Microglia heterogeneity along a spatio-temporal axis: More questions than answers

Microbiome Influences Prenatal and Adult Microglia in a Sex-Specific Manner

(2018) Morgane Sonia Thion et al.   CELL

High-Dimensional Single-Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease

(2018) Dunja Mrdjen et al.   IMMUNITY

Proteomic analysis of aged microglia: shifts in transcription, bioenergetics, and nutrient response

(2017) Antwoine Flowers et al.   Journal of Neuroinflammation

Microglia activation triggers oligodendrocyte precursor cells apoptosis via HSP60

(2017) Yunhong Li et al.   Molecular Medicine Reports

Maternal gut bacteria promote neurodevelopmental abnormalities in mouse offspring

(2017) Sangdoo Kim et al.   NATURE

A new fate mapping system reveals context-dependent random or clonal expansion of microglia

(2017) Tuan Leng Tay et al.   NATURE NEUROSCIENCE

Local Cues Establish and Maintain Region-Specific Phenotypes of Basal Ganglia Microglia

(2017) Lindsay M. De Biase et al.   NEURON

Temporal Tracking of Microglia Activation in Neurodegeneration at Single-Cell Resolution

(2017) Hansruedi Mathys et al.   Cell Reports

Alpha-tocopherol quinine ameliorates spatial memory deficits by reducing beta-amyloid oligomers, neuroinflammation and oxidative stress in transgenic mice with Alzheimer's disease

(2016) Shao-wei Wang et al.   BEHAVIOURAL BRAIN RESEARCH

The “Big-Bang” for modern glial biology: Translation and comments on Pío del Río-Hortega 1919 series of papers on microglia

(2016) Amanda Sierra et al.   GLIA

Tissue-Resident Macrophage Ontogeny and Homeostasis

(2016) Florent Ginhoux et al.   IMMUNITY

Phenotypic clustering: a novel method for microglial morphology analysis

(2016) Franck Verdonk et al.   Journal of Neuroinflammation

Sex differences in neurodevelopmental and neurodegenerative disorders: Focus on microglial function and neuroinflammation during development

(2016) Richa Hanamsagar et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

New insights into the multidimensional concept of macrophage ontogeny, activation and function

(2016) Florent Ginhoux et al.   NATURE IMMUNOLOGY

Origin, fate and dynamics of macrophages at central nervous system interfaces

(2016) Tobias Goldmann et al.   NATURE IMMUNOLOGY

Adult mouse cortical cell taxonomy revealed by single cell transcriptomics

(2016) Bosiljka Tasic et al.   NATURE NEUROSCIENCE

Microglial brain region−dependent diversity and selective regional sensitivities to aging

(2016) Kathleen Grabert et al.   NATURE NEUROSCIENCE

A polarizing question: do M1 and M2 microglia exist?

(2016) Richard M Ransohoff   NATURE NEUROSCIENCE

TREM2 variants: new keys to decipher Alzheimer disease pathogenesis

(2016) Marco Colonna et al.   NATURE REVIEWS NEUROSCIENCE

Depth and time-dependent heterogeneity of microglia in mouse hippocampal slice cultures

(2016) Yuka Kasahara et al.   NEUROSCIENCE RESEARCH

Microglia development follows a stepwise program to regulate brain homeostasis

(2016) O. Matcovitch-Natan et al.   SCIENCE

USP18 lack in microglia causes destructive interferonopathy of the mouse brain

(2015) T. Goldmann et al.   EMBO JOURNAL

Brain-wide analysis of electrophysiological diversity yields novel categorization of mammalian neuron types

(2015) Shreejoy J. Tripathy et al.   JOURNAL OF NEUROPHYSIOLOGY

A Distinct Population of Microglia Supports Adult Neurogenesis in the Subventricular Zone

(2015) A. L. Ribeiro Xavier et al.   JOURNAL OF NEUROSCIENCE

Host microbiota constantly control maturation and function of microglia in the CNS

(2015) Daniel Erny et al.   NATURE NEUROSCIENCE

Cell type– and brain region–resolved mouse brain proteome

(2015) Kirti Sharma et al.   NATURE NEUROSCIENCE

Immune attack: the role of inflammation in Alzheimer disease

(2015) Frank L. Heppner et al.   NATURE REVIEWS NEUROSCIENCE

Age- and location-related changes in microglial function

(2015) Rodney M. Ritzel et al.   NEUROBIOLOGY OF AGING

Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq

(2015) A. Zeisel et al.   SCIENCE

Brain region-specific gene expression profiles in freshly isolated rat microglia

(2015) Karlijn J. Doorn et al.   Frontiers in Cellular Neuroscience

Ontogeny of Tissue-Resident Macrophages

(2015) Guillaume Hoeffel et al.   Frontiers in Immunology

Disease-related microglia heterogeneity in the hippocampus of Alzheimer’s disease, dementia with Lewy bodies, and hippocampal sclerosis of aging

