Therapeutic expression of hairpins targeting apolipoprotein B100 induces phenotypic and transcriptome changes in murine liver

Optimization and comparison of knockdown efficacy between polymerase II expressed shRNA and artificial miRNA targeting luciferase and Apolipoprotein B100

(2012) Piotr Maczuga et al.   BMC BIOTECHNOLOGY

Fatty Acids - Induced Lipotoxicity and Inflammation

(2012) Stephane Savary et al.   CURRENT DRUG METABOLISM

Rescue of Mtp siRNA-induced hepatic steatosis by DGAT2 siRNA silencing

(2012) Samnang Tep et al.   JOURNAL OF LIPID RESEARCH

Safe, Long-term Hepatic Expression of Anti-HCV shRNA in a Nonhuman Primate Model

(2012) David A Suhy et al.   MOLECULAR THERAPY

Embedding siRNA sequences targeting Apolipoprotein B100 in shRNA and miRNA scaffolds results in differential processing and in vivo efficacy

(2012) Piotr Maczuga et al.   MOLECULAR THERAPY

Constitutive Expression of Short Hairpin RNA in Vivo Triggers Buildup of Mature Hairpin Molecules

(2011) M. Ahn et al.   HUMAN GENE THERAPY

Excessive activity of apolipoprotein B mRNA editing enzyme catalytic polypeptide 2 (APOBEC2) contributes to liver and lung tumorigenesis

(2011) Shunsuke Okuyama et al.   INTERNATIONAL JOURNAL OF CANCER

siRNA-induced liver ApoB knockdown lowers serum LDL-cholesterol in a mouse model with human-like serum lipids

(2011) Marija Tadin-Strapps et al.   JOURNAL OF LIPID RESEARCH

Rational Design of Therapeutic siRNAs: Minimizing Off-targeting Potential to Improve the Safety of RNAi Therapy for Huntington's Disease

(2011) Ryan L Boudreau et al.   MOLECULAR THERAPY

Apolipoprotein B Knockdown by AAV-delivered shRNA Lowers Plasma Cholesterol in Mice

(2011) Annemart Koornneef et al.   MOLECULAR THERAPY

siRNA Off-Target Effects Can Be Reduced at Concentrations That Match Their Individual Potency

(2011) Daniel R. Caffrey et al.   PLoS One

The dual-specificity MAP kinase phosphatases: critical roles in development and cancer

(2010) O. Bermudez et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Triglyceride lipases and atherosclerosis

(2010) Gunilla Olivecrona et al.   CURRENT OPINION IN LIPIDOLOGY

Nuclear receptor Nur77 suppresses inflammatory response dependent on COX-2 in macrophages induced by oxLDL

(2010) Qin Shao et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The STRING database in 2011: functional interaction networks of proteins, globally integrated and scored

(2010) D. Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Effect of apolipoprotein-B synthesis inhibition on liver triglyceride content in patients with familial hypercholesterolemia

(2009) Maartje E. Visser et al.   JOURNAL OF LIPID RESEARCH

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application

(2009) Aimee L. Jackson et al.   NATURE REVIEWS DRUG DISCOVERY

Short-hairpin RNAs delivered by lentiviral vector transduction trigger RIG-I-mediated IFN activation

(2009) Rachael Kenworthy et al.   NUCLEIC ACIDS RESEARCH

The nuclear receptors NUR77 and SF1 play additive roles with c-JUN through distinct elements on the mouse Star promoter

(2008) Luc J Martin et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Adeno-Associated Virus Vector Genomes Persist as Episomal Chromatin in Primate Muscle

(2008) M. Penaud-Budloo et al.   JOURNAL OF VIROLOGY

Expression of shRNA From a Tissue-specific pol II Promoter Is an Effective and Safe RNAi Therapeutic

(2008) Jeffery C Giering et al.   MOLECULAR THERAPY

Artificial MicroRNAs as siRNA Shuttles: Improved Safety as Compared to shRNAs In vitro and In vivo

(2008) Ryan L Boudreau et al.   MOLECULAR THERAPY

Sequence- and target-independent angiogenesis suppression by siRNA via TLR3

(2008) Mark E. Kleinman et al.   NATURE

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

(2008) Da Wei Huang et al.   NUCLEIC ACIDS RESEARCH

Artificial miRNAs mitigate shRNA-mediated toxicity in the brain: Implications for the therapeutic development of RNAi

(2008) J. L. McBride et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA