Article
Environmental Sciences
Nolwenn Adam, Marie-Amelie Lachayze, Caroline Parmentier, Helene Hardin-Pouzet, Sakina Mhaouty-Kodja
Summary: This study examined the effects of exposure to DEHP, an organic pollutant, on maternal behavior in mice. The findings suggest that exposure to DEHP can alter maternal behavior, possibly through neuroendocrine pathways involving oxytocin and estrogen.
ENVIRONMENTAL POLLUTION
(2022)
Article
Neurosciences
Kanza M. Khan, Nagalakshmi Balasubramanian, Gabriel Gaudencio, Ruixiang Wang, Govindhasamy Pushpavathi Selvakumar, Louis Kolling, Samantha Pierson, Satya M. Tadinada, Ted Abel, Marco Hefti, Catherine A. Marcinkiewcz
Summary: Alzheimer's disease (AD) affects over 6 million Americans and presents with mood and sleep changes in the early stages. This study evaluated depressive and anxiety-like behaviors in a mouse model of AD and found a correlation with tau pathology, neuroinflammation, and monoaminergic dysregulation. The results suggest that tau pathology in brainstem monoaminergic nuclei may underpin the behavioral changes observed in the early stages of AD.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2023)
Article
Behavioral Sciences
Kazumi Osada, Riyuki Kujirai, Akira Hosono, Masato Tsuda, Motoko Ohata, Tohru Ohta, Katsuhiko Nishimori
Summary: This study found that exposure to coffee aroma can rescue abnormal olfactory behaviors in OXTR knockout mice, and the rescue is associated with increased expression of OXTR gene.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2023)
Article
Cell Biology
Joowon Kim, Min Whan Jung, Doyun Lee
Summary: Social and reward signal processing and their association are critical elements of social motivation. This study found that social signal processing is selectively disrupted, whereas reward signal processing is intact in the medial prefrontal cortex of Shank2-knockout mice. Furthermore, reward learning not only allows Shank2-knockout mice to associate social stimuli with reward availability, but it also rescues the impaired social signal processing.
Article
Biochemistry & Molecular Biology
Yangsik Kim, Esther Yang, Hyun Kim
Summary: The study found that deletion of IRSp53 in mice leads to a decrease in prepulse inhibition (PPI), indicating that dysfunction of various modulatory neurons may result in PPI impairment. This suggests that PPI could be broadly affected by changes in various types of modulatory neurons.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Kenjiro Matsumoto, Kana Takata, Daisuke Yamada, Haruki Usuda, Koichiro Wada, Maaya Tada, Yoshiyuki Mishima, Shunji Ishihara, Syunji Horie, Akiyoshi Saitoh, Shinichi Kato
Summary: Juvenile social defeat stress (SDS) exposure in mice leads to social avoidance, anxiety, depression, and visceral hypersensitivity. The number of 5-HT-containing cells and calcitonin gene-related peptide-positive neurons in the colon increases, while gut microbiota remains largely similar. Responses to stress are exacerbated in the juvenile SDS group, suggesting later onset of IBS-like symptoms.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Aki Takahashi, Romain Durand-de Cuttoli, Meghan E. Flanigan, Emi Hasegawa, Tomomi Tsunematsu, Hossein Aleyasin, Yoan Cherasse, Ken Miya, Takuya Okada, Kazuko Keino-Masu, Koshiro Mitsui, Long Li, Vishwendra Patel, Robert D. Blitzer, Michael Lazarus, Kenji F. Tanaka, Akihiro Yamanaka, Takeshi Sakurai, Sonoko Ogawa, Scott J. Russo
Summary: The glutamatergic projections from the lateral habenula (LHb) to the dorsal raphe nucleus (DRN) modulate male mice's aggressive behavior. Inhibition of LHb-DRN projection blocks the increase in aggression after social instigation. The activity of this pathway is not necessary for the expression of species-typical aggressive behavior but essential for the increase in aggression resulting from social instigation.
