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A New insight into SIRS, SEPSIS, COVID-19 and CBRN - Prevention and therapy

PUBLISHED April 23, 2023 (DOI: https://doi.org/10.54985/peeref.2304p7212147)



Magdalena Filcek1
  1. Unaffiliated

Conference / event

VIII Scientific and training conference "Old and new pathogens - current problems" 2023, February 2023 (Virtual)

Poster summary

An original insight into the mechanisms of SIRS and SEPSIS, and thus the possibilities and effective application of measures in prevention, defense against disease, and support in treatment. The importance of mast cells and histamine storm as overlooked aspects during surgery, Covid-19 and ventilated patients in general are shown. The theoretical basis of the analysis are the principles of thermodynamics and gas physics in mechanical ventilation, mast cell activation factors and the cascading multi-organ interactions effects of histamine and its receptors on the body, which contribute to the formation of systemic inflammation. Presentation of the potential role of antihistamines, DAO enzymes and Immunoglobulins IgG. The discovery of the above mechanism provides knowledge on how to prevent and defend against the development of pathophysiology of diseases, and consequently translates, in a medical way into personal and structural security, strengthening military security in the field of CBRN.


SEPSIS, Histamine, Antihistamines, Enzyme DAO, Mast cells, SIRS, COVID-19, CBRN

Research areas

Immunology, Medicine


  1. Magdalena Filcek, Dr Mayank Vats, Anna Skrzyniarz Plutecka “Discovery of the Mechanism of COVID19, SIRS and SEPSIS, Defense and Treatment. Mast cells and Histamine Storm an Overlooked Aspects in COVID19 and in Ventilated Patients Potential Role of Antihistamine.” MAR Pulmonology 3.5 2021
  2. Magdalena Filcek, Dr Mayank Vats, Anna Skrzyniarz Plutecka "COVID-19 and Antihistaminic Medicines - Improving the Health of Millions by Strategically Disseminating a "Simple but Potential Solution"" MAR Pulmonology 3.1 2021
  3. Magdalena Filcek "NOWY WGLAD W PROFILAKTYKE I TERAPIE COVID-19, SIRS I SEPSY – RÓWNIEŻ JAKO WSPARCIE OCHRONNE PRZED PTSD I CBRN" Bezpieczenstwo Personalne a bezpieczenstwo strukturalne AWL2023


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Supplemental files

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Additional information

Competing interests
No competing interests were disclosed.
Data availability statement
The datasets generated during and / or analyzed during the current study are available from the corresponding author on reasonable request.
Creative Commons license
Copyright © 2023 Filcek. This is an open access work distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Filcek, M. A New insight into SIRS, SEPSIS, COVID-19 and CBRN - Prevention and therapy [not peer reviewed]. Peeref 2023 (poster).
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