标题
Targeting SH2 domains in breast cancer
作者
关键词
-
出版物
Future Medicinal Chemistry
Volume 6, Issue 17, Pages 1909-1926
出版商
Future Science, LTD
发表日期
2014-12-16
DOI
10.4155/fmc.14.120
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Comparisons of the Efficacy of a Jak1/2 Inhibitor (AZD1480) with a VEGF Signaling Inhibitor (Cediranib) and Sham Treatments in Mouse Tumors Using DCE-MRI, DW-MRI, and Histology
- (2015) Mary E. Loveless et al. NEOPLASIA
- Design and testing of bicyclic inhibitors of Grb7-are two cycles better than one?
- (2013) Menachem J. Gunzburg et al. BIOPOLYMERS
- A Novel Inhibitor of STAT3 Homodimerization Selectively Suppresses STAT3 Activity and Malignant Transformation
- (2013) X. Zhang et al. CANCER RESEARCH
- Inhibiting Aberrant Signal Transducer and Activator of Transcription Protein Activation with Tetrapodal, Small Molecule Src Homology 2 Domain Binders: Promising Agents against Multiple Myeloma
- (2013) Brent D. G. Page et al. JOURNAL OF MEDICINAL CHEMISTRY
- Genome Wide Proteomics of ERBB2 and EGFR and Other Oncogenic Pathways in Inflammatory Breast Cancer
- (2013) Emma Yue Zhang et al. JOURNAL OF PROTEOME RESEARCH
- Therapeutic modulators of STAT signalling for human diseases
- (2013) Gabriella Miklossy et al. NATURE REVIEWS DRUG DISCOVERY
- Development of new N-arylbenzamides as STAT3 dimerization inhibitors
- (2013) Murali K. Urlam et al. MedChemComm
- Potential of Selective Estrogen Receptor Modulators as Treatments and Preventives of Breast Cancer
- (2012) Jing Peng et al. Anti-Cancer Agents in Medicinal Chemistry
- The Discovery of Phenylbenzamide Derivatives as Grb7-Based Antitumor Agents
- (2012) Nigus D. Ambaye et al. ChemMedChem
- Metronomic Activity of CD44-Targeted Hyaluronic Acid-Paclitaxel in Ovarian Carcinoma
- (2012) S. J. Lee et al. CLINICAL CANCER RESEARCH
- Structure–Activity Studies of Phosphopeptidomimetic Prodrugs Targeting the Src Homology 2 (SH2) Domain of Signal Transducer and Activator of Transcription 3 (Stat3)
- (2012) Pijus K. Mandal et al. International Journal of Peptide Research and Therapeutics
- Comprehensive molecular portraits of human breast tumours
- (2012) Daniel C. Koboldt et al. NATURE
- STAT3 Is Activated by JAK2 Independent of Key Oncogenic Driver Mutations in Non-Small Cell Lung Carcinoma
- (2012) Brendan D. Looyenga et al. PLoS One
- Anti-Angiogenic Activity of a Small Molecule STAT3 Inhibitor LLL12
- (2012) Hemant K. Bid et al. PLoS One
- Selective Small Molecule Stat3 Inhibitor Reduces Breast Cancer Tumor-Initiating Cells and Improves Recurrence Free Survival in a Human-Xenograft Model
- (2012) Bhuvanesh Dave et al. PLoS One
- Orally bioavailable small-molecule inhibitor of transcription factor Stat3 regresses human breast and lung cancer xenografts
- (2012) X. Zhang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- GRB7 is required for triple-negative breast cancer cell invasion and survival
- (2011) Orsi Giricz et al. BREAST CANCER RESEARCH AND TREATMENT
- Genomic predictors of response to doxorubicin versus docetaxel in primary breast cancer
- (2011) M. Martin et al. BREAST CANCER RESEARCH AND TREATMENT
- Antiangiogenic and Antimetastatic Activity of JAK Inhibitor AZD1480
- (2011) H. Xin et al. CANCER RESEARCH
- Relationship between Quantitative GRB7 RNA Expression and Recurrence after Adjuvant Anthracycline Chemotherapy in Triple-Negative Breast Cancer
- (2011) J. A. Sparano et al. CLINICAL CANCER RESEARCH
- Interleukin-6 as a Therapeutic Target in Human Ovarian Cancer
- (2011) Jermaine Coward et al. CLINICAL CANCER RESEARCH
- STAT-3 Inhibitors: State of the Art and New Horizons for Cancer Treatment
- (2011) A. Lavecchia et al. CURRENT MEDICINAL CHEMISTRY
- The JAK2/STAT3 signaling pathway is required for growth of CD44+CD24– stem cell–like breast cancer cells in human tumors
- (2011) Lauren L.C. Marotta et al. JOURNAL OF CLINICAL INVESTIGATION
- Breast cancer stem cell markers CD44, CD24 and ALDH1: expression distribution within intrinsic molecular subtype
- (2011) S. Ricardo et al. JOURNAL OF CLINICAL PATHOLOGY
- Potent and Selective Phosphopeptide Mimetic Prodrugs Targeted to the Src Homology 2 (SH2) Domain of Signal Transducer and Activator of Transcription 3
- (2011) Pijus K. Mandal et al. JOURNAL OF MEDICINAL CHEMISTRY
- Structural Basis of Binding by Cyclic Nonphosphorylated Peptide Antagonists of Grb7 Implicated in Breast Cancer Progression
- (2011) Nigus D. Ambaye et al. JOURNAL OF MOLECULAR BIOLOGY
- Treatment of HER2-positive breast cancer: current status and future perspectives
- (2011) Carlos L. Arteaga et al. Nature Reviews Clinical Oncology
- Inhibiting aberrant Stat3 function with molecular therapeutics
- (2010) Sina Haftchenary et al. ANTI-CANCER DRUGS
- A novel small-molecule disrupts Stat3 SH2 domain–phosphotyrosine interactions and Stat3-dependent tumor processes
- (2010) Xiaolei Zhang et al. BIOCHEMICAL PHARMACOLOGY
- Design, synthesis, and in vitro characterization of novel hybrid peptidomimetic inhibitors of STAT3 protein
- (2010) Vijay M. Shahani et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Benzopyrazine derivatives: A novel class of growth factor receptor bound protein 7 antagonists
- (2010) Nigus D. Ambaye et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Uptake of a cell permeable G7-18NATE construct into cells and binding with the Grb7-SH2 domain
- (2010) Nigus D. Ambaye et al. BIOPOLYMERS
- Heterogeneity for Stem Cell-Related Markers According to Tumor Subtype and Histologic Stage in Breast Cancer
- (2010) S. Y. Park et al. CLINICAL CANCER RESEARCH
- Discovery of PDK1 Kinase Inhibitors with a Novel Mechanism of Action by Ultrahigh Throughput Screening
- (2010) Ekaterina V. Bobkova et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Discovery of 5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine (AZD1480) as a Novel Inhibitor of the Jak/Stat Pathway
- (2010) Stephanos Ioannidis et al. JOURNAL OF MEDICINAL CHEMISTRY
- The novel JAK inhibitor AZD1480 blocks STAT3 and FGFR3 signaling, resulting in suppression of human myeloma cell growth and survival
- (2010) A Scuto et al. LEUKEMIA
- Perspectives on medicinal properties of plumbagin and its analogs
- (2010) Subhash Padhye et al. MEDICINAL RESEARCH REVIEWS
- Deconstructing the molecular portraits of breast cancer
- (2010) Aleix Prat et al. Molecular Oncology
- Triple-Negative Breast Cancer
- (2010) William D. Foulkes et al. NEW ENGLAND JOURNAL OF MEDICINE
- Identification of a New Series of STAT3 Inhibitors by Virtual Screening
- (2010) Kenji Matsuno et al. ACS Medicinal Chemistry Letters
- The JAK2 Inhibitor AZD1480 Potently Blocks Stat3 Signaling and Oncogenesis in Solid Tumors
- (2009) Michael Hedvat et al. CANCER CELL
- Disruption of Transcriptionally Active Stat3 Dimers with Non-phosphorylated, Salicylic Acid-Based Small Molecules: Potent in vitro and Tumor Cell Activities
- (2009) Steven Fletcher et al. CHEMBIOCHEM
- Aldehyde Dehydrogenase 1-Positive Cancer Stem Cells Mediate Metastasis and Poor Clinical Outcome in Inflammatory Breast Cancer
- (2009) E. Charafe-Jauffret et al. CLINICAL CANCER RESEARCH
- Cryptotanshinone, a lipophilic compound of Salvia miltiorrriza root, inhibits TNF-α-induced expression of adhesion molecules in HUVEC and attenuates rat myocardial ischemia/reperfusion injury in vivo
- (2009) Yong Chun Jin et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Supervised Risk Predictor of Breast Cancer Based on Intrinsic Subtypes
- (2009) Joel S. Parker et al. JOURNAL OF CLINICAL ONCOLOGY
- Structure−Affinity Relationships of Glutamine Mimics Incorporated into Phosphopeptides Targeted to the SH2 Domain of Signal Transducer and Activator of Transcription 3
- (2009) Pijus K. Mandal et al. JOURNAL OF MEDICINAL CHEMISTRY
- Conformationally Constrained Peptidomimetic Inhibitors of Signal Transducer and Activator of Transcription 3: Evaluation and Molecular Modeling
- (2009) Pijus K. Mandal et al. JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis of Phosphatase-Stable, Cell-Permeable Peptidomimetic Prodrugs That Target the SH2 Domain of Stat3
- (2009) Pijus K. Mandal et al. ORGANIC LETTERS
- Chemical Probes that Competitively and Selectively Inhibit Stat3 Activation
- (2009) Xuejun Xu et al. PLoS One
- Cryptotanshinone Inhibits Constitutive Signal Transducer and Activator of Transcription 3 Function through Blocking the Dimerization in DU145 Prostate Cancer Cells
- (2008) D.-S. Shin et al. CANCER RESEARCH
- STAT 3 as a Target for Cancer Drug Discovery
- (2008) Luca Costantino et al. CURRENT MEDICINAL CHEMISTRY
- Grb2 signaling in cell motility and cancer
- (2008) Alessio Giubellino et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- Advances in Adjuvant Endocrine Therapy for Postmenopausal Women
- (2008) Nancy U. Lin et al. JOURNAL OF CLINICAL ONCOLOGY
- Cryptotanshinone protects primary rat cortical neurons from glutamate-induced neurotoxicity via the activation of the phosphatidylinositol 3-kinase/Akt signaling pathway
- (2008) Fangyan Zhang et al. EXPERIMENTAL BRAIN RESEARCH
- Design, synthesis, and studies of small molecule STAT3 inhibitors
- (2007) Deepak Bhasin et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now