Multilayered VBC score predicts sgRNAs that efficiently generate loss-of-function alleles
出版年份 2020 全文链接
标题
Multilayered VBC score predicts sgRNAs that efficiently generate loss-of-function alleles
作者
关键词
-
出版物
NATURE METHODS
Volume 17, Issue 7, Pages 708-716
出版商
Springer Science and Business Media LLC
发表日期
2020-06-09
DOI
10.1038/s41592-020-0850-8
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Prioritization of cancer therapeutic targets using CRISPR–Cas9 screens
- (2019) Fiona M. Behan et al. NATURE
- Gate-tunable giant nonreciprocal charge transport in noncentrosymmetric oxide interfaces
- (2019) Daeseong Choe et al. Nature Communications
- CRISPR-Cas9-based mutagenesis frequently provokes on-target mRNA misregulation
- (2019) Rubina Tuladhar et al. Nature Communications
- LKB1, Salt-Inducible Kinases, and MEF2C Are Linked Dependencies in Acute Myeloid Leukemia
- (2018) Yusuke Tarumoto et al. MOLECULAR CELL
- Target-Specific Precision of CRISPR-Mediated Genome Editing
- (2018) Anob M. Chakrabarti et al. MOLECULAR CELL
- Predictable and precise template-free CRISPR editing of pathogenic variants
- (2018) Max W. Shen et al. NATURE
- Predicting the mutations generated by repair of Cas9-induced double-strand breaks
- (2018) Felicity Allen et al. NATURE BIOTECHNOLOGY
- The Pfam protein families database in 2019
- (2018) Sara El-Gebali et al. NUCLEIC ACIDS RESEARCH
- Optimized libraries for CRISPR-Cas9 genetic screens with multiple modalities
- (2018) Kendall R. Sanson et al. Nature Communications
- A reversible haploid mouse embryonic stem cell biobank resource for functional genomics
- (2017) Ulrich Elling et al. NATURE
- Computational correction of copy number effect improves specificity of CRISPR–Cas9 essentiality screens in cancer cells
- (2017) Robin M Meyers et al. NATURE GENETICS
- CRISPR-UMI: single-cell lineage tracing of pooled CRISPR–Cas9 screens
- (2017) Georg Michlits et al. NATURE METHODS
- Refined sgRNA efficacy prediction improves large- and small-scale CRISPR–Cas9 applications
- (2017) Maurice Labuhn et al. NUCLEIC ACIDS RESEARCH
- sgRNA Scorer 2.0: A Species-Independent Model To Predict CRISPR/Cas9 Activity
- (2017) Raj Chari et al. ACS Synthetic Biology
- A Role for Mitochondrial Translation in Promotion of Viability in K-Ras Mutant Cells
- (2017) Timothy D. Martin et al. Cell Reports
- mRNA processing in mutant zebrafish lines generated by chemical and CRISPR-mediated mutagenesis produces unexpected transcripts that escape nonsense-mediated decay
- (2017) Jennifer L. Anderson et al. PLoS Genetics
- CRISPR-DO for genome-wide CRISPR design and optimization
- (2016) Jian Ma et al. BIOINFORMATICS
- DNA Repair Profiling Reveals Nonrandom Outcomes at Cas9-Mediated Breaks
- (2016) Megan van Overbeek et al. MOLECULAR CELL
- Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9
- (2016) John G Doench et al. NATURE BIOTECHNOLOGY
- Genome-wide CRISPR screens reveal a Wnt–FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors
- (2016) Zachary Steinhart et al. NATURE MEDICINE
- GenomeCRISPR - a database for high-throughput CRISPR/Cas9 screens
- (2016) Benedikt Rauscher et al. NUCLEIC ACIDS RESEARCH
- CRISPR Screens Provide a Comprehensive Assessment of Cancer Vulnerabilities but Generate False-Positive Hits for Highly Amplified Genomic Regions
- (2016) D. M. Munoz et al. Cancer Discovery
- Genomic Copy Number Dictates a Gene-Independent Cell Response to CRISPR/Cas9 Targeting
- (2016) A. J. Aguirre et al. Cancer Discovery
- A CRISPR Dropout Screen Identifies Genetic Vulnerabilities and Therapeutic Targets in Acute Myeloid Leukemia
- (2016) Konstantinos Tzelepis et al. Cell Reports
- High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities
- (2015) Traver Hart et al. CELL
- Discovery of cancer drug targets by CRISPR-Cas9 screening of protein domains
- (2015) Junwei Shi et al. NATURE BIOTECHNOLOGY
- The Pfam protein families database: towards a more sustainable future
- (2015) Robert D. Finn et al. NUCLEIC ACIDS RESEARCH
- Gene essentiality and synthetic lethality in haploid human cells
- (2015) V. A. Blomen et al. SCIENCE
- Identification and characterization of essential genes in the human genome
- (2015) T. Wang et al. SCIENCE
- Measuring error rates in genomic perturbation screens: gold standards for human functional genomics
- (2014) T. Hart et al. Molecular Systems Biology
- Rational design of highly active sgRNAs for CRISPR-Cas9–mediated gene inactivation
- (2014) John G Doench et al. NATURE BIOTECHNOLOGY
- Improved vectors and genome-wide libraries for CRISPR screening
- (2014) Neville E Sanjana et al. NATURE METHODS
- The UCSC Genome Browser database: 2015 update
- (2014) Kate R. Rosenbloom et al. NUCLEIC ACIDS RESEARCH
- Dynamic Imaging of Genomic Loci in Living Human Cells by an Optimized CRISPR/Cas System
- (2013) Baohui Chen et al. CELL
- Genome-wide recessive genetic screening in mammalian cells with a lentiviral CRISPR-guide RNA library
- (2013) Hiroko Koike-Yusa et al. NATURE BIOTECHNOLOGY
- Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells
- (2013) Ophir Shalem et al. SCIENCE
- Genetic Screens in Human Cells Using the CRISPR-Cas9 System
- (2013) Tim Wang et al. SCIENCE
- SIFT web server: predicting effects of amino acid substitutions on proteins
- (2012) Ngak-Leng Sim et al. NUCLEIC ACIDS RESEARCH
- Forward and Reverse Genetics through Derivation of Haploid Mouse Embryonic Stem Cells
- (2011) Ulrich Elling et al. Cell Stem Cell
- A method and server for predicting damaging missense mutations
- (2010) Ivan A Adzhubei et al. NATURE METHODS
Become a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get StartedAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started