Article
Chemistry, Multidisciplinary
Lanlan Li, Yongchang Ma, Yi Hu, Pengfei Wang, Songling Han, Xiangjun Zhang, Jianxiang Zhang
Summary: This article reports a targeted treatment method for asthma using a cyclic oligosaccharide-derived nanotherapy. The treatment effectively alleviates oxidative stress, suppresses inflammatory responses, reverses airway remodelling, and improves pulmonary function. The method shows promising results for the treatment of eosinophilic and neutrophilic asthma.
Article
Immunology
Jan Philipp Kolman, Laia Pagerols Raluy, Ingo Mueller, Viacheslav O. Nikolaev, Magdalena Trochimiuk, Birgit Appl, Hannah Wadehn, Charlotte Maria Duecker, Fabian David Stoll, Michael Boettcher, Konrad Reinshagen, Julian Trah
Summary: In this study, the researchers investigated the effect of different culture conditions, including the use of G-CSF, LPS, or TNF-alpha, on the survival and NET formation of neutrophils. They found that untreated neutrophils could form NETs after stimulation with PMA for up to 24 hours. Incubation with LPS or G-CSF extended the ability of neutrophils to form NETs for up to 48 hours, with LPS leading to significantly higher NET release at 48 hours compared to untreated cells. TNF-alpha had no influence on NET release but altered the survival counts of neutrophils.
FRONTIERS IN IMMUNOLOGY
(2022)
Editorial Material
Oncology
Phei Er Saw, Jianing Chen, Erwei Song
Summary: Neutrophil extracellular traps (NETs) are involved in both infection control and tumor metastasis. The study by Mousset et al. published in Cancer Cell reveals that chemotherapy-induced inflammation promotes NETosis in malignant tumors, leading to chemoresistance. This finding highlights the potential of targeting inflammatory NETs for cancer treatment.
Article
Medicine, Research & Experimental
Rachita Panda, Fernanda V. S. Castanheira, Jared M. Schlechte, Bas G. J. Surewaard, Hanjoo Brian Shim, Amanda Z. Zucoloto, Zdenka Slavikova, Bryan G. Yipp, Paul Kubes, Braedon McDonald
Summary: Acute respiratory distress syndrome (ARDS) is a life-threatening syndrome caused by immune activation and resulting lung damage. SARS-CoV-2 infection has become the main cause of ARDS worldwide, and neutrophils and their effector functions are believed to drive immune-mediated lung injury in COVID-19 ARDS. A study found that COVID-19 ARDS patients have a distinct functional landscape of neutrophils, providing a potential target for adjunctive immunotherapy.
Review
Biochemistry & Molecular Biology
Giacomo Buso, Elisabetta Faggin, Nathalie Rosenblatt-Velin, Maxime Pellegrin, Silvia Galliazzo, Luca Calanca, Marcello Rattazzi, Lucia Mazzolai
Summary: In recent years, the role of neutrophils in cardiovascular disease (CVD) has received increasing attention. Neutrophils have been found to play a role in the initiation, progression, and rupture of atherosclerotic plaque. While there has been extensive research on the role of neutrophils in coronary artery and cerebrovascular diseases, there is limited information available on their role in peripheral artery disease (PAD). This review aims to summarize the current understanding of neutrophil biology, their role in atherosclerosis, and the available evidence on their role in PAD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Michio Okamoto, Rei Mizuno, Kenji Kawada, Yoshiro Itatani, Yoshiyuki Kiyasu, Keita Hanada, Wataru Hirata, Yasuyo Nishikawa, Hideyuki Masui, Naoko Sugimoto, Takuya Tamura, Susumu Inamoto, Yoshiharu Sakai, Kazutaka Obama
Summary: This study investigated the expression and clinical relevance of neutrophil extracellular traps (NETs) in colorectal cancers (CRCs). The results showed that high expression of intratumoral or systemic NETs correlated with poor relapse-free survival (RFS) in CRC patients. In vitro and in vivo experiments demonstrated that NETs promoted CRC cell migration mediated by neutrophil elastase (NE), and NE inhibition suppressed liver metastases in CRC cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Hannes A. Baukmann, Justin L. Cope, Colin Bannard, Alexander R. E. C. Schwinges, Margaretha R. J. Lamparter, Sarah Groves, Charles N. J. Ravarani, Borko Amulic, Joern E. Klinger, Marco F. Schmidt
Summary: Despite the availability of vaccines to prevent SARS-CoV-2 infection, treating critically ill COVID-19 patients remains crucial. This study presents an alternative method for identifying drug repurposing targets by screening disease-causing traits, leading to the discovery of potential treatment targets for critical illness.
