)



Po-Hsiang Chang1 , Wei-Teh Jiang1 , Zhaohui Li2 , Chung-Yih Kuo3 , Jiin-Shuh Jean1 , Wan-Ru Chen4 , Guocheng Lv5
  1. Department of Earth Sciences, National Cheng Kung University
  2. Geosciences Department, University of Wisconsin – Parkside
  3. Department of Public Health, Chung Shan Medical University
  4. Department of Environmental Engineering, National Cheng Kung University
  5. School of Materials Science and Technology, China University of Geosciences

Conference / event

The 1st International Conference on Emerging Contaminants (EMCON Forum 2013), October 2013 (Kaohsiung, Taiwan)

Poster summary

The uptake of amitriptyline (AMI) from aqueous environment by Ca-montmorillonite (SAz-2) was studied in a batch system under different physicochemical conditions. The adsorbent was characterized by X-ray diffraction and Fourier transform infrared (FTIR) analyses. The AMI adsorption on SAz-2 obeyed the Langmuir isotherm with a capacity of 330 mg/g (1.05 mmol/g) at pH 6–7. The adsorption kinetics was fast, almost reaching equilibrium in 2 h, and followed a pseudo-second-order kinetic model. Desorption of exchangeable cations correlated with the AMI adsorption well, indicating that cation exchange was the major mechanism. The higher adsorption capacity suggested that SAz-2 could be a good candidate to remove AMI from wastewater and would be an important environmental sink for the fate and transport of AMI in soils and groundwater.


Amitriptyline, Cation exchange, Intercalation, Montmorillonite, FTIR

Research areas

Environmental Engineering


  1. L.C.G. Hoegberg, T.B. Groenlykke, U. Abildtrup, H.R. Angelo, Combined paracetamol and amitriptyline adsorption to activated charcoal, Clin. Toxicol. 48 (2010) 898–903.
  2. E.J.F. Franssen, P.W.A. Kunst, P.M. Bet, R. van Schijndel, A.C. van Loenen, A.J. Wilhelm, Toxicokinetics of nortriptyline and amitriptyline: Two case reports, Ther. Drug Monit. 25 (2003) 248–251.
  3. T. Brodin, J. Fick, M. Jonsson, J. Klaminder, Dilute Concentrations of a Psychiatric drug alter behavior of fish from natural populations, Science 339 (2013) 814–815.
  4. A.L. Green, Ionization constants and water solubilities of some aminoalkylphenothiazine tranquillizers and related compounds, J. Pharm. Pharmacol. 19 (1967) 10-16.
  5. S. Bindya, W.-T. Wong, M.A. Ashok, H.S. Yathirajan, R.S. Rathore, Amitriptylinium picrate: conformational disorder, Acta Crystallogr. Sect. C-Cryst. Struct. Commun. 63 (2007) O546–O548.
  6. I. Turku, T. Sainio, E. Paatero, Thermodynamics of tetracycline adsorption on silica, Environ. Chem. Lett. 5 (2007) 225–228.


No data provided

Supplemental files

No data provided

Additional information

Competing interests
No competing interests were disclosed.
Data availability statement
The datasets generated during and / or analyzed during the current study are available from the corresponding author on reasonable request.
Creative Commons license
Copyright © 2023 Chang et al. This is an open access work distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Chang, P., Jiang, W., Li, Z., Kuo, C., Jean, J., Chen, W., Lv, G. Mechanism of amitriptyline adsorption on Ca-montmorillonite [not peer reviewed]. Peeref 2023 (poster).
Copy citation

Find Funding. Review Successful Grants.

Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.


Publish scientific posters with Peeref

Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.

Learn More