Review
Neurosciences
Edyta Balcerek, Urszula Wlodkowska, Rafal Czajkowski
Summary: The ability to form, retrieve and update autobiographical memories is closely related to spatial memory, which involves various brain structures including the hippocampus and the retrosplenial cortex. The study of immediate early genes can provide insights into the formation of memory traces within the brain.
Article
Neurosciences
Jessica Leake, Raphael Zinn, Laura H. Corbit, Michael S. Fanselow, Bryce Vissel
Summary: Memories formed under inadequate learning time display maladaptive properties, with differences in neuronal activation impacting memory specificity. Larger memory engrams support better neuronal and behavioral discrimination, showing the influence of previous learning and present experience on behavior.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Sydney Weber Boutros, Kat Kessler, Vivek K. Unni, Jacob Raber
Summary: The tight regulation of immediate early gene (IEG) expression is crucial for synaptic plasticity, learning, and memory. Recent research suggests that DNA double strand breaks (DSBs) may play a role in inducing IEG expression in post-mitotic cells. This study demonstrates that etoposide, a cancer treatment that induces DSBs, alters IEG expression and impairs hippocampus-dependent contextual fear memory.
SCIENTIFIC REPORTS
(2022)
Article
Neurosciences
Maria Gomis-Gonzalez, Lorena Galera-Lopez, Marc Ten-Blanco, Arnau Busquets-Garcia, Thomas Cox, Rafael Maldonado, Andres Ozaita
Summary: The study revealed that PKC-gamma knockout mice exhibit severe impairment in hippocampal-dependent short-term memory performance while long-term memory tasks remain unaffected. This indicates that PKC-gamma plays a crucial role in memory processes, particularly in the formation of short-term memory and the differential involvement in short-term and long-term memory processes.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Virology
Serdal Arslan, Mehmet Bakir, Burcu Bayyurt, Eylem Aydemir, Kenan Kinaci, Aynur Engin
Summary: This study investigated the lncRNA gene expression profiles in CCHF using microarray for the first time. Several lncRNAs were found to be significantly regulated in both case and fatal case groups. These lncRNAs could be considered as important therapeutic targets for further studies on CCHF.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Clinical Neurology
Cassiano Ricardo Alves Faria Diniz, Leandro Antero da Silva, Luana Barreto Domingos, Andreza Buzolin Sonego, Leonardo Resstel Barbosa Moraes, Samia Joca
Summary: The study demonstrates that the dorsal and ventral subregions of the hippocampus play different roles in modulating the effects of the antidepressant drug fluoxetine in decreasing fear response. This suggests a discrepancy in fear response when BDNF is infused into the dorsal or ventral hippocampus.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2022)
Article
Fisheries
Ye Ge, Qiucheng Yao, Yingying Wang, Qing Wang, Weiwei Zeng
Summary: The study utilized miRNA library construction and microarray sequencing to screen out miRNAs with significant differences between the GCRV infection group and the control group. The results showed the importance of related miRNAs and mRNA target genes in immune effect processes, regulation of immune effect processes, cell death, regulation of leucocyte-mediated cytotoxicity, potentially involving deregulation of the PI3K/AKT, Toll-like, and RIG-I signaling pathways.
AQUACULTURE RESEARCH
(2021)
Article
Behavioral Sciences
Nae Saito, Makoto Itakura, Toshikuni Sasaoka
Summary: Dopaminergic neurotransmission via D1 receptors plays an important role in aversive learning. Using D1R knockdown mice, this study found that deficiency in D1R-mediated dopaminergic neurotransmission impairs contextual fear memory formation.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Dacheng Zhao, Jinwen He, Xiaobing Zhao, Xiaoyun Sheng, Zhiwei Feng, Xingwen Wang, Chengjun Zhang, Shenghong Wang, Bin Geng, Yayi Xia
Summary: The protein c-Fos and lncRNA GM15416 play important roles in regulating osteoblast cell death and osteogenesis. Overexpression of c-Fos leads to osteoblast apoptosis and osteoporosis, while decreased expression of lncRNA GM15416 helps prevent osteoporosis.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Behavioral Sciences
Sofia Leal Santos, Briana K. Chen, Guilherme R. Pereira, Vananh Pham, Christine A. Denny
Summary: Altered fear learning is a significant component of anxiety disorders, and the noradrenergic signaling system plays an important role in regulating stress responses and fear learning processes. Propranolol has been shown to reduce exaggerated fear responses and can impact the activity of the dentate gyrus and hilar layer. These findings contribute to our understanding of the neural mechanisms underlying anxiety disorders and provide a new possibility for improving treatment efficacy.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Neurosciences
Angeliki Velli, Chrysoula Iordanidou, Theodora Asimi, Maria-Ioanna Vynichaki, Anastasios Cholevas, Adamantia-Iliana Mantouka, Liesje Nassens, Kleanthi Chalkiadaki, Kyriaki Sidiropoulou
Summary: Gender differences play a role in the differential effects of acute restraint stress on the function of the prefrontal cortex in male and female mice. Females exhibit increased anxiety levels, while males show deficits in the temporal order object recognition task. Corticosterone signaling mediates some of the effects of stress on synaptic plasticity, affecting recency memory and anxiety in males and females differently.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Review
Psychology, Multidisciplinary
Anastasia Morandi-Raikova, Uwe Mayer
Summary: This review discusses the functional equivalence of the avian and mammalian hippocampus, focusing on research in domestic chicks. While the hippocampus plays a central role in processing spatial information in both birds and mammals, the structure of this area shows remarkable differences.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Nutrition & Dietetics
Lorenzo Nissen, Flavia Casciano, Elena Chiarello, Mattia Di Nunzio, Alessandra Bordoni, Andrea Gianotti
Summary: The study explored the prebiotic potential of bread enriched with Polyphenol Rich Fiber (PRF) and found that PRF-enriched bread had positive effects on the host gut model, such as increasing beneficial bacterial groups and producing certain bioactive metabolites. This research not only highlighted the prebiotic role of PRF-enriched bread but also emphasized the potential of the in vitro gut model MICODE in evaluating the functionality of food prototypes as gut microbiota modulators.
Article
Neurosciences
Hibiki Okamura, Shinnosuke Yasugaki, Haruka Suzuki-Abe, Yoshifumi Arai, Katsuyasu Sakurai, Masashi Yanagisawa, Hotaka Takizawa, Yu Hayashi
Summary: Understanding the long-term effects of stress on brain function is crucial for understanding the mechanisms of depression. This study investigated the effects of repeated social defeat stress (SDS) on behavior and brain activity in BALB/c mice over subsequent weeks. The results revealed the long-term effects of social stress on behavior and brain activity, providing insight into the underlying mechanisms of related diseases.
Article
Multidisciplinary Sciences
Noah L. Pettit, Ee-Lynn Yap, Michael E. Greenberg, Christopher D. Harvey
Summary: Fos-induced cells contribute to accurate, stable and spatially uniform place codes in the hippocampus and Fos itself has a causal role in shaping these place codes.
Article
Cell Biology