Review
Biochemistry & Molecular Biology
Marina Stoimenou, Georgios Tzoros, Panagiotis Skendros, Akrivi Chrysanthopoulou
Summary: Several studies suggest that NETs may play a role in inflammatory and thrombotic disorders, thus serving as potential therapeutic or diagnostic tools. This article compares commonly used techniques for assessing NET formation and discusses the challenges and advantages in evaluating NETs. The review provides insights into the molecular analysis of NETs in translational medicine today.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Microbiology
Luz E. Cabrera, Pirkka T. Pekkarinen, Maria Alander, Kirsten H. A. Nowlan, Ngoc Anh Nguyen, Suvi Jokiranta, Suvi Kuivanen, Anu Patjas, Sointu Mero, Sari H. Pakkanen, Santtu Heinonen, Anu Kantele, Olli Vapalahti, Eliisa Kekalainen, Tomas Strandin
Summary: This study identifies a population of low-density granulocytes (LDGs) in COVID-19 patients, which exhibit immature phenotypes and immunosuppressive characteristics, possibly contributing to disease progression. These findings suggest that LDG may play a role in severe COVID-19 characterized by extensive pulmonary complications.
Editorial Material
Medicine, Research & Experimental
Erin B. Taylor
Summary: This article discusses the importance of dysregulation of neutrophil extracellular trap formation in viral infections and explores treatment methods targeting NET formation.
Article
Environmental Sciences
Xuying Lv, Zixuan Liu, Lei Xu, Erqun Song, Yang Song
Summary: The possible immunotoxicity of TCBQ, a common metabolite of persistent organic pollutants PCP and HCB, remains unclear. Recent studies have shown that TCBQ can induce the formation of NETs in a ROS-dependent manner, with activation of JNK and NOX2 contributing to the process. Targeting NETs formation may be a promising therapeutic strategy in modulating the immunotoxicity of TCBQ.
ENVIRONMENTAL POLLUTION
(2021)
Article
Hematology
Agostina Carestia, Laura C. Godin, Craig N. Jenne
Summary: Platelets play a crucial role in immunity and coagulation, able to detect, interact with, and kill pathogens. They induce the formation of microthrombi to prevent pathogen spread and facilitate clearance in the process of immunothrombosis.
THROMBOSIS RESEARCH
(2023)
Review
Immunology
Edgar Ramos-Martinez, Leticia Hernandez-Gonzalez, Ivan Ramos-Martinez, Laura Perez-Campos Mayoral, Georgina Lopez-Cortes, Eduardo Perez-Campos, Gabriel Mayoral Andrade, Maria Teresa Hernandez-Huerta, Marco Jose
Summary: Extracellular DNA traps (ETs) are evolutionarily conserved antimicrobial mechanisms found in protozoa, plants, and animals. By comparing similarities in ETs across different taxa, it is suggested that ETs may have multiple origins. The presence of a mechanism initiating the formation of ETs in multicellular organisms indicates a relationship between multicellularity and the development of ETs.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Hematology
Camila Meirelles S. Silva, Carlos Wagner S. Wanderley, Flavio P. Veras, Fabiane Sonego, Daniele C. Nascimento, Augusto V. Goncalves, Timna V. Martins, David F. Colon, Vanessa F. Borges, Veronica S. Brauer, Luis Eduardo A. Damasceno, Katiussia P. Silva, Juliana E. Toller-Kawahisa, Sabrina S. Batah, Ana Leticia J. Souza, Valter S. Monteiro, Antonio Edson R. Oliveira, Paula B. Donate, Daniel Zoppi, Marcos C. Borges, Fausto Almeida, Helder I. Nakaya, Alexandre T. Fabro, Thiago M. Cunha, Jose Carlos Alves-Filho, Dario S. Zamboni, Fernando Q. Cunha
Summary: Research has shown that inhibition of the pore-forming protein GSDMD can reduce the formation of NETs during sepsis, thereby decreasing multiple organ dysfunction and sepsis lethality. This suggests that GSDMD could be a therapeutic target for improving sepsis treatment.
Review
Cell Biology
Fei Chen, Min Yu, Yonghong Zhong, Lina Wang, Huaqiong Huang
Summary: Asthma is a common chronic respiratory disease with increasing incidence. Neutrophil extracellular traps (NETs) play a significant role in asthma by enriching anti-bacterial substances and limiting pathogen migration, but they may also exacerbate asthma progression.
Article
Dentistry, Oral Surgery & Medicine
Roberta Grimaldi, Zehra Yonel, Iain Chapple, Andrew Butler, Claire Hall, Klaus Reinbold, Maria Mantzourani
Summary: This study aimed to evaluate the plaque removal efficacy of four marketed toothbrushes, finding that all toothbrushes provided significant plaque removal after single brushing events, with Toothbrushes A and B showing significant reductions at 7 and 28 days, Toothbrush C showing no significant differences, and Toothbrush D significantly reducing plaque at both time points.
