Structure–Activity Studies of Phosphopeptidomimetic Prodrugs Targeting the Src Homology 2 (SH2) Domain of Signal Transducer and Activator of Transcription 3 (Stat3)
出版年份 2012 全文链接
标题
Structure–Activity Studies of Phosphopeptidomimetic Prodrugs Targeting the Src Homology 2 (SH2) Domain of Signal Transducer and Activator of Transcription 3 (Stat3)
作者
关键词
Signal transducer and activator of transcription 3, Stat3, Src homology domain 2, SH2 domain, Peptidomimetic, Phosphopeptide, Prodrug
出版物
International Journal of Peptide Research and Therapeutics
Volume 19, Issue 1, Pages 3-12
出版商
Springer Nature
发表日期
2012-07-07
DOI
10.1007/s10989-012-9313-0
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- STAT3 Is Activated by JAK2 Independent of Key Oncogenic Driver Mutations in Non-Small Cell Lung Carcinoma
- (2012) Brendan D. Looyenga et al. PLoS One
- Potent and Selective Phosphopeptide Mimetic Prodrugs Targeted to the Src Homology 2 (SH2) Domain of Signal Transducer and Activator of Transcription 3
- (2011) Pijus K. Mandal et al. JOURNAL OF MEDICINAL CHEMISTRY
- A novel small-molecule disrupts Stat3 SH2 domain–phosphotyrosine interactions and Stat3-dependent tumor processes
- (2010) Xiaolei Zhang et al. BIOCHEMICAL PHARMACOLOGY
- Design, synthesis, and in vitro characterization of novel hybrid peptidomimetic inhibitors of STAT3 protein
- (2010) Vijay M. Shahani et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Identification of Purine-Scaffold Small-Molecule Inhibitors of Stat3 Activation by QSAR Studies
- (2010) Vijay M. Shahani et al. ACS Medicinal Chemistry Letters
- Structure-Based Design of Conformationally Constrained, Cell-Permeable STAT3 Inhibitors
- (2010) Jianyong Chen et al. ACS Medicinal Chemistry Letters
- The JAK2 Inhibitor AZD1480 Potently Blocks Stat3 Signaling and Oncogenesis in Solid Tumors
- (2009) Michael Hedvat et al. CANCER CELL
- Disruption of Transcriptionally Active Stat3 Dimers with Non-phosphorylated, Salicylic Acid-Based Small Molecules: Potent in vitro and Tumor Cell Activities
- (2009) Steven Fletcher et al. CHEMBIOCHEM
- Structure−Affinity Relationships of Glutamine Mimics Incorporated into Phosphopeptides Targeted to the SH2 Domain of Signal Transducer and Activator of Transcription 3
- (2009) Pijus K. Mandal et al. JOURNAL OF MEDICINAL CHEMISTRY
- Conformationally Constrained Peptidomimetic Inhibitors of Signal Transducer and Activator of Transcription 3: Evaluation and Molecular Modeling
- (2009) Pijus K. Mandal et al. JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis of Phosphatase-Stable, Cell-Permeable Peptidomimetic Prodrugs That Target the SH2 Domain of Stat3
- (2009) Pijus K. Mandal et al. ORGANIC LETTERS
- Stereoelectronic effects on the transition barrier of polyproline conformational interconversion
- (2009) Yi-Chun Chiang et al. PROTEIN SCIENCE
- Targeting Protein-Protein Interactions: Suppression of Stat3 Dimerization with Rationally Designed Small-Molecule, Nonpeptidic SH2 Domain Binders
- (2008) Patrick T. Gunning et al. CHEMBIOCHEM
- Molecular Approaches towards the Inhibition of the Signal Transducer and Activator of Transcription 3 (Stat3) Protein
- (2008) Steven Fletcher et al. ChemMedChem
- Prodrugs of Phosphates and Phosphonates
- (2008) Scott J. Hecker et al. JOURNAL OF MEDICINAL CHEMISTRY
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