siRNA Off-Target Effects Can Be Reduced at Concentrations That Match Their Individual Potency

Origins and Mechanisms of miRNAs and siRNAs

(2009) Richard W. Carthew et al.   CELL

Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application

(2009) Aimee L. Jackson et al.   NATURE REVIEWS DRUG DISCOVERY

Novel recognition motifs and biological functions of the RNA-binding protein HuD revealed by genome-wide identification of its targets

(2009) Federico Bolognani et al.   NUCLEIC ACIDS RESEARCH

siRNA and Innate Immunity

(2009) Marjorie Robbins et al.   OLIGONUCLEOTIDES

mirWIP: microRNA target prediction based on microRNA-containing ribonucleoprotein–enriched transcripts

(2008) Molly Hammell et al.   NATURE METHODS

Detecting microRNA binding and siRNA off-target effects from expression data

(2008) Stijn van Dongen et al.   NATURE METHODS

The art and design of genetic screens: RNA interference

(2008) Michael Boutros et al.   NATURE REVIEWS GENETICS

Thermodynamic stability and Watson–Crick base pairing in the seed duplex are major determinants of the efficiency of the siRNA-based off-target effect

(2008) Kumiko Ui-Tei et al.   NUCLEIC ACIDS RESEARCH

In vitro reconstitution of the human RISC-loading complex

(2008) I. J. MacRae et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MOLECULAR BIOLOGY: Slicing and Dicing for Small RNAs

(2008) J. A. Birchler et al.   SCIENCE