Article
Cell Biology
Yingying Tong, Zheng Zhang, Yurong Cheng, Jing Yang, Cong Fan, Xuyang Zhang, Jiandong Yang, Li Wang, Dong Guo, Dong Yan
Summary: NFATc3 is a transcriptional regulator that is constitutively activated in various cancer types, playing crucial roles in cancer development. In pancreatic ductal adenocarcinoma cells, excessive activation of NFATc3 is associated with advanced disease stages and shorter survival time. The deSUMOylation of NFATc3 by SENP3 under hypoxia serves as an essential modulator in PDAC tumor progression.
CELL DEATH & DISEASE
(2022)
Article
Cell Biology
Qian Wang, Ci Xu, Qiang Fan, Haihua Yuan, Xin Zhang, Biying Chen, Renjie Cai, Yanjie Zhang, Moubin Lin, Ming Xu
Summary: This study reveals novel insights into p38 alpha-SUMOylation and its association with the intracellular oxidative stress response, which is closely related to the processes of gastric cancer. Furthermore, the PIASx alpha/p38 alpha-SUMOylation/MK2 cis-axis may serve as a desirable therapeutic target in gastric cancer as targeting PIASx alpha, MK2, or a specific peptide region of p38 alpha may reconcile the aberrant oxidative stress response in gastric cancer cells.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Krishna M. Chauhan, Yingxiao Chen, Yiyi Chen, Andrew T. Liu, Xiao-Xin Sun, Mu-Shui Dai
Summary: The study reveals that SENP1 is a critical p53 deSUMOylating enzyme, and its depletion induces p53 transactivation activity and synergizes with DNA damage-inducing agent etoposide to activate p53 and inhibit cancer cell growth.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2021)
Article
Biology
Calvin Jon A. Leonen, Miho Shimada, Caroline E. Weller, Tomoyoshi Nakadai, Peter L. Hsu, Elizabeth L. Tyson, Arpit Mishra, Patrick M. M. Shelton, Martin Sadilek, R. David Hawkins, Ning Zheng, Robert G. Roeder, Champak Chatterjee
Summary: Post-translational modification of histones by the small ubiquitin-like modifier protein SUMO plays a key role in gene silencing, centromeric localization, and DNA repair in eukaryotes. The study demonstrated that H4K12su inhibits acetylation of H4 tail and methylation of H3K4 associated with transcription activation, as well as transcription mediated by RNA polymerase II. Cell-based assays confirmed the negative crosstalk between histone sumoylation and acetylation/methylation in human cells.
Article
Biochemistry & Molecular Biology
Xiaoxia Shi, Yixin Du, Shujing Li, Huijian Wu
Summary: SUMOylation, a reversible post-translational modification process, plays crucial roles in cell physiology, including cell cycle regulation, DNA damage repair, and protein trafficking and turnover. Dysregulated SUMO E3 ligases may be associated with the occurrence and development of cancers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ayan Chanda, Yoshiho Ikeuchi, Kunal Karve, Anusi Sarkar, Amrita Singh Chandhoke, Lili Deng, Azad Bonni, Shirin Bonni
Summary: Studies show that SUMO E3 ligases PIAS1 and TIF1γ collaborate to promote the SUMOylation of SnoN, suppressing EMT in breast cell-derived tissue organoids. These E3 ligases act in an interdependent manner in the regulation process.
CELL DEATH AND DIFFERENTIATION
(2021)
Review
Medical Laboratory Technology
Wenhui Liu, Min Zeng, Nian Fu
Summary: The nuclear receptor superfamily, a family of ligand-activated transcription factors, plays a key role in cell metabolism and human diseases. They undergo various post-translational modifications, influencing diverse physiological activities. Nuclear receptors are crucial in lipid metabolism, inflammation, while SUMOylation nuclear receptors regulate function and impact cell metabolism.
CLINICA CHIMICA ACTA
(2021)
Article
Microbiology
Junping Li, Libin Liang, Li Jiang, Qian Wang, Xia Wen, Yuhui Zhao, Pengfei Cui, Yaping Zhang, Guangwen Wang, Qibing Li, Guohua Deng, Jianzhong Shi, Guobin Tian, Xianying Zeng, Yongping Jiang, Liling Liu, Hualan Chen, Chengjun Li
Summary: Our study demonstrates the vital role of PB1 K612 SUMOylation in the pathogenesis and transmission of IAVs, providing a potential target for anti-influenza therapies. The SUMOylation at K612 is crucial for PB1 to efficiently bind viral RNA, facilitating the transcription and replication of the viral genome.
Review
Plant Sciences
Shumei Fang, Xue Hou, Xilong Liang
Summary: SUMOylation is a crucial posttranslational modification in eukaryotes, involved in metabolic regulation under various stresses. SIZ1, a SUMO E3 ligase, plays a vital role in substrate-specific recognition and facilitates the binding of SUMO proteins to target proteins. This review provides insights into the characteristics of SUMOylation and the role of SIZ1 in plant adaptation to abiotic stresses, offering valuable references for crop improvement and future research on plant responses to environmental stress.
ENVIRONMENTAL AND EXPERIMENTAL BOTANY
(2022)
Article
Biochemistry & Molecular Biology
Mingchao Mu, Qin Zhang, Jing Li, Chenye Zhao, Xiaopeng Li, Zilu Chen, Xuejun Sun, Junhui Yu
Summary: The current study reveals that USP51 promotes colorectal cancer stemness and chemoresistance, and its high expression is associated with poor survival in colorectal cancer patients. USP51 forms a positive feedback loop with HIF1A, regulating its deubiquitination and stabilization. The interaction between USP51 and ELOC is facilitated by the deSUMOylation of ELOC mediated by SENP1. Importantly, USP51 plays a crucial role in promoting HIF1A and SENP1-dependent proliferation, migration, stemness, and chemoresistance under hypoxia in colorectal cancer.
