Article
Materials Science, Multidisciplinary
Jinpeng Sun, Gang Wang, Haoran Wang, Feng Hua, Zeyuan Song, Zhen Jin, Jun Liu, Hongliang Xin, Mingshun Zhang
Summary: This study reports a temperature-sensitive hydroxypropyl chitin hydrogel encapsulating DNase I, which effectively reduces epidural fibrosis after spine surgery. By degrading the DNA backbone of neutrophil extracellular traps (NETs) and dispersing the clustering of myeloperoxidase (MPO) in NETs, the hydrogels loaded with DNase I demonstrated a significant decrease in fibronectin accumulation in the wound.
NPG ASIA MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Apparao B. Kummarapurugu, Shuo Zheng, Jonathan Ma, Shobha Ghosh, Adam Hawkridge, Judith A. Voynow
Summary: Neutrophil extracellular traps (NE) increase cystic fibrosis (CF) airway inflammation. This study found that NE triggers the release of macrophage extracellular traps (METs), thereby enhancing NE-induced CF airway inflammation.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Long Zhang, Bin Zheng, Yang Bai, Jing Zhou, Xin-hua Zhang, Yu-qin Yang, Jing Yu, Hong-ye Zhao, Dong Ma, Han Wu, Jin-kun Wen
Summary: Epidemiological studies have found an association between inflammatory bowel disease (IBD) and increased risk of thrombosis, but the mechanism is unclear. This study demonstrates that IBD promotes the formation of neutrophil extracellular traps (NETs), which contributes to thrombus formation in IBD mice. Furthermore, exosomes derived from IBD mice's plasma induce arterial and venous thrombosis. The study also implicates LINC00668 in the release of NETs and suggests that targeting it could be a potential treatment for IBD-related thrombosis.
Editorial Material
Oncology
Phei Er Saw, Jianing Chen, Erwei Song
Summary: Neutrophil extracellular traps (NETs) are involved in both infection control and tumor metastasis. The study by Mousset et al. published in Cancer Cell reveals that chemotherapy-induced inflammation promotes NETosis in malignant tumors, leading to chemoresistance. This finding highlights the potential of targeting inflammatory NETs for cancer treatment.
Article
Biochemistry & Molecular Biology
Remo Poto, Leonardo Cristinziano, Luca Modestino, Amato de Paulis, Gianni Marone, Stefania Loffredo, Maria Rosaria Galdiero, Gilda Varricchi
Summary: Human neutrophils play a significant role in the host response against pathogens, and recent research has revealed their functional plasticity and involvement in cancer and angiogenesis. Neutrophils release angiogenic factors and form NETs, which promote tumor growth and metastasis through various mechanisms. Understanding the functions of NETs in cancer and angiogenesis could be important for early diagnosis, prevention, and treatment of tumors.
Article
Gastroenterology & Hepatology
Joachim Hog Mortensen, Dovile Sinkeviciute, Tina Manon-Jensen, Viktor Domislovic, Kathryn McCall, Christian S. Thudium, Marko Brinar, Patrik Onnerfjord, Carl S. Goodyear, Zeljko Krznaric, Morten Asser Karsdal, Anne-Christine Bay-Jensen
Summary: The study developed a novel serum calprotectin enzyme-linked immunosorbent assay for monitoring disease activity in inflammatory bowel disease patients. This method showed strong correlations with endoscopic scores and disease severity.
JOURNAL OF CROHNS & COLITIS
(2022)
Article
Biochemistry & Molecular Biology
Wenyuan Zhu, Siqi Yang, Delan Meng, Qingsong Wang, Jianguo Ji
Summary: Increased neutrophil extracellular traps (NETs) formation contributes to the metastasis of colorectal cancer (CRC). This study found that neutrophils from CRC patients have enhanced NETs formation capacity and increased NETs positively correlate with CRC progression. Quantitative proteomic analysis identified decreased secreted protein acidic and rich in cysteine (SPARC) as a key factor in driving massive NETs formation, with integrin alpha 5 beta 1 being the hub protein of NETs-tumor cell interaction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Muhammad H. Shahzad, Lixuan Feng, Xin Su, Ariane Brassard, Iqraa Dhoparee-Doomah, Lorenzo E. Ferri, Jonathan D. Spicer, Jonathan J. Cools-Lartigue
Summary: Neutrophils play a role in cancer by releasing neutrophil extracellular traps (NETs) that interact with cancer cells, driving resistance to therapy. NETs are involved in various mechanisms of therapy resistance, including T-cell exhaustion, drug detoxification, angiogenesis, and extracellular matrix remodeling. Therefore, understanding and targeting NETs is crucial for effective cancer treatment.