(2015) Adam D Bachstetter et al.   Acta Neuropathologica Communications

Tissue-Resident Macrophage Enhancer Landscapes Are Shaped by the Local Microenvironment

(2014) Yonit Lavin et al.   CELL

Environment Drives Selection and Function of Enhancers Controlling Tissue-Specific Macrophage Identities

(2014) David Gosselin et al.   CELL

Microglia from neurogenic and non-neurogenic regions display differential proliferative potential and neuroblast support

(2014) Gregory P. Marshall et al.   Frontiers in Cellular Neuroscience

Neural progenitor cells orchestrate microglia migration and positioning into the developing cortex

(2014) Benedetta Arnò et al.   Nature Communications

Maternal Inflammation Contributes to Brain Overgrowth and Autism-Associated Behaviors through Altered Redox Signaling in Stem and Progenitor Cells

(2014) Janel E. Le Belle et al.   Stem Cell Reports

TREM2 and the neuroimmunology of Alzheimer's disease

(2013) Suzanne E. Hickman et al.   BIOCHEMICAL PHARMACOLOGY

Gestational flu exposure induces changes in neurochemicals, affiliative hormones and brainstem inflammation, in addition to autism-like behaviors in mice

(2013) V.M. Miller et al.   BRAIN BEHAVIOR AND IMMUNITY

Layer V cortical neurons require microglial support for survival during postnatal development

(2013) Masaki Ueno et al.   NATURE NEUROSCIENCE

Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways

(2013) Katrin Kierdorf et al.   NATURE NEUROSCIENCE

The microglial sensome revealed by direct RNA sequencing

(2013) Suzanne E Hickman et al.   NATURE NEUROSCIENCE

The blood-brain barrier in health and disease

(2012) Richard Daneman   ANNALS OF NEUROLOGY

Transcriptome analysis of amoeboid and ramified microglia isolated from the corpus callosum of rat brain

(2012) Rangarajan Parakalan et al.   BMC NEUROSCIENCE

Behaviour and hippocampus-specific changes in spiny mouse neonates after treatment of the mother with the viral-mimetic Poly I:C at mid-pregnancy

(2012) Udani Ratnayake et al.   BRAIN BEHAVIOR AND IMMUNITY

Distribution of microglia in the postnatal murine nigrostriatal system

(2012) Ahmed Sharaf et al.   CELL AND TISSUE RESEARCH

Toll-like receptor activation reveals developmental reorganization and unmasks responder subsets of microglia

(2012) Jörg Scheffel et al.   GLIA

Complex invasion pattern of the cerebral cortex bymicroglial cells during development of the mouse embryo

(2012) Nina Swinnen et al.   GLIA

Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages

(2012) Emmanuel L Gautier et al.   NATURE IMMUNOLOGY

Review: Microglia of the aged brain: primed to be activated and resistant to regulation

(2012) D. M. Norden et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

(2012) Thorlakur Jonsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells

(2012) C. Schulz et al.   SCIENCE

Genetic Heritability and Shared Environmental Factors Among Twin Pairs With Autism

(2011) Joachim Hallmayer   ARCHIVES OF GENERAL PSYCHIATRY

Transmitter- and hormone-activated Ca2+ responses in adult microglia/brain macrophages in situ recorded after viral transduction of a recombinant Ca2+ sensor

(2011) Stefanie Seifert et al.   CELL CALCIUM

Selective transfer of exosomes from oligodendrocytes to microglia by macropinocytosis

(2011) D. Fitzner et al.   JOURNAL OF CELL SCIENCE

Endogenous microglia regulate development of embryonic cortical precursor cells

(2011) Joseph M. Antony et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Transcriptomic analysis of autistic brain reveals convergent molecular pathology

(2011) Irina Voineagu et al.   NATURE

Microglial Activation and Increased Microglial Density Observed in the Dorsolateral Prefrontal Cortex in Autism

(2010) John T. Morgan et al.   BIOLOGICAL PSYCHIATRY

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

Microglia Protect Neurons against Ischemia by Synthesis of Tumor Necrosis Factor

(2009) K. L. Lambertsen et al.   JOURNAL OF NEUROSCIENCE

Peripheral lipopolysaccharide (LPS) challenge promotes microglial hyperactivity in aged mice that is associated with exaggerated induction of both pro-inflammatory IL-1β and anti-inflammatory IL-10 cytokines

(2008) Christopher J. Henry et al.   BRAIN BEHAVIOR AND IMMUNITY

Subventricular zone microglia possess a unique capacity for massivein vitroexpansion

(2008) Gregory P. Marshall et al.   GLIA

Region-specific expression of immunoregulatory proteins on microglia in the healthy CNS

(2008) Alexander H. de Haas et al.   GLIA

Interleukin-1beta and tumor necrosis factor-alpha are expressed by different subsets of microglia and macrophages after ischemic stroke in mice

(2008) Bettina H Clausen et al.   Journal of Neuroinflammation