NATURE COMMUNICATIONS
(2022)
Article
Public, Environmental & Occupational Health
Soe-Minn Htway, Takehiro Suzuki, Sanda Kyaw, Keiko Nohara, Tin-Tin Win-Shwe
Summary: Maternal arsenic exposure affects social behavior in F2 male mice through alterations in the serotonergic system in the prefrontal cortex. Gene expressions related to social behavior, such as serotonin receptor 5B, brain-derived neurotrophic factor, and dopamine receptor D1a, were significantly altered in arsenite-F2 male mice. Additionally, oxidative stress marker HO-1 was increased in arsenite-F2 male mice, while COX-2 expression remained unchanged.
ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE
(2021)
Article
Environmental Sciences
Ruqin Lin, Danyang Li, Yangyang Xu, Mengyao Wei, Qingmei Chen, Yiqun Deng, Jikai Wen
Summary: Chronic exposure to low doses of Cereulide can lead to intestinal inflammation, gut microbiota dysbiosis, and reduced food intake. Activation of the endoplasmic reticulum stress IRE1/XBP1/CHOP pathway by low dose Cereulide exposure disrupts intestinal barrier function, leading to intestinal inflammation.
ENVIRONMENTAL POLLUTION
(2021)
Review
Biochemical Research Methods
Leslie A. A. Ramsey, Fernanda M. M. Holloman, Samantha S. S. Lee, Marco Venniro
Summary: Little is known about the contribution of social factors to neurobiology or neuropsychiatric disorders. This study compares the social self-administration and choice behavior of female adolescent and adult C57BL/6 mice and outbred CD1 mice, finding that CD1 mice show stronger social self-administration and social seeking compared to C57BL/6J mice. The study introduces a new method for studying operant social reward in mice.
Article
Biochemistry & Molecular Biology
Damien Hunter, Kee Heng, Navdeep Mann, Ravinder Anand-Ivell, Richard Ivell
Summary: This study found that maternal exposure to xenobiotics DBP or DES may cause long-term changes in hypothalamic gene expression and reproductive behavior in offspring, particularly leading to significant impact on gene expression and sexual behavior with DES treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Alexandra M. Yaw, J. David Glass, Rebecca A. Prosser, Heather K. Caldwell
Summary: It has been established that the damaging effects of drug abuse, such as cocaine, can extend to the offspring of the users. This study focuses on the effects of paternal cocaine use on the social behaviors of the first generation offspring. The results suggest that paternal cocaine use can alter social behaviors in male offspring, including increased investigation times and decreased anxiety-like behaviors, possibly through modulation of the oxytocin system.
Article
Behavioral Sciences
Tomonori Fujiwara, Takefumi Kofuji, Kimio Akagawa
Summary: Oxytocin and dopamine are both involved in regulating social behavior and interact with each other in the central nervous system. STX1A KO mice serve as a suitable animal model for studying the neural mechanisms regulating social behavior.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Endocrinology & Metabolism
Erin A. Semple, Mitchell T. Harberson, Baijie Xu, Rebecca Rashleigh, Tori L. Cartwright, Jessica J. Braun, Amy C. Custer, Chen Liu, Jennifer W. Hill
Summary: This study found that the sexual behavior of female MC4R knockout mice lacking melanocortin 4 receptors (MC4Rs) was altered. Further research revealed that the expression of MC4Rs in Sim1 neurons could restore sexual responsivity in female mice, while its expression in oxytocin neurons could improve sexual receptivity. These results suggest that MC4R signaling in oxytocin neurons is involved in appetitive behaviors, while MC4R signaling in Sim1 neurons plays a role in female sexual receptivity, indicating that melanocortin-driven sexual function does not rely on metabolic neural circuits.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Multidisciplinary Sciences
Caleigh D. Guoynes, Catherine A. Marler
Summary: The study reveals that the administration of OXT through the intranasal route rapidly and selectively enhances maternal USV production, and improves maternal care efficiency towards offspring. The frequency of USVs between mothers and offspring are correlated during reunions, but IN OXT does not influence this correlation.