JOURNAL OF DENTISTRY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Tayse Caroline Cunha de Medeiros, Alessandra Areas e Souza, Rodolfo Coelho Prates, Iain Chapple, Joao Paulo Steffens
Summary: This study found an association between systemic non-communicable diseases and tooth loss in Brazilian adults. Risk factors such as diabetes, smoking, and a cariogenic diet were significantly related to tooth loss. Regular consumption of vegetables, fruits, and beef, moderate alcohol intake, and physical exercise were associated with a lower risk of tooth loss. Obesity and other diseases may also increase the risk of tooth loss in individuals with diabetes.
JOURNAL OF PERIODONTOLOGY
(2022)
Article
Respiratory System
Hayley Holt, Mohammad Talaei, Matthew Greenig, Dominik Zenner, Jane Symons, Clare Relton, Katherine S. Young, Molly R. Davies, Katherine N. Thompson, Jed Ashman, Sultan Saeed Rajpoot, Ahmed Ali Kayyale, Sarah El Rifai, Philippa J. Lloyd, David Jolliffe, Olivia Timmis, Sarah Finer, Stamatina Iliodromiti, Alec Miners, Nicholas S. Hopkinson, Bodrul Alam, Graham Lloyd-Jones, Thomas Dietrich, Iain Chapple, Paul E. Pfeffer, David McCoy, Gwyneth Davies, Ronan A. Lyons, Christopher Griffiths, Frank Kee, Aziz Sheikh, Gerome Breen, Seif O. Shaheen, Adrian R. Martineau
Summary: The study found that Asian/Asian British ethnicity and a higher body mass index were associated with an increased odds of developing COVID-19, while atopic disease was associated with decreased odds.
Article
Dentistry, Oral Surgery & Medicine
Melissa M. Grant, John J. Taylor, Katrin Jaedicke, Andrew Creese, Catherine Gowland, Bernard Burke, Khawla Doudin, Upen Patel, Paul Weston, Michael Milward, Susan M. Bissett, Helen J. Cooper, Gerben Kooijman, Amir Rmaile, Marko de Jager, Philip M. Preshaw, Iain L. C. Chapple
Summary: Differential protein biomarkers in saliva and gingival crevicular fluid can be used to objectively distinguish between periodontal health and disease states.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2022)
Article
Environmental Sciences
Helen M. Roberts, Zehra Yonel, Alpdogan Kantarci, Melissa M. Grant, Iain L. C. Chapple
Summary: This study aimed to investigate the impact of experimental gingivitis on the function of peripheral blood neutrophils (PBN). The results showed that experimental gingivitis had a lasting effect on the function of neutrophils, even after clinical symptoms disappeared.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Dentistry, Oral Surgery & Medicine
Z. Yonel, T. Kocher, I. L. C. Chapple, T. Dietrich, H. Voelzke, M. Nauck, G. Collins, L. J. Gray, B. Holtfreter
Summary: The study aims to develop and validate a score in dental settings to identify individuals at risk of undiagnosed nondiabetic hyperglycemia or type 2 diabetes. The model includes several variables such as age, sex, body mass index, smoking status, and dental factors. The predictive performance and clinical utility of the model were assessed.
JOURNAL OF DENTAL RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Paola de Pablo, Stefan Serban, Isabel Lopez-Oliva, Joanna Rooney, Kirsty Hill, Karim Raza, Andrew Filer, Iain Chapple, Thomas Dietrich
Summary: This study investigated the impact of periodontal treatment on disease activity in patients with active rheumatoid arthritis (RA) through a randomized controlled trial. The results showed that periodontal therapy can significantly improve periodontal disease outcomes and overall RA disease activity, although complete resolution of periodontal inflammation was difficult to achieve in some cases.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Praveen Sharma, Caroline Kristunas, Iain L. Chapple, Thomas Dietrich
Summary: This study investigates the associations between periodontal health and patient-reported outcomes in a large non-specialist dental practice patient cohort, considering changes over time. The results show that worsening periodontal health is associated with increased odds of oral pain/discomfort, dietary restrictions, and poor dental appearance.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
David Herrera, Tord Berglundh, Frank Schwarz, Iain Chapple, Soren Jepsen, Anton Sculean, Moritz Kebschull, Panos N. Papapanou, Maurizio S. Tonetti, Mariano Sanz
Summary: This study aims to develop clinical practice guidelines for the prevention and treatment of peri-implant diseases, emphasizing the need for interdisciplinary approaches and interventions at different stages. The guidelines provide recommendations for maintaining healthy peri-implant tissues and managing peri-implant diseases.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Melissa M. M. Grant, Ann E. E. Scott, John B. B. Matthews, Helen R. R. Griffiths, Iain L. C. Chapple
Summary: Curcumin can decrease inflammatory response induced by oral bacterium and be potentially useful in treating gingivitis. Its mechanism of action involves the modulation of transcription factors and enzymes related to the inflammatory cascade.
