Review
Immunology
Zaib A. Shaheryar, Mahtab A. Khan, Ch. Sherjeel Adnan, Awais Ali Zaidi, Daniel Hanggi, Sajjad Muhammad
Summary: Ischemic stroke is a major cause of mortality and morbidity globally, but there is currently no definitive and effective treatment. Various treatment options have been proposed, but targeting the intricate intracellular signaling pathways of the 'neuroinflammatory triangle' may be more pragmatic in limiting post-stroke damage and disabilities.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Peripheral Vascular Disease
Jiping Yang, Zairan Wang, Xiuying Liu, Pengchao Lu
Summary: Ischemic stroke leads to oxidative stress damage to endothelial cells and disruption of the blood-brain barrier, potentially causing inflammation and progression of brain injury. Antioxidants and Peroxiredoxin 4 (Prx4) may play a protective role in ECs and contribute to vascular integrity following a cerebral I/R injury.
MICROVASCULAR RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
S. M. Lunin, E. G. Novoselova, O. V. Glushkova, S. B. Parfenyuk, A. A. Kuzekova, T. V. Novoselova, M. G. Sharapov, E. K. Mubarakshina, R. G. Goncharov, M. O. Khrenov
Summary: This study showed that the immunomodulator thymulin and the antioxidant enzyme Prdx6 can improve the condition of blood-brain barrier (BBB) and alleviate symptoms of experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis. Thymulin decreased immune cell activation, while Prdx6 reduced NOX1 and NOX4 gene expression in brain tissue, contributing to the improvements in BBB condition and health status. Simultaneous administration of thymulin and Prdx6 resulted in complete symptomatic restoration of mice with EAE.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2023)
Review
Biochemistry & Molecular Biology
Sara Salatin, Mehdi Farhoudi, Afsaneh Farjami, Solmaz Maleki Dizaj, Simin Sharifi, Shahriar Shahi
Summary: Stroke is a leading cause of morbidity and mortality worldwide, but effective treatment options are lacking. Reactive oxygen species (ROS) have been identified as a major factor in brain injury after ischemic stroke. Antioxidant therapy appears to be effective in managing oxidative stress related to inflammatory disorders like stroke, but traditional antioxidants are limited in their distribution and localization in the body. However, recent breakthroughs in the use of antioxidant nanoparticles (NPs) have shown promise in stroke treatment by efficiently delivering antioxidants to the damaged areas of the brain.
Article
Medicine, Research & Experimental
Xingyong Chen, Yanguang Mao, Yueting Guo, Dongyun Xiao, Zejing Lin, Yiyi Huang, Ying Chun Liu, Xu Zhang, Yinzhou Wang
Summary: This study aims to explore the contribution of the immunoproteasome subunit LMP2 in neurobehavioral functions. The results showed that LMP2 gene deletion caused metabolic abnormalities, cognitive impairment, increased anxiety-like behavior, multiple myelin loss, increased blood-brain barrier leakage, and enhanced amyloid-beta protein deposition in rats. These factors led to chronic oxidative stress and neuroinflammation in the brain, contributing to cognitive impairment.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Immunology
Dandan Wu, Xuehui Chen, Shuqiu Zhou, Bin Li
Summary: Glioma, the most common primary intracranial tumor in adults, has poor prognosis. Current treatment methods, including surgery and chemoradiotherapy, have limited efficacy. The emerging field of nanotechnology offers a new approach called reactive oxygen species (ROS)-based nanotherapy, which generates large amounts of ROS in glioma cells to effectively eliminate the tumor. Nanotechnology also provides strategies to cross the blood-brain barrier, allowing effective ROS-based nanotherapy for glioma. This review summarizes the application of ROS-based nanomedicine in glioma treatment and discusses the current challenges and future prospects for clinical translation.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Yeonjae Kim, A. Yeon Cho, Hong Cheol Kim, Dajung Ryu, Sangmee Ahn Jo, Yi-Sook Jung
Summary: Blood-brain barrier dysfunction is a common feature of neurodegenerative diseases, and reactive oxygen species play a key role in this process. Antioxidants have been shown to have beneficial effects on BBB dysfunction-related brain diseases.
Article
Clinical Neurology
Mark A. Petersen, Reshmi Tognatta, Anke Meyer-Franke, Eric A. Bushong, Andrew S. Mendiola, Zhaoqi Yan, Abinaya Muthusamy, Mario Merlini, Rosa Meza-Acevedo, Belinda Cabriga, Yungui Zhou, Reuben Thomas, Jae Kyu Ryu, Hans Lassmann, Mark H. Ellisman, Katerina Akassoglou
Summary: In neuroinflammatory lesions, extrinsic inhibitors such as fibrinogen lead to clustering of oligodendrocyte precursor cells and hinder remyelination, but blocking the bone morphogenetic protein signaling pathway can restore the promyelinating niche and have therapeutic effects.