Review
Virology
Lisa Kathleen Ryan, Gill Diamond
Article
Multidisciplinary Sciences
Lorenzo P. Menzel, Hossain Mobaswar Chowdhury, Jorge Adrian Masso-Silva, William Ruddick, Klaudia Falkovsky, Rafael Vorona, Andrew Malsbary, Kartikeya Cherabuddi, Lisa K. Ryan, Kristina M. DiFranco, David C. Brice, Michael J. Costanzo, Damian Weaver, Katie B. Freeman, Richard W. Scott, Gill Diamond
SCIENTIFIC REPORTS
(2017)
Article
Microbiology
Lisa K. Ryan, Katie B. Freeman, Jorge A. Masso-Silva, Klaudia Falkovsky, Ashwag Aloyouny, Kenneth Markowitz, Amy G. Hise, Mahnaz Fatahzadeh, Richard W. Scott, Gill Diamond
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2014)
Article
Immunology
Laura McMahon, Kyell Schwartz, Ozlem Yilmaz, Eleith Brown, Lisa K. Ryan, Gill Diamond
INFECTION AND IMMUNITY
(2011)
Article
Biochemistry & Molecular Biology
Isaura Rigo, Laura McMahon, Puneet Dhawan, Sylvia Christakos, Sunghan Yim, Lisa K. Ryan, Gill Diamond
Review
Dentistry, Oral Surgery & Medicine
G. Diamond, L. K. Ryan
Article
Dentistry, Oral Surgery & Medicine
Lorenzo P. Menzel, Willam Ruddick, Mobaswar H. Chowdhury, David C. Brice, Ryan Clance, Emily Porcelli, Lisa K. Ryan, Jungnam Lee, Ozlem Yilmaz, Keith L. Kirkwood, Laura McMahon, Amy Tran, Gill Diamond
JOURNAL OF PERIODONTAL RESEARCH
(2019)
Article
Microbiology
Lisa K. Ryan, Amy G. Hise, Chowdhury Mobaswar Hossain, William Ruddick, Rezwana Parveen, Katie B. Freeman, Damian G. Weaver, Hema P. Narra, Richard W. Scott, Gill Diamond
Article
Chemistry, Medicinal
Gill Diamond, Natalia Molchanova, Claudine Herlan, John A. Fortkort, Jennifer S. Lin, Erika Figgins, Nathen Bopp, Lisa K. Ryan, Donghoon Chung, Robert Scott Adcock, Michael Sherman, Annelise E. Barron
Summary: Antimicrobial peptides (AMPs) have shown potential as novel antiviral drugs by inactivating viruses through disrupting their envelopes. However, their clinical development has been hindered by their enzymatically labile structure. Peptoid mimics of AMPs have been investigated for their potent in vitro antiviral activity against HSV-1 and SARS-CoV-2, with potential as safe and effective broad-spectrum antiviral agents due to their stability and bioavailability.
Meeting Abstract
Immunology
Lisa K. Ryan, Tanya O. Robinson, Erika H. Figgins, Uyen Emily' Do, Kenneth J. Wilson, Sarah C. Glover, Gill Diamond
JOURNAL OF IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sarah C. Glover, Mohammad-Zaman Nouri, Kubra M. Tuna, Lybil B. Mendoza Alvarez, Lisa K. Ryan, James F. Shirley, Ying Tang, Nancy D. Denslow, Abdel A. Alli
Meeting Abstract
Immunology
James Forrest Shirley, Joshua Drourr, W. Taylor Edwards, Kubra Tuna, Lisa K. Ryan, Abdel Alli, Ying Tang, Sarah C. Glover
JOURNAL OF IMMUNOLOGY
(2019)
Article
Microbiology
Mobaswar Hossain Chowdhury, Lisa Kathleen Ryan, Kartikeya Cherabuddi, Katie B. Freeman, Damian G. Weaver, Jeffry C. Pelletier, Richard W. Scott, Gill Diamond
Article
Immunology
Lisa Kathleen Ryan, Jichuan Wu, Kyell Schwartz, Sunghan Yim, Gill Diamond
Letter
Immunology
Wan-Ju Cheng, Hong-Mo Shih, Kuan-Pin Su, Po-Ren Hsueh
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Felipe Kenji Sudo, Talita P. Pinto, Fernanda G. Q. Barros-Aragao, Ivanei Bramati, Theo F. Marins, Marina Monteiro, Fernanda Meireles, Rejane Soares, Pilar Erthal, Victor Calil, Naima Assuncao, Natalia Oliveira, Joana Bondarovsky, Camila Lima, Beatriz Chagas, Alana Batista, Julia Lins, Thais L. Pinheiro, Felippe Mendonca, Andrea Silveira de Souza, Fernanda C. Rodrigues, Gabriel R. de Freitas, Pedro Kurtz, Paulo Mattos, Erika C. Rodrigues, Fernanda G. De Felice, Fernanda Tovar-Moll
Summary: Post-COVID-19 Condition (PCC) is a multisystemic syndrome that persists for months after SARS-CoV-2 infection, affecting cognitive function and neuropsychiatric features. A study on COVID-19 survivors in Brazil found that these patients experienced significant difficulties in overall cognition, memory, working memory, and inhibitory control, as well as fatigue, anxiety, and depressive symptoms. In addition, elevated levels of inflammatory markers in the blood were associated with brain microstructural damage and cognitive impairments.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Letter