JOURNAL OF PERIODONTAL RESEARCH
(2023)
Review
Dentistry, Oral Surgery & Medicine
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira
Summary: Neutrophils, also called granulocytes, are myeloid cells that play a critical role in acute and chronic inflammation, as well as wound healing. They express a variety of surface receptors to facilitate their migration, recognition, and destruction of pathogens or damaged tissues. Neutrophils can undergo different forms of programmed cell death and exhibit heterogeneous behavior and biological repertoire.
PERIODONTOLOGY 2000
(2023)
Article
Dentistry, Oral Surgery & Medicine
Beant Singh Thandi, Rosemarie Jane, Vinay Chavda, Iain L. C. Chapple
Summary: This case report describes the successful diagnosis and management of a rare condition called non-ulcerating necrotising sialometaplasia, which was confounded by a simultaneous episode of pericoronitis. The importance of investigating suspicious lesions and listening to patients' complaints is emphasized.
BRITISH DENTAL JOURNAL
(2023)
Article
Infectious Diseases
Sian E. Faustini, Alex Cook, Harriet Hill, Saly Al-Taei, Jennifer Heaney, Elena Efstathiou, Chloe Tanner, Neal Townsend, Zahra Ahmed, Mohammad Dinally, Madeeha Hoque, Margaret Goodall, Zania Stamataki, Timothy Plant, Iain Chapple, Pitch Consortium, Adrian M. Shields, Alex G. Richter
Summary: This study investigated the importance of salivary SARS-CoV-2 antibodies and found that salivary antibody responses differ from serum antibody responses, typically lacking neutralizing activity. While saliva is an attractive non-invasive surveillance tool, it cannot be used as a proxy for serum antibody measurement.
JOURNAL OF INFECTION
(2023)
Review
Dentistry, Oral Surgery & Medicine
P. A. Miguez, E. Bash, M. L. Musskopf, S. A. Tuin, A. Rivera-Concepcion, I. L. C. Chapple, J. Liu
Summary: Proteoglycans are core proteins associated with highly variable carbohydrate/sugar moieties. These carbohydrates, named glycosaminoglycans, play multiple roles in inflammation, immunity, and tissue structure. Heparan sulfate, a highly sulfated polysaccharide, has been found to be involved in regulating interactions between damage associated molecular patterns and inflammatory receptors. Recent advancements in producing structurally defined heparan sulfate have provided new insights into its potential therapeutic applications for periodontitis and bone formation.
PERIODONTOLOGY 2000
(2023)
Article
Engineering, Biomedical
Thomas E. Robinson, Mathieu Y. Brunet, Iain Chapple, Adrian H. M. Heagerty, Anthony D. Metcalfe, Liam M. Grover
Summary: A novel approach using low-cost polysaccharide iota carrageenan is effective at preventing fibrotic diseases and improving quality of life. It inhibits collagen fibril formation, abrogates the TGF-beta 1 pathway, and provides lubrication. The study demonstrates the potential of self-delivering immunomodulatory polysaccharides as a safe and cost-effective platform for clinical benefit.
ADVANCED NANOBIOMED RESEARCH
(2023)
Correction
Biochemistry & Molecular Biology
Siew Chin Chan, Chih-Wei Tung, Chia-Wei Lin, Yun-Shiuan Tung, Po-Min Wu, Pei-Hsun Cheng, Chuan-Mu Chen, Shang-Hsun Yang
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Suyuan Liu, Meiling Tan, Jiangxue Cai, Chenxuan Li, Miaoxin Yang, Xiaoxiao Sun, Bin He
Summary: This study reveals that the antibiotic doxycycline effectively inhibits NLRP3 inflammasome activation by targeting mitochondrial translation and mtDNA synthesis, offering potential for the treatment of NLRP3-related diseases.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Hao Liu, Nana Li, Ge Kuang, Xia Gong, Ting Wang, Jun Hu, Hui Du, Minxuan Zhong, Jiashi Guo, Yao Xie, Yang Xiang, Shengwang Wu, Yiling Yuan, Xinru Yin, Jingyuan Wan, Ke Li
Summary: Protectin D1 (PTD1) improves hepatic steatosis, inflammation and fibrosis in a NASH mouse model by inhibiting the activation of TLR4 downstream signaling pathway, possibly through upregulation of IRAK-M expression, suggesting a potential new treatment for NASH.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