Article
Chemistry, Multidisciplinary
Zhaozhong Wang, Chen Chen, Chongdeng Shi, Xiaotian Zhao, Lin Gao, Feiyue Guo, Maosen Han, Zhenmei Yang, Jing Zhang, Chunwei Tang, Cai Zhang, Ying Liu, Peng Sun, Xinyi Jiang
Summary: Neutrophil extracellular traps (NETs) are web-like chromatin structures coated with granule proteins that can trap microorganisms. However, they can also cause damage to host tissue and contribute to the development of various diseases. Researchers developed biomimetic CCDC25-overexpressing cell membrane hybrid liposomes that specifically target NETs and efficiently eliminate them, providing a promising therapeutic approach for NET-associated diseases.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Oncology
Christof Kaltenmeier, Richard L. Simmons, Samer Tohme, Hamza O. Yazdani
Summary: Neutrophil Extracellular Traps (NETs) play a crucial role in cancer progression, particularly in promoting premetastatic niche formation, interacting with circulating cancer cells, and facilitating epithelial to mesenchymal transition during cancer metastasis. Targeting NETs may offer potential treatment options to impede tumor progression.
Article
Oncology
Wei-Wei Wang, Lipei Wu, Wenying Lu, Wei Chen, Wenhui Yan, Chunrun Qi, Shihai Xuan, Anquan Shang
Summary: The study demonstrates that LPS-induced formation of NETs promotes the development and metastasis of colorectal cancer, involving the TLR9 and mitogen-activated protein kinase signaling pathway.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Yan Wang, Mao Yang, Yuanyuan Xu, Shujun Yan, Enze Jin, Xueqi Li
Summary: This study evaluated the association between circulating neutrophil extracellular traps (NETs) markers and coronary artery disease (CAD) in Chinese adults. The levels of dsDNA, MPO, and NE were significantly elevated in patients with CAD, and correlated with the risk factors of atherosclerosis. NET markers were identified as independent risk factors for severe coronary stenosis and also as predictors of severe CAD.
Review
Oncology
Dingchang Li, Jiakang Shao, Bo Cao, Ruiyang Zhao, Hanghang Li, Wenxing Gao, Peng Chen, Lujia Jin, Li Cao, Shuaifei Ji, Guanglong Dong
Summary: Neutrophil extracellular traps (NETs) are products of neutrophil death in response to infection and inflammation, and closely associated with tumor development. The application of NETs in clinical diagnosis, treatment, and prognosis has great potential.
FRONTIERS IN ONCOLOGY
(2022)
Article
Pharmacology & Pharmacy
Ershun Zhou, Youpeng Sun, Yiwu Fu, Xia Wang, Xingyi Zhu, Zhikai Wu, Peixuan Li, Jingjing Wang, Zhengtao Yang
Summary: The study found that BKA triggers NET formation through immunostaining, which is dose- and time-dependent. Furthermore, BKA increased ROS production in neutrophils, and the formation of NETs was associated with ROS-p38 and -ERK signaling pathways, PAD4, and P2X1 receptor.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Hannes A. Baukmann, Justin L. Cope, Colin Bannard, Alexander R. E. C. Schwinges, Margaretha R. J. Lamparter, Sarah Groves, Charles N. J. Ravarani, Borko Amulic, Joern E. Klinger, Marco F. Schmidt
Summary: Despite the availability of vaccines to prevent SARS-CoV-2 infection, treating critically ill COVID-19 patients remains crucial. This study presents an alternative method for identifying drug repurposing targets by screening disease-causing traits, leading to the discovery of potential treatment targets for critical illness.
Article
Orthopedics
Takuya Takami, Yoshiro Itatani, Rintaro Shibuya, Yoshiyuki Kiyasu, Keiko Kasahara, Daisuke Nishizaki, Ryosuke Okamura, Tomoaki Okada, Tatsuto Nishigori, Nobuaki Hoshino, Shigeo Hisamori, Shigeru Tsunoda, Koya Hida, Kenji Kawada, Kazutaka Obama
Summary: Erythropoietic protoporphyria (EPP) is a rare hereditary skin disease characterized by photosensitivity. We report a case of EPP patient who underwent laparoscopic surgery using a laparoscope that did not cause photosensitivity. The surgery was successful without any complications.
ASIAN JOURNAL OF ENDOSCOPIC SURGERY
(2023)
Letter
Gastroenterology & Hepatology
Keita Hanada, Kenji Kawada, Tomoaki Okada, Koji Yamanoi, Masaki Mandai, Kazutaka Obama
COLORECTAL DISEASE
(2023)
Article
Oncology
Hiroyuki Matsubara, Hiroyuki Miyoshi, Fumihiko Kakizaki, Tomonori Morimoto, Kenji Kawada, Takehito Yamamoto, Kazutaka Obama, Yoshiharu Sakai, Makoto Mark Taketo
Summary: Recent advancements in combinatorial chemistry led to the discovery of inhibitors targeting the KRAS G12C-mutant protein, but its monotherapy has limited efficacy on colorectal cancer. Therefore, effective combination drugs should be explored for applicable patients to fully benefit from KRAS G12C inhibitor treatment.