Immunology
Tieh-Cheng Fu, Juei-Chao Chen, Ching-Mao Chang
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Aastha Dheer, Dale B. Bosco, Jiaying Zheng, Lingxiao Wang, Shunyi Zhao, Koichiro Haruwaka, Min-Hee Yi, Abhijeet Barath, Dai-Shi Tian, Long-Jun Wu
Summary: Microglial activation plays a crucial role in the pathology of epilepsy, with both acute and prolonged activation affecting seizure severity and neuronal loss.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Julie B. Rosenberg, Jens Richardt Mollegaard Jepsen, Parisa Mohammadzadeh, Astrid Sevelsted, Rebecca Vinding, Mikkel E. Sorensen, David Horner, Kristina Aagaard, Birgitte Fagerlund, Susanne Brix, Nilofar Folsgaard, Ann -Marie M. Schoos, Jakob Stokholm, Bo Chawes, Christos Pantelis, Soren Dalsgaard, Birte Y. Glenthoj, Niels Bilenberg, Klaus Bonnelykke, Bjorn H. Ebdrup
Summary: Clinical data demonstrates a strong association between prenatal maternal inflammation assessed by hs-CRP and a diagnosis of ADHD by age 10. Maternal inflammation is also associated with ADHD symptom load in the entire cohort.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Suzanne M. Green-Fulgham, Michael J. Lacagnina, Kendal F. Willcox, Jiahe Li, Michael E. Harland, Adriano Polican Ciena, Igor R. Correia Rocha, Jayson B. Ball, Renee A. Dreher, Younus A. Zuberi, Joseph M. Dragavon, Marucia Chacur, Steven F. Maier, Linda R. Watkins, Peter M. Grace
Summary: Regular aerobic activity, specifically voluntary wheel running, can reduce the risk of chronic pain by inhibiting MAC and preserving myelin integrity at the site of peripheral nerve injury.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
India Boyton, Stella M. Valenzuela, Lyndsey E. Collins-Praino, Andrew Care
Summary: Neuronanomedicine is a multidisciplinary field that aims to develop innovative nanotechnologies for the treatment of neurodegenerative disorders. Nanoparticles are an important component of neuronanomedicine, as they can improve drug properties and enhance safety and delivery across the blood-brain barrier. However, a major challenge for neuronanomedicine translation is the poor understanding of bio-nano interactions, partly due to inconsistent reporting in published works. This review provides specific recommendations to guide researchers in harnessing the unique properties of nanoparticles for breakthrough treatments of Alzheimer's and Parkinson's disease.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Celine De Looze, Cathal McCrory, Aisling O'Halloran, Silvia Polidoro, Rose Anne Kenny, Joanne Feeney
Summary: Our study found that subjective measures of stress and biological metrics may be independently associated with cognitive function over time in older adults, hinting at potential different underlying mechanisms.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Beatrice Bravi, Elisa Maria Teresa Melloni, Marco Paolini, Mariagrazia Palladini, Federico Calesella, Laura Servidio, Elena Agnoletto, Sara Poletti, Cristina Lorenzi, Cristina Colombo, Francesco Benedetti
Summary: Depressed patients show changes in immune-inflammatory markers in their blood and cerebrospinal fluid. The Choroid Plexus, located at the base of the brain ventricles, plays a key role in regulating the exchange of substances between the brain and immune cells. Patients with bipolar disorder or major depressive disorder have larger Choroid Plexus volumes compared to healthy controls. Age and levels of circulating cytokines are associated with Choroid Plexus volumes in the clinical groups.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Mingxuan Zheng, Huaiyu Ye, Xiaoying Yang, Lijun Shen, Xuemei Dang, Xiaoli Liu, Yuying Gong, Qingyuan Wu, Li Wang, Xing Ge, Xiaoli Fang, Benchi Hou, Peng Zhang, Renxian Tang, Kuiyang Zheng, Xu-Feng Huang, Yinghua Yu
