Evidence-based support for the use of proton pump inhibitors in cancer therapy

Proton channels and exchangers in cancer

(2015) Enrico Pierluigi Spugnini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Global cancer statistics, 2012

(2015) Lindsey A. Torre et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Lansoprazole induces sensitivity to suboptimal doses of paclitaxel in human melanoma

(2015) Tommaso Azzarito et al.   CANCER LETTERS

Proton pump inhibitors while belonging to the same family of generic drugs show different anti-tumor effect

(2015) Luana Lugini et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Intermittent high dose proton pump inhibitor enhances the antitumor effects of chemotherapy in metastatic breast cancer

(2015) Bi-Yun Wang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Paradoxically Augmented Anti-Tumorigenic Action of Proton Pump Inhibitor and Gastrin in APCMin/+ Intestinal Polyposis Model1

(2015) Young-Min Han et al.   NEOPLASIA

Microenvironmental acidosis in carcinogenesis and metastases: new strategies in prevention and therapy

(2014) Stefano Fais et al.   CANCER AND METASTASIS REVIEWS

Proton Pump Inhibitors and Histamine 2 Blockers Are Associated with Improved Overall Survival in Patients with Head and Neck Squamous Carcinoma

(2014) S. Papagerakis et al.   Cancer Prevention Research

High dose lansoprazole combined with metronomic chemotherapy: a phase I/II study in companion animals with spontaneously occurring tumors

(2014) Enrico P Spugnini et al.   Journal of Translational Medicine

V-ATPase Inhibition Regulates Anoikis Resistance and Metastasis of Cancer Cells

(2014) C. M. Schempp et al.   MOLECULAR CANCER THERAPEUTICS

Atp6v1c1 May Regulate Filament Actin Arrangement in Breast Cancer Cells

(2014) Shengmei Feng et al.   PLoS One

Regulation of endothelial signaling and migration by v-ATPase

(2013) Sebastian Rath et al.   ANGIOGENESIS

The role of proton dynamics in the development and maintenance of multidrug resistance in cancer

(2013) Chloë Daniel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

V-ATPase is a candidate therapeutic target for Ewing sarcoma

(2013) Sofia Avnet et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The expression of V-ATPase is associated with drug resistance and pathology of non-small-cell lung cancer

(2013) Qiang Lu et al.   Diagnostic Pathology

V-ATPase as an effective therapeutic target for sarcomas

(2013) Francesca Perut et al.   EXPERIMENTAL CELL RESEARCH

Silencing of Atp6v1c1 Prevents Breast Cancer Growth and Bone Metastasis

(2013) Shengmei Feng et al.   International Journal of Biological Sciences

Cariporide and other new and powerful NHE1 inhibitors as potentially selective anticancer drugs – an integral molecular/biochemical/metabolic/clinical approach after one hundred years of cancer research

(2013) Salvador Harguindey et al.   Journal of Translational Medicine

Proton pump inhibitor chemosensitization in human osteosarcoma: from the bench to the patients’ bed

(2013) Stefano Ferrari et al.   Journal of Translational Medicine

V-ATPase inhibition overcomes trastuzumab resistance in breast cancer

(2013) Karin von Schwarzenberg et al.   Molecular Oncology

Modulation of Microenvironment Acidity Reverses Anergy in Human and Murine Tumor-Infiltrating T Lymphocytes

(2012) A. Calcinotto et al.   CANCER RESEARCH

Expression and functional role of vacuolar H+-ATPase in human hepatocellular carcinoma

(2012) J. Xu et al.   CARCINOGENESIS

ABCG2/V-ATPase was associated with the drug resistance and tumor metastasis of esophageal squamous cancer cells

(2012) Lijun Huang et al.   Diagnostic Pathology

Epigenetic mechanisms in tumorigenesis, tumor cell heterogeneity and drug resistance

(2012) Roel H. Wilting et al.   DRUG RESISTANCE UPDATES

Mode of Cell Death Induction by Pharmacological Vacuolar H+-ATPase (V-ATPase) Inhibition

(2012) Karin von Schwarzenberg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

V-ATPase engagement in autophagic processes

(2011) Dalibor Mijaljica et al.   Autophagy

Immunohistochemical localization of C1 subunit of V-ATPase (ATPase C1) in oral squamous cell cancer and normal oral mucosa

(2011) A García-García et al.   BIOTECHNIC & HISTOCHEMISTRY

Lansoprazole as a rescue agent in chemoresistant tumors: a phase I/II study in companion animals with spontaneously occurring tumors

(2011) Enrico P Spugnini et al.   Journal of Translational Medicine

The vacuolar-ATPase modulates matrix metalloproteinase isoforms in human pancreatic cancer

(2011) Chuhan Chung et al.   LABORATORY INVESTIGATION

Drug Resistance and Cellular Adaptation to Tumor Acidic pH Microenvironment

(2011) Jonathan W. Wojtkowiak et al.   MOLECULAR PHARMACEUTICS

mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase

(2011) R. Zoncu et al.   SCIENCE

Measurement of ATP6V1C1 expression in brush cytology samples as a diagnostic and prognostic marker in oral squamous cell carcinoma

(2010) Mario Pérez-Sayáns et al.   CANCER BIOLOGY & THERAPY

Multidrug resistance in oral squamous cell carcinoma: The role of vacuolar ATPases

(2010) Mario Pérez-Sayáns et al.   CANCER LETTERS

Proton dynamics in cancer

(2010) Veronica Huber et al.   Journal of Translational Medicine

Small interfering RNA targeting the subunit ATP6L of proton pump V-ATPase overcomes chemoresistance of breast cancer cells

(2009) Haiyan You et al.   CANCER LETTERS

Proton pump inhibitors: actions and reactions

(2009) James M. Mullin et al.   DRUG DISCOVERY TODAY

pH-dependent antitumor activity of proton pump inhibitors against human melanoma is mediated by inhibition of tumor acidity

(2009) Angelo De Milito et al.   INTERNATIONAL JOURNAL OF CANCER

Role of V-ATPases in solid tumors: Importance of the subunit C (Review)

(2009) Pérez-Sayáns   INTERNATIONAL JOURNAL OF ONCOLOGY

A change of strategy in the war on cancer

(2009) Robert A. Gatenby   NATURE