Metabolic complications associated with lipodystrophic obesity and diabetes

---

Authors

Kruthica Jaganathan Geethalakshmi¹ , Iyshwarya Bhaskar Kalarani¹ , Ramakrishnan Veerabathiran¹

1. Chettinad Academy of Research and Education

Conference / event

CODI Controversies in Obesity & Diabetes, October 2022 (Virtual)

Poster summary

Lipoatrophic diabetes and insulin resistance are typical of lipodystrophy disorders. The excess fat in the organs makes it difficult for the cells to use glucose, resulting in high blood sugar levels. Lipodystrophies may affect adipokine secretion and/or interaction with stromal cells in adipose tissue. Ultimately, fats get deposited in non-adipose tissue as a result of the inadequacy of subcutaneous adipose tissues to store fat. Berardinelli-Seip syndrome, also known as lipodystrophy, is characterized by incomplete and unclear adipose tissue at birth or early in life. This study examines the relationship between lipodystrophy and both obesity and diabetes. An investigation of thiazolidinedione is currently in progress. The potential treatment for LPD includes insulin-like growth factor-1, leptin, and growth releasing hormone, however, none of these have been approved for treating severe insulin resistance or reducing fat loss caused by LPD.

Keywords

Lipodystrophy, Obesity, Diabetes, Cell signaling, Polymorphism, Oxidative stress

Research areas

Genetics

References

No data provided

Funding

No data provided

Supplemental files

No data provided

Additional information

Competing interests

No competing interests were disclosed.

Data availability statement

Data sharing not applicable to this poster as no datasets were generated or analyzed during the current study.

Creative Commons license

Copyright © 2022 Jaganathan Geethalakshmi et al. This is an open access work distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.