Summary: Obesity is linked to cognitive dysfunction and neurodegenerative disease. The connection between the gut microbiota and the brain is altered in obesity. The probiotic Clostridium butyricum can improve cognitive impairment caused by obesity and prevent gut microbiota dysbiosis and inflammation.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Edward Drydale, Phalguni Rath, Katie Holden, Gregory Holt, Laurissa Havins, Thomas Johnson, James Bancroft, Lahiru Handunnetthi
Summary: This study created a novel three-dimensional neurosphere assay using induced pluripotent stem cell differentiation and live cell imaging techniques to investigate the effect of a simulated viral infection on cortical development. The findings demonstrated that the infection led to reduced radial glial growth and neural migration.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Yuancheng Weng, Ningting Chen, Rui Zhang, Jian He, Xukai Ding, Guo Cheng, Qianqian Bi, Ying-mei Lu, Xiao Z. Shen, Shu Wan, Peng Shi
Summary: This study reveals that microglia is the primary cellular source of PDGFB in adults, and microglial PDGFB is crucial for maintaining BBB integrity in adult mice.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Evan A. Bordt, Haley A. Moya, Young Chan Jo, Caitlin T. Ravichandran, Izabella M. Bankowski, Alexis M. Ceasrine, Christopher J. Mcdougle, William A. Carlezon Jr, Staci D. Bilbo
Summary: There is a strong male bias in many neurodevelopmental disorders such as autism spectrum disorder, but the mechanisms behind this bias are unknown. Infection during the perinatal period increases the risk of neurodevelopmental disorders. Using a mouse model, researchers found that early-life immune activation only induced deficits in social behaviors in male mice. These behavioral changes were associated with alterations in microglial immune signaling, mitochondrial morphology, gene expression, and function specifically in microglia, the brain's innate immune cells. Furthermore, the vulnerability to early-life immune activation and its effects on behavior and microglial mitochondria were programmed by the male-typical perinatal gonadal hormone surge. These findings highlight the role of microglia-specific mechanisms shaped by early developmental events in regulating male social behavior throughout lifespan.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Maria Amalia Di Castro, Stefano Garofalo, Alessandro Mormino, Laura Carbonari, Erika Di Pietro, Eleonora De Felice, Myriam Catalano, Laura Maggi, Cristina Limatola
Summary: Cytokines, such as interleukin-15 (IL-15), play important roles in modulating the central nervous system (CNS). In this study, the authors found that exposure to IL-15 enhances GABA release and reduces glutamatergic currents in hippocampal slices. Chronic treatment with IL-15 has negative effects on memory formation. Serotonin is involved in mediating these effects, as a selective 5-HT3A receptor antagonist prevents the effects on inhibitory neurotransmission and improves performance in a memory test.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Nikhitha Sreenivas, Michael Maes, Hansashree Padmanabha, Apoorva Dharmendra, Priyanka Chakkera, Saptamita Paul Choudhury, Fazal Abdul, Thrinath Mullapudi, Vykuntaraju K. Gowda, Michael Berk, John Vijay Sagar Kommu, Monojit Debnath
Summary: Neurodevelopmental disorders (NDDs) are a spectrum of conditions with both common and differing characteristics in terms of phenome, symptomatome, neuropathology, risk factors and underlying mechanisms. This study investigates the possibility of a shared immune etiology among three early-onset NDDs, namely Autism Spectrum Disorder (ASD), Attention Deficit Hyperactivity Disorder (ADHD) and Intellectual Disability Disorder (IDD).
BRAIN BEHAVIOR AND IMMUNITY
(2024)