The dual-specificity MAP kinase phosphatases: critical roles in development and cancer

Dual-specificity phosphatases: critical regulators with diverse cellular targets

(2015) Kate I. Patterson et al.   BIOCHEMICAL JOURNAL

Constitutive ERK MAPK Activity Regulates Macrophage ATP Production and Mitochondrial Integrity

(2014) M. M. Monick et al.   JOURNAL OF IMMUNOLOGY

Dual specificity phosphatase 6 (DUSP6) is an ETS-regulated negative feedback mediator of oncogenic ERK signaling in lung cancer cells

(2010) Zhenfeng Zhang et al.   CARCINOGENESIS

Down-Regulation of DUSP6 Expression in Lung Cancer

(2009) Koji Okudela et al.   AMERICAN JOURNAL OF PATHOLOGY

MKP1 repression is required for the chemosensitizing effects of NF-κB and PI3K inhibitors to cisplatin in non-small cell lung cancer

(2009) María Cortes-Sempere et al.   CANCER LETTERS

Biological Functions of miR-29b Contribute to Positive Regulation of Osteoblast Differentiation

(2009) Zhaoyong Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting the mTOR Signaling Network for Cancer Therapy

(2009) Funda Meric-Bernstam et al.   JOURNAL OF CLINICAL ONCOLOGY

Zebrafish chemical screening reveals an inhibitor of Dusp6 that expands cardiac cell lineages

(2009) Gabriela Molina et al.   Nature Chemical Biology

An integrated genomic analysis of lung cancer reveals loss of DUSP4 in EGFR-mutant tumors

(2009) D Chitale et al.   ONCOGENE

Medical and legal implications for necessary requirements to diagnose damaging hypoxic-ischemic encephalopathy leading to later cerebral palsy

(2008) Roger K. Freeman   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Histone H3 as a novel substrate for MAP kinase phosphatase-1

(2008) Corttrell M. Kinney et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Feedback regulation of DUSP6 transcription responding to MAPK1 via ETS2 in human cells

(2008) Toru Furukawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Identification of an ES cell pluripotent state-specific DUSP6 enhancer

(2008) Jiaxing Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Negative-feedback regulation of FGF signalling by DUSP6/MKP-3 is driven by ERK1/2 and mediated by Ets factor binding to a conserved site within theDUSP6/MKP-3gene promoter

(2008) Maria Ekerot et al.   BIOCHEMICAL JOURNAL

Dusp-5 and Snrk-1 coordinately function during vascular development and disease

(2008) K. Pramanik et al.   BLOOD

Dual-specificity MAP kinase phosphatases (MKPs) and cancer

(2008) Stephen M. Keyse   CANCER AND METASTASIS REVIEWS

Loss of MKP3 mediated by oxidative stress enhances tumorigenicity and chemoresistance of ovarian cancer cells

(2008) David W. Chan et al.   CARCINOGENESIS

The complexity of mitogen-activated protein kinases (MAPKs) made simple

(2008) M. Krishna et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Gene expression analysis of BCR/ABL1-dependent transcriptional response reveals enrichment for genes involved in negative feedback regulation

(2008) Petra Håkansson et al.   GENES CHROMOSOMES & CANCER

Negative and Positive Regulation of MAPK Phosphatase 3 Controls Platelet-derived Growth Factor-induced Erk Activation

(2008) Aleksandra Jurek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

T-cell Development and Function Are Modulated by Dual Specificity Phosphatase DUSP5

(2008) Panu E. Kovanen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epidermal Growth Factor Receptor and Protein Kinase C Signaling to ERK2

(2008) Christopher J. Caunt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DUSP6 (MKP3) Null Mice Show Enhanced ERK1/2 Phosphorylation at Baseline and Increased Myocyte Proliferation in the Heart Affecting Disease Susceptibility

(2008) Marjorie Maillet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acetylation of mitogen-activated protein kinase phosphatase-1 inhibits Toll-like receptor signaling

(2008) Wangsen Cao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

MKP-1 mRNA Stabilization and Translational Control by RNA-Binding Proteins HuR and NF90

(2008) Y. Kuwano et al.   MOLECULAR AND CELLULAR BIOLOGY

Genetic Complementation Screen Identifies a Mitogen-activated Protein Kinase Phosphatase, MKP3, as a Regulator of Dopamine Transporter Trafficking

(2008) Ole Valente Mortensen et al.   MOLECULAR BIOLOGY OF THE CELL

A cell-active inhibitor of mitogen-activated protein kinase phosphatases restores paclitaxel-induced apoptosis in dexamethasone-protected cancer cells

(2008) A. Vogt et al.   MOLECULAR CANCER THERAPEUTICS

Nitric oxide-proton stimulation of trigeminal ganglion neurons increases mitogen-activated protein kinase and phosphatase expression in neurons and satellite glial cells

(2008) S.E. Freeman et al.   NEUROSCIENCE

Post-translational regulation of the ERK phosphatase DUSP6/MKP3 by the mTOR pathway

(2008) O Bermudez et al.   ONCOGENE

High level of mitogen-activated protein kinase phosphatase-1 expression is associated with cisplatin resistance in osteosarcoma

(2008) Zhihong Wang et al.   PEDIATRIC BLOOD & CANCER

Mitogen-Activated Protein (MAP) Kinase/MAP Kinase Phosphatase Regulation: Roles in Cell Growth, Death, and Cancer

(2008) T. Boutros et al.   PHARMACOLOGICAL REVIEWS

Transcriptional profiling of endogenous germ layer precursor cells identifies dusp4 as an essential gene in zebrafish endoderm specification

(2008) J. L. Brown et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of TTP mRNA targets in human dendritic cells reveals TTP as a critical regulator of dendritic cell maturation

(2008) J. Emmons et al.   RNA

Acetylation of MKP-1 and the Control of Inflammation

(2008) H. Chi et al.   Science Signaling

DUSP6/MKP-3 inactivates ERK1/2 but fails to bind and inactivate ERK5

(2007) Rebecca S. Arkell et al.   CELLULAR SIGNALLING