MOLECULAR CANCER THERAPEUTICS
(2023)
Article
Oncology
Daisuke Nishizaki, Yusuke Fujita, Takashi Sakamoto, Akihiro Ueda, Hiroto Kawakami, Masahiro Yamada, Kae Okoshi, Koya Hida, Kazutaka Obama
Summary: This study aimed to support the employment of patients with colorectal cancer by investigating their work-related issues, and found that nonregular employees and the self-employed face difficulties in keeping their jobs after diagnosis. The study suggests that surgeons should address work-related issues at cancer diagnosis and collaborate with occupational physicians.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Oncology
Tomohiro Tate, Saki Matsumoto, Kensaku Nemoto, Matthias Leisegang, Satoshi Nagayama, Kazutaka Obama, Yusuke Nakamura, Kazuma Kiyotani
Summary: This study identified a shared neoantigen derived from FGFR3(Y373C) and demonstrated that immunotherapies targeting shared neoantigens are a promising approach for cancer treatment.
Article
Gastroenterology & Hepatology
Nobuaki Hoshino, Koya Hida, Shinya Yoshida, Kohei Ueno, Tatsuki Noguchi, Soichiro Ishihara, Kenichi Sugihara, Yoichi Ajioka, Kazutaka Obama
Summary: Patients with ulcerative colitis undergoing surgery for colorectal cancer are at risk of postoperative complications, and the type of surgical technique used affects prognosis.
ANNALS OF GASTROENTEROLOGICAL SURGERY
(2023)
Article
Gastroenterology & Hepatology
Hiromitsu Kinoshita, Tatsuto Nishigori, Susumu Kunisawa, Koya Hida, Hisahiro Hosogi, Susumu Inamoto, Hiroaki Hata, Ryo Matsusue, Yuichi Imanaka, Kazutaka Obama, Yumi Matsumura
Summary: This study aims to evaluate the accuracy of extracting patients who underwent GI cancer surgery and postoperative complications from Japanese administrative claims data. The method was validated using data from Kyoto University Hospital and two other hospitals, and the results showed that it accurately identified postoperative complications requiring interventions. This study is of great importance for hospital quality improvement or large-scale comparison studies among nationwide hospitals.
ANNALS OF GASTROENTEROLOGICAL SURGERY
(2023)
Article
Orthopedics
Yusuke Fujita, Yoshiro Itatani, Kenji Kawada, Takayuki Sumiyoshi, Shusuke Akamatsu, Itaru Tsuge, Takuya Okada, Masakazu Fujimoto, Takuya Okamoto, Kazuhiro Nishiyama, Keiko Kasahara, Shintaro Okumura, Ryosuke Okamura, Hisatsugu Maekawa, Tatsuto Nishigori, Nobuaki Hoshino, Shigeo Hisamori, Shigeru Tsunoda, Koya Hida, Kazutaka Obama
Summary: A 47-year-old man who had previously undergone low anterior resection for rectal cancer developed an implantation cyst at the anastomotic site 24 years later. Two years after the cyst was diagnosed, pathological examination revealed adenocarcinoma. The patient underwent laparoscopic total pelvic exenteration for suspected invasion into surrounding organs.
ASIAN JOURNAL OF ENDOSCOPIC SURGERY
(2023)
Article
Otorhinolaryngology
Yo Kishimoto, Yoshitaka Kawai, Shintaro Fujimura, Ayana Komurasaki, Katsuyuki Sakanaka, Shigeru Tsunoda, Takashi Mizowaki, Kazutaka Obama, Manabu Muto, Koichi Omori
CLINICAL OTOLARYNGOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Daigo Gunji, Ryohei Narumi, Satoshi Muraoka, Junko Isoyama, Narumi Ikemoto, Mimiko Ishida, Takeshi Tomonaga, Yoshiharu Sakai, Kazutaka Obama, Jun Adachi
Summary: Colorectal cancer is a common and life-threatening tumor worldwide. Mutations in KRAS and BRAF, the major driver mutations in CRC, activate the RAS pathway and contribute to tumorigenesis. In this study, we conducted proteomics and phosphoproteomics analysis on CRC cell lines, revealing dysregulated protein-protein associations specific to KRAS-mutant cells and activation of EPHA2 kinase and downstream signaling. Additionally, we identified a phosphorylation site Y378 in the tight junction protein PARD3 as a vulnerability in KRAS-mutant cells. These findings provide valuable insights into the molecular characteristics of oncogenic mutations in CRC.