Article
Neurosciences
Ege Kingir, Cem Sevinc, Gunes Unal
Summary: Chronic oral ketamine prevents the reduction of daily activity and loss of desire caused by chronic unpredictable mild stress. This preventive effect is achieved by altering neuronal activation in the lateral habenula and nucleus accumbens shell.
Review
Cell Biology
Gunter Emons, Carsten Gruendker
Summary: Endometrial cancer expresses GnRH and its receptor, which can regulate proliferation, the cell cycle, and apoptosis. GnRH agonists are used in fertility preserving therapy for early EC, but show limited activity in advanced or recurrent EC. Further clinical trials exploring the GnRH-system in EC may be beneficial.
Article
Biology
Chirine Toufaily, Jerome Fortin, Carlos A. Alonso, Evelyne Lapointe, Xiang Zhou, Yorgui Santiago-Andres, Yeu-Farn Lin, Yiming Cui, Ying Wang, Dominic Devost, Ferdinand Roelfsema, Frederik Steyn, Aylin C. Hanyaloglu, Terence E. Hebert, Tatiana Fiordelisio, Derek Boerboom, Daniel J. Bernard
Summary: Gonadotropin-releasing hormone (GnRH) controls reproduction by stimulating FSH and LH synthesis via its receptor GnRHR, but the lack of Ctail in mammalian GnRHR may not provide an advantage for LH surge generation. In transgenic mice, addition of Ctail resulted in reduced FSH production and fertility, suggesting a potential role of Ctail in normal reproductive function.
Review
Cell Biology
Carsten Gruendker, Guenter Emons
Summary: The HPG axis regulates the female menstrual cycle through GnRH, which can impact ovarian cancer either indirectly through the HPG axis or directly through receptors on the surface of tumor cells.
Article
Immunology
Ai-Mei Chang, Chen-Chih Chen, Ding-Liang Hou, Guan-Ming Ke, Jai-Wei Lee
Summary: The study revealed that GnRH vaccine can reduce hormone concentrations, lead to testicular atrophy and decreased sperm quality, and have an impact on animal mating and reproductive abilities.
Review
Chemistry, Medicinal
Yi-Fu Liu, Sheng-Qiang Fu, Yu-Chang Yan, Bin-Bin Gong, Wen-Jie Xie, Xiao-Rong Yang, Ting Sun, Ming Ma
Summary: This review discusses the usage, administration, and impact on serum testosterone levels of GnRH receptor agonists and antagonists, focusing on the mechanism of action of the antagonists and their development in clinical studies.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Neurosciences
Linjuan Feng, Hsuan Lo, Hanlin You, Wei Wu, Xiaojuan Cheng, Jiawei Xin, Zucheng Ye, Xiaochun Chen, Xiaodong Pan
Summary: This study reveals the important role of CB2 receptors in modulating synaptic pruning in the nucleus accumbens (NAc) during alpha-Synucleinopathy. CB2 receptor knockout leads to changes in microglial morphology and phenotype and affects the activation of related signaling pathways. The findings provide important insights into the mechanisms underlying the development of Alpha-Synucleinopathy.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Tracy A. Burnett, Augusto M. L. Madureira, Janet W. Bauer, Ronaldo L. A. Cerri
Summary: This study found that administration of GnRH at the time of artificial insemination can improve fertility in cows with reduced estrous expression, but increased ovulation rate does not seem to be the direct mechanism behind this relationship.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Multidisciplinary Sciences
Lisa-Marie Sattler, Hanna A. Schniewind, Waldemar B. Minich, Christoph W. Haudum, Petra Niklowitz, Julia Muenzker, Gabor L. Kovacs, Thomas Reinehr, Barbara Obermayer-Pietsch, Lutz Schomburg
Summary: In European adult control groups and PCOS patients, only a very small fraction have natural GnRH-R-aAb. Our results do not support the hypothesis that GnRH-R is a significant autoantigen in PCOS.