CELL DEATH AND DIFFERENTIATION
(2023)
Review
Genetics & Heredity
Hong Xiao, Hong Zhou, Gaofeng Zeng, Zhenjiang Mao, Junfa Zeng, Anbo Gao
Summary: Small ubiquitin-like modifier (SUMO) plays a key regulatory role in cardiovascular diseases, particularly in the regulation of mitochondrial dynamics and mitophagy. SUMOylation triggers mitochondrial fusion and modifies specific proteins to promote mitochondrial dysfunction. SUMOylation and deSUMOylation regulate the initiation and activation of mitophagy.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2022)
Article
Cell Biology
Mritunjay Kasera, Kishor D. Ingole, Sakshi Rampuria, Yashika Walia, Walter Gassmann, Saikat Bhattacharjee
Summary: The study reveals that plant SUMOylation undergoes local and global adjustments during developmental transitions and stress exposures. The negative regulator SRFR1 plays a key role in maintaining SUMOylation homeostasis and impacting immune responses. Additionally, SRFR1 degradation and interaction with salicylic acid are important for the regulation of the SUMOylome during immune responses.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biology
Zhenkai Dai, Kayvan Etebari, Sassan Asgari
Summary: The analysis of m(6)A RNA modifications in the mosquito transcriptome and their changes during dengue virus infection provides insights into the role of epigenetics in regulating viral replication in mosquitoes.
COMMUNICATIONS BIOLOGY
(2022)
Review
Immunology
Daffiny Sumam de Oliveira, Thales Kronenberger, Giuseppe Palmisano, Carsten Wrenger, Edmarcia Elisa de Souza
Summary: Malaria caused by Plasmodium parasites requires post-translational modifications for controlling cellular activities, indicating potential new drug targets and therapeutic directions for malaria treatment.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Plant Sciences
Ruiqiang Lai, Jieming Jiang, Jun Wang, Jinju Du, Jianbin Lai, Chengwei Yang
Summary: SUMOylation is a crucial post-translational modification that regulates protein substrates. The maize SIZ1 homologs ZmSIZ1a, ZmSIZ1b, and ZmSIZ1c were functionally characterized in this study, showing potential roles in development regulation and stress responses. Overexpression of ZmSIZ1c in Arabidopsis resulted in early flowering and improved salt tolerance, suggesting distinct functions among the ZmSIZ1 members.
JOURNAL OF PLANT PHYSIOLOGY
(2022)
Review
Cell Biology
Yongsheng Shi, James L. Manley
GENES & DEVELOPMENT
(2015)
Article
Cell Biology
Tristan H. Coady, James L. Manley
GENES & DEVELOPMENT
(2015)
Article
Cell Biology
Neil T. Pfister, Vitalay Fomin, Kausik Regunath, Jeffrey Y. Zhou, Wen Zhou, Laxmi Silwal-Pandit, William A. Freed-Pastor, Oleg Laptenko, Suat Peng Neo, Jill Bargonetti, Mainul Hoque Bin Tian, Jayantha Gunaratne, Olav Engebraaten, James L. Manley, Anne-Lise Borresen-Dale, Paul M. Neilsen, Carol Prives
GENES & DEVELOPMENT
(2015)
Article
Multidisciplinary Sciences
Jian Zhang, Yen K. Lieu, Abdullah M. Ali, Alex Penson, Kathryn S. Reggio, Raul Rabadan, Azra Raza, Siddhartha Mukherjee, James L. Manley
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2015)
Article
Genetics & Heredity
Akhi Akhter, Emanuel Rosonina
Review
Cell Biology
Bin Tian, James L. Manley
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2017)
Article
Cell Biology
Lulzim Shkreta, Johanne Toutant, Mathieu Durand, James L. Manley, Benoit Chabot
Article
Genetics & Heredity
Julio C. Morales, Patricia Richard, Praveen L. Patidar, Edward A. Motea, Tuyen T. Dang, James L. Manley, David A. Boothman
Article
Biology
Erin G. Conlon, Lei Lu, Aarti Sharma, Takashi Yamazaki, Timothy Tang, Neil A. Shneider, James L. Manley
Article
Genetics & Heredity
Akhi Akhter, Emanuel Rosonina
Review
Biochemistry & Molecular Biology
Patricia Richard, James L. Manley
JOURNAL OF MOLECULAR BIOLOGY
(2017)
Article
Genetics & Heredity
Veroni S. Sri Theivakadadcham, Benjamin G. Bergey, Emanuel Rosonina
Review
Genetics & Heredity
Emanuel Rosonina
Article
Biochemistry & Molecular Biology
Marjan Moallem, Akhi Akhter, Giovanni L. Burke, John Babu, Benjamin G. Bergey, J. Bryan McNeil, Mohammad S. Baig, Emanuel Rosonina
Summary: Numerous proteins are sumoylated in normally growing yeast and SUMO conjugation levels rise upon exposure to several stress conditions. Reduced sumoylation is well-tolerated under nonstress conditions, but strains with reduced activity of Ubc9, the sole SUMO conjugase, are temperature-sensitive, implicating sumoylation in the heat stress response. Increased sumoylation is triggered by mild heat shock which requires functional levels of Ubc9 and decreased desumoylation. A ubc9 mutant strain with low sumoylation levels shows a growth defect, abnormal distribution of RNA polymerase II, and expanded redistribution of RNAPII after heat shock.
MOLECULAR AND CELLULAR BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Emanuel Rosonina, Akhi Akhter, Yimo Dou, John Babu, Veroni S. Sri Theivakadadcham
TRANSCRIPTION-AUSTIN
(2017)