Review
Biochemistry & Molecular Biology
Thomas Gabriel Schreiner, Constantin Romanescu, Bogdan Ovidiu Popescu
Summary: This article reviews the role of the blood-brain barrier (BBB) in multiple sclerosis (MS) pathology, emphasizing the importance of neurovascular unit damage in MS onset and progression, as well as the impact of BBB cell alterations and immune cell penetration into the central nervous system on MS pathology.
Article
Biochemistry & Molecular Biology
Mohammad S. Akhter, Nektarios Barabutis
Summary: GHRH is a hypothalamic hormone that regulates growth hormone secretion, and GHRHAnt can counteract the pathological effects of GHRH while also exhibiting anti-inflammatory and antioxidative properties. Research shows that GHRHAnt has antioxidative effects in cells expressing GHRH receptors.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2021)
Article
Pharmacology & Pharmacy
Qianqian Zhao, Wenxian Du, Lingling Zhou, Jianrong Wu, Xiaoxing Zhang, Xiaoer Wei, Sijia Wang, Yu Huang, Yuehua Li
Summary: In this study, a targeted transferrin-based manganese dioxide nanozyme was designed to rebalance reactive oxygen species (ROS) levels for neuroprotection. The nanozyme not only crossed the blood-brain barrier and accumulated in the lesion area, but also demonstrated satisfactory biocompatibility and biosafety. In addition to its ability to scavenge free radicals and reduce inflammatory response, the nanozyme released Mn2+ ions that can be used for magnetic resonance imaging to monitor the treatment process.
Article
Chemistry, Multidisciplinary
Wenlong Zhang, Huaqing Chen, Liuyan Ding, Junwei Gong, Mengran Zhang, Wenyuan Guo, Pingyi Xu, Shiying Li, Yunlong Zhang
Summary: In this study, a Trojan horse system was used for targeted delivery of a blood brain barrier-penetrating peptide (RVG29) conjugated to nanoparticles loaded with the natural autophagy inducer 4,4 '-dimethoxychalcone (DMC) for the treatment of Parkinson's disease. The neuroprotective effects of DMC were demonstrated, showing improvement in motor deficits and nigral DA neuron death in PD mice without causing adverse effects. rvanism by using RVG-nDMC provides a potentially effective approach for intervention against Parkinson's disease.
Review
Biochemistry & Molecular Biology
Jeanette A. M. Maier, Laura Locatelli, Giorgia Fedele, Alessandra Cazzaniga, Andre Mazur
Summary: Magnesium plays a crucial role in regulating metabolism and maintaining tissue homeostasis, including the brain. It is essential for nerve signal transmission and protecting the blood-brain barrier. Deficiency in magnesium can lead to systemic low-grade inflammation, which is common in various diseases, particularly neurodegenerative disorders. This review provides evidence linking magnesium imbalance to multiple sclerosis, Alzheimer's, and Parkinson's diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, Research & Experimental
Lu Pang, Yun Wang
Summary: This review discusses the impact of METH abuse on the blood-brain barrier (BBB) and its potential role in neurodegenerative diseases. It also explores the risk factors and potential therapeutic agents for treating METH-induced BBB dysfunction.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Biochemistry & Molecular Biology
Roberta Lattanzi, Rossella Miele
Summary: Prokineticins are a new class of peptides that play a crucial role in neuroinflammatory processes, regulating neuronal-glial interactions and T cell function. PK2 and PKRs are upregulated during inflammation, influencing inflammatory responses and directing T cells towards a pro-inflammatory phenotype.
Article
Pharmacology & Pharmacy
Mohammed A. A. Saleh, Elizabeth C. M. de Lange
Summary: This study investigated the impact of altered cerebral blood flow, tight junction paracellular pore radius, brain extracellular fluid volume, and pH values on drug transport and concentrations in the central nervous system. The results showed drug-dependent effects of pathophysiological changes on blood-brain barrier transport and drug concentrations within the brain extracellular and intracellular fluid. Changes in pore radius, pH values, and blood flow affected the rate and extent of drug transport, highlighting the importance of considering these factors in drug delivery to the brain.