Article
Behavioral Sciences
Alexa Brown, Franz R. Villaruel, Nadia Chaudhri
Summary: Extinction is a fundamental form of inhibitory learning that is important for adapting to changing environmental contingencies. This study aimed to generate an extensive brain activation map of extinction learning in a rat model of appetitive Pavlovian conditioning. The findings provide novel evidence for the contribution of different brain areas and neural networks in the recall versus extinction of appetitive Pavlovian conditioned responding.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Medicine, General & Internal
Ying Liu, Xiao-Ya Ren, Ya-Guang Peng, Shao-Ke Chen, Xin-Ran Cheng, Miao Qin, Xiao-Ling Wang, Yan-Ning Song, Li-Jun Fan, Chun-Xiu Gong
Summary: The study demonstrated that hCG/hMG therapy is feasible and effective for treating male adolescents with CHH, with the initial 3 months of treatment showing the strongest effects. Results from the extended time-period also showed positive outcomes at the 1-year mark, indicating the potential of hCG/hMG regimen, although further research is needed to assess its long-term effectiveness and limitations.
CHINESE MEDICAL JOURNAL
(2021)
Article
Agriculture, Dairy & Animal Science
M. H. C. Pereira, B. I. Cappellozza, R. L. A. Cerri, C. P. Sanches Jr, T. G. Guida, L. F. S. P. Barbosa, J. E. P. Santos, J. L. M. Vasconcelos
Summary: This study evaluated the use of a second PGF(2 alpha) treatment in improving pregnancy rates of lactating Holstein cows undergoing timed embryo transfer. The results showed that the use of a second PGF(2 alpha) treatment increased estrus expression and ovulation rates, but did not affect pregnancy rates.
JOURNAL OF DAIRY SCIENCE
(2023)
Article
Neurosciences
Mattia Camera, Isabella Russo, Valentina Zamboni, Alessandra Ammoni, Simona Rando, Alessandro Morellato, Irene Cimino, Costanza Angelini, Paolo Giacobini, Roberto Oleari, Federica Amoruso, Anna Cariboni, Isabelle Franceschini, Emilia Turco, Paola Defilippi, Giorgio R. Merlo
Summary: The absence of the p140Cap gene in mice leads to abnormalities in fertility, puberty development, and hormone secretion. This may be due to its role in the development of the hypothalamic gonadotropic system and modulation of glutamatergic signaling.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Andrology
Hiroshi Sasaki, Kenta Miki, Kojiro Tashiro, Keiichiro Mori, Fumihiko Urabe, Wataru Fukuokaya, Takahiro Kimura, Shun Sato, Hiroyuki Takahashi, Manabu Aoki, Shin Egawa
Summary: The recovery patterns of hormonal profiles after short-term (12 weeks) neoadjuvant ADT differ between GnRH antagonists and GnRH agonists. The choice between these drugs matters and may have a clinical impact depending on the primary objective of ADT.
Article
Biochemistry & Molecular Biology
Juan Zegers-Delgado, Alejandro Aguilera-Soza, Florencia Calderon, Harley Davidson, Daniel Verbel-Vergara, Hector E. Yarur, Javier Novoa, Camila Blanlot, Cristian P. Bastias, Maria Estela Andres, Katia Gysling
Summary: The study found that the control of neurotransmission by CRF receptors in the NAc is influenced by life stage. In adult rats, the CRF-R1 antagonist decreased DA levels and increased glutamate levels in response to a depolarizing stimulus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Behavioral Sciences
Eun-Joo Shin, Chu Xuan Duong, Xuan-Khanh Thi Nguyen, Zhengyi Li, Guoying Bing, Jae-Hyung Bach, Dae Hun Park, Keiichi Nakayama, Syed F. Ali, Anumantha G. Kanthasamy, Jean Lud Cadet, Toshitaka Nabeshima, Hyoung-Chun Kim
