Fruit Extract of Thaumatococcus daniellii Reduces Oxidative Stress in Rats

Authors

Franklyn Iheagwam¹ , Shalom Chinedu¹ , Opeyemi Emiloju¹ , Augustine Okenmuo¹

1. Covenant University

Conference / event

Experimental Biology, April 2017 (Chicago, IL, United States)

Poster summary

The effect of Thaumatococcus daniellii seed ethanol extract on oxidative stress parameters in male Wistar rats was assessed using standard methods. The extract decreased hepatic lipid peroxidation while superoxide dismutase activity and glutathione level was increased in the experimental animals. Histological analyses of the liver showed no significant abnormality indicating little or no toxicity to the hepatocytes. Ethanolic extract of Thaumatococcus daniellii fruit pulp showed antioxidant properties, comparable to commercial vitamin C supplement. Further work is needed to characterize the bioactive compounds and their mechanisms of action.

Keywords

Thaumatococcus daniellii, Lipid profile, Hypolipidaemic

Research areas

Agriculture, Pharmacy and Pharmacology, Biochemistry, Toxicology, Biological Sciences

References

1. Van der Wel, H. and K. Loeve (1972). Isolation and characterization of thaumatinI and II, the sweet tasting proteins from Thaumotococcus daniellii benth. European Journal of Biochemistry, 31: 221- 225.
2. Chinedu, S.N., Oluwadamisi, A.Y., Popoola, S.T., David, B.J. and Epelle, T. (2014). Analyses of the leaf, fruit and seed of Thaumatococcus daniellii (Benth): Exploring potential uses. Pakistan Journal of Biological Sciences 17: 840-854.
3. Vuppalanchi, R., Juluri R., Bell, L.N. et al. (2011). Oxidative stress in chronic liver disease: relationship between peripheral and hepatic measurements. Am. J. Med. Sci. 342(4): 314-7.
4. Moskaug, J.Ø., Carlsen, H., Myhrstad, M.C.W. and Blomhoff, R. (2005). Polyphenols and glutathione synthesis regulation. American Journal of Clinical Nutrition 81: 277S– 83S.
5. Ahmadvand, H., Fadaei, B., Dehnoo, M.G. and Mirzaei, S. (2015). Inhibitory effects of myrtle (Myrtus communis L.) leaves hydroalcoholic extract on LDL oxidation in vitro. Journal of Chemical and Pharmaceutical Research 7(2): 42-46.

Funding

No data provided

Supplemental files

No data provided

Additional information

Competing interests

None declared.

Data availability statement

Data sharing not applicable to this poster as no datasets were generated or analyzed during the current study.

Creative Commons license

Copyright © 2022 Iheagwam et al. This is an open access work distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.