Article
Clinical Neurology
Carmen Picon, Anusha Jayaraman, Rachel James, Catriona Beck, Patricia Gallego, Maarten E. Witte, Jack van Horssen, Nicholas D. Mazarakis, Richard Reynolds
Summary: The study suggests that in the cortex of multiple sclerosis, necroptosis induced by TNF may be more common than apoptosis, possibly initiated by chronic meningeal inflammation. Neuronal necroptosis represents a pathogenetic mechanism that is amenable to therapeutic intervention at several points in the signaling pathway.
ACTA NEUROPATHOLOGICA
(2021)
Review
Hematology
Sanny Scheffer, Dorien M. A. Hermkens, Louise van der Weerd, Helga E. de Vries, Mat J. A. P. Daemen
Summary: Alzheimer's disease is characterized by neurodegeneration, neuroinflammation, and cognitive decline. Cardiovascular disease has been identified as an important contributor to the development and progression of AD, known as the vascular hypothesis. Vascular risk factors are associated with an increased chance of developing AD, with chronic cerebral hypoperfusion suggested to play a key role in disease onset.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Wieke M. van Oostveen, Elizabeth C. M. de Lange
Summary: This review discusses the contemporary methods of early diagnosis and longitudinal monitoring of AD using imaging techniques, examining their diagnostic utility, benefits, and limitations. Additionally, it assesses novel techniques, applications, and biomarkers for AD research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Nienke M. de Wit, Kevin Mol, Sabela Rodriguez-Lorenzo, Helga E. de Vries, Gijs Kooij
Summary: Alzheimer's disease is the leading cause of dementia worldwide, characterized by extracellular amyloid deposition, neurofibrillary tangles, and chronic neuroinflammation. There is currently no cure for prevention of Alzheimer's disease, but manipulating bioactive lipid pathways may offer novel therapeutic approaches to resolve chronic neuroinflammation.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Oncology
Asima Abidi, Mark A. J. Gorris, Evan Brennan, Marjolijn C. J. Jongmans, Dilys D. Weijers, Roland P. Kuiper, Richarda M. de Voer, Nicoline Hoogerbrugge, Gerty Schreibelt, I. Jolanda M. de Vries
Summary: Lynch syndrome (LS) and constitutional mismatch repair deficiency (CMMRD) are hereditary disorders characterized by a significantly increased risk of cancer development due to germline mutations in DNA repair genes. Although the high mutation load in tumors of these patients may generate neoantigens for immune therapies, challenges such as tumor heterogeneity and resistance to immune checkpoint therapy need to be addressed. New approaches, including precise HLA binding algorithms and additional therapies to counter immune evasion, are warranted to optimize neoantigen targeting strategies.
Review
Biochemistry & Molecular Biology
Merel Rijnsburger, Niek Djuric, Inge A. Mulder, Helga E. de Vries
Summary: Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system, with significant impact on patients and their proxies. Obesity is associated with an increased risk of developing MS. Adipokines play a crucial role in MS pathology and may have therapeutic potential in targeting neuroinflammation and neurodegeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Geriatrics & Gerontology
Sandra den Hoedt, Simone M. Crivelli, Frank P. J. Leijten, Mario Losen, Jo A. A. Stevens, Marina Mane-Damas, Helga E. de Vries, Jochen Walter, Mina Mirzaian, Eric J. G. Sijbrands, Johannes M. F. G. Aerts, Adrie J. M. Verhoeven, Pilar Martinez-Martinez, Monique T. Mulder
Summary: The study found that sex is a stronger determinant of brain ceramide levels in mice than APOE genotype, AD background, or age. Whether these differences impact AD neuropathology in men and women remains to be investigated.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Review
Geriatrics & Gerontology
Antia Custodia, Alberto Ouro, Daniel Romaus-Sanjurjo, Juan Manuel Pias-Peleteiro, Helga E. de Vries, Jose Castillo, Tomas Sobrino
Summary: Alzheimer's disease is a neurodegenerative disease with a complex and unknown etiology. The two-hit vascular hypothesis suggests that brain vascular damage leads to the accumulation of beta-amyloid protein. Research has shown that endothelial progenitor cells play a significant role in understanding the disease etiology and developing potential therapies.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Cell Biology
Haoxiao Zuo, Marie-Jose C. Van Lierop, Jorn Kaspers, Remco Bos, Anneke Reurs, Saheli Sarkar, Tania Konry, Alwin Kamermans, Gijs Kooij, Helga E. de Vries, Tanja D. de Gruijl, Alex Karlsson-Parra, Erik H. Manting, Ada M. Kruisbeek, Satwinder Kaur Singh
Summary: DCP-001 is a cell-based cancer vaccine that has been shown to be safe and feasible as a post-remission therapy in acute myeloid leukemia. It works by activating and recruiting host antigen-presenting cells to capture tumor-associated antigens and stimulate tumor-reactive T-cells. The improved uptake of DCP-001 by blocking CD47 suggests potential combination therapies with CD47 blocking agents.