BEHAVIOURAL BRAIN RESEARCH
(2012)
Article
Cell Biology
Beom Keun Kim, Haong-Yen Phi Tran, Eun-Joo Shin, Chaeyoung Lee, Yoon Hee Chung, Ji Hoon Jeong, Jae-Hyung Bach, Won-Ki Kim, Dae Hoon Park, Kuniaki Saito, Toshitaka Nabeshima, Hyoung-Chun Kim
CELLULAR SIGNALLING
(2013)
Article
Neurosciences
E. -J. Shin, J. -H. Bach, T. -T. L. Nguyen, X. -K. T. Nguyen, B. -D. Jung, K. -W. Oh, M. J. Kim, S. K. Ko, C. G. Jang, S. F. Ali, H. -C. Kim
CURRENT NEUROPHARMACOLOGY
(2011)
Article
Neurosciences
E. -J. Shin, J. -H. Bach, T. -T. L. Nguyen, B. -D. Jung, K. -W. Oh, M. J. Kim, C. G. Jang, S. F. Ali, S. K. Ko, C. H. Yang, H. -C. Kim
CURRENT NEUROPHARMACOLOGY
(2011)
Meeting Abstract
Biochemistry & Molecular Biology
Yunsung Nam, Duy-Khanh Dang, Thu-Hien Thi Tu, Jae-Hyung Bach, Eun-Joo Shin, Guoying Bing, Jau-Shyong Hong, Hyoung-Chun Kim
FREE RADICAL BIOLOGY AND MEDICINE
(2012)
Meeting Abstract
Biochemistry & Molecular Biology
Eun-Joo Shin, Jeong Hyun Lee, Thai-Ha Nguyen Tran, Jae-Hyung Bach, Hyoung-Chun Kim
FREE RADICAL BIOLOGY AND MEDICINE
(2012)
Article
Biochemistry & Molecular Biology
Hoang-Yen Phi Tran, Eun-Joo Shin, Kuniaki Saito, Xuan-Khanh Thi Nguyen, Yoon Hee Chung, Ji Hoon Jeong, Jae-Hyung Bach, Dae Hun Park, Kiyofumi Yamada, Toshitaka Nabeshima, Yukio Yoneda, Hyoung-Chun Kim
FREE RADICAL BIOLOGY AND MEDICINE
(2012)
Article
Biochemistry & Molecular Biology
Jae Hyung Bach, Kwang Mook Jung, Jae Sin Choi, Sung Yun Jung, Mi Reyoung Chin, Kyong Hoon Ahn, Seok Kyun Kim, Dae Kyong Kim
JOURNAL OF BIOCHEMISTRY
(2011)
Article
Immunology
Qingshan Wang, Eun-Joo Shin, Xuan-Khanh Thi Nguyen, Quan Li, Jae-Hyung Bach, Guoying Bing, Won-Ki Kim, Hyoung-Chun Kim, Jau-Shyong Hong
JOURNAL OF NEUROINFLAMMATION
(2012)
Article
Pharmacology & Pharmacy
Eun-Joo Shin, Wan Kyunn Whang, Sungun Kim, Jae-Hyung Bach, Jin-Man Kim, Xuan-Khanh Thi Nguyen, Thuy-Ty Lan Nguyen, Bae Dong Jung, Kiyofumi Yamada, Toshitaka Nabeshima, Hyoung-Chun Kim
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2010)
Review
Pharmacology & Pharmacy
Eun-Joo Shin, Jae-Hyung Bach, Sung Youl Lee, Jeong Min Kim, Jinhwa Lee, Jau-Shyong Hong, Toshitaka Nabeshima, Hyoung-Chun Kim
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2011)
Article
Biochemistry & Molecular Biology
Eun-Joo Shin, Chu Xuan Duong, Xuan-Khanh Thi Nguyen, Guoying Bing, Jae-Hyung Bach, Dae Hun Park, Keiichi Nakayama, Syed F. Ali, Anumantha G. Kanthasamy, Jean L. Cadet, Toshitaka Nabeshima, Hyoung-Chun Kim
NEUROCHEMISTRY INTERNATIONAL
(2011)
Review
Biochemistry & Molecular Biology
Eun-Joo Shin, Ji Hoon Jeong, Yoon Hee Chung, Won-Ki Kim, Kwang-Ho Ko, Jae-Hyung Bach, Jau-Shyong Hong, Yukio Yoneda, Hyoung-Chun Kim
NEUROCHEMISTRY INTERNATIONAL
(2011)
Article
Neurosciences
Seok-Joo Park, Eun-Joo Shin, Sun Seek Min, Jihua An, Zhengyi Li, Yoon Hee Chung, Ji Hoon Jeong, Jae-Hyung Bach, Seung-Yeol Nah, Won-Ki Kim, Choon-Gon Jang, Yong-Sun Kim, Yo-ichi Nabeshima, Toshitaka Nabeshima, Hyoung-Chun Kim
NEUROPSYCHOPHARMACOLOGY
(2013)
Article
Biochemistry & Molecular Biology
Hui-Ting Huang, Shun-Fen Tzeng
Summary: Our study demonstrates the role of interleukin-33 (IL-33) in a demyelinating mouse model induced by cuprizone (CPZ), showing that IL-33 can alleviate the reduction of APC+ OLs and the decline of IL-33 levels in the corpus callosum, and promote the expression of myelin basic protein (MBP).
NEUROCHEMISTRY INTERNATIONAL
(2024)