Vasja Urbancic, Richard Butler, Benjamin Richier, Manuel Peter, Julia Mason, Frederick J. Livesey, Christine E. Holt, Jennifer L. Gallop
JOURNAL OF CELL BIOLOGY
(2017)
Article
Cell & Tissue Engineering
Nina S. Corsini, Angela M. Peer, Paul Moeseneder, Mykola Roiuk, Thomas R. Burkard, Hans-Christian Theussl, Isabella Moll, Juergen A. Knoblich
Article
Cell Biology
Sebastian Wissel, Heike Harzer, Francois Bonnay, Thomas R. Burkard, Ralph A. Neumueller, Juergen A. Knoblich
JOURNAL OF CELL BIOLOGY
(2018)
Article
Biochemical Research Methods
Chiara Alberti, Raphael A. Manzenreither, Ivica Sowemimo, Thomas R. Burkard, Jingkui Wang, Katharina Mahofsky, Stefan L. Ameres, Luisa Cochella
Article
Biochemical Research Methods
Shan Bian, Marko Repic, Zhenming Guo, Anoop Kavirayani, Thomas Burkard, Joshua A. Bagley, Christian Krauditsch, Juergen A. Knoblich
Article
Biology
Lisa Landskron, Victoria Steinmann, Francois Bonney, Thomas R. Burkard, Jonas Steinmann, Ilka Reichardt, Heike Harzer, Anne-Sophie Laurenson, Heinrich Reichert, Juergen A. Knoblich
Article
Immunology
Anna Ohradanova-Repic, Christian Machacek, Celine Charyet, Franck Lager, Delphine Le Roux, Rene Platzer, Vladimir Leksa, Goran Mituloyic, Thomas R. Burkard, Gerhard J. Zlabingee, Michael B. Fischer, Vincent Feuillet, Gilles Renault, Stephan Blueml, Miroslay Benko, Miloslav Suchanek, Johannes B. Huppa, Takami Matsuyama, Artur Cayaco-Paulo, Georges Bismuth, Hannes Stockinger
FRONTIERS IN IMMUNOLOGY
(2018)
Correction
Biochemical Research Methods
Shan Bian, Marko Repic, Zhenming Guo, Anoop Kavirayani, Thomas Burkard, Joshua A. Bagley, Christian Krauditsch, Juergen A. Knoblich
Article
Multidisciplinary Sciences
Raquel Real, Manuel Peter, Antonio Trabalza, Shabana Khan, Mark A. Smith, Joana Dopp, Samuel J. Barnes, Ayiba Momoh, Alessio Strano, Emanuela Volpi, Graham Knott, Frederick J. Livesey, Vincenzo De Paola
Article
Multidisciplinary Sciences
J. A. Zepeda-Martinez, C. Pribitzer, J. Wang, D. Bsteh, S. Golumbeanu, Q. Zhao, T. R. Burkard, B. Reichholf, S. K. Rhie, J. Jude, H. F. Moussa, J. Zuber, O. Bell
Article
Biotechnology & Applied Microbiology
Christian Umkehrer, Felix Holstein, Laura Formenti, Julian Jude, Kimon Froussios, Tobias Neumann, Shona M. Cronin, Lisa Haas, Jesse J. Lipp, Thomas R. Burkard, Michaela Fellner, Thomas Wiesner, Johannes Zuber, Anna C. Obenauf
Summary: CaTCH is a functional lineage tracing tool that allows precise clonal tracing of millions of cells and retrospective isolation of founding clones for functional experiments. It enables the capture of rare clones and investigation of resistance emergence in targeted therapy for melanoma in vivo.
NATURE BIOTECHNOLOGY
(2021)
Article
Biochemical Research Methods
Georg Michlits, Julian Jude, Matthias Hinterndorfer, Melanie de Almeida, Gintautas Vainorius, Maria Hubmann, Tobias Neumann, Alexander Schleiffer, Thomas Rainer Burkard, Michaela Fellner, Max Gijsbertsen, Anna Traunbauer, Johannes Zuber, Ulrich Elling
Article
Biology
Stephanie Devignot, Tim Wai Sha, Thomas R. Burkard, Patrick Schmerer, Astrid Hagelkruys, Ali Mirazimi, Ulrich Elling, Josef M. Penninger, Friedemann Weber
Summary: Researchers have discovered that LRP1, a plasma membrane protein, plays a crucial role in supporting the infection of various RNA viruses, including Rift Valley fever virus and SARS-CoV-2. The function of LRP1 is dependent on physiological levels of cholesterol and endocytosis.
LIFE SCIENCE ALLIANCE
(2023)
Article
Multidisciplinary Sciences
Chong Li, Jonas Simon Fleck, Catarina Martins-Costa, Thomas R. Burkard, Jan Themann, Marlene Stuempflen, Angela Maria Peer, Abel Vertesy, Jamie B. Littleboy, Christopher Esk, Ulrich Elling, Gregor Kasprian, Nina S. Corsini, Barbara Treutlein, Juergen A. Knoblich
Summary: The study develops a high-throughput CRISPR screening system in cerebral organoids to identify vulnerable cell types and gene regulatory networks associated with autism spectrum disorder. The researchers found that perturbing members of the chromatin remodelling complex can affect cell fate determination in progenitor cells.
Article
Biochemistry & Molecular Biology
Ilka Reichardt, Francois Bonnay, Victoria Steinmann, Inga Loedige, Thomas R. Burkard, Gunter Meister, Juergen A. Knoblich