Article
Neurosciences
Nienke R. Wevers, Arya Lekshmi Nair, Tania M. Fowke, Maria Pontier, Dhanesh G. Kasi, Xandor M. Spijkers, Charlie Hallard, Gwenaelle Rabussier, Remko van Vught, Paul Vulto, Helga E. de Vries, Henriette L. Lanz
Summary: The study introduces a human NVU on-a-chip model that mimics ischemic stroke, offering potential applications in NVU function research and drug screening. Key findings include insights into brain endothelial cells and neuronal function within the model, highlighting its potential for further investigations in neurological disorders.
FLUIDS AND BARRIERS OF THE CNS
(2021)
Review
Neurosciences
I. A. Mulder, E. T. van Bavel, H. E. de Vries, J. M. Coutinho
Summary: This review provides an overview of compounds tested in clinical AIS trials and gives insight into which of these drugs warrant a re-evaluation as an add-on therapy for AIS in the era of EVT. Main trial outcomes and safety issues are summarized and promising compounds for re-evaluation are highlighted. Looking at group effect, drugs intervening with oxidative and nitrosative stress and neurogenesis/-regeneration and -recovery appear to have a favourable safety profile and show the most promising results regarding efficacy.
FLUIDS AND BARRIERS OF THE CNS
(2021)
Article
Biology
Sabela Rodriguez-Lorenzo, Lynn van Olst, Carla Rodriguez-Mogeda, Alwin Kamermans, Susanne M. A. van der Pol, Ernesto Rodriguez, Gijs Kooij, Helga E. de Vries
Summary: In this study, the immune landscape of periventricular brain regions in patients with MS was analyzed using single-cell mass cytometry (CyTOF). The results showed the accumulation of CD56(bright) NK cells in the brain regions of MS patients, bringing NK cells back into the spotlight of MS pathology.
Review
Neurosciences
Parand Zarekiani, Henrique Nogueira Pinto, Elly M. Hol, Marianna Bugiani, Helga E. de Vries
Summary: The neurovascular unit (NVU) is a highly organized multicellular system in the brain, consisting of neuronal, glial, and vascular cells. Dysfunctions of the NVU occur in various neurological disorders, but little is known about its function in leukodystrophies. Human induced pluripotent stem cells (hiPSC) offer a solution to overcome the limitations of studying leukodystrophies, providing a biologically relevant human context and preserving the patient's genetic background. This review focuses on the NVU function in leukodystrophies and the use of hiPSC-derived models to study neurovascular pathophysiology in these diseases.
FLUIDS AND BARRIERS OF THE CNS
(2022)
Review
Biochemistry & Molecular Biology
Chunyuan Yin, Amy C. C. Harms, Thomas Hankemeier, Alida Kindt, Elizabeth C. M. de Lange
Summary: Alzheimer's disease is an aging-related neurodegenerative disease that leads to progressive memory loss and cognitive decline. Understanding the pathogenesis and etiology of the disease is still limited, and there are no effective treatments available. Metabolomics offers a valuable approach to studying biochemical changes and discovering potential therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Correction
Biochemistry & Molecular Biology
Siew Chin Chan, Chih-Wei Tung, Chia-Wei Lin, Yun-Shiuan Tung, Po-Min Wu, Pei-Hsun Cheng, Chuan-Mu Chen, Shang-Hsun Yang
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Suyuan Liu, Meiling Tan, Jiangxue Cai, Chenxuan Li, Miaoxin Yang, Xiaoxiao Sun, Bin He
Summary: This study reveals that the antibiotic doxycycline effectively inhibits NLRP3 inflammasome activation by targeting mitochondrial translation and mtDNA synthesis, offering potential for the treatment of NLRP3-related diseases.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Hao Liu, Nana Li, Ge Kuang, Xia Gong, Ting Wang, Jun Hu, Hui Du, Minxuan Zhong, Jiashi Guo, Yao Xie, Yang Xiang, Shengwang Wu, Yiling Yuan, Xinru Yin, Jingyuan Wan, Ke Li
Summary: Protectin D1 (PTD1) improves hepatic steatosis, inflammation and fibrosis in a NASH mouse model by inhibiting the activation of TLR4 downstream signaling pathway, possibly through upregulation of IRAK-M expression, suggesting a potential new treatment for NASH.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)