Effects of dextromethorphan on glial cell function: Proliferation, maturation, and protection from cytotoxic molecules

Oligodendroglia: new players in amyotrophic lateral sclerosis

(2013) Albert C. Ludolph   BRAIN

Oligodendrocyte dysfunction in the pathogenesis of amyotrophic lateral sclerosis

(2013) Thomas Philips et al.   BRAIN

Sigma-1 Receptor Knockout Impairs Neurogenesis in Dentate Gyrus of Adult HippocampusViaDown-Regulation of NMDA Receptors

(2013) Sha Sha et al.   CNS Neuroscience & Therapeutics

ACTH protects mature oligodendroglia from excitotoxic and inflammation-related damagein vitro

(2013) Joyce A. Benjamins et al.   GLIA

A functional role of NMDA receptor in regulating the differentiation of oligodendrocyte precursor cells and remyelination

(2013) Cui Li et al.   GLIA

NADPH oxidase expression in active multiple sclerosis lesions in relation to oxidative tissue damage and mitochondrial injury

(2012) Marie T. Fischer et al.   BRAIN

Neuroprotective effects of the sigma-1 receptor ligand PRE-084 against excitotoxic perinatal brain injury in newborn mice

(2012) E. Griesmaier et al.   EXPERIMENTAL NEUROLOGY

The Lifetime of UDP-galactose:Ceramide Galactosyltransferase Is Controlled by a Distinct Endoplasmic Reticulum-associated Degradation (ERAD) Regulated by Sigma-1 Receptor Chaperones

(2012) Teruo Hayashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Secretory products of multiple sclerosis B cells are cytotoxic to oligodendroglia in vitro

(2012) Robert P. Lisak et al.   JOURNAL OF NEUROIMMUNOLOGY

Disruption of NMDA Receptors in Oligodendroglial Lineage Cells Does Not Alter Their Susceptibility to Experimental Autoimmune Encephalomyelitis or Their Normal Development

(2012) F. Guo et al.   JOURNAL OF NEUROSCIENCE

Oligodendroglia metabolically support axons and contribute to neurodegeneration

(2012) Youngjin Lee et al.   NATURE

Dextromethorphan-induced psychotoxic behaviors cause sexual dysfunction in male mice via stimulation of σ-1 receptors

(2012) Yunsung Nam et al.   NEUROCHEMISTRY INTERNATIONAL

Sigma-1 Receptor Agonists Directly Inhibit NaV1.2/1.4 Channels

(2012) Xiao-Fei Gao et al.   PLoS One

Sigma-1 receptor chaperones regulate the secretion of brain-derived neurotrophic factor

(2012) Michiko Fujimoto et al.   SYNAPSE

The sigma-1 receptor: roles in neuronal plasticity and disease

(2012) Saïd Kourrich et al.   TRENDS IN NEUROSCIENCES

A mutation in sigma-1 receptor causes juvenile amyotrophic lateral sclerosis

(2011) Amr Al-Saif et al.   ANNALS OF NEUROLOGY

Oxidative damage in multiple sclerosis lesions

(2011) L. Haider et al.   BRAIN

Low doses of dextromethorphan attenuate morphine-induced rewarding via the sigma-1 receptor at ventral tegmental area in rats

(2011) Shiou-Lan Chen et al.   DRUG AND ALCOHOL DEPENDENCE

Current Concepts in the Pharmacotherapy of Pseudobulbar Affect

(2011) Erik P. Pioro   DRUGS

The molecular basis of neurodegeneration in multiple sclerosis

(2011) Hans Lassmann et al.   FEBS LETTERS

NMDA Receptor Signaling in Oligodendrocyte Progenitors Is Not Required for Oligodendrogenesis and Myelination

(2011) L. M. De Biase et al.   JOURNAL OF NEUROSCIENCE

Low dose dextromethorphan attenuates moderate experimental autoimmune encephalomyelitis by inhibiting NOX2 and reducing peripheral immune cells infiltration in the spinal cord

(2011) Olga V. Chechneva et al.   NEUROBIOLOGY OF DISEASE

A clinical trial of dextromethorphan in amyotrophic lateral sclerosis

(2010) O. Gredal et al.   ACTA NEUROLOGICA SCANDINAVICA

Current hypotheses for the underlying biology of amyotrophic lateral sclerosis

(2010) Jeffrey D. Rothstein   ANNALS OF NEUROLOGY

Dextromethorphan Plus Ultra Low-Dose Quinidine Reduces Pseudobulbar Affect

(2010) Erik P. Pioro et al.   ANNALS OF NEUROLOGY

Sigma nonopioid intracellular receptor 1 mutations cause frontotemporal lobar degeneration-motor neuron disease

(2010) Agnes A. Luty et al.   ANNALS OF NEUROLOGY

Regulated Release of BDNF by Cortical Oligodendrocytes is Mediated Through Metabotropic Glutamate Receptors and the PLC Pathway

(2009) Issa P Bagayogo et al.   ASN Neuro

Differential effects of Th1, monocyte/macrophage and Th2 cytokine mixtures on early gene expression for molecules associated with metabolism, signaling and regulation in central nervous system mixed glial cell cultures

(2009) Robert P Lisak et al.   Journal of Neuroinflammation

The role of kynurenines in disorders of the central nervous system: Possibilities for neuroprotection

(2009) Eniko Vamos et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

The pharmacology of sigma-1 receptors

(2009) Tangui Maurice et al.   PHARMACOLOGY & THERAPEUTICS

Brain levels of dextromethorphan and the intensity of opioid withdrawal in mice

(2008) Adam Bisaga et al.   DRUG AND ALCOHOL DEPENDENCE

Dextromethorphan is protective against sensitized N-methyl-d-aspartate receptor-mediated excitotoxic brain damage in the developing mouse brain

(2008) Matthias Keller et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Sigma receptors suppress multiple aspects of microglial activation

(2008) Aaron A. Hall et al.   GLIA

Signal transduction pathways involved in interaction of galactosylceramide/sulfatide-containing liposomes with cultured oligodendrocytes and requirement for myelin basic protein and glycosphingolipids

(2008) Joan M. Boggs et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Neurodegeneration in multiple sclerosis: The role of oxidative stress and excitotoxicity

(2008) R.E. Gonsette   JOURNAL OF THE NEUROLOGICAL SCIENCES

Glutamate Receptor Expression in Multiple Sclerosis Lesions

(2007) Jia Newcombe et al.   BRAIN PATHOLOGY